4j5l - Revision history

OCA at 12:01, 1 March 2024

2024-03-01T12:01:28Z

←Older revision		Revision as of 12:01, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j5l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J5L FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j5l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J5L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5l OCA], [https://pdbe.org/4j5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j5l RCSB], [https://www.ebi.ac.uk/pdbsum/4j5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j5l ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5l OCA], [https://pdbe.org/4j5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j5l RCSB], [https://www.ebi.ac.uk/pdbsum/4j5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j5l ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN] Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.<ref>PMID:10448864</ref>		[https://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN] Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.<ref>PMID:10448864</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Myosin V (MyoV) motors have been implicated in the intracellular transport of diverse cargoes including vesicles, organelles, RNA-protein complexes and regulatory proteins. Here, we have solved the cargo-binding domain (CBD) structures of the three human MyoV paralogs (Va, Vb and Vc), revealing subtle structural changes that drive functional differentiation and a novel redox mechanism controlling the CBD dimerization process, which is unique for the MyoVc subclass. Moreover, the cargo- and motor-binding sites were structurally assigned indicating the conservation of residues involved in the recognition of adaptors for peroxisome transport and providing high-resolution insights into motor domain (MD) inhibition by CBD. These results contribute to understanding the structural requirements for cargo transport, auto-inhibition and regulatory mechanisms in myosin V motors.
-
-	Structural insights into functional overlapping and differentiation among myosin V motors.,Nascimento AF, Trindade DM, Tonoli CC, de Giuseppe PO, Assis LH, Honorato RV, de Oliveira PS, Mahajan P, Burgess-Brown NA, von Delft F, Larson RE, Murakami MT J Biol Chem. 2013 Oct 4. PMID:24097982<ref>PMID:24097982</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4j5l" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 21:33, 16 November 2022

2022-11-16T21:33:46Z

←Older revision		Revision as of 21:33, 16 November 2022
Line 1:		Line 1:

	==Structure of the Cargo Binding Domain from Human Myosin Va==		==Structure of the Cargo Binding Domain from Human Myosin Va==
-	<StructureSection load='4j5l' size='340' side='right' caption='[[4j5l]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='4j5l' size='340' side='right'caption='[[4j5l]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j5l]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5L OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4J5L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j5l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J5L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j5m\|4j5m]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5l OCA], [https://pdbe.org/4j5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j5l RCSB], [https://www.ebi.ac.uk/pdbsum/4j5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j5l ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYH12, MYO5A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4j5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5l OCA], [~~http~~://pdbe.org/4j5l PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4j5l RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4j5l PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4j5l ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN]] Griscelli disease type 3;Neuroectodermal melanolysosomal disease;Griscelli disease type 1. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN] Griscelli disease type 3;Neuroectodermal melanolysosomal disease;Griscelli disease type 1. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN]] Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.<ref>PMID:10448864</ref>	+	[https://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN] Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.<ref>PMID:10448864</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4j5l" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4j5l" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Myosin 3D Structures\|Myosin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Assis~~, L H.P~~]]	+	[[Category: Large Structures]]
-	[[Category: Berridge, G]]	+	[[Category: Assis LHP]]
-	[[Category: Burgess-Brown, N]]	+	[[Category: Berridge G]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Burgess-Brown N]]
-	[[Category: Krojer, T]]	+	[[Category: Krojer T]]
-	[[Category: Mahajan, P]]	+	[[Category: Mahajan P]]
-	[[Category: Murakami~~, M T~~]]	+	[[Category: Murakami MT]]
-	[[Category: Nascimento~~, A F.Z~~]]	+	[[Category: Nascimento AFZ]]
-	[[Category: Tonoli~~, C C.C~~]]	+	[[Category: Tonoli CCC]]
-	[[Category: Trindade~~, D M~~]]	+	[[Category: Trindade DM]]
-	[[Category: Vollmar, M]]	+	[[Category: Vollmar M]]
-	[[Category: ~~C-terminal globular tail]]~~	+	[[Category: Von Delft F]]
-	~~[[Category: Human myosin va]]~~	+
-	~~[[Category: Intracellular traffic]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Vesicle~~]]	+

OCA at 09:05, 15 November 2017

2017-11-15T09:05:56Z

←Older revision		Revision as of 09:05, 15 November 2017
Line 22:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 4j5l" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4j5l" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Myosin\|Myosin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:11, 5 August 2016

2016-08-05T06:11:53Z

←Older revision		Revision as of 06:11, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of the Cargo Binding Domain from Human Myosin Va==		==Structure of the Cargo Binding Domain from Human Myosin Va==
	<StructureSection load='4j5l' size='340' side='right' caption='[[4j5l]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4j5l' size='340' side='right' caption='[[4j5l]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j5m\|4j5m]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j5m\|4j5m]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYH12, MYO5A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYH12, MYO5A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j5l RCSB], [http://www.ebi.ac.uk/pdbsum/4j5l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5l OCA], [http://pdbe.org/4j5l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j5l RCSB], [http://www.ebi.ac.uk/pdbsum/4j5l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j5l ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4j5l" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:19, 21 December 2014

2014-12-21T17:19:43Z

←Older revision		Revision as of 17:19, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4j5l\| PDB=4j5l \| SCENE= }}~~	+	==Structure of the Cargo Binding Domain from Human Myosin Va==
-	===Structure of the Cargo Binding Domain from Human Myosin Va===	+	<StructureSection load='4j5l' size='340' side='right' caption='[[4j5l]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24097982}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4j5l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J5L FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j5m\|4j5m]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYH12, MYO5A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j5l RCSB], [http://www.ebi.ac.uk/pdbsum/4j5l PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN]] Griscelli disease type 3;Neuroectodermal melanolysosomal disease;Griscelli disease type 1. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.		[[http://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN]] Griscelli disease type 3;Neuroectodermal melanolysosomal disease;Griscelli disease type 1. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN]] Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.<ref>PMID:10448864</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Myosin V (MyoV) motors have been implicated in the intracellular transport of diverse cargoes including vesicles, organelles, RNA-protein complexes and regulatory proteins. Here, we have solved the cargo-binding domain (CBD) structures of the three human MyoV paralogs (Va, Vb and Vc), revealing subtle structural changes that drive functional differentiation and a novel redox mechanism controlling the CBD dimerization process, which is unique for the MyoVc subclass. Moreover, the cargo- and motor-binding sites were structurally assigned indicating the conservation of residues involved in the recognition of adaptors for peroxisome transport and providing high-resolution insights into motor domain (MD) inhibition by CBD. These results contribute to understanding the structural requirements for cargo transport, auto-inhibition and regulatory mechanisms in myosin V motors.

-	~~==Function==~~	+	Structural insights into functional overlapping and differentiation among myosin V motors.,Nascimento AF, Trindade DM, Tonoli CC, de Giuseppe PO, Assis LH, Honorato RV, de Oliveira PS, Mahajan P, Burgess-Brown NA, von Delft F, Larson RE, Murakami MT J Biol Chem. 2013 Oct 4. PMID:24097982<ref>PMID:24097982</ref>
-	~~[[http://www~~.~~uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN]] Processive actin~~-~~based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament~~. ~~Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation~~.<ref>PMID:~~10448864~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4j5l]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4J5L OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024097982</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Myosin\|Myosin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Assis, L H.P.]]	+	[[Category: Assis, L H.P]]
-	[[Category: Berridge, G.]]	+	[[Category: Berridge, G]]
-	[[Category: Burgess-Brown, N.]]	+	[[Category: Burgess-Brown, N]]
-	[[Category: Delft, F von.]]	+	[[Category: Delft, F von]]
-	[[Category: Krojer, T.]]	+	[[Category: Krojer, T]]
-	[[Category: Mahajan, P.]]	+	[[Category: Mahajan, P]]
-	[[Category: Murakami, M T.]]	+	[[Category: Murakami, M T]]
-	[[Category: Nascimento, A F.Z.]]	+	[[Category: Nascimento, A F.Z]]
-	[[Category: Tonoli, C C.C.]]	+	[[Category: Tonoli, C C.C]]
-	[[Category: Trindade, D M.]]	+	[[Category: Trindade, D M]]
-	[[Category: Vollmar, M.]]	+	[[Category: Vollmar, M]]
	[[Category: C-terminal globular tail]]		[[Category: C-terminal globular tail]]
	[[Category: Human myosin va]]		[[Category: Human myosin va]]

OCA at 12:37, 11 December 2013

2013-12-11T12:37:28Z

←Older revision		Revision as of 12:37, 11 December 2013
Line 10:		Line 10:

	==About this Structure==		==About this Structure==
-	[[4j5l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5L OCA].	+	[[4j5l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5L OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:024097982</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024097982</ref><references group="xtra"/><references/>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Assis, L H.P.]]		[[Category: Assis, L H.P.]]
	[[Category: Berridge, G.]]		[[Category: Berridge, G.]]

OCA at 05:26, 23 October 2013

2013-10-23T05:26:40Z

←Older revision		Revision as of 05:26, 23 October 2013
Line 1:		Line 1:
	{{STRUCTURE_4j5l\| PDB=4j5l \| SCENE= }}		{{STRUCTURE_4j5l\| PDB=4j5l \| SCENE= }}
	===Structure of the Cargo Binding Domain from Human Myosin Va===		===Structure of the Cargo Binding Domain from Human Myosin Va===
		+	{{ABSTRACT_PUBMED_24097982}}

	==Disease==		==Disease==
Line 12:		Line 13:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:024097982</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Assis, L H.P.]]		[[Category: Assis, L H.P.]]

OCA at 06:38, 10 October 2013

2013-10-10T06:38:40Z

←Older revision		Revision as of 06:38, 10 October 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4j5l\| PDB=4j5l \| SCENE= }}
		+	===Structure of the Cargo Binding Domain from Human Myosin Va===

-	The entry ~~4j5l~~ is ~~ON HOLD~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN]] Griscelli disease type 3;Neuroectodermal melanolysosomal disease;Griscelli disease type 1. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

-	~~Authors~~: ~~Nascimento, A~~.F.~~Z., Trindade, D.M., Tonoli, C.C.C., Assis, L.H.P., Mahajan, P., Berridge, G., Krojer, T., Vollmar, M., Burgess~~-~~Brown, N~~.~~, von Delft, F~~.~~, Murakami, M~~.T.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN]] Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.<ref>PMID:10448864</ref>

-	~~Description:~~ Structure ~~of the Cargo Binding Domain~~ from Human ~~Myosin Va~~	+	==About this Structure==
		+	[[4j5l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5L OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Assis, L H.P.]]
		+	[[Category: Berridge, G.]]
		+	[[Category: Burgess-Brown, N.]]
		+	[[Category: Delft, F von.]]
		+	[[Category: Krojer, T.]]
		+	[[Category: Mahajan, P.]]
		+	[[Category: Murakami, M T.]]
		+	[[Category: Nascimento, A F.Z.]]
		+	[[Category: Tonoli, C C.C.]]
		+	[[Category: Trindade, D M.]]
		+	[[Category: Vollmar, M.]]
		+	[[Category: C-terminal globular tail]]
		+	[[Category: Human myosin va]]
		+	[[Category: Intracellular traffic]]
		+	[[Category: Protein transport]]
		+	[[Category: Vesicle]]

OCA: Protected "4j5l" [edit=sysop:move=sysop]

2013-02-20T13:31:01Z

Protected "4j5l" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:31, 20 February 2013

OCA: New page: '''Unreleased structure''' The entry 4j5l is ON HOLD Authors: Nascimento, A.F.Z., Trindade, D.M., Tonoli, C.C.C., Assis, L.H.P., Mahajan, P., Berridge, G., Krojer, T., Vollmar, M., Burg...

2013-02-20T13:31:00Z

New page: '''Unreleased structure''' The entry 4j5l is ON HOLD Authors: Nascimento, A.F.Z., Trindade, D.M., Tonoli, C.C.C., Assis, L.H.P., Mahajan, P., Berridge, G., Krojer, T., Vollmar, M., Burg...

New page

'''Unreleased structure'''

The entry 4j5l is ON HOLD

Authors: Nascimento, A.F.Z., Trindade, D.M., Tonoli, C.C.C., Assis, L.H.P., Mahajan, P., Berridge, G., Krojer, T., Vollmar, M., Burgess-Brown, N., von Delft, F., Murakami, M.T.

Description: Structure of the Cargo Binding Domain from Human Myosin Va