4ihb - Revision history

OCA at 15:22, 20 September 2023

2023-09-20T15:22:57Z

←Older revision		Revision as of 15:22, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ihb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IHB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ihb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IHB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.044Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ihb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ihb OCA], [https://pdbe.org/4ihb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ihb RCSB], [https://www.ebi.ac.uk/pdbsum/4ihb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ihb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ihb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ihb OCA], [https://pdbe.org/4ihb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ihb RCSB], [https://www.ebi.ac.uk/pdbsum/4ihb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ihb ProSAT]</span></td></tr>
	</table>		</table>

OCA at 20:44, 16 November 2022

2022-11-16T20:44:58Z

←Older revision		Revision as of 20:44, 16 November 2022
Line 1:		Line 1:

	==X-RAY STRUCTURE OF THE canonical C2A DOMAIN FROM HUMAN DYSFERLIN==		==X-RAY STRUCTURE OF THE canonical C2A DOMAIN FROM HUMAN DYSFERLIN==
-	<StructureSection load='4ihb' size='340' side='right' caption='[[4ihb]], [[Resolution\|resolution]] 2.04Å' scene=''>	+	<StructureSection load='4ihb' size='340' side='right'caption='[[4ihb]], [[Resolution\|resolution]] 2.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ihb]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IHB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ihb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IHB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dmh\|2dmh]], [[3l9b\|3l9b]], [[4iqh\|4iqh]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ihb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ihb OCA], [https://pdbe.org/4ihb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ihb RCSB], [https://www.ebi.ac.uk/pdbsum/4ihb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ihb ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DYSF, FER1L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ihb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ihb OCA], [~~http~~://pdbe.org/4ihb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ihb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ihb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ihb ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/DYSF_HUMAN DYSF_HUMAN]] Miyoshi myopathy;Distal myopathy with anterior tibial onset;Congenital myopathy, Paradas type;Autosomal recessive limb-girdle muscular dystrophy type 2B. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/DYSF_HUMAN DYSF_HUMAN] Miyoshi myopathy;Distal myopathy with anterior tibial onset;Congenital myopathy, Paradas type;Autosomal recessive limb-girdle muscular dystrophy type 2B. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DYSF_HUMAN DYSF_HUMAN]] Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity).	+	[https://www.uniprot.org/uniprot/DYSF_HUMAN DYSF_HUMAN] Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Fuson, K L~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Sutton, R B~~]]	+	[[Category: Fuson KL]]
-	[[Category: ~~Beta sandwich]]~~	+	[[Category: Sutton RB]]
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Membrane repair]]~~	+
-	~~[[Category: Muscular dystrophy]]~~	+
-	~~[[Category: Plasma membrane]]~~	+
-	~~[[Category: Type ii c2 domain~~]]	+

OCA at 07:23, 23 December 2016

2016-12-23T07:23:07Z

←Older revision		Revision as of 07:23, 23 December 2016
Line 1:		Line 1:
		+
	==X-RAY STRUCTURE OF THE canonical C2A DOMAIN FROM HUMAN DYSFERLIN==		==X-RAY STRUCTURE OF THE canonical C2A DOMAIN FROM HUMAN DYSFERLIN==
	<StructureSection load='4ihb' size='340' side='right' caption='[[4ihb]], [[Resolution\|resolution]] 2.04Å' scene=''>		<StructureSection load='4ihb' size='340' side='right' caption='[[4ihb]], [[Resolution\|resolution]] 2.04Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dmh\|2dmh]], [[3l9b\|3l9b]], [[4iqh\|4iqh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dmh\|2dmh]], [[3l9b\|3l9b]], [[4iqh\|4iqh]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DYSF, FER1L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DYSF, FER1L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ihb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ihb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ihb RCSB], [http://www.ebi.ac.uk/pdbsum/4ihb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ihb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ihb OCA], [http://pdbe.org/4ihb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ihb RCSB], [http://www.ebi.ac.uk/pdbsum/4ihb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ihb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ihb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:27, 15 February 2015

2015-02-15T08:27:27Z

←Older revision		Revision as of 08:27, 15 February 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4ihb\| PDB=4ihb \| SCENE= }}~~	+	==X-RAY STRUCTURE OF THE canonical C2A DOMAIN FROM HUMAN DYSFERLIN==
-	===X-RAY STRUCTURE OF THE canonical C2A DOMAIN FROM HUMAN DYSFERLIN===	+	<StructureSection load='4ihb' size='340' side='right' caption='[[4ihb]], [[Resolution\|resolution]] 2.04Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24239457}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4ihb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IHB FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dmh\|2dmh]], [[3l9b\|3l9b]], [[4iqh\|4iqh]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DYSF, FER1L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ihb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ihb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ihb RCSB], [http://www.ebi.ac.uk/pdbsum/4ihb PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/DYSF_HUMAN DYSF_HUMAN]] Miyoshi myopathy;Distal myopathy with anterior tibial onset;Congenital myopathy, Paradas type;Autosomal recessive limb-girdle muscular dystrophy type 2B. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.		[[http://www.uniprot.org/uniprot/DYSF_HUMAN DYSF_HUMAN]] Miyoshi myopathy;Distal myopathy with anterior tibial onset;Congenital myopathy, Paradas type;Autosomal recessive limb-girdle muscular dystrophy type 2B. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/DYSF_HUMAN DYSF_HUMAN]] Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity).		[[http://www.uniprot.org/uniprot/DYSF_HUMAN DYSF_HUMAN]] Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dysferlin plays a critical role in the Ca2+-dependent repair of microlesions that occur in the muscle sarcolemma. Of the seven C2 domains in dysferlin, only C2A is reported to bind both Ca2+ and phospholipid, thus acting as a key sensor in membrane repair. Dysferlin C2A exists as two isoforms, the "canonical" C2A and C2A variant 1 (C2Av1). Interestingly, these isoforms have markedly different responses to Ca2+ and phospholipid. Structural and thermodynamic analyses are consistent with the canonical C2A domain as a Ca2+-dependent, phospholipid-binding domain, whereas C2Av1 would likely be Ca2+-independent under physiological conditions. Additionally, both isoforms display remarkably low free energies of stability, indicative of a highly flexible structure. The inverted ligand preference and flexibility for both C2A isoforms suggest the capability for both constitutive and Ca2+-regulated effector interactions, an activity that would be essential in its role as a mediator of membrane repair.

-	~~==About this~~ Structure==	+	Alternate Splicing of Dysferlin C2A Confers Ca-Dependent and Ca-Independent Binding for Membrane Repair.,Fuson K, Rice A, Mahling R, Snow A, Nayak K, Shanbhogue P, Meyer AG, Redpath GM, Hinderliter A, Cooper ST, Sutton RB Structure. 2013 Nov 13. pii: S0969-2126(13)00392-4. doi:, 10.1016/j.str.2013.10.001. PMID:24239457<ref>PMID:24239457</ref>
-	~~[[4ihb]] is a 6 chain structure~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=4IHB OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024239457</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Fuson, K L.]]	+	== References ==
-	[[Category: Sutton, R B.]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Fuson, K L]]
		+	[[Category: Sutton, R B]]
	[[Category: Beta sandwich]]		[[Category: Beta sandwich]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 10:20, 18 December 2013

2013-12-18T10:20:21Z

←Older revision		Revision as of 10:20, 18 December 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4ihb\| PDB=4ihb \| SCENE= }}
		+	===X-RAY STRUCTURE OF THE canonical C2A DOMAIN FROM HUMAN DYSFERLIN===
		+	{{ABSTRACT_PUBMED_24239457}}

-	The entry ~~4ihb~~ is ~~ON HOLD~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/DYSF_HUMAN DYSF_HUMAN]] Miyoshi myopathy;Distal myopathy with anterior tibial onset;Congenital myopathy, Paradas type;Autosomal recessive limb-girdle muscular dystrophy type 2B. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

-	~~Authors~~: ~~Sutton, R~~.B.~~, Fuson, K~~.L.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/DYSF_HUMAN DYSF_HUMAN]] Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity).

-	~~Description~~: X-~~RAY STRUCTURE OF THE canonical C2A DOMAIN FROM HUMAN DYSFERLIN~~	+	==About this Structure==
		+	[[4ihb]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHB OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024239457</ref><references group="xtra"/><references/>
		+	[[Category: Fuson, K L.]]
		+	[[Category: Sutton, R B.]]
		+	[[Category: Beta sandwich]]
		+	[[Category: Membrane protein]]
		+	[[Category: Membrane repair]]
		+	[[Category: Muscular dystrophy]]
		+	[[Category: Plasma membrane]]
		+	[[Category: Type ii c2 domain]]

OCA: Protected "4ihb" [edit=sysop:move=sysop]

2013-01-02T08:58:27Z

Protected "4ihb" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:58, 2 January 2013

OCA: New page: '''Unreleased structure''' The entry 4ihb is ON HOLD Authors: Sutton, R.B., Fuson, K.L. Description: X-RAY STRUCTURE OF THE canonical C2A DOMAIN FROM HUMAN DYSFERLIN

2013-01-02T08:58:26Z

New page: '''Unreleased structure''' The entry 4ihb is ON HOLD Authors: Sutton, R.B., Fuson, K.L. Description: X-RAY STRUCTURE OF THE canonical C2A DOMAIN FROM HUMAN DYSFERLIN

New page

'''Unreleased structure'''

The entry 4ihb is ON HOLD

Authors: Sutton, R.B., Fuson, K.L.

Description: X-RAY STRUCTURE OF THE canonical C2A DOMAIN FROM HUMAN DYSFERLIN