4its - Revision history

OCA at 21:10, 16 November 2022

2022-11-16T21:10:41Z

←Older revision		Revision as of 21:10, 16 November 2022
Line 1:		Line 1:

	==Crystal structure of the catalytic domain of human Pus1 with MES in the active site==		==Crystal structure of the catalytic domain of human Pus1 with MES in the active site==
-	<StructureSection load='4its' size='340' side='right' caption='[[4its]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='4its' size='340' side='right'caption='[[4its]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4its]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ITS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4its]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ITS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4iqm\|4iqm]], [[4j37\|4j37]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4its FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4its OCA], [https://pdbe.org/4its PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4its RCSB], [https://www.ebi.ac.uk/pdbsum/4its PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4its ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PUS1, PP8985 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_pseudouridine(38-40)_synthase tRNA pseudouridine(38-40) synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.12 5.4.99.12] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4its FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4its OCA], [~~http~~://pdbe.org/4its PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4its RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4its PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4its ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/~~TRUA_HUMAN TRUA_HUMAN]~~] Mitochondrial myopathy and sideroblastic anemia. Myopathy with lactic acidosis and sideroblastic anemia 1 (MLASA1) [MIM:[http://omim.org/entry/600462 600462]]: A rare oxidative phosphorylation disorder specific to skeletal muscle and bone marrow. Affected individuals manifest progressive muscle weakness, exercise intolerance, lactic acidosis, sideroblastic anemia and delayed growth. Note=The disease is caused by ~~mutations~~ affecting the gene represented in this entry.~~<ref>PMID:15108122</ref>~~	+	[https://www.uniprot.org/uniprot/PUS1_HUMAN PUS1_HUMAN] Mitochondrial myopathy and sideroblastic anemia. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~TRUA_HUMAN TRUA_HUMAN~~]~~] Converts specific uridines to PSI in a number~~ of ~~tRNA substrates~~. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity ~~possibly~~ through pseudouridylation of SRA1 ~~RNA~~ (~~By similarity~~).	+	[https://www.uniprot.org/uniprot/PUS1_HUMAN PUS1_HUMAN] Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs (PubMed:15772074, PubMed:24722331). Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA (PubMed:24722331). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:31477916, PubMed:35051350). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA (PubMed:24722331).<ref>PMID:15772074</ref> <ref>PMID:24722331</ref> <ref>PMID:31477916</ref> <ref>PMID:35051350</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:

	==See Also==		==See Also==
-	*[[~~TRNA pseudouridine~~ synthase\|~~TRNA pseudouridine~~ synthase]]	+	*[[Guide-independent Pseudouridine synthase\|Guide-independent Pseudouridine synthase]]
		+	*[[Pseudouridine synthase 3D structures\|Pseudouridine synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Czudnochowski, N~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Finer-Moore, J S~~]]	+	[[Category: Czudnochowski N]]
-	[[Category: ~~Stroud, R M]]~~	+	[[Category: Finer-Moore JS]]
-	~~[[Category: Beta sheet]]~~	+	[[Category: Stroud RM]]
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Pre~~-~~trna~~]]	+
-	[[Category: ~~Pseudouridine synthase]]~~	+
-	~~[[Category: Rna binding protein]]~~	+
-	~~[[Category: Rna modification]]~~	+
-	~~[[Category: Steroid receptor rna activator]]~~	+
-	~~[[Category: Trna]]~~	+
-	~~[[Category: U2 snrna~~]]	+

OCA at 20:37, 11 August 2016

2016-08-11T20:37:59Z

←Older revision		Revision as of 20:37, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the catalytic domain of human Pus1 with MES in the active site==		==Crystal structure of the catalytic domain of human Pus1 with MES in the active site==
	<StructureSection load='4its' size='340' side='right' caption='[[4its]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4its' size='340' side='right' caption='[[4its]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4its]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ITS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4its]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ITS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4iqm\|4iqm]], [[4j37\|4j37]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4iqm\|4iqm]], [[4j37\|4j37]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PUS1, PP8985 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PUS1, PP8985 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_pseudouridine(38-40)_synthase tRNA pseudouridine(38-40) synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.12 5.4.99.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_pseudouridine(38-40)_synthase tRNA pseudouridine(38-40) synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.12 5.4.99.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4its FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4its OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4its RCSB], [http://www.ebi.ac.uk/pdbsum/4its PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4its FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4its OCA], [http://pdbe.org/4its PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4its RCSB], [http://www.ebi.ac.uk/pdbsum/4its PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4its ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 22:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4its" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 28:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Czudnochowski, N]]		[[Category: Czudnochowski, N]]
	[[Category: Finer-Moore, J S]]		[[Category: Finer-Moore, J S]]

OCA at 13:44, 4 January 2015

2015-01-04T13:44:01Z

←Older revision		Revision as of 13:44, 4 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4its\| PDB=4its \| SCENE= }}~~	+	==Crystal structure of the catalytic domain of human Pus1 with MES in the active site==
-	===Crystal structure of the catalytic domain of human Pus1 with MES in the active site===	+	<StructureSection load='4its' size='340' side='right' caption='[[4its]], [[Resolution\|resolution]] 1.85Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23707380}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4its]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ITS FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4iqm\|4iqm]], [[4j37\|4j37]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PUS1, PP8985 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_pseudouridine(38-40)_synthase tRNA pseudouridine(38-40) synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.12 5.4.99.12] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4its FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4its OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4its RCSB], [http://www.ebi.ac.uk/pdbsum/4its PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/TRUA_HUMAN TRUA_HUMAN]] Mitochondrial myopathy and sideroblastic anemia. Myopathy with lactic acidosis and sideroblastic anemia 1 (MLASA1) [MIM:[http://omim.org/entry/600462 600462]]: A rare oxidative phosphorylation disorder specific to skeletal muscle and bone marrow. Affected individuals manifest progressive muscle weakness, exercise intolerance, lactic acidosis, sideroblastic anemia and delayed growth. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:15108122</ref>		[[http://www.uniprot.org/uniprot/TRUA_HUMAN TRUA_HUMAN]] Mitochondrial myopathy and sideroblastic anemia. Myopathy with lactic acidosis and sideroblastic anemia 1 (MLASA1) [MIM:[http://omim.org/entry/600462 600462]]: A rare oxidative phosphorylation disorder specific to skeletal muscle and bone marrow. Affected individuals manifest progressive muscle weakness, exercise intolerance, lactic acidosis, sideroblastic anemia and delayed growth. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:15108122</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TRUA_HUMAN TRUA_HUMAN]] Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human pseudouridine (Psi) synthase Pus1 (hPus1) modifies specific uridine residues in several non-coding RNAs: tRNA, U2 spliceosomal RNA, and steroid receptor activator RNA. We report three structures of the catalytic core domain of hPus1 from two crystal forms, at 1.8A resolution. The structures are the first of a mammalian Psi synthase from the set of five Psi-synthase families common to all kingdoms of life. Pus1 adopts a fold similar to bacterial Psi synthases, with a central antiparallel beta-sheet flanked by helices and loops. A flexible hinge at the base of the sheet allows the enzyme to open and close around an electropositive active-site cleft. In one crystal form, a molecule of Mes [2-(N-morpholino)ethane sulfonic acid] mimics the target uridine of an RNA substrate. A positively charged electrostatic surface extends from the active site towards the N-terminus of the catalytic domain, suggesting an extensive binding site specific for target RNAs. Two alpha-helices C-terminal to the core domain, but unique to hPus1, extend along the back and top of the central beta-sheet and form the walls of the RNA binding surface. Docking of tRNA to hPus1 in a productive orientation requires only minor conformational changes to enzyme and tRNA. The docked tRNA is bound by the electropositive surface of the protein employing a completely different binding mode than that seen for the tRNA complex of the Escherichia coli homologue TruA.

-	~~==Function==~~	+	In Human Pseudouridine Synthase 1 (hPus1), a C-Terminal Helical Insert Blocks tRNA from Binding in the Same Orientation as in the Pus1 Bacterial Homologue TruA, Consistent with Their Different Target Selectivities.,Czudnochowski N, Wang AL, Finer-Moore J, Stroud RM J Mol Biol. 2013 May 23. pii: S0022-2836(13)00328-8. doi:, 10.1016/j.jmb.2013.05.014. PMID:23707380<ref>PMID:23707380</ref>
-	~~[[http://www.uniprot.org/uniprot/TRUA_HUMAN TRUA_HUMAN]] Converts specific uridines to PSI in~~ a ~~number of~~ tRNA ~~substrates. Acts on positions 27/28~~ in the ~~anticodon stem and also positions 34 and 36~~ in the ~~anticodon of an intron containing tRNA~~. ~~Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA~~ (~~By similarity~~).	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4its]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4ITS OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023707380</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[TRNA pseudouridine synthase\|TRNA pseudouridine synthase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Czudnochowski, N.]]	+	[[Category: Czudnochowski, N]]
-	[[Category: Finer-Moore, J S.]]	+	[[Category: Finer-Moore, J S]]
-	[[Category: Stroud, R M.]]	+	[[Category: Stroud, R M]]
	[[Category: Beta sheet]]		[[Category: Beta sheet]]
	[[Category: Isomerase]]		[[Category: Isomerase]]

OCA at 15:22, 19 June 2013

2013-06-19T15:22:47Z

←Older revision		Revision as of 15:22, 19 June 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4its\| PDB=4its \| SCENE= }}
		+	===Crystal structure of the catalytic domain of human Pus1 with MES in the active site===
		+	{{ABSTRACT_PUBMED_23707380}}

-	~~The~~ entry ~~4its~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/TRUA_HUMAN TRUA_HUMAN]] Mitochondrial myopathy and sideroblastic anemia. Myopathy with lactic acidosis and sideroblastic anemia 1 (MLASA1) [MIM:[http://omim.org/entry/600462 600462]]: A rare oxidative phosphorylation disorder specific to skeletal muscle and bone marrow. Affected individuals manifest progressive muscle weakness, exercise intolerance, lactic acidosis, sideroblastic anemia and delayed growth. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:15108122</ref>

-	~~Authors~~: ~~Czudnochowski, N~~.~~, Finer-Moore, J~~.S.~~, Stroud, R~~.M.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/TRUA_HUMAN TRUA_HUMAN]] Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA (By similarity).

-	~~Description: Crystal~~ structure ~~of the catalytic domain of human Pus1~~ with ~~MES in the active site~~	+	==About this Structure==
		+	[[4its]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITS OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023707380</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Czudnochowski, N.]]
		+	[[Category: Finer-Moore, J S.]]
		+	[[Category: Stroud, R M.]]
		+	[[Category: Beta sheet]]
		+	[[Category: Isomerase]]
		+	[[Category: Pre-trna]]
		+	[[Category: Pseudouridine synthase]]
		+	[[Category: Rna binding protein]]
		+	[[Category: Rna modification]]
		+	[[Category: Steroid receptor rna activator]]
		+	[[Category: Trna]]
		+	[[Category: U2 snrna]]

OCA at 14:20, 27 February 2013

2013-02-27T14:20:41Z

←Older revision		Revision as of 14:20, 27 February 2013
Line 5:		Line 5:
	Authors: Czudnochowski, N., Finer-Moore, J.S., Stroud, R.M.		Authors: Czudnochowski, N., Finer-Moore, J.S., Stroud, R.M.

-	Description: ~~crystal~~ structure of ~~human Pus1~~ catalytic domain with MES in the active site	+	Description: Crystal structure of the catalytic domain of human Pus1 with MES in the active site

OCA at 13:26, 20 February 2013

2013-02-20T13:26:29Z

←Older revision		Revision as of 13:26, 20 February 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4its is ON HOLD	+	The entry 4its is ON HOLD until Paper Publication

	Authors: Czudnochowski, N., Finer-Moore, J.S., Stroud, R.M.		Authors: Czudnochowski, N., Finer-Moore, J.S., Stroud, R.M.

	Description: crystal structure of human Pus1 catalytic domain with MES in the active site		Description: crystal structure of human Pus1 catalytic domain with MES in the active site

OCA: Protected "4its" [edit=sysop:move=sysop]

2013-01-30T12:04:30Z

Protected "4its" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:04, 30 January 2013

OCA: New page: '''Unreleased structure''' The entry 4its is ON HOLD Authors: Czudnochowski, N., Finer-Moore, J.S., Stroud, R.M. Description: crystal structure of human Pus1 catalytic domain with MES ...

2013-01-30T12:04:29Z

New page: '''Unreleased structure''' The entry 4its is ON HOLD Authors: Czudnochowski, N., Finer-Moore, J.S., Stroud, R.M. Description: crystal structure of human Pus1 catalytic domain with MES ...

New page

'''Unreleased structure'''

The entry 4its is ON HOLD

Authors: Czudnochowski, N., Finer-Moore, J.S., Stroud, R.M.

Description: crystal structure of human Pus1 catalytic domain with MES in the active site