4isk - Revision history

OCA at 21:07, 16 November 2022

2022-11-16T21:07:32Z

←Older revision		Revision as of 21:07, 16 November 2022
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	==Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor==		==Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor==
-	<StructureSection load='4isk' size='340' side='right' caption='[[4isk]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='4isk' size='340' side='right'caption='[[4isk]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4isk]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ISK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4isk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ISK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1JY:N-(4-{[(6S)-2-(HYDROXYMETHYL)-4-OXO-4,6,7,8-TETRAHYDRO-1H-CYCLOPENTA[G]QUINAZOLIN-6-YL](PROP-2-YN-1-YL)AMINO}BENZOYL)-L-GAMMA-GLUTAMYL-D-GLUTAMIC+ACID'>1JY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UMC:2-DEOXY-5-URIDYLIC+ACID'>UMC</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1JY:N-(4-{[(6S)-2-(HYDROXYMETHYL)-4-OXO-4,6,7,8-TETRAHYDRO-1H-CYCLOPENTA[G]QUINAZOLIN-6-YL](PROP-2-YN-1-YL)AMINO}BENZOYL)-L-GAMMA-GLUTAMYL-D-GLUTAMIC+ACID'>1JY</scene>, <scene name='pdbligand=CXM:N-CARBOXYMETHIONINE'>CXM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UMC:2-DEOXY-5-URIDYLIC+ACID'>UMC</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CXM:N-CARBOXYMETHIONINE'>CXM</scene></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4isk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4isk OCA], [https://pdbe.org/4isk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4isk RCSB], [https://www.ebi.ac.uk/pdbsum/4isk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4isk ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kce\|2kce]], [[1hvy\|1hvy]], [[1an5\|1an5]], [[1axw\|1axw]]</td></tr>~~	+
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">thyA, b2827, JW2795 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4isk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4isk OCA], [~~http~~://pdbe.org/4isk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4isk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4isk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4isk ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TYSY_ECOLI TYSY_ECOLI]] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.	+	[https://www.uniprot.org/uniprot/TYSY_ECOLI TYSY_ECOLI] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 20:

	==See Also==		==See Also==
-	*[[Thymidylate synthase\|Thymidylate synthase]]	+	*[[Thymidylate synthase 3D structures\|Thymidylate synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
-	[[Category: ~~Thymidylate synthase~~]]	+	[[Category: Large Structures]]
-	[[Category: Finer-Moore, J]]	+	[[Category: Finer-Moore J]]
-	[[Category: Stroud~~, R M~~]]	+	[[Category: Stroud RM]]
-	[[Category: Tochowicz, A]]	+	[[Category: Tochowicz A]]
-	~~[[Category: Alpha/beta protein]]~~	+
-	~~[[Category: Dump subtrate]]~~	+
-	~~[[Category: Methylase]]~~	+
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 11:37, 5 August 2016

2016-08-05T11:37:23Z

←Older revision		Revision as of 11:37, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor==		==Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor==
	<StructureSection load='4isk' size='340' side='right' caption='[[4isk]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='4isk' size='340' side='right' caption='[[4isk]], [[Resolution\|resolution]] 1.75Å' scene=''>
Line 8:		Line 9:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">thyA, b2827, JW2795 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">thyA, b2827, JW2795 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4isk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4isk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4isk RCSB], [http://www.ebi.ac.uk/pdbsum/4isk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4isk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4isk OCA], [http://pdbe.org/4isk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4isk RCSB], [http://www.ebi.ac.uk/pdbsum/4isk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4isk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4isk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 02:05, 25 December 2014

2014-12-25T02:05:36Z

←Older revision		Revision as of 02:05, 25 December 2014
Line 10:		Line 10:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4isk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4isk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4isk RCSB], [http://www.ebi.ac.uk/pdbsum/4isk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4isk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4isk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4isk RCSB], [http://www.ebi.ac.uk/pdbsum/4isk PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TYSY_ECOLI TYSY_ECOLI]] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:34, 21 December 2014

2014-12-21T17:34:03Z

←Older revision		Revision as of 17:34, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4isk\| PDB=4isk \| SCENE= }}~~	+	==Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor==
-	===Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor===	+	<StructureSection load='4isk' size='340' side='right' caption='[[4isk]], [[Resolution\|resolution]] 1.75Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23710599}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4isk]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ISK FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1JY:N-(4-{[(6S)-2-(HYDROXYMETHYL)-4-OXO-4,6,7,8-TETRAHYDRO-1H-CYCLOPENTA[G]QUINAZOLIN-6-YL](PROP-2-YN-1-YL)AMINO}BENZOYL)-L-GAMMA-GLUTAMYL-D-GLUTAMIC+ACID'>1JY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UMC:2-DEOXY-5-URIDYLIC+ACID'>UMC</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CXM:N-CARBOXYMETHIONINE'>CXM</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kce\|2kce]], [[1hvy\|1hvy]], [[1an5\|1an5]], [[1axw\|1axw]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">thyA, b2827, JW2795 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4isk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4isk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4isk RCSB], [http://www.ebi.ac.uk/pdbsum/4isk PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta [g]quinazolin-6-yl]amino]benzoyl]-l-gamma-glutamyl-d-glutamic acid 1 (BGC 945, now known as ONX 0801), is a small molecule thymidylate synthase (TS) inhibitor discovered at the Institute of Cancer Research in London. It is licensed by Onyx Pharmaceuticals and is in phase 1 clinical studies. It is a novel antifolate drug resembling TS inhibitors plevitrexed and raltitrexed that combines enzymatic inhibition of thymidylate synthase with alpha-folate receptor-mediated targeting of tumor cells. Thus, it has potential for efficacy with lower toxicity due to selective intracellular accumulation through alpha-folate receptor (alpha-FR) transport. The alpha-FR, a cell-surface receptor glycoprotein, which is overexpressed mainly in ovarian and lung cancer tumors, has an affinity for 1 similar to that for its natural ligand, folic acid. This study describes a novel synthesis of 1, an X-ray crystal structure of its complex with Escherichia coli TS and 2'-deoxyuridine-5'-monophosphate, and a model for a similar complex with human TS.

-	~~==Function==~~	+	Development and Binding Mode Assessment of N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta [g]quinazolin-6-yl]amino]benzoyl]-l-gamma-glutamyl-d-glutamic Acid (BGC 945), a Novel Thymidylate Synthase Inhibitor That Targets Tumor Cells.,Tochowicz A, Dalziel S, Eidam O, O'Connell JD 3rd, Griner S, Finer-Moore JS, Stroud RM J Med Chem. 2013 Jun 21. PMID:23710599<ref>PMID:23710599</ref>
-	[[~~http://www.uniprot.org/uniprot/TYSY_ECOLI TYSY_ECOLI~~]] ~~Provides the sole de novo source of dTMP for DNA biosynthesis~~. ~~This protein also binds to its mRNA thus repressing its own translation~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4isk]] is~~ a ~~8 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4ISK OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023710599</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Thymidylate synthase\|Thymidylate synthase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ecoli]]
	[[Category: Thymidylate synthase]]		[[Category: Thymidylate synthase]]
-	[[Category: Finer-Moore, J.]]	+	[[Category: Finer-Moore, J]]
-	[[Category: Stroud, R M.]]	+	[[Category: Stroud, R M]]
-	[[Category: Tochowicz, A.]]	+	[[Category: Tochowicz, A]]
	[[Category: Alpha/beta protein]]		[[Category: Alpha/beta protein]]
	[[Category: Dump subtrate]]		[[Category: Dump subtrate]]

OCA at 10:17, 25 December 2013

2013-12-25T10:17:24Z

←Older revision		Revision as of 10:17, 25 December 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4isk\| PDB=4isk \| SCENE= }}
		+	===Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor===
		+	{{ABSTRACT_PUBMED_23710599}}

-	~~The entry 4isk is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/TYSY_ECOLI TYSY_ECOLI]] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.

-	~~Authors~~: ~~Tochowicz, A~~.~~, Finer-Moore, J~~.~~, Stroud, R~~.M.	+	==About this Structure==
		+	[[4isk]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISK OCA].

-	~~Description~~: ~~Crystal structure of E.coli thymidylate~~ synthase ~~with dUMP and the BGC 945~~ inhibitor	+	==Reference==
		+	<ref group="xtra">PMID:023710599</ref><references group="xtra"/><references/>
		+	[[Category: Thymidylate synthase]]
		+	[[Category: Finer-Moore, J.]]
		+	[[Category: Stroud, R M.]]
		+	[[Category: Tochowicz, A.]]
		+	[[Category: Alpha/beta protein]]
		+	[[Category: Dump subtrate]]
		+	[[Category: Methylase]]
		+	[[Category: Methyltransferase]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 00:48, 4 April 2013

2013-04-04T00:48:34Z

←Older revision		Revision as of 00:48, 4 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4isk is ON HOLD	+	The entry 4isk is ON HOLD until Paper Publication

	Authors: Tochowicz, A., Finer-Moore, J., Stroud, R.M.		Authors: Tochowicz, A., Finer-Moore, J., Stroud, R.M.

	Description: Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor		Description: Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor

OCA at 13:46, 6 March 2013

2013-03-06T13:46:40Z

←Older revision		Revision as of 13:46, 6 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4isk is ON HOLD ~~until sometime in the future~~	+	The entry 4isk is ON HOLD

	Authors: Tochowicz, A., Finer-Moore, J., Stroud, R.M.		Authors: Tochowicz, A., Finer-Moore, J., Stroud, R.M.

	Description: Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor		Description: Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor

OCA at 13:26, 20 February 2013

2013-02-20T13:26:11Z

←Older revision		Revision as of 13:26, 20 February 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4isk is ON HOLD	+	The entry 4isk is ON HOLD until sometime in the future

	Authors: Tochowicz, A., Finer-Moore, J., Stroud, R.M.		Authors: Tochowicz, A., Finer-Moore, J., Stroud, R.M.

-	Description: Crystal ~~strcuture~~ of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor	+	Description: Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor

OCA: Protected "4isk" [edit=sysop:move=sysop]

2013-01-23T11:15:19Z

Protected "4isk" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:15, 23 January 2013

OCA: New page: '''Unreleased structure''' The entry 4isk is ON HOLD Authors: Tochowicz, A., Finer-Moore, J., Stroud, R.M. Description: Crystal strcuture of E.coli thymidylate synthase with dUMP and t...

2013-01-23T11:15:18Z

New page: '''Unreleased structure''' The entry 4isk is ON HOLD Authors: Tochowicz, A., Finer-Moore, J., Stroud, R.M. Description: Crystal strcuture of E.coli thymidylate synthase with dUMP and t...

New page

'''Unreleased structure'''

The entry 4isk is ON HOLD

Authors: Tochowicz, A., Finer-Moore, J., Stroud, R.M.

Description: Crystal strcuture of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor