4il8 - Revision history

OCA at 14:27, 29 November 2023

2023-11-29T14:27:36Z

←Older revision		Revision as of 14:27, 29 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4il8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IL8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4il8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IL8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4il8 OCA], [https://pdbe.org/4il8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4il8 RCSB], [https://www.ebi.ac.uk/pdbsum/4il8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4il8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4il8 OCA], [https://pdbe.org/4il8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4il8 RCSB], [https://www.ebi.ac.uk/pdbsum/4il8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4il8 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 20:53, 16 November 2022

2022-11-16T20:53:45Z

←Older revision		Revision as of 20:53, 16 November 2022
Line 1:		Line 1:

	==Crystal structure of an H329A mutant of p. aeruginosa PMM/PGM==		==Crystal structure of an H329A mutant of p. aeruginosa PMM/PGM==
-	<StructureSection load='4il8' size='340' side='right' caption='[[4il8]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4il8' size='340' side='right'caption='[[4il8]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4il8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IL8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IL8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4il8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IL8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4il8 OCA], [https://pdbe.org/4il8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4il8 RCSB], [https://www.ebi.ac.uk/pdbsum/4il8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4il8 ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k35\|1k35]], [[1k2y\|1k2y]], [[1p5d\|1p5d]], [[1p5g\|1p5g]], [[1pcj\|1pcj]]</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">algC, PA5322 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4il8 OCA], [~~http~~://pdbe.org/4il8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4il8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4il8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4il8 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ALGC_PSEAE ALGC_PSEAE]] The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity, and for biofilm production.<ref>PMID:7515870</ref> <ref>PMID:10481091</ref>	+	[https://www.uniprot.org/uniprot/ALGC_PSEAE ALGC_PSEAE] The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity, and for biofilm production.<ref>PMID:7515870</ref> <ref>PMID:10481091</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4il8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4il8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphomannomutase\|Phosphomannomutase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pseae~~]]	+	[[Category: Large Structures]]
-	[[Category: Beamer, L]]	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	[[Category: Furdui, C]]	+	[[Category: Beamer L]]
-	[[Category: Lee, Y]]	+	[[Category: Furdui C]]
-	[[Category: Mehra-Chaudhary, R]]	+	[[Category: Lee Y]]
-	~~[[Category: A-d-phosphohexomutase]]~~	+	[[Category: Mehra-Chaudhary R]]
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Phosphoserine~~]]	+

OCA at 08:58, 15 November 2017

2017-11-15T08:58:09Z

←Older revision		Revision as of 08:58, 15 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4il8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4il8" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Phosphomannomutase\|Phosphomannomutase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:57, 4 August 2016

2016-08-04T07:57:19Z

←Older revision		Revision as of 07:57, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of an H329A mutant of p. aeruginosa PMM/PGM==		==Crystal structure of an H329A mutant of p. aeruginosa PMM/PGM==
	<StructureSection load='4il8' size='340' side='right' caption='[[4il8]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4il8' size='340' side='right' caption='[[4il8]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4il8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IL8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4il8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IL8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k35\|1k35]], [[1k2y\|1k2y]], [[1p5d\|1p5d]], [[1p5g\|1p5g]], [[1pcj\|1pcj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k35\|1k35]], [[1k2y\|1k2y]], [[1p5d\|1p5d]], [[1p5g\|1p5g]], [[1pcj\|1pcj]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">algC, PA5322 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 ~~Pseudomonas aeruginosa PAO1~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">algC, PA5322 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4il8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4il8 RCSB], [http://www.ebi.ac.uk/pdbsum/4il8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4il8 OCA], [http://pdbe.org/4il8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4il8 RCSB], [http://www.ebi.ac.uk/pdbsum/4il8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4il8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4il8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pseudomonas aeruginosa pao1~~]]	+	[[Category: Pseae]]
	[[Category: Beamer, L]]		[[Category: Beamer, L]]
	[[Category: Furdui, C]]		[[Category: Furdui, C]]

OCA at 07:17, 24 December 2014

2014-12-24T07:17:20Z

←Older revision		Revision as of 07:17, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4il8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4il8 RCSB], [http://www.ebi.ac.uk/pdbsum/4il8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4il8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4il8 RCSB], [http://www.ebi.ac.uk/pdbsum/4il8 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ALGC_PSEAE ALGC_PSEAE]] The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity, and for biofilm production.<ref>PMID:7515870</ref> <ref>PMID:10481091</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:47, 21 December 2014

2014-12-21T12:47:02Z

←Older revision		Revision as of 12:47, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4il8\| PDB=4il8 \| SCENE= }}~~	+	==Crystal structure of an H329A mutant of p. aeruginosa PMM/PGM==
-	===Crystal structure of an H329A mutant of p. aeruginosa PMM/PGM===	+	<StructureSection load='4il8' size='340' side='right' caption='[[4il8]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23517223}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4il8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IL8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1k35\|1k35]], [[1k2y\|1k2y]], [[1p5d\|1p5d]], [[1p5g\|1p5g]], [[1pcj\|1pcj]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">algC, PA5322 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 Pseudomonas aeruginosa PAO1])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4il8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4il8 RCSB], [http://www.ebi.ac.uk/pdbsum/4il8 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Enzymes in the alpha-d-phosphohexomutase superfamily catalyze the conversion of 1-phosphosugars to their 6-phospho counterparts. Their phosphoryl transfer reaction has long been proposed to require general acid-base catalysts, but candidate residues for these key roles have not been identified. In this study, we show through mutagenesis and kinetic studies that a histidine (His329) in the active site is critical for enzyme activity in a well-studied member of the superfamily, phosphomannomutase/phosphoglucomutase from Pseudomonas aeruginosa. Crystallographic characterization of an H329A mutant protein showed no significant changes from the wild-type enzyme, excluding structural disruption as the source of its compromised activity. Mutation of the structurally analogous lysine residue in a related protein, phosphoglucomutase from Salmonella typhimurium, also results in significant catalytic impairment. Analyses of protein-ligand complexes of the P. aeruginosa enzyme show that His329 is appropriately positioned to abstract a proton from the O1/O6 hydroxyl of the phosphosugar substrates, and thus may serve as the general base in the reaction. Histidine is strongly conserved at this position in many proteins in the superfamily, and lysine is also often conserved at a structurally corresponding position, particularly in the phosphoglucomutase enzyme sub-group. These studies shed light on the mechanism of this important enzyme superfamily, and may facilitate the design of mechanism-based inhibitors. DATABASE: Structural data have been deposited in the Protein Data Bank with accession number 4IL8.

-	~~==Function==~~	+	Identification of an essential active-site residue in the alpha-D-phosphohexomutase enzyme superfamily.,Lee Y, Mehra-Chaudhary R, Furdui C, Beamer LJ FEBS J. 2013 Jun;280(11):2622-32. doi: 10.1111/febs.12249. Epub 2013 Apr 8. PMID:23517223<ref>PMID:23517223</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/ALGC_PSEAE ALGC_PSEAE]] The phosphomannomutase activity produces a precursor for alginate polymerization~~. ~~The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics~~. ~~Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity~~. ~~Essential for rhamnolipid production, an exoproduct correlated with pathogenicity, and for biofilm production.<ref>~~PMID:~~7515870</ref>~~ <ref>PMID:~~10481091~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4il8]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4IL8 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023517223</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Phosphomannomutase\|Phosphomannomutase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Pseudomonas aeruginosa pao1]]		[[Category: Pseudomonas aeruginosa pao1]]
-	[[Category: Beamer, L.]]	+	[[Category: Beamer, L]]
-	[[Category: Furdui, C.]]	+	[[Category: Furdui, C]]
-	[[Category: Lee, Y.]]	+	[[Category: Lee, Y]]
-	[[Category: Mehra-Chaudhary, R.]]	+	[[Category: Mehra-Chaudhary, R]]
	[[Category: A-d-phosphohexomutase]]		[[Category: A-d-phosphohexomutase]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Phosphoserine]]		[[Category: Phosphoserine]]

OCA at 07:50, 14 August 2013

2013-08-14T07:50:44Z

←Older revision		Revision as of 07:50, 14 August 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4il8\| PDB=4il8 \| SCENE= }}
		+	===Crystal structure of an H329A mutant of p. aeruginosa PMM/PGM===
		+	{{ABSTRACT_PUBMED_23517223}}

-	The ~~entry 4il8 is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/ALGC_PSEAE ALGC_PSEAE]] The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity, and for biofilm production.<ref>PMID:7515870</ref> <ref>PMID:10481091</ref>

-	~~Authors~~: ~~Lee, Y~~.~~, Mehra-Chaudhary, R~~.~~, Furdui, C~~.~~, Beamer, L~~.	+	==About this Structure==
		+	[[4il8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IL8 OCA].

-	~~Description~~: ~~Crystal structure of an H329A mutant of p. aeruginosa PMM~~/~~PGM~~	+	==Reference==
		+	<ref group="xtra">PMID:023517223</ref><references group="xtra"/><references/>
		+	[[Category: Pseudomonas aeruginosa pao1]]
		+	[[Category: Beamer, L.]]
		+	[[Category: Furdui, C.]]
		+	[[Category: Lee, Y.]]
		+	[[Category: Mehra-Chaudhary, R.]]
		+	[[Category: A-d-phosphohexomutase]]
		+	[[Category: Isomerase]]
		+	[[Category: Phosphoserine]]

OCA at 14:18, 27 February 2013

2013-02-27T14:18:52Z

←Older revision		Revision as of 14:18, 27 February 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4il8 is ON HOLD	+	The entry 4il8 is ON HOLD until Paper Publication

	Authors: Lee, Y., Mehra-Chaudhary, R., Furdui, C., Beamer, L.		Authors: Lee, Y., Mehra-Chaudhary, R., Furdui, C., Beamer, L.

	Description: Crystal structure of an H329A mutant of p. aeruginosa PMM/PGM		Description: Crystal structure of an H329A mutant of p. aeruginosa PMM/PGM

OCA: Protected "4il8" [edit=sysop:move=sysop]

2013-01-09T07:51:25Z

Protected "4il8" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:51, 9 January 2013

OCA: New page: '''Unreleased structure''' The entry 4il8 is ON HOLD Authors: Lee, Y., Mehra-Chaudhary, R., Furdui, C., Beamer, L. Description: Crystal structure of an H329A mutant of p. aeruginosa PM...

2013-01-09T07:51:23Z

New page: '''Unreleased structure''' The entry 4il8 is ON HOLD Authors: Lee, Y., Mehra-Chaudhary, R., Furdui, C., Beamer, L. Description: Crystal structure of an H329A mutant of p. aeruginosa PM...

New page

'''Unreleased structure'''

The entry 4il8 is ON HOLD

Authors: Lee, Y., Mehra-Chaudhary, R., Furdui, C., Beamer, L.

Description: Crystal structure of an H329A mutant of p. aeruginosa PMM/PGM