4i9u - Revision history

OCA at 15:18, 20 September 2023

2023-09-20T15:18:12Z

←Older revision		Revision as of 15:18, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4i9u]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I9U FirstGlance]. <br>		<table><tr><td colspan='2'>[[4i9u]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I9U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1E7:6-({2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-2-OXOETHYL}SULFANYL)PYRIDINE-3-CARBOXYLIC+ACID'>1E7</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1E7:6-({2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-2-OXOETHYL}SULFANYL)PYRIDINE-3-CARBOXYLIC+ACID'>1E7</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i9u OCA], [https://pdbe.org/4i9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i9u RCSB], [https://www.ebi.ac.uk/pdbsum/4i9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i9u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i9u OCA], [https://pdbe.org/4i9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i9u RCSB], [https://www.ebi.ac.uk/pdbsum/4i9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i9u ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:50, 9 November 2022

2022-11-09T08:50:42Z

←Older revision		Revision as of 08:50, 9 November 2022
Line 3:		Line 3:
	<StructureSection load='4i9u' size='340' side='right'caption='[[4i9u]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4i9u' size='340' side='right'caption='[[4i9u]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4i9u]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4I9U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4i9u]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I9U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1E7:6-({2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-2-OXOETHYL}SULFANYL)PYRIDINE-3-CARBOXYLIC+ACID'>1E7</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1E7:6-({2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-2-OXOETHYL}SULFANYL)PYRIDINE-3-CARBOXYLIC+ACID'>1E7</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i8x\|4i8x]], [[4i9h\|4i9h]], [[4i9n\|4i9n]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i9u OCA], [https://pdbe.org/4i9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i9u RCSB], [https://www.ebi.ac.uk/pdbsum/4i9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i9u ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4i9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i9u OCA], [~~http~~://pdbe.org/4i9u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4i9u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4i9u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4i9u ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LDHA_RABIT LDHA_RABIT]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Lactate ~~Dehydrogenase~~\|Lactate ~~Dehydrogenase~~]]	+	*[[Lactate dehydrogenase 3D structures\|Lactate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: L-lactate dehydrogenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Commodore, L]]	+	[[Category: Commodore L]]
-	[[Category: Dalgarno~~, D C~~]]	+	[[Category: Dalgarno DC]]
-	[[Category: Greenfield~~, M T~~]]	+	[[Category: Greenfield MT]]
-	[[Category: Kohlmann, A]]	+	[[Category: Kohlmann A]]
-	[[Category: Stephan~~, Z G~~]]	+	[[Category: Stephan ZG]]
-	[[Category: Zhou, T]]	+	[[Category: Zhou T]]
-	[[Category: Zhu, X]]	+	[[Category: Zhu X]]
-	~~[[Category: Cancer]]~~	+
-	~~[[Category: Fragment]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex~~]]	+

OCA at 07:30, 27 March 2019

2019-03-27T07:30:31Z

←Older revision		Revision as of 07:30, 27 March 2019
Line 1:		Line 1:

	==Crystal structure of rabbit LDHA in complex with a fragment inhibitor AP26256==		==Crystal structure of rabbit LDHA in complex with a fragment inhibitor AP26256==
-	<StructureSection load='4i9u' size='340' side='right' caption='[[4i9u]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4i9u' size='340' side='right'caption='[[4i9u]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4i9u]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I9U FirstGlance]. <br>		<table><tr><td colspan='2'>[[4i9u]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I9U FirstGlance]. <br>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
		+	[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Commodore, L]]		[[Category: Commodore, L]]

OCA at 07:19, 23 December 2016

2016-12-23T07:19:31Z

←Older revision		Revision as of 07:19, 23 December 2016
Line 1:		Line 1:
		+
	==Crystal structure of rabbit LDHA in complex with a fragment inhibitor AP26256==		==Crystal structure of rabbit LDHA in complex with a fragment inhibitor AP26256==
	<StructureSection load='4i9u' size='340' side='right' caption='[[4i9u]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4i9u' size='340' side='right' caption='[[4i9u]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i8x\|4i8x]], [[4i9h\|4i9h]], [[4i9n\|4i9n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i8x\|4i8x]], [[4i9h\|4i9h]], [[4i9n\|4i9n]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i9u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i9u RCSB], [http://www.ebi.ac.uk/pdbsum/4i9u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i9u OCA], [http://pdbe.org/4i9u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i9u RCSB], [http://www.ebi.ac.uk/pdbsum/4i9u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i9u ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4i9u" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 16:54, 10 December 2014

2014-12-10T16:54:19Z

←Older revision		Revision as of 16:54, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4i9u.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of rabbit LDHA in complex with a fragment inhibitor AP26256==
		+	<StructureSection load='4i9u' size='340' side='right' caption='[[4i9u]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4i9u]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I9U FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1E7:6-({2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-2-OXOETHYL}SULFANYL)PYRIDINE-3-CARBOXYLIC+ACID'>1E7</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i8x\|4i8x]], [[4i9h\|4i9h]], [[4i9n\|4i9n]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i9u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i9u RCSB], [http://www.ebi.ac.uk/pdbsum/4i9u PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lactate dehydrogenase A (LDH-A) catalyzes the interconversion of lactate and pyruvate in the glycolysis pathway. Cancer cells rely heavily on glycolysis instead of oxidative phosphorylation to generate ATP, a phenomenon known as the Warburg effect. The inhibition of LDH-A by small molecules is therefore of interest for potential cancer treatments. We describe the identification and optimization of LDH-A inhibitors by fragment-based drug discovery. We applied ligand based NMR screening to identify low affinity fragments binding to LDH-A. The dissociation constants (K(d)) and enzyme inhibition (IC(50)) of fragment hits were measured by surface plasmon resonance (SPR) and enzyme assays, respectively. The binding modes of selected fragments were investigated by X-ray crystallography. Fragment growing and linking, followed by chemical optimization, resulted in nanomolar LDH-A inhibitors that demonstrated stoichiometric binding to LDH-A. Selected molecules inhibited lactate production in cells, suggesting target-specific inhibition in cancer cell lines.

-	~~{{STRUCTURE_4i9u\| PDB=4i9u \| SCENE= }}~~	+	Fragment Growing and Linking Lead to Novel Nanomolar Lactate Dehydrogenase Inhibitors.,Kohlmann A, Zech SG, Li F, Zhou T, Squillace RM, Commodore L, Greenfield MT, Lu X, Miller DP, Huang WS, Qi J, Thomas RM, Wang Y, Zhang S, Dodd R, Liu S, Xu R, Xu Y, Miret JJ, Rivera V, Clackson T, Shakespeare WC, Zhu X, Dalgarno DC J Med Chem. 2013 Jan 9. PMID:23302067<ref>PMID:23302067</ref>

-	~~===Crystal structure of rabbit LDHA in complex with~~ a ~~fragment inhibitor AP26256===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23302067}}~~	+	==See Also==
-		+	*[[Lactate Dehydrogenase\|Lactate Dehydrogenase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4i9u~~]] ~~is a 8 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9U OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Commodore, L.]]	+	[[Category: Commodore, L]]
-	[[Category: Dalgarno, D C.]]	+	[[Category: Dalgarno, D C]]
-	[[Category: Greenfield, M T.]]	+	[[Category: Greenfield, M T]]
-	[[Category: Kohlmann, A.]]	+	[[Category: Kohlmann, A]]
-	[[Category: Stephan, Z G.]]	+	[[Category: Stephan, Z G]]
-	[[Category: Zhou, T.]]	+	[[Category: Zhou, T]]
-	[[Category: Zhu, X.]]	+	[[Category: Zhu, X]]
	[[Category: Cancer]]		[[Category: Cancer]]
	[[Category: Fragment]]		[[Category: Fragment]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]		[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 13:26, 27 February 2013

2013-02-27T13:26:47Z

←Older revision		Revision as of 13:26, 27 February 2013
Line 1:		Line 1:
-	[[Image:4i9u.~~jpg~~\|left\|200px]]	+	[[Image:4i9u.png\|left\|200px]]

	{{STRUCTURE_4i9u\| PDB=4i9u \| SCENE= }}		{{STRUCTURE_4i9u\| PDB=4i9u \| SCENE= }}

OCA at 11:39, 23 January 2013

2013-01-23T11:39:06Z

←Older revision		Revision as of 11:39, 23 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4i9u.jpg\|left\|200px]]

-	~~The entry~~ 4i9u ~~is ON HOLD~~	+	{{STRUCTURE_4i9u\| PDB=4i9u \| SCENE= }}

-	~~Authors: Zhou, T., Kohlmann, A., Stephan, Z.G., Commodore, L., Greenfield, M.T., Zhu, X., Dalgarno, D.C.~~	+	===Crystal structure of rabbit LDHA in complex with a fragment inhibitor AP26256===

-	~~Description: Crystal~~ structure ~~of rabbit LDHA in complex~~ with ~~a fragment~~ inhibitor ~~AP26256~~	+	{{ABSTRACT_PUBMED_23302067}}
		+
		+	==About this Structure==
		+	[[4i9u]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9U OCA].
		+	[[Category: L-lactate dehydrogenase]]
		+	[[Category: Oryctolagus cuniculus]]
		+	[[Category: Commodore, L.]]
		+	[[Category: Dalgarno, D C.]]
		+	[[Category: Greenfield, M T.]]
		+	[[Category: Kohlmann, A.]]
		+	[[Category: Stephan, Z G.]]
		+	[[Category: Zhou, T.]]
		+	[[Category: Zhu, X.]]
		+	[[Category: Cancer]]
		+	[[Category: Fragment]]
		+	[[Category: Inhibitor]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 08:54, 2 January 2013

2013-01-02T08:54:28Z

←Older revision		Revision as of 08:54, 2 January 2013
Line 3:		Line 3:
	The entry 4i9u is ON HOLD		The entry 4i9u is ON HOLD

-	Authors: Zhou, T, Kohlmann, A, Stephan, Z.G., Commodore, L, Greenfield, M.T., Zhu, X, Dalgarno, D.C.	+	Authors: Zhou, T., Kohlmann, A., Stephan, Z.G., Commodore, L., Greenfield, M.T., Zhu, X., Dalgarno, D.C.

	Description: Crystal structure of rabbit LDHA in complex with a fragment inhibitor AP26256		Description: Crystal structure of rabbit LDHA in complex with a fragment inhibitor AP26256

OCA: Protected "4i9u" [edit=sysop:move=sysop]

2012-12-12T20:52:02Z

Protected "4i9u" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:52, 12 December 2012

OCA: New page: '''Unreleased structure''' The entry 4i9u is ON HOLD Authors: Zhou, T, Kohlmann, A, Stephan, Z.G., Commodore, L, Greenfield, M.T., Zhu, X, Dalgarno, D.C. Description: Crystal structure...

2012-12-12T20:52:01Z

New page: '''Unreleased structure''' The entry 4i9u is ON HOLD Authors: Zhou, T, Kohlmann, A, Stephan, Z.G., Commodore, L, Greenfield, M.T., Zhu, X, Dalgarno, D.C. Description: Crystal structure...

New page

'''Unreleased structure'''

The entry 4i9u is ON HOLD

Authors: Zhou, T, Kohlmann, A, Stephan, Z.G., Commodore, L, Greenfield, M.T., Zhu, X, Dalgarno, D.C.

Description: Crystal structure of rabbit LDHA in complex with a fragment inhibitor AP26256