4ixv - Revision history

OCA at 15:32, 20 September 2023

2023-09-20T15:32:59Z

←Older revision		Revision as of 15:32, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ixv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IXV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ixv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IXV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XA1:{(5R)-5-AMINO-5-CARBOXY-5-[1-(4-CHLOROBENZYL)PIPERIDIN-4-YL]PENTYL}(TRIHYDROXY)BORATE(1-)'>XA1</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XA1:{(5R)-5-AMINO-5-CARBOXY-5-[1-(4-CHLOROBENZYL)PIPERIDIN-4-YL]PENTYL}(TRIHYDROXY)BORATE(1-)'>XA1</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ixv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixv OCA], [https://pdbe.org/4ixv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ixv RCSB], [https://www.ebi.ac.uk/pdbsum/4ixv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ixv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ixv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixv OCA], [https://pdbe.org/4ixv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ixv RCSB], [https://www.ebi.ac.uk/pdbsum/4ixv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ixv ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:19, 16 November 2022

2022-11-16T21:19:43Z

←Older revision		Revision as of 21:19, 16 November 2022
Line 1:		Line 1:

	==Crystal structure of human Arginase-2 complexed with inhibitor 2d: {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)==		==Crystal structure of human Arginase-2 complexed with inhibitor 2d: {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)==
-	<StructureSection load='4ixv' size='340' side='right' caption='[[4ixv]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4ixv' size='340' side='right'caption='[[4ixv]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ixv]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ixv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IXV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XA1:{(5R)-5-AMINO-5-CARBOXY-5-[1-(4-CHLOROBENZYL)PIPERIDIN-4-YL]PENTYL}(TRIHYDROXY)BORATE(1-)'>XA1</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XA1:{(5R)-5-AMINO-5-CARBOXY-5-[1-(4-CHLOROBENZYL)PIPERIDIN-4-YL]PENTYL}(TRIHYDROXY)BORATE(1-)'>XA1</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d3v\|1d3v]], [[1pq3\|1pq3]], [[4ixu\|4ixu]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ixv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixv OCA], [https://pdbe.org/4ixv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ixv RCSB], [https://www.ebi.ac.uk/pdbsum/4ixv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ixv ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ARG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ixv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixv OCA], [~~http~~://pdbe.org/4ixv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ixv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ixv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ixv ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN]] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.	+	[https://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4ixv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ixv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Arginase 3D structures\|Arginase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arginase~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Andreoli, M]]	+	[[Category: Andreoli M]]
-	[[Category: Beckett, P]]	+	[[Category: Beckett P]]
-	[[Category: Cousido-Siah, A]]	+	[[Category: Cousido-Siah A]]
-	[[Category: Czestkowski, W]]	+	[[Category: Czestkowski W]]
-	[[Category: Golebiowski, A]]	+	[[Category: Golebiowski A]]
-	[[Category: Jagdmann, R]]	+	[[Category: Jagdmann R]]
-	[[Category: Ji~~, M K~~]]	+	[[Category: Ji MK]]
-	[[Category: Mazur, M]]	+	[[Category: Mazur M]]
-	[[Category: Mitschler, A]]	+	[[Category: Mitschler A]]
-	[[Category: Olczak, J]]	+	[[Category: Olczak J]]
-	[[Category: Piotrowska, W]]	+	[[Category: Piotrowska W]]
-	[[Category: Podjarny, A]]	+	[[Category: Podjarny A]]
-	[[Category: Ruiz~~, F X~~]]	+	[[Category: Ruiz FX]]
-	[[Category: Ryder, T]]	+	[[Category: Ryder T]]
-	[[Category: Schroeter, H]]	+	[[Category: Schroeter H]]
-	[[Category: ~~Whitehouse, D]]~~	+	[[Category: Van Zandt MC]]
-	~~[[Category:~~ Zandt~~, M C.Van~~]]	+	[[Category: Whitehouse D]]
-	[[Category: ~~Alpha/beta fold]]~~	+
-	~~[[Category: Arginine metabolism]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Metalloenzyme]]~~	+
-	~~[[Category: Mitochondrion~~]]	+

OCA at 09:03, 15 November 2017

2017-11-15T09:03:58Z

←Older revision		Revision as of 09:03, 15 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4ixv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ixv" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Arginase\|Arginase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:39, 4 August 2016

2016-08-04T14:39:37Z

←Older revision		Revision as of 14:39, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human Arginase-2 complexed with inhibitor 2d: {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)==		==Crystal structure of human Arginase-2 complexed with inhibitor 2d: {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)==
	<StructureSection load='4ixv' size='340' side='right' caption='[[4ixv]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4ixv' size='340' side='right' caption='[[4ixv]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ARG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ARG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ixv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ixv RCSB], [http://www.ebi.ac.uk/pdbsum/4ixv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ixv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixv OCA], [http://pdbe.org/4ixv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ixv RCSB], [http://www.ebi.ac.uk/pdbsum/4ixv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ixv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ixv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Arginase\|Arginase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:53, 24 December 2014

2014-12-24T15:53:55Z

←Older revision		Revision as of 15:53, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ixv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ixv RCSB], [http://www.ebi.ac.uk/pdbsum/4ixv PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ixv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ixv RCSB], [http://www.ebi.ac.uk/pdbsum/4ixv PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN]] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:24, 21 December 2014

2014-12-21T16:24:00Z

←Older revision		Revision as of 16:24, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ixv\| PDB=4ixv \| SCENE= }}~~	+	==Crystal structure of human Arginase-2 complexed with inhibitor 2d: {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)==
-	===Crystal structure of human Arginase-2 complexed with inhibitor 2d: {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)===	+	<StructureSection load='4ixv' size='340' side='right' caption='[[4ixv]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23886684}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ixv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IXV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XA1:{(5R)-5-AMINO-5-CARBOXY-5-[1-(4-CHLOROBENZYL)PIPERIDIN-4-YL]PENTYL}(TRIHYDROXY)BORATE(1-)'>XA1</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d3v\|1d3v]], [[1pq3\|1pq3]], [[4ixu\|4ixu]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ARG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ixv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ixv RCSB], [http://www.ebi.ac.uk/pdbsum/4ixv PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Ugi reaction has been successfully applied to the synthesis of novel arginase inhibitors. In an effort to decrease conformational flexibility of the previously reported series of 2-amino-6-boronohexanoic acid (ABH) analogs 1, we designed and synthesized a series of compounds, 2, in which a piperidine ring is linked directly to a quaternary amino acid center. Further improvement of in vitro activity was achieved by adding two carbon bridge in the piperidine ring, that is, tropane analogs 11. These improvements in activity are rationalized by X-ray crystallography analysis, which show that the tropane ring nitrogen atom moves into direct contact with Asp202 (arginase II numbering). The synthetic routes described here enabled the design of novel arginase inhibitors with improved potency and markedly different physico-chemical properties compared to ABH. Compound 11c represents the most in vitro active arginase inhibitor reported to date.

-	~~==Function==~~	+	Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction.,Golebiowski A, Whitehouse D, Beckett RP, Van Zandt M, Ji MK, Ryder TR, Jagdmann E, Andreoli M, Lee Y, Sheeler R, Conway B, Olczak J, Mazur M, Czestkowski W, Piotrowska W, Cousido-Siah A, Ruiz FX, Mitschler A, Podjarny A, Schroeter H Bioorg Med Chem Lett. 2013 Sep 1;23(17):4837-41. doi: 10.1016/j.bmcl.2013.06.092., Epub 2013 Jul 8. PMID:23886684<ref>PMID:23886684</ref>
-	~~[[http://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN]] May play a role in the regulation~~ of ~~extra~~-~~urea cycle arginine metabolism and also in down~~-~~regulation of nitric oxide synthesis. Extrahepatic~~ arginase ~~functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in~~ the ~~penile corpus cavernosum smooth muscle~~, ~~the clitoral corpus cavernosum and the vagina~~, ~~arginase II plays a role in both male and female sexual arousal~~. ~~It is therefore a potential target for the treatment of male and female sexual arousal disorders~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4ixv]] is~~ a ~~3 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4IXV OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023886684</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Arginase]]		[[Category: Arginase]]
-	[[Category: Andreoli, M.]]	+	[[Category: Human]]
-	[[Category: Beckett, P.]]	+	[[Category: Andreoli, M]]
-	[[Category: Cousido-Siah, A.]]	+	[[Category: Beckett, P]]
-	[[Category: Czestkowski, W.]]	+	[[Category: Cousido-Siah, A]]
-	[[Category: Golebiowski, A.]]	+	[[Category: Czestkowski, W]]
-	[[Category: Jagdmann, R.]]	+	[[Category: Golebiowski, A]]
-	[[Category: Ji, M K.]]	+	[[Category: Jagdmann, R]]
-	[[Category: Mazur, M.]]	+	[[Category: Ji, M K]]
-	[[Category: Mitschler, A.]]	+	[[Category: Mazur, M]]
-	[[Category: Olczak, J.]]	+	[[Category: Mitschler, A]]
-	[[Category: Piotrowska, W.]]	+	[[Category: Olczak, J]]
-	[[Category: Podjarny, A.]]	+	[[Category: Piotrowska, W]]
-	[[Category: Ruiz, F X.]]	+	[[Category: Podjarny, A]]
-	[[Category: Ryder, T.]]	+	[[Category: Ruiz, F X]]
-	[[Category: Schroeter, H.]]	+	[[Category: Ryder, T]]
-	[[Category: Whitehouse, D.]]	+	[[Category: Schroeter, H]]
-	[[Category: Zandt, M C.Van.]]	+	[[Category: Whitehouse, D]]
		+	[[Category: Zandt, M C.Van]]
	[[Category: Alpha/beta fold]]		[[Category: Alpha/beta fold]]
	[[Category: Arginine metabolism]]		[[Category: Arginine metabolism]]

OCA at 13:37, 11 December 2013

2013-12-11T13:37:43Z

←Older revision		Revision as of 13:37, 11 December 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4ixv\| PDB=4ixv \| SCENE= }}
		+	===Crystal structure of human Arginase-2 complexed with inhibitor 2d: {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)===
		+	{{ABSTRACT_PUBMED_23886684}}

-	~~The entry 4ixv~~ is ~~ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN]] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.

-	~~Authors~~: ~~Cousido-Siah, A~~.~~, Mitschler, A~~.~~, Ruiz, F~~.~~X., Whitehouse, D., Beckett, P., Van Zandt, M.C., Ji, M.K., Ryder, T., Jagdmann, R., Andreoli, M., Olczak, J., Mazur, M., Czestkowski, W., Piotrowska, W., Schroeter, H., Golebiowski, A., Podjarny, A~~.	+	==About this Structure==
		+	[[4ixv]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXV OCA].

-	~~Description~~: ~~Crystal structure of human~~ Arginase-~~2 complexed with inhbitor 2d~~	+	==Reference==
		+	<ref group="xtra">PMID:023886684</ref><references group="xtra"/><references/>
		+	[[Category: Arginase]]
		+	[[Category: Andreoli, M.]]
		+	[[Category: Beckett, P.]]
		+	[[Category: Cousido-Siah, A.]]
		+	[[Category: Czestkowski, W.]]
		+	[[Category: Golebiowski, A.]]
		+	[[Category: Jagdmann, R.]]
		+	[[Category: Ji, M K.]]
		+	[[Category: Mazur, M.]]
		+	[[Category: Mitschler, A.]]
		+	[[Category: Olczak, J.]]
		+	[[Category: Piotrowska, W.]]
		+	[[Category: Podjarny, A.]]
		+	[[Category: Ruiz, F X.]]
		+	[[Category: Ryder, T.]]
		+	[[Category: Schroeter, H.]]
		+	[[Category: Whitehouse, D.]]
		+	[[Category: Zandt, M C.Van.]]
		+	[[Category: Alpha/beta fold]]
		+	[[Category: Arginine metabolism]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Metalloenzyme]]
		+	[[Category: Mitochondrion]]

OCA at 16:15, 20 March 2013

2013-03-20T16:15:01Z

←Older revision		Revision as of 16:15, 20 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ixv is ON HOLD	+	The entry 4ixv is ON HOLD until Paper Publication

	Authors: Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Whitehouse, D., Beckett, P., Van Zandt, M.C., Ji, M.K., Ryder, T., Jagdmann, R., Andreoli, M., Olczak, J., Mazur, M., Czestkowski, W., Piotrowska, W., Schroeter, H., Golebiowski, A., Podjarny, A.		Authors: Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Whitehouse, D., Beckett, P., Van Zandt, M.C., Ji, M.K., Ryder, T., Jagdmann, R., Andreoli, M., Olczak, J., Mazur, M., Czestkowski, W., Piotrowska, W., Schroeter, H., Golebiowski, A., Podjarny, A.

	Description: Crystal structure of human Arginase-2 complexed with inhbitor 2d		Description: Crystal structure of human Arginase-2 complexed with inhbitor 2d

OCA at 13:27, 20 February 2013

2013-02-20T13:27:30Z

←Older revision		Revision as of 13:27, 20 February 2013
Line 3:		Line 3:
	The entry 4ixv is ON HOLD		The entry 4ixv is ON HOLD

-	Authors: Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Whitehouse, D., Beckett ,P., Van Zandt, M.C., Ji,M.K., Ryder, T., Jagdmann, R., Andreoli, M., Olczak, J., Mazur, M., Czestkowski, W., Piotrowska, W., Schroeter, H., Golebiowski,A., Podjarny, A.	+	Authors: Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Whitehouse, D., Beckett, P., Van Zandt, M.C., Ji, M.K., Ryder, T., Jagdmann, R., Andreoli, M., Olczak, J., Mazur, M., Czestkowski, W., Piotrowska, W., Schroeter, H., Golebiowski, A., Podjarny, A.

	Description: Crystal structure of human Arginase-2 complexed with inhbitor 2d		Description: Crystal structure of human Arginase-2 complexed with inhbitor 2d

OCA: Protected "4ixv" [edit=sysop:move=sysop]

2013-02-06T12:30:56Z

Protected "4ixv" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:30, 6 February 2013