4j3d - Revision history

OCA at 12:00, 1 March 2024

2024-03-01T12:00:56Z

←Older revision		Revision as of 12:00, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j3d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J3D FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j3d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J3D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1JS:N~1~-HYDROXY-N~5~-(3-HYDROXYPROPYL)-N~2~-[4-(PHENYLETHYNYL)BENZOYL]-L-GLUTAMAMIDE'>1JS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1JS:N~1~-HYDROXY-N~5~-(3-HYDROXYPROPYL)-N~2~-[4-(PHENYLETHYNYL)BENZOYL]-L-GLUTAMAMIDE'>1JS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j3d OCA], [https://pdbe.org/4j3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j3d RCSB], [https://www.ebi.ac.uk/pdbsum/4j3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j3d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j3d OCA], [https://pdbe.org/4j3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j3d RCSB], [https://www.ebi.ac.uk/pdbsum/4j3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j3d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.		[https://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Lipopolysaccharide (LPS) biosynthesis is an attractive antibacterial target as it is both conserved and essential for the survival of key pathogenic bacteria. Lipid A is the hydrophobic anchor for LPS and a key structural component of the outer membrane of Gram-negative bacteria. Lipid A biosynthesis is performed in part by a unique zinc dependent metalloamidase, LpxC (UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase), which catalyzes the first non-reversible step in lipid A biosynthesis. The UDP portion of the LpxC substrate-binding pocket has been relatively unexplored. We have designed and evaluated a series of hydroxamate based inhibitors which explore the SAR of substitutions directed into the UDP pocket with a range of substituted alpha-amino acid based linkers. We also provide the first wild type structure of Pseudomonas aeruginosa LpxC which was utilized in the design of many of these analogs.
-
-	Exploring the UDP pocket of LpxC through amino acid analogs.,Hale MR, Hill P, Lahiri S, Miller MD, Ross P, Alm R, Gao N, Kutschke A, Johnstone M, Prince B, Thresher J, Yang W Bioorg Med Chem Lett. 2013 Apr 15;23(8):2362-7. doi: 10.1016/j.bmcl.2013.02.055. , Epub 2013 Mar 1. PMID:23499237<ref>PMID:23499237</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4j3d" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase\|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]		*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase\|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 21:30, 16 November 2022

2022-11-16T21:30:19Z

←Older revision		Revision as of 21:30, 16 November 2022
Line 1:		Line 1:

	==Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor==		==Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor==
-	<StructureSection load='4j3d' size='340' side='right' caption='[[4j3d]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4j3d' size='340' side='right'caption='[[4j3d]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j3d]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J3D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4J3D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j3d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J3D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1JS:N~1~-HYDROXY-N~5~-(3-HYDROXYPROPYL)-N~2~-[4-(PHENYLETHYNYL)BENZOYL]-L-GLUTAMAMIDE'>1JS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1JS:N~1~-HYDROXY-N~5~-(3-HYDROXYPROPYL)-N~2~-[4-(PHENYLETHYNYL)BENZOYL]-L-GLUTAMAMIDE'>1JS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpxC, envA, PA4406 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j3d OCA], [https://pdbe.org/4j3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j3d RCSB], [https://www.ebi.ac.uk/pdbsum/4j3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j3d ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4j3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j3d OCA], [~~http~~://pdbe.org/4j3d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4j3d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4j3d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4j3d ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.	+	[https://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4j3d" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4j3d" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase\|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pseae~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Lahiri, S~~]]	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	[[Category: ~~Hydrolase-hydrolase inhibitor complex]]~~	+	[[Category: Lahiri S]]
-	~~[[Category: Lpxc]]~~	+
-	~~[[Category: Metalloamidase~~]]	+

OCA at 06:36, 7 February 2018

2018-02-07T06:36:01Z

←Older revision		Revision as of 06:36, 7 February 2018
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4j3d" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4j3d" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase\|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:37, 4 August 2016

2016-08-04T19:37:23Z

←Older revision		Revision as of 19:37, 4 August 2016
Line 1:		Line 1:
		+
	==Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor==		==Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor==
	<StructureSection load='4j3d' size='340' side='right' caption='[[4j3d]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4j3d' size='340' side='right' caption='[[4j3d]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j3d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J3D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J3D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j3d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J3D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J3D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1JS:N~1~-HYDROXY-N~5~-(3-HYDROXYPROPYL)-N~2~-[4-(PHENYLETHYNYL)BENZOYL]-L-GLUTAMAMIDE'>1JS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1JS:N~1~-HYDROXY-N~5~-(3-HYDROXYPROPYL)-N~2~-[4-(PHENYLETHYNYL)BENZOYL]-L-GLUTAMAMIDE'>1JS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpxC, envA, PA4406 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 ~~Pseudomonas aeruginosa PAO1~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpxC, envA, PA4406 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j3d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j3d RCSB], [http://www.ebi.ac.uk/pdbsum/4j3d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j3d OCA], [http://pdbe.org/4j3d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j3d RCSB], [http://www.ebi.ac.uk/pdbsum/4j3d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j3d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4j3d" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pseudomonas aeruginosa pao1~~]]	+	[[Category: Pseae]]
	[[Category: Lahiri, S]]		[[Category: Lahiri, S]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Lpxc]]		[[Category: Lpxc]]
	[[Category: Metalloamidase]]		[[Category: Metalloamidase]]

OCA at 18:51, 24 December 2014

2014-12-24T18:51:11Z

←Older revision		Revision as of 18:51, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j3d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j3d RCSB], [http://www.ebi.ac.uk/pdbsum/4j3d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j3d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j3d RCSB], [http://www.ebi.ac.uk/pdbsum/4j3d PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:46, 21 December 2014

2014-12-21T12:46:57Z

←Older revision		Revision as of 12:46, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4j3d\| PDB=4j3d \| SCENE= }}~~	+	==Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor==
-	===Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor===	+	<StructureSection load='4j3d' size='340' side='right' caption='[[4j3d]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23499237}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4j3d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J3D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J3D FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1JS:N~1~-HYDROXY-N~5~-(3-HYDROXYPROPYL)-N~2~-[4-(PHENYLETHYNYL)BENZOYL]-L-GLUTAMAMIDE'>1JS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpxC, envA, PA4406 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 Pseudomonas aeruginosa PAO1])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j3d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j3d RCSB], [http://www.ebi.ac.uk/pdbsum/4j3d PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lipopolysaccharide (LPS) biosynthesis is an attractive antibacterial target as it is both conserved and essential for the survival of key pathogenic bacteria. Lipid A is the hydrophobic anchor for LPS and a key structural component of the outer membrane of Gram-negative bacteria. Lipid A biosynthesis is performed in part by a unique zinc dependent metalloamidase, LpxC (UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase), which catalyzes the first non-reversible step in lipid A biosynthesis. The UDP portion of the LpxC substrate-binding pocket has been relatively unexplored. We have designed and evaluated a series of hydroxamate based inhibitors which explore the SAR of substitutions directed into the UDP pocket with a range of substituted alpha-amino acid based linkers. We also provide the first wild type structure of Pseudomonas aeruginosa LpxC which was utilized in the design of many of these analogs.

-	~~==Function==~~	+	Exploring the UDP pocket of LpxC through amino acid analogs.,Hale MR, Hill P, Lahiri S, Miller MD, Ross P, Alm R, Gao N, Kutschke A, Johnstone M, Prince B, Thresher J, Yang W Bioorg Med Chem Lett. 2013 Apr 15;23(8):2362-7. doi: 10.1016/j.bmcl.2013.02.055. , Epub 2013 Mar 1. PMID:23499237<ref>PMID:23499237</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/LPXC_PSEAE LPXC_PSEAE]] Involved in the biosynthesis of lipid A~~, ~~a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell~~.	+

-	==~~About this Structure~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[~~4j3d~~]] ~~is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J3D OCA].~~	+	</div>
		+
		+	==See Also==
		+	*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase\|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Pseudomonas aeruginosa pao1]]		[[Category: Pseudomonas aeruginosa pao1]]
-	[[Category: Lahiri, S.]]	+	[[Category: Lahiri, S]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Lpxc]]		[[Category: Lpxc]]
	[[Category: Metalloamidase]]		[[Category: Metalloamidase]]

OCA at 01:30, 4 April 2013

2013-04-04T01:30:22Z

←Older revision		Revision as of 01:30, 4 April 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4j3d\| PDB=4j3d \| SCENE= }}
		+	===Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor===
		+	{{ABSTRACT_PUBMED_23499237}}

-	~~The entry 4j3d is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

-	~~Authors~~: Lahiri, S.	+	==About this Structure==
-		+	[[4j3d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J3D OCA].
-	~~Description~~: ~~Pseudomonas aeruginosa LpxC in complex with a hydroxamate~~ inhibitor	+	[[Category: Pseudomonas aeruginosa pao1]]
		+	[[Category: Lahiri, S.]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Lpxc]]
		+	[[Category: Metalloamidase]]

OCA at 16:15, 20 March 2013

2013-03-20T16:15:53Z

←Older revision		Revision as of 16:15, 20 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4j3d is ON HOLD	+	The entry 4j3d is ON HOLD until Paper Publication

	Authors: Lahiri, S.		Authors: Lahiri, S.

	Description: Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor		Description: Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor

OCA at 14:23, 27 February 2013

2013-02-27T14:23:16Z

←Older revision		Revision as of 14:23, 27 February 2013
Line 3:		Line 3:
	The entry 4j3d is ON HOLD		The entry 4j3d is ON HOLD

-	Authors: ~~Sushmita~~ Lahiri	+	Authors: Lahiri, S.

	Description: Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor		Description: Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor

OCA: Protected "4j3d" [edit=sysop:move=sysop]

2013-02-13T10:11:18Z

Protected "4j3d" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:11, 13 February 2013