4i12 - Revision history

OCA at 08:33, 9 November 2022

2022-11-09T08:33:12Z

←Older revision		Revision as of 08:33, 9 November 2022
Line 1:		Line 1:

	==Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors==		==Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors==
-	<StructureSection load='4i12' size='340' side='right' caption='[[4i12]], [[Resolution\|resolution]] 1.78Å' scene=''>	+	<StructureSection load='4i12' size='340' side='right'caption='[[4i12]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4i12]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I12 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4I12 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4i12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I12 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1BC:2-{(1S)-1-{[(1Z)-6-CHLORO-3,3-DIMETHYL-3,4-DIHYDROISOQUINOLIN-1(2H)-YLIDENE]AMINO}-2-[2-PROPYL-4-(1H-PYRAZOL-4-YL)THIOPHEN-3-YL]ETHYL}PYRIMIDIN-4(5H)-ONE'>1BC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1BC:2-{(1S)-1-{[(1Z)-6-CHLORO-3,3-DIMETHYL-3,4-DIHYDROISOQUINOLIN-1(2H)-YLIDENE]AMINO}-2-[2-PROPYL-4-(1H-PYRAZOL-4-YL)THIOPHEN-3-YL]ETHYL}PYRIMIDIN-4(5H)-ONE'>1BC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hzi\|4hzi]], [[4i0z\|4i0z]], [[4i0e\|4i0e]], [[4i0d\|4i0d]], [[4i0f\|4i0f]], [[4i0g\|4i0g]], [[4i10\|4i10]], [[4i1c\|4i1c]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i12 OCA], [https://pdbe.org/4i12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i12 RCSB], [https://www.ebi.ac.uk/pdbsum/4i12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i12 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4i12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i12 OCA], [~~http~~://pdbe.org/4i12 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4i12 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4i12 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4i12 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>	+	[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4i12" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4i12" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta secretase 3D structures\|Beta secretase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Memapsin 2~~]]	+	[[Category: Large Structures]]
-	[[Category: Brecht, E]]	+	[[Category: Brecht E]]
-	[[Category: Lougheed~~, J C~~]]	+	[[Category: Lougheed JC]]
-	[[Category: Yao~~, N H]]~~	+	[[Category: Yao NH]]
-	~~[[Category: Aspartic protease]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 20:01, 24 January 2018

2018-01-24T20:01:38Z

←Older revision		Revision as of 20:01, 24 January 2018
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4i12" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4i12" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Beta secretase\|Beta secretase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:20, 4 August 2016

2016-08-04T14:20:43Z

←Older revision		Revision as of 14:20, 4 August 2016
Line 1:		Line 1:
		+
	==Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors==		==Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors==
	<StructureSection load='4i12' size='340' side='right' caption='[[4i12]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='4i12' size='340' side='right' caption='[[4i12]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4i12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I12 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4i12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I12 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1BC:2-{(1S)-1-{[(1Z)-6-CHLORO-3,3-DIMETHYL-3,4-DIHYDROISOQUINOLIN-1(2H)-YLIDENE]AMINO}-2-[2-PROPYL-4-(1H-PYRAZOL-4-YL)THIOPHEN-3-YL]ETHYL}PYRIMIDIN-4(5H)-ONE'>1BC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1BC:2-{(1S)-1-{[(1Z)-6-CHLORO-3,3-DIMETHYL-3,4-DIHYDROISOQUINOLIN-1(2H)-YLIDENE]AMINO}-2-[2-PROPYL-4-(1H-PYRAZOL-4-YL)THIOPHEN-3-YL]ETHYL}PYRIMIDIN-4(5H)-ONE'>1BC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hzi\|4hzi]], [[4i0z\|4i0z]], [[4i0e\|4i0e]], [[4i0d\|4i0d]], [[4i0f\|4i0f]], [[4i0g\|4i0g]], [[4i10\|4i10]], [[4i1c\|4i1c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hzi\|4hzi]], [[4i0z\|4i0z]], [[4i0e\|4i0e]], [[4i0d\|4i0d]], [[4i0f\|4i0f]], [[4i0g\|4i0g]], [[4i10\|4i10]], [[4i1c\|4i1c]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i12 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i12 RCSB], [http://www.ebi.ac.uk/pdbsum/4i12 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i12 OCA], [http://pdbe.org/4i12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i12 RCSB], [http://www.ebi.ac.uk/pdbsum/4i12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i12 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4i12" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Brecht, E]]		[[Category: Brecht, E]]

OCA at 15:38, 24 December 2014

2014-12-24T15:38:18Z

←Older revision		Revision as of 15:38, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4i12\| PDB=4i12 \| SCENE= }}~~	+	==Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors==
-	===Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors===	+	<StructureSection load='4i12' size='340' side='right' caption='[[4i12]], [[Resolution\|resolution]] 1.78Å' scene=''>
-	{{~~ABSTRACT_PUBMED_23570791~~}}	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4i12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I12 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1BC:2-{(1S)-1-{[(1Z)-6-CHLORO-3,3-DIMETHYL-3,4-DIHYDROISOQUINOLIN-1(2H)-YLIDENE]AMINO}-2-[2-PROPYL-4-(1H-PYRAZOL-4-YL)THIOPHEN-3-YL]ETHYL}PYRIMIDIN-4(5H)-ONE'>1BC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hzi\|4hzi]], [[4i0z\|4i0z]], [[4i0e\|4i0e]], [[4i0d\|4i0d]], [[4i0f\|4i0f]], [[4i0g\|4i0g]], [[4i10\|4i10]], [[4i1c\|4i1c]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i12 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i12 RCSB], [http://www.ebi.ac.uk/pdbsum/4i12 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>		[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Utilizing a structure based design approach, combined with extensive medicinal chemistry execution, highly selective, potent and novel BACE1 inhibitor 8 (BACE1 Alpha assay IC50=8nM) was made from a weak muM potency hit in an extremely efficient way. The detailed SAR and general design approaches will be discussed.

-	~~==About this Structure==~~	+	Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.,Xu YZ, Yuan S, Bowers S, Hom RK, Chan W, Sham HL, Zhu YL, Beroza P, Pan H, Brecht E, Yao N, Lougheed J, Yan J, Tam D, Ren Z, Ruslim L, Bova MP, Artis DR Bioorg Med Chem Lett. 2013 May 15;23(10):3075-80. doi:, 10.1016/j.bmcl.2013.03.009. Epub 2013 Mar 21. PMID:23570791<ref>PMID:23570791</ref>
-	~~[[4i12]] is a 1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4I12 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Beta secretase\|Beta secretase]]		*[[Beta secretase\|Beta secretase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023570791</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Brecht, E]]		[[Category: Brecht, E]]
-	[[Category: Lougheed, J C.]]	+	[[Category: Lougheed, J C]]
-	[[Category: Yao, N H.]]	+	[[Category: Yao, N H]]
	[[Category: Aspartic protease]]		[[Category: Aspartic protease]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 14:03, 3 July 2013

2013-07-03T14:03:28Z

←Older revision		Revision as of 14:03, 3 July 2013
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4i12]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I12 OCA].	+	[[4i12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I12 OCA].

	==See Also==		==See Also==
Line 14:		Line 14:
	==Reference==		==Reference==
	<ref group="xtra">PMID:023570791</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:023570791</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Brecht, E]]		[[Category: Brecht, E]]

OCA at 12:19, 3 July 2013

2013-07-03T12:19:57Z

←Older revision		Revision as of 12:19, 3 July 2013
Line 1:		Line 1:
-	[[Image:4i12.jpg\|left\|200px]]
-
	{{STRUCTURE_4i12\| PDB=4i12 \| SCENE= }}		{{STRUCTURE_4i12\| PDB=4i12 \| SCENE= }}
-
	===Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors===		===Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors===
		+	{{ABSTRACT_PUBMED_23570791}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>

	==About this Structure==		==About this Structure==
-	[[4i12]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I12 OCA].	+	[[4i12]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I12 OCA].
-	[[~~Category: Homo sapiens~~]]	+
		+	==See Also==
		+	*[[Beta secretase\|Beta secretase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023570791</ref><references group="xtra"/><references/>
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Brecht, E]]		[[Category: Brecht, E]]

OCA at 14:29, 6 March 2013

2013-03-06T14:29:02Z

←Older revision		Revision as of 14:29, 6 March 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4i12.jpg\|left\|200px]]

-	~~The entry~~ 4i12 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_4i12\| PDB=4i12 \| SCENE= }}

-	~~Authors: Lougheed, J.C., Brecht, E, Yao, N.H.~~	+	===Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors===

-	~~Description~~: ~~Design and synthesis of thiophene dihydroisoquinolins as novel BACE~~-~~1 inhibitors~~	+
		+	==About this Structure==
		+	[[4i12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I12 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Memapsin 2]]
		+	[[Category: Brecht, E]]
		+	[[Category: Lougheed, J C.]]
		+	[[Category: Yao, N H.]]
		+	[[Category: Aspartic protease]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 11:02, 19 December 2012

2012-12-19T11:02:14Z

←Older revision		Revision as of 11:02, 19 December 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4i12 is ON HOLD	+	The entry 4i12 is ON HOLD until Paper Publication

	Authors: Lougheed, J.C., Brecht, E, Yao, N.H.		Authors: Lougheed, J.C., Brecht, E, Yao, N.H.

	Description: Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors		Description: Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors

OCA: Protected "4i12" [edit=sysop:move=sysop]

2012-11-28T14:06:52Z

Protected "4i12" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:06, 28 November 2012

OCA: New page: '''Unreleased structure''' The entry 4i12 is ON HOLD Authors: Lougheed, J.C., Brecht, E, Yao, N.H. Description: Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 in...

2012-11-28T14:06:51Z

New page: '''Unreleased structure''' The entry 4i12 is ON HOLD Authors: Lougheed, J.C., Brecht, E, Yao, N.H. Description: Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 in...

New page

'''Unreleased structure'''

The entry 4i12 is ON HOLD

Authors: Lougheed, J.C., Brecht, E, Yao, N.H.

Description: Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors