4imb - Revision history

OCA at 20:55, 16 November 2022

2022-11-16T20:55:41Z

←Older revision		Revision as of 20:55, 16 November 2022
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	==Structure of strictosidine synthase in complex with 2-(1-methyl-1H-indol-3-yl)ethanamine==		==Structure of strictosidine synthase in complex with 2-(1-methyl-1H-indol-3-yl)ethanamine==
-	<StructureSection load='4imb' size='340' side='right' caption='[[4imb]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4imb' size='340' side='right'caption='[[4imb]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4imb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Devilpepper Devilpepper~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IMB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4imb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IMB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1ES:2-(1-METHYL-1H-INDOL-3-YL)ETHANAMINE'>1ES</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1ES:2-(1-METHYL-1H-INDOL-3-YL)ETHANAMINE'>1ES</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 Devilpepper])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4imb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imb OCA], [https://pdbe.org/4imb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4imb RCSB], [https://www.ebi.ac.uk/pdbsum/4imb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4imb ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Strictosidine_synthase Strictosidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.2 4.3.3.2] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4imb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imb OCA], [~~http~~://pdbe.org/4imb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4imb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4imb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4imb ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE]] Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.	+	[https://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE] Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Devilpepper~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Strictosidine synthase~~]]	+	[[Category: Rauvolfia serpentina]]
-	[[Category: Fangrui, W]]	+	[[Category: Fangrui W]]
-	[[Category: Rajendran, C]]	+	[[Category: Rajendran C]]
-	[[Category: Stoeckigt, J]]	+	[[Category: Stoeckigt J]]
-	[[Category: Wang, M]]	+	[[Category: Wang M]]
-	~~[[Category: Lyase-lyase inhibitor complex]]~~	+
-	~~[[Category: Strictosidine~~]]	+

OCA at 20:42, 3 August 2016

2016-08-03T20:42:04Z

←Older revision		Revision as of 20:42, 3 August 2016
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 Devilpepper])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 Devilpepper])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Strictosidine_synthase Strictosidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.2 4.3.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Strictosidine_synthase Strictosidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.2 4.3.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imb OCA], [http://pdbe.org/4imb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4imb RCSB], [http://www.ebi.ac.uk/pdbsum/4imb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imb OCA], [http://pdbe.org/4imb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4imb RCSB], [http://www.ebi.ac.uk/pdbsum/4imb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4imb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 10:21, 26 February 2016

2016-02-26T10:21:56Z

←Older revision		Revision as of 10:21, 26 February 2016
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		+
	==Structure of strictosidine synthase in complex with 2-(1-methyl-1H-indol-3-yl)ethanamine==		==Structure of strictosidine synthase in complex with 2-(1-methyl-1H-indol-3-yl)ethanamine==
	<StructureSection load='4imb' size='340' side='right' caption='[[4imb]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4imb' size='340' side='right' caption='[[4imb]], [[Resolution\|resolution]] 2.70Å' scene=''>

OCA at 07:43, 16 December 2015

2015-12-16T07:43:33Z

←Older revision		Revision as of 07:43, 16 December 2015
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 Devilpepper])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 Devilpepper])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Strictosidine_synthase Strictosidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.2 4.3.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Strictosidine_synthase Strictosidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.2 4.3.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4imb RCSB], [http://www.ebi.ac.uk/pdbsum/4imb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imb OCA], [http://pdbe.org/4imb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4imb RCSB], [http://www.ebi.ac.uk/pdbsum/4imb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4imb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:43, 10 June 2015

2015-06-10T07:43:27Z

←Older revision		Revision as of 07:43, 10 June 2015
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE]] Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.		[[http://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE]] Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Pictet-Spenglerasestrictosidine synthase (STR) has been characterized as the central enzyme in the biosynthesis of around 2000 monoterpenoid indole alkaloids in plants. In the light of a high therapeutic value and huge scaffold diversity these alkaloids represent, STR as an enzyme has attracted great attentions in recent years, intending to be utilized in the formation of new interesting alkaloids with unusual substitution pattern or even with novel scaffolds. For outlining the application potential that STR possesses, together with insight into the reaction mechanism catalyzed by STR, strategies and methods for exploring the applicability of STR have been updated in this article by taking R. serpertina STR(RS-STR) and C. roseus.STR (CR-STR) as representative models, followed by introducing the latest released complex structures of RS-STR with new substrates. Examples provided here, including substrate scaffold tailoring, X-ray crystal complex structure comparison, protein engineering and biosynthetic pathway reprogramming, pave the way to finally construct novel alkaloids libraries by chemo-enzymatic approaches.
		+
		+	Using Strictosidine Synthase to Prepare Novel Alkaloids.,Zhu H, Kercmar P, Wu F, Rajendran C, Sun L, Wang M, Stockigt J Curr Med Chem. 2015 Apr 8. PMID:25850764<ref>PMID:25850764</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Strictosidine Synthase\|Strictosidine Synthase]]		*[[Strictosidine Synthase\|Strictosidine Synthase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:11, 25 December 2014

2014-12-25T05:11:41Z

←Older revision		Revision as of 05:11, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4imb RCSB], [http://www.ebi.ac.uk/pdbsum/4imb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4imb RCSB], [http://www.ebi.ac.uk/pdbsum/4imb PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE]] Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.

	==See Also==		==See Also==

OCA at 17:34, 21 December 2014

2014-12-21T17:34:30Z

←Older revision		Revision as of 17:34, 21 December 2014
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-	~~{{STRUCTURE_4imb\| PDB=4imb \| SCENE= }}~~	+	==Structure of strictosidine synthase in complex with 2-(1-methyl-1H-indol-3-yl)ethanamine==
-	===Structure of strictosidine synthase in complex with 2-(1-methyl-1H-indol-3-yl)ethanamine===	+	<StructureSection load='4imb' size='340' side='right' caption='[[4imb]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4imb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Devilpepper Devilpepper]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IMB FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1ES:2-(1-METHYL-1H-INDOL-3-YL)ETHANAMINE'>1ES</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 Devilpepper])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Strictosidine_synthase Strictosidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.2 4.3.3.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4imb RCSB], [http://www.ebi.ac.uk/pdbsum/4imb PDBsum]</span></td></tr>
		+	</table>

-	==~~Function~~==	+	==See Also==
-	[[~~http://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE~~]] ~~Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.~~	+	*[[Strictosidine Synthase\|Strictosidine Synthase]]
-		+	__TOC__
-	~~==About this Structure==~~	+	</StructureSection>
-	[[~~4imb~~]] ~~is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMB OCA].~~	+	[[Category: Devilpepper]]
	[[Category: Strictosidine synthase]]		[[Category: Strictosidine synthase]]
-	[[Category: Fangrui, W.]]	+	[[Category: Fangrui, W]]
-	[[Category: Rajendran, C.]]	+	[[Category: Rajendran, C]]
-	[[Category: Stoeckigt, J.]]	+	[[Category: Stoeckigt, J]]
-	[[Category: Wang, M.]]	+	[[Category: Wang, M]]
	[[Category: Lyase-lyase inhibitor complex]]		[[Category: Lyase-lyase inhibitor complex]]
	[[Category: Strictosidine]]		[[Category: Strictosidine]]
-	[[Category: Strictosidine synthase]]

OCA at 07:45, 29 January 2014

2014-01-29T07:45:07Z

←Older revision		Revision as of 07:45, 29 January 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4imb\| PDB=4imb \| SCENE= }}
		+	===Structure of strictosidine synthase in complex with 2-(1-methyl-1H-indol-3-yl)ethanamine===

-	~~The entry 4imb is ON HOLD until Jan 29 2015~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE]] Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.

-	~~Authors~~: ~~Stoeckigt, J~~., Fangrui, W., Wang, M.~~, Rajendran, C.~~	+	==About this Structure==
-		+	[[4imb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMB OCA].
-	~~Description~~:	+	[[Category: Strictosidine synthase]]
		+	[[Category: Fangrui, W.]]
		+	[[Category: Rajendran, C.]]
		+	[[Category: Stoeckigt, J.]]
		+	[[Category: Wang, M.]]
		+	[[Category: Lyase-lyase inhibitor complex]]
		+	[[Category: Strictosidine]]
		+	[[Category: Strictosidine synthase]]

OCA at 08:52, 18 December 2013

2013-12-18T08:52:48Z

←Older revision		Revision as of 08:52, 18 December 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4imb is ON HOLD until ~~Paper Publication~~	+	The entry 4imb is ON HOLD until Jan 29 2015

	Authors: Stoeckigt, J., Fangrui, W., Wang, M., Rajendran, C.		Authors: Stoeckigt, J., Fangrui, W., Wang, M., Rajendran, C.

	Description:		Description:

OCA at 12:26, 6 February 2013

2013-02-06T12:26:30Z

←Older revision		Revision as of 12:26, 6 February 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4imb is ON HOLD	+	The entry 4imb is ON HOLD until Paper Publication

	Authors: Stoeckigt, J., Fangrui, W., Wang, M., Rajendran, C.		Authors: Stoeckigt, J., Fangrui, W., Wang, M., Rajendran, C.

	Description:		Description: