4ijh - Revision history

OCA at 15:24, 20 September 2023

2023-09-20T15:24:33Z

←Older revision		Revision as of 15:24, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ijh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IJH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ijh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IJH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1EJ:3-CHLORO-6-[3-(4-FLUOROPHENYL)-5-SULFANYL-4H-1,2,4-TRIAZOL-4-YL]-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>1EJ</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.498Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1EJ:3-CHLORO-6-[3-(4-FLUOROPHENYL)-5-SULFANYL-4H-1,2,4-TRIAZOL-4-YL]-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>1EJ</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ijh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijh OCA], [https://pdbe.org/4ijh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ijh RCSB], [https://www.ebi.ac.uk/pdbsum/4ijh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ijh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ijh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijh OCA], [https://pdbe.org/4ijh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ijh RCSB], [https://www.ebi.ac.uk/pdbsum/4ijh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ijh ProSAT]</span></td></tr>
	</table>		</table>

OCA at 20:51, 16 November 2022

2022-11-16T20:51:07Z

←Older revision		Revision as of 20:51, 16 November 2022
Line 1:		Line 1:

	==Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A==		==Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A==
-	<StructureSection load='4ijh' size='340' side='right' caption='[[4ijh]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='4ijh' size='340' side='right'caption='[[4ijh]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ijh]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IJH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ijh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IJH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1EJ:3-CHLORO-6-[3-(4-FLUOROPHENYL)-5-SULFANYL-4H-1,2,4-TRIAZOL-4-YL]-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>1EJ</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1EJ:3-CHLORO-6-[3-(4-FLUOROPHENYL)-5-SULFANYL-4H-1,2,4-TRIAZOL-4-YL]-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>1EJ</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ijl\|4ijl]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ijh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijh OCA], [https://pdbe.org/4ijh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ijh RCSB], [https://www.ebi.ac.uk/pdbsum/4ijh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ijh ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">REPA1, RPA1, RPA70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ijh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijh OCA], [~~http~~://pdbe.org/4ijh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ijh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ijh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ijh ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN]] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>	+	[https://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Single-stranded DNA-binding protein\|Single-stranded DNA-binding protein]]	+	*[[Single-stranded DNA-binding protein 3D structures\|Single-stranded DNA-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Chazin~~, W J~~]]	+	[[Category: Large Structures]]
-	[[Category: Feldkamp~~, M D~~]]	+	[[Category: Chazin WJ]]
-	[[Category: Fesik~~, S W~~]]	+	[[Category: Feldkamp MD]]
-	[[Category: Frank~~, A O~~]]	+	[[Category: Fesik SW]]
-	[[Category: Kennedy~~, J P~~]]	+	[[Category: Frank AO]]
-	[[Category: Patrone~~, J D~~]]	+	[[Category: Kennedy JP]]
-	[[Category: Pelz~~, N F~~]]	+	[[Category: Patrone JD]]
-	[[Category: Rossanese~~, O W~~]]	+	[[Category: Pelz NF]]
-	[[Category: Vangamudi, B]]	+	[[Category: Rossanese OW]]
-	[[Category: Waterson~~, A G]]~~	+	[[Category: Vangamudi B]]
-	~~[[Category: Dna binding protein-inhibitor complex]]~~	+	[[Category: Waterson AG]]
-	~~[[Category: Ob-fold]]~~	+
-	~~[[Category: Protein-protein interaction~~]]	+

OCA at 10:57, 5 August 2016

2016-08-05T10:57:40Z

←Older revision		Revision as of 10:57, 5 August 2016
Line 1:		Line 1:
		+
	==Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A==		==Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A==
	<StructureSection load='4ijh' size='340' side='right' caption='[[4ijh]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4ijh' size='340' side='right' caption='[[4ijh]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ijh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IJH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ijh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IJH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1EJ:3-CHLORO-6-[3-(4-FLUOROPHENYL)-5-SULFANYL-4H-1,2,4-TRIAZOL-4-YL]-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>1EJ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1EJ:3-CHLORO-6-[3-(4-FLUOROPHENYL)-5-SULFANYL-4H-1,2,4-TRIAZOL-4-YL]-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>1EJ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ijl\|4ijl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ijl\|4ijl]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">REPA1, RPA1, RPA70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">REPA1, RPA1, RPA70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ijh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ijh RCSB], [http://www.ebi.ac.uk/pdbsum/4ijh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ijh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijh OCA], [http://pdbe.org/4ijh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ijh RCSB], [http://www.ebi.ac.uk/pdbsum/4ijh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ijh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ijh" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chazin, W J]]		[[Category: Chazin, W J]]
	[[Category: Feldkamp, M D]]		[[Category: Feldkamp, M D]]

OCA at 18:13, 25 December 2014

2014-12-25T18:13:38Z

←Older revision		Revision as of 18:13, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ijh\| PDB=4ijh \| SCENE= }}~~	+	==Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A==
-	===Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A===	+	<StructureSection load='4ijh' size='340' side='right' caption='[[4ijh]], [[Resolution\|resolution]] 1.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23914285}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4ijh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IJH FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1EJ:3-CHLORO-6-[3-(4-FLUOROPHENYL)-5-SULFANYL-4H-1,2,4-TRIAZOL-4-YL]-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>1EJ</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ijl\|4ijl]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">REPA1, RPA1, RPA70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ijh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ijh RCSB], [http://www.ebi.ac.uk/pdbsum/4ijh PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN]] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>		[[http://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN]] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Replication Protein A (RPA) is a ssDNA binding protein that is essential for DNA replication and repair. The initiation of the DNA damage response by RPA is mediated by protein-protein interactions involving the N-terminal domain of the 70 kDa subunit with partner proteins. Inhibition of these interactions increases sensitivity towards DNA damage and replication stress and may therefore be a potential strategy for cancer drug discovery. Towards this end, we have discovered two lead series of compounds, derived from hits obtained from a fragment-based screen, that bind to RPA70N with low micromolar affinity and inhibit the binding of an ATRIP-derived peptide to RPA. These compounds may offer a promising starting point for the discovery of clinically useful RPA inhibitors.
		+
		+	Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A.,Patrone JD, Kennedy JP, Frank AO, Feldkamp MD, Vangamudi B, Pelz NF, Rossanese OW, Waterson AG, Chazin WJ, Fesik SW ACS Med Chem Lett. 2013 Jul 11;4(7):601-605. PMID:23914285<ref>PMID:23914285</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4ijh]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4IJH OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023914285</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Single-stranded DNA-binding protein\|Single-stranded DNA-binding protein]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chazin, W J.]]	+	[[Category: Chazin, W J]]
-	[[Category: Feldkamp, M D.]]	+	[[Category: Feldkamp, M D]]
-	[[Category: Fesik, S W.]]	+	[[Category: Fesik, S W]]
-	[[Category: Frank, A O.]]	+	[[Category: Frank, A O]]
-	[[Category: Kennedy, J P.]]	+	[[Category: Kennedy, J P]]
-	[[Category: Patrone, J D.]]	+	[[Category: Patrone, J D]]
-	[[Category: Pelz, N F.]]	+	[[Category: Pelz, N F]]
-	[[Category: Rossanese, O W.]]	+	[[Category: Rossanese, O W]]
-	[[Category: Vangamudi, B.]]	+	[[Category: Vangamudi, B]]
-	[[Category: Waterson, A G.]]	+	[[Category: Waterson, A G]]
	[[Category: Dna binding protein-inhibitor complex]]		[[Category: Dna binding protein-inhibitor complex]]
	[[Category: Ob-fold]]		[[Category: Ob-fold]]
	[[Category: Protein-protein interaction]]		[[Category: Protein-protein interaction]]

OCA at 07:51, 14 August 2013

2013-08-14T07:51:22Z

←Older revision		Revision as of 07:51, 14 August 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4ijh\| PDB=4ijh \| SCENE= }}
		+	===Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A===
		+	{{ABSTRACT_PUBMED_23914285}}

-	~~The entry 4ijh is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN]] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>

-	~~Authors~~: ~~Feldkamp, M~~.D.~~, Patrone, J~~.~~D., Kennedy, J.P., Frank, A.O., Vangamudi, B., Pelz, N.F., Rossanese, O.W., Waterson, A.G., Fesik, S~~.W.~~, Chazin, W~~.J.	+	==About this Structure==
		+	[[4ijh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJH OCA].

-	~~Description~~:	+	==Reference==
		+	<ref group="xtra">PMID:023914285</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Chazin, W J.]]
		+	[[Category: Feldkamp, M D.]]
		+	[[Category: Fesik, S W.]]
		+	[[Category: Frank, A O.]]
		+	[[Category: Kennedy, J P.]]
		+	[[Category: Patrone, J D.]]
		+	[[Category: Pelz, N F.]]
		+	[[Category: Rossanese, O W.]]
		+	[[Category: Vangamudi, B.]]
		+	[[Category: Waterson, A G.]]
		+	[[Category: Dna binding protein-inhibitor complex]]
		+	[[Category: Ob-fold]]
		+	[[Category: Protein-protein interaction]]

OCA at 11:10, 23 January 2013

2013-01-23T11:10:49Z

←Older revision		Revision as of 11:10, 23 January 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ijh is ON HOLD	+	The entry 4ijh is ON HOLD until Paper Publication

-	Authors: Patrone, J.D., Kennedy, J.P., Frank, A.O~~., Feldkamp, M.D~~., Vangamudi, B., Pelz, N.F., Rossanese, O.W., Waterson, A.G., ~~Chazin~~, W.J., ~~Fesik~~, S.W.	+	Authors: Feldkamp, M.D., Patrone, J.D., Kennedy, J.P., Frank, A.O., Vangamudi, B., Pelz, N.F., Rossanese, O.W., Waterson, A.G., Fesik, S.W., Chazin, W.J.

	Description:		Description:

OCA at 07:50, 9 January 2013

2013-01-09T07:50:38Z

←Older revision		Revision as of 07:50, 9 January 2013
Line 5:		Line 5:
	Authors: Patrone, J.D., Kennedy, J.P., Frank, A.O., Feldkamp, M.D., Vangamudi, B., Pelz, N.F., Rossanese, O.W., Waterson, A.G., Chazin, W.J., Fesik, S.W.		Authors: Patrone, J.D., Kennedy, J.P., Frank, A.O., Feldkamp, M.D., Vangamudi, B., Pelz, N.F., Rossanese, O.W., Waterson, A.G., Chazin, W.J., Fesik, S.W.

-	Description: ~~Structure of RPA70N in Complex with a Small Molecule Ligand~~	+	Description:

OCA: Protected "4ijh" [edit=sysop:move=sysop]

2013-01-02T09:00:47Z

Protected "4ijh" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:00, 2 January 2013

OCA: New page: '''Unreleased structure''' The entry 4ijh is ON HOLD Authors: Patrone, J.D., Kennedy, J.P., Frank, A.O., Feldkamp, M.D., Vangamudi, B., Pelz, N.F., Rossanese, O.W., Waterson, A.G., Chaz...

2013-01-02T09:00:46Z

New page: '''Unreleased structure''' The entry 4ijh is ON HOLD Authors: Patrone, J.D., Kennedy, J.P., Frank, A.O., Feldkamp, M.D., Vangamudi, B., Pelz, N.F., Rossanese, O.W., Waterson, A.G., Chaz...

New page

'''Unreleased structure'''

The entry 4ijh is ON HOLD

Authors: Patrone, J.D., Kennedy, J.P., Frank, A.O., Feldkamp, M.D., Vangamudi, B., Pelz, N.F., Rossanese, O.W., Waterson, A.G., Chazin, W.J., Fesik, S.W.

Description: Structure of RPA70N in Complex with a Small Molecule Ligand