4j6m - Revision history

OCA at 15:37, 20 September 2023

2023-09-20T15:37:05Z

←Older revision		Revision as of 15:37, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j6m]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J6M FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j6m]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J6M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.48Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j6m OCA], [https://pdbe.org/4j6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j6m RCSB], [https://www.ebi.ac.uk/pdbsum/4j6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j6m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j6m OCA], [https://pdbe.org/4j6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j6m RCSB], [https://www.ebi.ac.uk/pdbsum/4j6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j6m ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:55, 24 November 2022

2022-11-24T10:55:17Z

←Older revision		Revision as of 10:55, 24 November 2022
Line 1:		Line 1:

	==Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form D)==		==Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form D)==
-	<StructureSection load='4j6m' size='340' side='right' caption='[[4j6m]], [[Resolution\|resolution]] 2.48Å' scene=''>	+	<StructureSection load='4j6m' size='340' side='right'caption='[[4j6m]], [[Resolution\|resolution]] 2.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j6m]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J6M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4J6M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j6m]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J6M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g96\|4g96]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j6m OCA], [https://pdbe.org/4j6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j6m RCSB], [https://www.ebi.ac.uk/pdbsum/4j6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j6m ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD23A, CLEC4J, FCE2, FCER2, IGEBF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4j6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j6m OCA], [~~http~~://pdbe.org/4j6m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4j6m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4j6m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4j6m ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FCER2_HUMAN FCER2_HUMAN]] Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).	+	[https://www.uniprot.org/uniprot/FCER2_HUMAN FCER2_HUMAN] Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4j6m" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4j6m" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[CD23\|CD23]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Dhaliwal, B~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Fabiane, S M]]~~	+	[[Category: Dhaliwal B]]
-	~~[[Category: Sutton,~~ B J]]	+	[[Category: Fabiane SM]]
-	[[Category: ~~Antibody receptor~~]]	+	[[Category: Sutton BJ]]
-	[[Category: ~~Immune system]]~~	+
-	~~[[Category: Immunoglobulin fold lectin~~]]	+

OCA at 16:58, 4 August 2016

2016-08-04T16:58:51Z

←Older revision		Revision as of 16:58, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form D)==		==Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form D)==
	<StructureSection load='4j6m' size='340' side='right' caption='[[4j6m]], [[Resolution\|resolution]] 2.48Å' scene=''>		<StructureSection load='4j6m' size='340' side='right' caption='[[4j6m]], [[Resolution\|resolution]] 2.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j6m]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J6M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J6M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j6m]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J6M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J6M FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g96\|4g96]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g96\|4g96]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD23A, CLEC4J, FCE2, FCER2, IGEBF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD23A, CLEC4J, FCE2, FCER2, IGEBF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j6m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j6m RCSB], [http://www.ebi.ac.uk/pdbsum/4j6m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j6m OCA], [http://pdbe.org/4j6m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j6m RCSB], [http://www.ebi.ac.uk/pdbsum/4j6m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j6m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4j6m" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dhaliwal, B]]		[[Category: Dhaliwal, B]]
	[[Category: Fabiane, S M]]		[[Category: Fabiane, S M]]

OCA at 11:11, 25 December 2014

2014-12-25T11:11:16Z

←Older revision		Revision as of 11:11, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4j6m\| PDB=4j6m \| SCENE= }}~~	+	==Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form D)==
-	===Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form D)===	+	<StructureSection load='4j6m' size='340' side='right' caption='[[4j6m]], [[Resolution\|resolution]] 2.48Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23933509}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4j6m]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J6M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J6M FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4g96\|4g96]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD23A, CLEC4J, FCE2, FCER2, IGEBF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j6m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j6m RCSB], [http://www.ebi.ac.uk/pdbsum/4j6m PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/FCER2_HUMAN FCER2_HUMAN]] Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).		[[http://www.uniprot.org/uniprot/FCER2_HUMAN FCER2_HUMAN]] Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	IgE antibodies play a central role in allergic disease. They recognize allergens via their Fab regions, whilst their effector functions are controlled through interactions of the Fc region with two principal cell surface receptors, FcvarepsilonRI and CD23. Crosslinking of FcvarepsilonRI-bound IgE on mast cells and basophils by allergen initiates an immediate inflammatory response, while the interaction of IgE with CD23 on B-cells regulates IgE production. We have determined the structures of the C-type lectin "head" domain of CD23 from seven crystal forms. The thirty-five independent structures reveal extensive conformational plasticity in two loops that are critical for IgE binding.

-	~~==About this Structure==~~	+	Conformational plasticity at the IgE-binding site of the B-cell receptor CD23.,Dhaliwal B, Pang MO, Yuan D, Yahya N, Fabiane SM, McDonnell JM, Gould HJ, Beavil AJ, Sutton BJ Mol Immunol. 2013 Aug 6;56(4):693-697. doi: 10.1016/j.molimm.2013.07.005. PMID:23933509<ref>PMID:23933509</ref>
-	~~[[4j6m]] is a 8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=4J6M OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023933509</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dhaliwal, B.]]	+	[[Category: Dhaliwal, B]]
-	[[Category: Fabiane, S M.]]	+	[[Category: Fabiane, S M]]
-	[[Category: Sutton, B J.]]	+	[[Category: Sutton, B J]]
	[[Category: Antibody receptor]]		[[Category: Antibody receptor]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin fold lectin]]		[[Category: Immunoglobulin fold lectin]]

OCA at 07:28, 28 August 2013

2013-08-28T07:28:47Z

←Older revision		Revision as of 07:28, 28 August 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4j6m\| PDB=4j6m \| SCENE= }}
		+	===Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form D)===
		+	{{ABSTRACT_PUBMED_23933509}}

-	~~The entry 4j6m~~ is ~~ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/FCER2_HUMAN FCER2_HUMAN]] Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

-	~~Authors~~: ~~Dhaliwal, B~~.~~, Fabiane, S~~.M.~~, Sutton, B~~.J.	+	==About this Structure==
		+	[[4j6m]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J6M OCA].

-	~~Description~~: ~~Crystal structure of calcium2+-free wild-type CD23~~ lectin ~~domain (crystal form D)~~	+	==Reference==
		+	<ref group="xtra">PMID:023933509</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Dhaliwal, B.]]
		+	[[Category: Fabiane, S M.]]
		+	[[Category: Sutton, B J.]]
		+	[[Category: Antibody receptor]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin fold lectin]]

OCA at 10:52, 24 April 2013

2013-04-24T10:52:08Z

←Older revision		Revision as of 10:52, 24 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4j6m is ON HOLD	+	The entry 4j6m is ON HOLD until Paper Publication

	Authors: Dhaliwal, B., Fabiane, S.M., Sutton, B.J.		Authors: Dhaliwal, B., Fabiane, S.M., Sutton, B.J.

	Description: Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form D)		Description: Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form D)

OCA: Protected "4j6m" [edit=sysop:move=sysop]

2013-02-20T13:32:13Z

Protected "4j6m" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:32, 20 February 2013

OCA: New page: '''Unreleased structure''' The entry 4j6m is ON HOLD Authors: Dhaliwal, B., Fabiane, S.M., Sutton, B.J. Description: Crystal structure of calcium2+-free wild-type CD23 lectin domain (c...

2013-02-20T13:32:12Z

New page: '''Unreleased structure''' The entry 4j6m is ON HOLD Authors: Dhaliwal, B., Fabiane, S.M., Sutton, B.J. Description: Crystal structure of calcium2+-free wild-type CD23 lectin domain (c...

New page

'''Unreleased structure'''

The entry 4j6m is ON HOLD

Authors: Dhaliwal, B., Fabiane, S.M., Sutton, B.J.

Description: Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form D)