4itm - Revision history

OCA at 15:30, 20 September 2023

2023-09-20T15:30:32Z

←Older revision		Revision as of 15:30, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4itm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ITM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4itm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ITM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1994Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4itm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4itm OCA], [https://pdbe.org/4itm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4itm RCSB], [https://www.ebi.ac.uk/pdbsum/4itm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4itm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4itm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4itm OCA], [https://pdbe.org/4itm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4itm RCSB], [https://www.ebi.ac.uk/pdbsum/4itm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4itm ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:10, 16 November 2022

2022-11-16T21:10:31Z

←Older revision		Revision as of 21:10, 16 November 2022
Line 1:		Line 1:

	==Crystal structure of "apo" form LpxK from Aquifex aeolicus in complex with ATP at 2.2 angstrom resolution==		==Crystal structure of "apo" form LpxK from Aquifex aeolicus in complex with ATP at 2.2 angstrom resolution==
-	<StructureSection load='4itm' size='340' side='right' caption='[[4itm]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='4itm' size='340' side='right'caption='[[4itm]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4itm]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Aquae Aquae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ITM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4itm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ITM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ehw\|4ehw]], [[4ehx\|4ehx]], [[4ehy\|4ehy]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4itm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4itm OCA], [https://pdbe.org/4itm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4itm RCSB], [https://www.ebi.ac.uk/pdbsum/4itm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4itm ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpxK, aq_1656 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224324 AQUAE])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tetraacyldisaccharide_4'-kinase Tetraacyldisaccharide 4'-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.130 2.7.1.130] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4itm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4itm OCA], [~~http~~://pdbe.org/4itm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4itm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4itm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4itm ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LPXK_AQUAE LPXK_AQUAE]] Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity).	+	[https://www.uniprot.org/uniprot/LPXK_AQUAE LPXK_AQUAE] Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aquae~~]]	+	[[Category: Aquifex aeolicus VF5]]
-	[[Category: ~~Tetraacyldisaccharide 4'-kinase~~]]	+	[[Category: Large Structures]]
-	[[Category: Emptage~~, R P~~]]	+	[[Category: Emptage RP]]
-	[[Category: IV~~, C W.Pemble~~]]	+	[[Category: Pemble IV CW]]
-	[[Category: Raetz~~, C R.H~~]]	+	[[Category: Raetz CRH]]
-	[[Category: York~~, J D~~]]	+	[[Category: York JD]]
-	[[Category: Zhou, P]]	+	[[Category: Zhou P]]
-	~~[[Category: Disaccharide-1-phosphate 4'-kinase]]~~	+
-	~~[[Category: Ipid metabolism]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Lipid some]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: P-loop]]~~	+
-	~~[[Category: P-loop containing nucleoside triphosphate hydrolase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:47, 5 August 2016

2016-08-05T11:47:06Z

←Older revision		Revision as of 11:47, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of "apo" form LpxK from Aquifex aeolicus in complex with ATP at 2.2 angstrom resolution==		==Crystal structure of "apo" form LpxK from Aquifex aeolicus in complex with ATP at 2.2 angstrom resolution==
	<StructureSection load='4itm' size='340' side='right' caption='[[4itm]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4itm' size='340' side='right' caption='[[4itm]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4itm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aquifex_aeolicus_vf5 Aquifex aeolicus vf5~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ITM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4itm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquae Aquae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ITM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ehw\|4ehw]], [[4ehx\|4ehx]], [[4ehy\|4ehy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ehw\|4ehw]], [[4ehx\|4ehx]], [[4ehy\|4ehy]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpxK, aq_1656 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224324 ~~Aquifex aeolicus VF5~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpxK, aq_1656 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224324 AQUAE])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tetraacyldisaccharide_4'-kinase Tetraacyldisaccharide 4'-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.130 2.7.1.130] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tetraacyldisaccharide_4'-kinase Tetraacyldisaccharide 4'-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.130 2.7.1.130] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4itm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4itm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4itm RCSB], [http://www.ebi.ac.uk/pdbsum/4itm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4itm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4itm OCA], [http://pdbe.org/4itm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4itm RCSB], [http://www.ebi.ac.uk/pdbsum/4itm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4itm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4itm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aquifex aeolicus vf5~~]]	+	[[Category: Aquae]]
	[[Category: Tetraacyldisaccharide 4'-kinase]]		[[Category: Tetraacyldisaccharide 4'-kinase]]
	[[Category: Emptage, R P]]		[[Category: Emptage, R P]]

OCA at 02:09, 25 December 2014

2014-12-25T02:09:58Z

←Older revision		Revision as of 02:09, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4itm\| PDB=4itm \| SCENE= }}~~	+	==Crystal structure of "apo" form LpxK from Aquifex aeolicus in complex with ATP at 2.2 angstrom resolution==
-	===Crystal structure of "apo" form LpxK from Aquifex aeolicus in complex with ATP at 2.2 angstrom resolution===	+	<StructureSection load='4itm' size='340' side='right' caption='[[4itm]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23464738}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4itm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus_vf5 Aquifex aeolicus vf5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ITM FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ehw\|4ehw]], [[4ehx\|4ehx]], [[4ehy\|4ehy]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpxK, aq_1656 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224324 Aquifex aeolicus VF5])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tetraacyldisaccharide_4'-kinase Tetraacyldisaccharide 4'-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.130 2.7.1.130] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4itm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4itm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4itm RCSB], [http://www.ebi.ac.uk/pdbsum/4itm PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/LPXK_AQUAE LPXK_AQUAE]] Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity).		[[http://www.uniprot.org/uniprot/LPXK_AQUAE LPXK_AQUAE]] Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The sixth step in the lipid A biosynthetic pathway involves phosphorylation of the tetraacyldisaccharide-1-phosphate (DSMP) intermediate by the cytosol-facing inner membrane kinase LpxK, a member of the P-loop-containing nucleoside triphosphate (NTP) hydrolase superfamily. We report the kinetic characterization of LpxK from Aquifex aeolicus and the crystal structures of LpxK in complex with ATP in a precatalytic binding state, the ATP analogue AMP-PCP in the closed catalytically competent conformation, and a chloride anion revealing an inhibitory conformation of the nucleotide-binding P-loop. We demonstrate that LpxK activity in vitro requires the presence of a detergent micelle and formation of a ternary LpxK-ATP/Mg(2+)-DSMP complex. Using steady-state kinetics, we have identified crucial active site residues, leading to the proposal that the interaction of D99 with H261 acts to increase the pKa of the imidazole moiety, which in turn serves as the catalytic base to deprotonate the 4'-hydroxyl of the DSMP substrate. The fact that an analogous mechanism has not yet been observed for other P-loop kinases highlights LpxK as a distinct member of the P-loop kinase family, a notion that is also reflected through its localization at the membrane, lipid substrate, and overall structure.

-	~~==About this Structure==~~	+	Mechanistic Characterization of the Tetraacyldisaccharide-1-phosphate 4'-Kinase LpxK Involved in Lipid A Biosynthesis.,Emptage RP, Pemble CW 4th, York JD, Raetz CR, Zhou P Biochemistry. 2013 Apr 2;52(13):2280-90. doi: 10.1021/bi400097z. Epub 2013 Mar, 19. PMID:23464738<ref>PMID:23464738</ref>
-	~~[[4itm]] is a~~ 1 ~~chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Aquifex_aeolicus_vf5 Aquifex aeolicus vf5]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id~~=~~4ITM OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Aquifex aeolicus vf5]]		[[Category: Aquifex aeolicus vf5]]
	[[Category: Tetraacyldisaccharide 4'-kinase]]		[[Category: Tetraacyldisaccharide 4'-kinase]]
-	[[Category: Emptage, R P.]]	+	[[Category: Emptage, R P]]
-	[[Category: IV, C W.Pemble.]]	+	[[Category: IV, C W.Pemble]]
-	[[Category: Raetz, C R.H.]]	+	[[Category: Raetz, C R.H]]
-	[[Category: York, J D.]]	+	[[Category: York, J D]]
-	[[Category: Zhou, P.]]	+	[[Category: Zhou, P]]
	[[Category: Disaccharide-1-phosphate 4'-kinase]]		[[Category: Disaccharide-1-phosphate 4'-kinase]]
	[[Category: Ipid metabolism]]		[[Category: Ipid metabolism]]
Line 23:		Line 38:
	[[Category: P-loop]]		[[Category: P-loop]]
	[[Category: P-loop containing nucleoside triphosphate hydrolase]]		[[Category: P-loop containing nucleoside triphosphate hydrolase]]
-	[[Category: Tetraacyldisaccharide 4'-kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 01:29, 4 April 2013

2013-04-04T01:29:00Z

←Older revision		Revision as of 01:29, 4 April 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4itm\| PDB=4itm \| SCENE= }}
		+	===Crystal structure of "apo" form LpxK from Aquifex aeolicus in complex with ATP at 2.2 angstrom resolution===
		+	{{ABSTRACT_PUBMED_23464738}}

-	~~The entry 4itm is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/LPXK_AQUAE LPXK_AQUAE]] Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity).

-	~~Authors~~: Emptage, R.P.~~, Pemble~~ IV, C.W.~~, York, J~~.~~D.,~~ Raetz, C.R.H., Zhou, P.	+	==About this Structure==
-		+	[[4itm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus_vf5 Aquifex aeolicus vf5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITM OCA].
-	~~Description~~: ~~Crystal structure of "apo" form LpxK from Aquifex aeolicus in complex with ATP at 2.2 angstrom resolution~~	+	[[Category: Aquifex aeolicus vf5]]
		+	[[Category: Tetraacyldisaccharide 4'-kinase]]
		+	[[Category: Emptage, R P.]]
		+	[[Category: IV, C W.Pemble.]]
		+	[[Category: Raetz, C R.H.]]
		+	[[Category: York, J D.]]
		+	[[Category: Zhou, P.]]
		+	[[Category: Disaccharide-1-phosphate 4'-kinase]]
		+	[[Category: Ipid metabolism]]
		+	[[Category: Kinase]]
		+	[[Category: Lipid some]]
		+	[[Category: Membrane]]
		+	[[Category: Membrane protein]]
		+	[[Category: P-loop]]
		+	[[Category: P-loop containing nucleoside triphosphate hydrolase]]
		+	[[Category: Tetraacyldisaccharide 4'-kinase]]
		+	[[Category: Transferase]]

OCA at 09:54, 13 March 2013

2013-03-13T09:54:52Z

←Older revision		Revision as of 09:54, 13 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4itm is ON HOLD	+	The entry 4itm is ON HOLD until Paper Publication

	Authors: Emptage, R.P., Pemble IV, C.W., York, J.D., Raetz, C.R.H., Zhou, P.		Authors: Emptage, R.P., Pemble IV, C.W., York, J.D., Raetz, C.R.H., Zhou, P.

	Description: Crystal structure of "apo" form LpxK from Aquifex aeolicus in complex with ATP at 2.2 angstrom resolution		Description: Crystal structure of "apo" form LpxK from Aquifex aeolicus in complex with ATP at 2.2 angstrom resolution

OCA: Protected "4itm" [edit=sysop:move=sysop]

2013-01-30T12:04:19Z

Protected "4itm" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:04, 30 January 2013

OCA: New page: '''Unreleased structure''' The entry 4itm is ON HOLD Authors: Emptage, R.P., Pemble IV, C.W., York, J.D., Raetz, C.R.H., Zhou, P. Description: Crystal structure of "apo" form LpxK from...

2013-01-30T12:04:18Z

New page: '''Unreleased structure''' The entry 4itm is ON HOLD Authors: Emptage, R.P., Pemble IV, C.W., York, J.D., Raetz, C.R.H., Zhou, P. Description: Crystal structure of "apo" form LpxK from...

New page

'''Unreleased structure'''

The entry 4itm is ON HOLD

Authors: Emptage, R.P., Pemble IV, C.W., York, J.D., Raetz, C.R.H., Zhou, P.

Description: Crystal structure of "apo" form LpxK from Aquifex aeolicus in complex with ATP at 2.2 angstrom resolution