4j9a - Revision history

OCA at 12:02, 1 March 2024

2024-03-01T12:02:32Z

←Older revision		Revision as of 12:02, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j9a]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J9A FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j9a]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J9A FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOG:DIGOXIGENIN'>DOG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOG:DIGOXIGENIN'>DOG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j9a OCA], [https://pdbe.org/4j9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j9a RCSB], [https://www.ebi.ac.uk/pdbsum/4j9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j9a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j9a OCA], [https://pdbe.org/4j9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j9a RCSB], [https://www.ebi.ac.uk/pdbsum/4j9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j9a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Y3332_PSEAE Y3332_PSEAE]		[https://www.uniprot.org/uniprot/Y3332_PSEAE Y3332_PSEAE]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The ability to design proteins with high affinity and selectivity for any given small molecule is a rigorous test of our understanding of the physiochemical principles that govern molecular recognition. Attempts to rationally design ligand-binding proteins have met with little success, however, and the computational design of protein-small-molecule interfaces remains an unsolved problem. Current approaches for designing ligand-binding proteins for medical and biotechnological uses rely on raising antibodies against a target antigen in immunized animals and/or performing laboratory-directed evolution of proteins with an existing low affinity for the desired ligand, neither of which allows complete control over the interactions involved in binding. Here we describe a general computational method for designing pre-organized and shape complementary small-molecule-binding sites, and use it to generate protein binders to the steroid digoxigenin (DIG). Of seventeen experimentally characterized designs, two bind DIG; the model of the higher affinity binder has the most energetically favourable and pre-organized interface in the design set. A comprehensive binding-fitness landscape of this design, generated by library selections and deep sequencing, was used to optimize its binding affinity to a picomolar level, and X-ray co-crystal structures of two variants show atomic-level agreement with the corresponding computational models. The optimized binder is selective for DIG over the related steroids digitoxigenin, progesterone and beta-oestradiol, and this steroid binding preference can be reprogrammed by manipulation of explicitly designed hydrogen-bonding interactions. The computational design method presented here should enable the development of a new generation of biosensors, therapeutics and diagnostics.
-
-	Computational design of ligand-binding proteins with high affinity and selectivity.,Tinberg CE, Khare SD, Dou J, Doyle L, Nelson JW, Schena A, Jankowski W, Kalodimos CG, Johnsson K, Stoddard BL, Baker D Nature. 2013 Sep 12;501(7466):212-6. doi: 10.1038/nature12443. Epub 2013 Sep 4. PMID:24005320<ref>PMID:24005320</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4j9a" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:00, 24 November 2022

2022-11-24T11:00:19Z

←Older revision		Revision as of 11:00, 24 November 2022
Line 1:		Line 1:

	==Engineered Digoxigenin binder DIG10.3==		==Engineered Digoxigenin binder DIG10.3==
-	<StructureSection load='4j9a' size='340' side='right' caption='[[4j9a]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='4j9a' size='340' side='right'caption='[[4j9a]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j9a]] is a 9 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J9A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4J9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j9a]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J9A FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOG:DIGOXIGENIN'>DOG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOG:DIGOXIGENIN'>DOG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j8t\|4j8t]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j9a OCA], [https://pdbe.org/4j9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j9a RCSB], [https://www.ebi.ac.uk/pdbsum/4j9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j9a ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA3332 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4j9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j9a OCA], [~~http~~://pdbe.org/4j9a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4j9a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4j9a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4j9a ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Y3332_PSEAE Y3332_PSEAE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pseae~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Doyle, L A~~]]	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	[[Category: ~~Stoddard, B L~~]]	+	[[Category: Doyle LA]]
-	[[Category: ~~Computationally designed]]~~	+	[[Category: Stoddard BL]]
-	~~[[Category: Digoxigenin binding protein]]~~	+
-	~~[[Category: Digoxigenin-binding]]~~	+
-	~~[[Category: Engineered~~]]	+

OCA at 19:35, 4 August 2016

2016-08-04T19:35:40Z

←Older revision		Revision as of 19:35, 4 August 2016
Line 1:		Line 1:
		+
	==Engineered Digoxigenin binder DIG10.3==		==Engineered Digoxigenin binder DIG10.3==
	<StructureSection load='4j9a' size='340' side='right' caption='[[4j9a]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='4j9a' size='340' side='right' caption='[[4j9a]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j9a]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j9a]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J9A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOG:DIGOXIGENIN'>DOG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOG:DIGOXIGENIN'>DOG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j8t\|4j8t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j8t\|4j8t]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA3332 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 ~~Pseudomonas aeruginosa PAO1~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA3332 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j9a RCSB], [http://www.ebi.ac.uk/pdbsum/4j9a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j9a OCA], [http://pdbe.org/4j9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j9a RCSB], [http://www.ebi.ac.uk/pdbsum/4j9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j9a ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4j9a" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pseudomonas aeruginosa pao1~~]]	+	[[Category: Pseae]]
	[[Category: Doyle, L A]]		[[Category: Doyle, L A]]
	[[Category: Stoddard, B L]]		[[Category: Stoddard, B L]]

OCA at 12:45, 21 December 2014

2014-12-21T12:45:30Z

←Older revision		Revision as of 12:45, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4j9a~~\| ~~PDB~~=4j9a \| ~~SCENE~~= }}	+	==Engineered Digoxigenin binder DIG10.3==
-	===~~Engineered Digoxigenin binder DIG10~~.3===	+	<StructureSection load='4j9a' size='340' side='right' caption='[[4j9a]], [[Resolution\|resolution]] 3.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24005320}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4j9a]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J9A FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOG:DIGOXIGENIN'>DOG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j8t\|4j8t]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA3332 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 Pseudomonas aeruginosa PAO1])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j9a RCSB], [http://www.ebi.ac.uk/pdbsum/4j9a PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ability to design proteins with high affinity and selectivity for any given small molecule is a rigorous test of our understanding of the physiochemical principles that govern molecular recognition. Attempts to rationally design ligand-binding proteins have met with little success, however, and the computational design of protein-small-molecule interfaces remains an unsolved problem. Current approaches for designing ligand-binding proteins for medical and biotechnological uses rely on raising antibodies against a target antigen in immunized animals and/or performing laboratory-directed evolution of proteins with an existing low affinity for the desired ligand, neither of which allows complete control over the interactions involved in binding. Here we describe a general computational method for designing pre-organized and shape complementary small-molecule-binding sites, and use it to generate protein binders to the steroid digoxigenin (DIG). Of seventeen experimentally characterized designs, two bind DIG; the model of the higher affinity binder has the most energetically favourable and pre-organized interface in the design set. A comprehensive binding-fitness landscape of this design, generated by library selections and deep sequencing, was used to optimize its binding affinity to a picomolar level, and X-ray co-crystal structures of two variants show atomic-level agreement with the corresponding computational models. The optimized binder is selective for DIG over the related steroids digitoxigenin, progesterone and beta-oestradiol, and this steroid binding preference can be reprogrammed by manipulation of explicitly designed hydrogen-bonding interactions. The computational design method presented here should enable the development of a new generation of biosensors, therapeutics and diagnostics.

-	~~==About this Structure==~~	+	Computational design of ligand-binding proteins with high affinity and selectivity.,Tinberg CE, Khare SD, Dou J, Doyle L, Nelson JW, Schena A, Jankowski W, Kalodimos CG, Johnsson K, Stoddard BL, Baker D Nature. 2013 Sep 12;501(7466):212-6. doi: 10.1038/nature12443. Epub 2013 Sep 4. PMID:24005320<ref>PMID:24005320</ref>
-	~~[[4j9a]] is a 9 chain structure~~ with ~~sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4J9A OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024005320</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Pseudomonas aeruginosa pao1]]		[[Category: Pseudomonas aeruginosa pao1]]
-	[[Category: Doyle, L A.]]	+	[[Category: Doyle, L A]]
-	[[Category: Stoddard, B L.]]	+	[[Category: Stoddard, B L]]
	[[Category: Computationally designed]]		[[Category: Computationally designed]]
	[[Category: Digoxigenin binding protein]]		[[Category: Digoxigenin binding protein]]
	[[Category: Digoxigenin-binding]]		[[Category: Digoxigenin-binding]]
	[[Category: Engineered]]		[[Category: Engineered]]

OCA at 02:43, 20 September 2013

2013-09-20T02:43:46Z

←Older revision		Revision as of 02:43, 20 September 2013
Line 1:		Line 1:
	{{STRUCTURE_4j9a\| PDB=4j9a \| SCENE= }}		{{STRUCTURE_4j9a\| PDB=4j9a \| SCENE= }}
	===Engineered Digoxigenin binder DIG10.3===		===Engineered Digoxigenin binder DIG10.3===
		+	{{ABSTRACT_PUBMED_24005320}}

	==About this Structure==		==About this Structure==
	[[4j9a]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J9A OCA].		[[4j9a]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J9A OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024005320</ref><references group="xtra"/><references/>
	[[Category: Pseudomonas aeruginosa pao1]]		[[Category: Pseudomonas aeruginosa pao1]]
	[[Category: Doyle, L A.]]		[[Category: Doyle, L A.]]

OCA at 10:28, 30 June 2013

2013-06-30T10:28:38Z

←Older revision		Revision as of 10:28, 30 June 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4j9a\| PDB=4j9a \| SCENE= }}
		+	===Engineered Digoxigenin binder DIG10.3===

-	~~The entry~~ 4j9a is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4j9a]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J9A OCA].
-	~~Authors~~: ~~Stoddard~~, B.L., ~~Doyle,~~ L.A.	+	[[Category: Pseudomonas aeruginosa pao1]]
-		+	[[Category: Doyle, L A.]]
-	~~Description~~: ~~Engineered~~ Digoxigenin ~~binder DIG10.3~~	+	[[Category: Stoddard, B L.]]
		+	[[Category: Computationally designed]]
		+	[[Category: Digoxigenin binding protein]]
		+	[[Category: Digoxigenin-binding]]
		+	[[Category: Engineered]]

OCA at 00:50, 4 April 2013

2013-04-04T00:50:51Z

←Older revision		Revision as of 00:50, 4 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4j9a is ON HOLD	+	The entry 4j9a is ON HOLD until Paper Publication

	Authors: Stoddard, B.L., Doyle, L.A.		Authors: Stoddard, B.L., Doyle, L.A.

	Description: Engineered Digoxigenin binder DIG10.3		Description: Engineered Digoxigenin binder DIG10.3

OCA at 09:57, 13 March 2013

2013-03-13T09:57:29Z

←Older revision		Revision as of 09:57, 13 March 2013
Line 3:		Line 3:
	The entry 4j9a is ON HOLD		The entry 4j9a is ON HOLD

-	Authors: Stoddard, ~~Barry~~ L., Doyle, ~~Lindsey~~ A.,	+	Authors: Stoddard, B.L., Doyle, L.A.

	Description: Engineered Digoxigenin binder DIG10.3		Description: Engineered Digoxigenin binder DIG10.3

OCA: Protected "4j9a" [edit=sysop:move=sysop]

2013-02-27T14:26:00Z

Protected "4j9a" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:26, 27 February 2013

OCA: New page: '''Unreleased structure''' The entry 4j9a is ON HOLD Authors: Stoddard, Barry L., Doyle, Lindsey A., Description: Engineered Digoxigenin binder DIG10.3

2013-02-27T14:25:59Z

New page: '''Unreleased structure''' The entry 4j9a is ON HOLD Authors: Stoddard, Barry L., Doyle, Lindsey A., Description: Engineered Digoxigenin binder DIG10.3

New page

'''Unreleased structure'''

The entry 4j9a is ON HOLD

Authors: Stoddard, Barry L., Doyle, Lindsey A.,

Description: Engineered Digoxigenin binder DIG10.3