4jbg - Revision history

OCA at 12:02, 1 March 2024

2024-03-01T12:02:53Z

←Older revision		Revision as of 12:02, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4jbg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrobaculum_aerophilum_str._IM2 Pyrobaculum aerophilum str. IM2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JBG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4jbg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrobaculum_aerophilum_str._IM2 Pyrobaculum aerophilum str. IM2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JBG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbg OCA], [https://pdbe.org/4jbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jbg RCSB], [https://www.ebi.ac.uk/pdbsum/4jbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jbg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbg OCA], [https://pdbe.org/4jbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jbg RCSB], [https://www.ebi.ac.uk/pdbsum/4jbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jbg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q8ZUP0_PYRAE Q8ZUP0_PYRAE]		[https://www.uniprot.org/uniprot/Q8ZUP0_PYRAE Q8ZUP0_PYRAE]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	In this work we characterize an alcohol dehydrogenase (ADH) from the hyperthermophilic archaeon Pyrobaculum aerophilum (PyAeADHII). We have previously found that PyAeADHII has no activity when standard ADH substrates are used but is active when alpha-tetralone is used as substrate. Here, to gain insights into enzyme function, we screened several chemical libraries for enzymatic modulators using an assay employing alpha-tetralone. The results indicate that PyAeADHII activity in the presence of alpha-tetralone was inhibited by compounds such as flunarizine. We also examined metal coordination of the enzyme in solution by performing metal substitution of the enzyme-bound zinc (Zn(2+)) with cobalt. The solution-based absorption spectra for cobalt substituted PyAeADHII supports substitution at the structural Zn(2+) site. To gain structural insight, we obtained the crystal structure of both wild-type and cobalt-substituted PyAeADHII at 1.75 A and 2.20 A resolution, respectively. The X-ray data confirmed one metal ion per monomer present only at the structural site with otherwise close conservation to other ADH enzymes. We next determined the co-crystal structure of the NADPH-bound form of the enzyme at 2.35 A resolution to help define the active site region of the enzyme and this data shows close structural conservation with horse ADH, despite the lack of a catalytic Zn(2+) ion in PyAeADHII. Modeling of alpha-tetralone into the NADPH bound structure suggests an arginine as a possible catalytic residue. The data presented here can yield a better understanding of alcohol dehydrogenases lacking the catalytic zinc as well as the structural features inherent to thermostable enzymes.
-
-	Physicochemical Characterization of a Thermostable Alcohol Dehydrogenase from Pyrobaculum aerophilum.,Vitale A, Thorne N, Lovell S, Battaile KP, Hu X, Shen M, D'Auria S, Auld DS PLoS One. 2013 Jun 5;8(6):e63828. doi: 10.1371/journal.pone.0063828. Print 2013. PMID:23755111<ref>PMID:23755111</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4jbg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Alcohol dehydrogenase 3D structures\|Alcohol dehydrogenase 3D structures]]		*[[Alcohol dehydrogenase 3D structures\|Alcohol dehydrogenase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:03, 24 November 2022

2022-11-24T11:03:34Z

←Older revision		Revision as of 11:03, 24 November 2022
Line 1:		Line 1:

	==1.75A resolution structure of a thermostable alcohol dehydrogenase from Pyrobaculum aerophilum==		==1.75A resolution structure of a thermostable alcohol dehydrogenase from Pyrobaculum aerophilum==
-	<StructureSection load='4jbg' size='340' side='right' caption='[[4jbg]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='4jbg' size='340' side='right'caption='[[4jbg]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jbg]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pyrae Pyrae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4JBG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jbg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrobaculum_aerophilum_str._IM2 Pyrobaculum aerophilum str. IM2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JBG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jbh\|4jbh]], [[4jbi\|4jbi]], [[4jbu\|4jbu]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbg OCA], [https://pdbe.org/4jbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jbg RCSB], [https://www.ebi.ac.uk/pdbsum/4jbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jbg ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PAE2687 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=178306 PYRAE])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4jbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbg OCA], [~~http~~://pdbe.org/4jbg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4jbg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4jbg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4jbg ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8ZUP0_PYRAE Q8ZUP0_PYRAE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4jbg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4jbg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Alcohol dehydrogenase 3D structures\|Alcohol dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Alcohol dehydrogenase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Pyrae~~]]	+	[[Category: Pyrobaculum aerophilum str. IM2]]
-	[[Category: Auld~~, D S~~]]	+	[[Category: Auld DS]]
-	[[Category: ~~Auria, S D~~]]	+	[[Category: Battaile KP]]
-	[[Category: ~~Battaile, K P~~]]	+	[[Category: D'Auria S]]
-	[[Category: Hu, X]]	+	[[Category: Hu X]]
-	[[Category: Lovell, S]]	+	[[Category: Lovell S]]
-	[[Category: Shen, M]]	+	[[Category: Shen M]]
-	[[Category: Throne, N]]	+	[[Category: Throne N]]
-	[[Category: Vitale, A]]	+	[[Category: Vitale A]]
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Thermostability]]~~	+
-	~~[[Category: Zinc binding~~]]	+

OCA at 09:07, 15 November 2017

2017-11-15T09:07:55Z

←Older revision		Revision as of 09:07, 15 November 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4jbg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4jbg" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Alcohol dehydrogenase\|Alcohol dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:29, 11 August 2016

2016-08-11T12:29:08Z

←Older revision		Revision as of 12:29, 11 August 2016
Line 1:		Line 1:
		+
	==1.75A resolution structure of a thermostable alcohol dehydrogenase from Pyrobaculum aerophilum==		==1.75A resolution structure of a thermostable alcohol dehydrogenase from Pyrobaculum aerophilum==
	<StructureSection load='4jbg' size='340' side='right' caption='[[4jbg]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='4jbg' size='340' side='right' caption='[[4jbg]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jbg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pyrobaculum_aerophilum_str._im2 Pyrobaculum aerophilum str. im2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JBG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jbg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrae Pyrae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JBG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jbh\|4jbh]], [[4jbi\|4jbi]], [[4jbu\|4jbu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jbh\|4jbh]], [[4jbi\|4jbi]], [[4jbu\|4jbu]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PAE2687 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=178306 ~~Pyrobaculum aerophilum str. IM2~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PAE2687 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=178306 PYRAE])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jbg RCSB], [http://www.ebi.ac.uk/pdbsum/4jbg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbg OCA], [http://pdbe.org/4jbg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jbg RCSB], [http://www.ebi.ac.uk/pdbsum/4jbg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jbg ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4jbg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Alcohol dehydrogenase]]		[[Category: Alcohol dehydrogenase]]
-	[[Category: ~~Pyrobaculum aerophilum str. im2~~]]	+	[[Category: Pyrae]]
	[[Category: Auld, D S]]		[[Category: Auld, D S]]
	[[Category: Auria, S D]]		[[Category: Auria, S D]]

OCA at 12:26, 5 January 2015

2015-01-05T12:26:08Z

←Older revision		Revision as of 12:26, 5 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4jbg\| PDB=4jbg \| SCENE= }}~~	+	==1.75A resolution structure of a thermostable alcohol dehydrogenase from Pyrobaculum aerophilum==
-	===1.75A resolution structure of a thermostable alcohol dehydrogenase from Pyrobaculum aerophilum===	+	<StructureSection load='4jbg' size='340' side='right' caption='[[4jbg]], [[Resolution\|resolution]] 1.75Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23755111}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4jbg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrobaculum_aerophilum_str._im2 Pyrobaculum aerophilum str. im2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JBG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jbh\|4jbh]], [[4jbi\|4jbi]], [[4jbu\|4jbu]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PAE2687 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=178306 Pyrobaculum aerophilum str. IM2])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jbg RCSB], [http://www.ebi.ac.uk/pdbsum/4jbg PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In this work we characterize an alcohol dehydrogenase (ADH) from the hyperthermophilic archaeon Pyrobaculum aerophilum (PyAeADHII). We have previously found that PyAeADHII has no activity when standard ADH substrates are used but is active when alpha-tetralone is used as substrate. Here, to gain insights into enzyme function, we screened several chemical libraries for enzymatic modulators using an assay employing alpha-tetralone. The results indicate that PyAeADHII activity in the presence of alpha-tetralone was inhibited by compounds such as flunarizine. We also examined metal coordination of the enzyme in solution by performing metal substitution of the enzyme-bound zinc (Zn(2+)) with cobalt. The solution-based absorption spectra for cobalt substituted PyAeADHII supports substitution at the structural Zn(2+) site. To gain structural insight, we obtained the crystal structure of both wild-type and cobalt-substituted PyAeADHII at 1.75 A and 2.20 A resolution, respectively. The X-ray data confirmed one metal ion per monomer present only at the structural site with otherwise close conservation to other ADH enzymes. We next determined the co-crystal structure of the NADPH-bound form of the enzyme at 2.35 A resolution to help define the active site region of the enzyme and this data shows close structural conservation with horse ADH, despite the lack of a catalytic Zn(2+) ion in PyAeADHII. Modeling of alpha-tetralone into the NADPH bound structure suggests an arginine as a possible catalytic residue. The data presented here can yield a better understanding of alcohol dehydrogenases lacking the catalytic zinc as well as the structural features inherent to thermostable enzymes.

-	~~==About this Structure==~~	+	Physicochemical Characterization of a Thermostable Alcohol Dehydrogenase from Pyrobaculum aerophilum.,Vitale A, Thorne N, Lovell S, Battaile KP, Hu X, Shen M, D'Auria S, Auld DS PLoS One. 2013 Jun 5;8(6):e63828. doi: 10.1371/journal.pone.0063828. Print 2013. PMID:23755111<ref>PMID:23755111</ref>
-	~~[[4jbg]] is~~ a ~~4 chain structure with sequence~~ from ~~[http://en.wikipedia.org/wiki/Pyrobaculum_aerophilum_str._im2~~ Pyrobaculum aerophilum ~~str~~. ~~im2]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4JBG OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group~~=~~"xtra">PMID:023755111</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+
		+	==See Also==
		+	*[[Alcohol dehydrogenase\|Alcohol dehydrogenase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Alcohol dehydrogenase]]		[[Category: Alcohol dehydrogenase]]
	[[Category: Pyrobaculum aerophilum str. im2]]		[[Category: Pyrobaculum aerophilum str. im2]]
-	[[Category: Auld, D S.]]	+	[[Category: Auld, D S]]
-	[[Category: Auria, S D.]]	+	[[Category: Auria, S D]]
-	[[Category: Battaile, K P.]]	+	[[Category: Battaile, K P]]
-	[[Category: Hu, X.]]	+	[[Category: Hu, X]]
-	[[Category: Lovell, S.]]	+	[[Category: Lovell, S]]
-	[[Category: Shen, M.]]	+	[[Category: Shen, M]]
-	[[Category: Throne, N.]]	+	[[Category: Throne, N]]
-	[[Category: Vitale, A~~.]]~~	+	[[Category: Vitale, A]]
-	~~[[Category: Alcohol dehydrogenase~~]]	+
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Thermostability]]		[[Category: Thermostability]]
	[[Category: Zinc binding]]		[[Category: Zinc binding]]

OCA at 14:02, 3 July 2013

2013-07-03T14:02:13Z

←Older revision		Revision as of 14:02, 3 July 2013
Line 4:		Line 4:

	==About this Structure==		==About this Structure==
-	[[4jbg]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBG OCA].	+	[[4jbg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrobaculum_aerophilum_str._im2 Pyrobaculum aerophilum str. im2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBG OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:023755111</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:023755111</ref><references group="xtra"/><references/>
	[[Category: Alcohol dehydrogenase]]		[[Category: Alcohol dehydrogenase]]
		+	[[Category: Pyrobaculum aerophilum str. im2]]
	[[Category: Auld, D S.]]		[[Category: Auld, D S.]]
	[[Category: Auria, S D.]]		[[Category: Auria, S D.]]

OCA at 10:10, 3 July 2013

2013-07-03T10:10:11Z

←Older revision		Revision as of 10:10, 3 July 2013
Line 1:		Line 1:
	{{STRUCTURE_4jbg\| PDB=4jbg \| SCENE= }}		{{STRUCTURE_4jbg\| PDB=4jbg \| SCENE= }}
	===1.75A resolution structure of a thermostable alcohol dehydrogenase from Pyrobaculum aerophilum===		===1.75A resolution structure of a thermostable alcohol dehydrogenase from Pyrobaculum aerophilum===
		+	{{ABSTRACT_PUBMED_23755111}}

	==About this Structure==		==About this Structure==
-	[[4jbg]] is a 4 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Pyrobaculum_aerophilum_str._im2 Pyrobaculum aerophilum str. im2]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBG OCA].	+	[[4jbg]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBG OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023755111</ref><references group="xtra"/><references/>
	[[Category: Alcohol dehydrogenase]]		[[Category: Alcohol dehydrogenase]]
-	[[Category: Pyrobaculum aerophilum str. im2]]
	[[Category: Auld, D S.]]		[[Category: Auld, D S.]]
	[[Category: Auria, S D.]]		[[Category: Auria, S D.]]

OCA at 07:25, 20 June 2013

2013-06-20T07:25:07Z

←Older revision		Revision as of 07:25, 20 June 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4jbg\| PDB=4jbg \| SCENE= }}
		+	===1.75A resolution structure of a thermostable alcohol dehydrogenase from Pyrobaculum aerophilum===

-	~~The entry~~ 4jbg is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4jbg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrobaculum_aerophilum_str._im2 Pyrobaculum aerophilum str. im2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBG OCA].
-	~~Authors~~: ~~Lovell~~, S., Battaile, K.P.~~, Vitale, A., Throne, N.,~~ Hu, X., Shen, M., ~~D'Auria, S~~., ~~Auld, D~~.S.	+	[[Category: Alcohol dehydrogenase]]
-		+	[[Category: Pyrobaculum aerophilum str. im2]]
-	~~Description~~: ~~1.75A resolution structure of a thermostable alcohol~~ dehydrogenase ~~from Pyrobaculum aerophilum~~	+	[[Category: Auld, D S.]]
		+	[[Category: Auria, S D.]]
		+	[[Category: Battaile, K P.]]
		+	[[Category: Hu, X.]]
		+	[[Category: Lovell, S.]]
		+	[[Category: Shen, M.]]
		+	[[Category: Throne, N.]]
		+	[[Category: Vitale, A.]]
		+	[[Category: Alcohol dehydrogenase]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Thermostability]]
		+	[[Category: Zinc binding]]

OCA at 16:17, 20 March 2013

2013-03-20T16:17:29Z

←Older revision		Revision as of 16:17, 20 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4jbg is ON HOLD	+	The entry 4jbg is ON HOLD until Paper Publication

-	Authors: Lovell, ~~Scott~~, Battaile, ~~Kevin~~ P., Vitale, ~~Annalisa~~, Throne, ~~Natasha~~, Hu, ~~Xin~~, Shen, ~~Min~~, D'Auria, ~~Sabato~~, Auld, ~~Douglas~~ S.	+	Authors: Lovell, S., Battaile, K.P., Vitale, A., Throne, N., Hu, X., Shen, M., D'Auria, S., Auld, D.S.

	Description: 1.75A resolution structure of a thermostable alcohol dehydrogenase from Pyrobaculum aerophilum		Description: 1.75A resolution structure of a thermostable alcohol dehydrogenase from Pyrobaculum aerophilum

OCA: Protected "4jbg" [edit=sysop:move=sysop]

2013-02-27T14:28:24Z

Protected "4jbg" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:28, 27 February 2013