4je3 - Revision history

OCA at 12:03, 1 March 2024

2024-03-01T12:03:10Z

←Older revision		Revision as of 12:03, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4je3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JE3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4je3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JE3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4je3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4je3 OCA], [https://pdbe.org/4je3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4je3 RCSB], [https://www.ebi.ac.uk/pdbsum/4je3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4je3 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.282Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4je3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4je3 OCA], [https://pdbe.org/4je3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4je3 RCSB], [https://www.ebi.ac.uk/pdbsum/4je3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4je3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/CENPL_YEAST CENPL_YEAST] Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.<ref>PMID:11361335</ref> <ref>PMID:15241623</ref>		[https://www.uniprot.org/uniprot/CENPL_YEAST CENPL_YEAST] Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.<ref>PMID:11361335</ref> <ref>PMID:15241623</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Accurate segregation of genetic material in eukaryotes relies on the kinetochore, a multiprotein complex that connects centromeric DNA with microtubules. In yeast and humans, two proteins-Mif2/CENP-C and Chl4/CNEP-N-interact with specialized centromeric nucleosomes and establish distinct but cross-connecting axes of chromatin-microtubule linkage. Proteins recruited by Chl4/CENP-N include a subset that regulates chromosome transmission fidelity. We show that Chl4 and a conserved member of this subset, Iml3, both from Saccharomyces cerevisiae, form a stable protein complex that interacts with Mif2 and Sgo1. We have determined the structures of an Iml3 homodimer and an Iml3-Chl4 heterodimer, which suggest a mechanism for regulating the assembly of this functional axis of the kinetochore. We propose that at the core centromere, the Chl4-Iml3 complex participates in recruiting factors, such as Sgo1, that influence sister chromatid cohesion and encourage sister kinetochore biorientation.
-
-	An Iml3-Chl4 Heterodimer Links the Core Centromere to Factors Required for Accurate Chromosome Segregation.,Hinshaw SM, Harrison SC Cell Rep. 2013 Sep 25. pii: S2211-1247(13)00477-4. doi:, 10.1016/j.celrep.2013.08.036. PMID:24075991<ref>PMID:24075991</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4je3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:08, 24 November 2022

2022-11-24T11:08:29Z

←Older revision		Revision as of 11:08, 24 November 2022
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	==An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation==		==An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation==
-	<StructureSection load='4je3' size='340' side='right' caption='[[4je3]], [[Resolution\|resolution]] 2.28Å' scene=''>	+	<StructureSection load='4je3' size='340' side='right'caption='[[4je3]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4je3]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JE3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4JE3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4je3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JE3 FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4it3\|4it3]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4je3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4je3 OCA], [https://pdbe.org/4je3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4je3 RCSB], [https://www.ebi.ac.uk/pdbsum/4je3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4je3 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IML3, MCM19, YBR107C, YBR0836 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), CHL4, CTF17, MCM17, YDR254W, YD9320A.04 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4je3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4je3 OCA], [~~http~~://pdbe.org/4je3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4je3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4je3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4je3 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~IML3_YEAST IML3_YEAST]~~] Component of the ~~central~~ kinetochore, ~~which mediates the attachment of the centromere~~ to ~~the mitotic~~ spindle ~~by forming essential interactions between~~ the ~~microtubule-associated outer~~ kinetochore ~~proteins and the~~ centromere-associated ~~inner~~ kinetochore ~~proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation~~.<ref>PMID:11361335</ref> <ref>PMID:15241623</ref> [[http://www.uniprot.org/uniprot/CHL4_YEAST CHL4_YEAST]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.<ref>PMID:9339342</ref>	+	[https://www.uniprot.org/uniprot/CENPL_YEAST CENPL_YEAST] Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.<ref>PMID:11361335</ref> <ref>PMID:15241623</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 18824~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Harrison, S C~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Hinshaw, S M~~]]	+	[[Category: Harrison SC]]
-	[[Category: ~~Beta sheet]]~~	+	[[Category: Hinshaw SM]]
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Chromosome segregation]]~~	+
-	~~[[Category: Iml3-chl4 dimer]]~~	+
-	~~[[Category: Kinetochore]]~~	+
-	~~[[Category: Nucleus~~]]	+

OCA at 00:54, 5 August 2016

2016-08-05T00:54:25Z

←Older revision		Revision as of 00:54, 5 August 2016
Line 1:		Line 1:
		+
	==An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation==		==An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation==
	<StructureSection load='4je3' size='340' side='right' caption='[[4je3]], [[Resolution\|resolution]] 2.28Å' scene=''>		<StructureSection load='4je3' size='340' side='right' caption='[[4je3]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4je3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JE3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JE3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4je3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JE3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JE3 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4it3\|4it3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4it3\|4it3]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IML3, MCM19, YBR107C, YBR0836 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~]), CHL4, CTF17, MCM17, YDR254W, YD9320A.04 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IML3, MCM19, YBR107C, YBR0836 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), CHL4, CTF17, MCM17, YDR254W, YD9320A.04 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4je3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4je3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4je3 RCSB], [http://www.ebi.ac.uk/pdbsum/4je3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4je3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4je3 OCA], [http://pdbe.org/4je3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4je3 RCSB], [http://www.ebi.ac.uk/pdbsum/4je3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4je3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4je3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Harrison, S C]]		[[Category: Harrison, S C]]
	[[Category: Hinshaw, S M]]		[[Category: Hinshaw, S M]]

OCA at 21:22, 24 December 2014

2014-12-24T21:22:25Z

←Older revision		Revision as of 21:22, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4je3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4je3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4je3 RCSB], [http://www.ebi.ac.uk/pdbsum/4je3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4je3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4je3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4je3 RCSB], [http://www.ebi.ac.uk/pdbsum/4je3 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IML3_YEAST IML3_YEAST]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.<ref>PMID:11361335</ref> <ref>PMID:15241623</ref> [[http://www.uniprot.org/uniprot/CHL4_YEAST CHL4_YEAST]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.<ref>PMID:9339342</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:03, 21 December 2014

2014-12-21T13:03:17Z

←Older revision		Revision as of 13:03, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4je3\| PDB=4je3 \| SCENE= }}~~	+	==An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation==
-	===An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation===	+	<StructureSection load='4je3' size='340' side='right' caption='[[4je3]], [[Resolution\|resolution]] 2.28Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24075991}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4je3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JE3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JE3 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4it3\|4it3]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IML3, MCM19, YBR107C, YBR0836 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), CHL4, CTF17, MCM17, YDR254W, YD9320A.04 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4je3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4je3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4je3 RCSB], [http://www.ebi.ac.uk/pdbsum/4je3 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Accurate segregation of genetic material in eukaryotes relies on the kinetochore, a multiprotein complex that connects centromeric DNA with microtubules. In yeast and humans, two proteins-Mif2/CENP-C and Chl4/CNEP-N-interact with specialized centromeric nucleosomes and establish distinct but cross-connecting axes of chromatin-microtubule linkage. Proteins recruited by Chl4/CENP-N include a subset that regulates chromosome transmission fidelity. We show that Chl4 and a conserved member of this subset, Iml3, both from Saccharomyces cerevisiae, form a stable protein complex that interacts with Mif2 and Sgo1. We have determined the structures of an Iml3 homodimer and an Iml3-Chl4 heterodimer, which suggest a mechanism for regulating the assembly of this functional axis of the kinetochore. We propose that at the core centromere, the Chl4-Iml3 complex participates in recruiting factors, such as Sgo1, that influence sister chromatid cohesion and encourage sister kinetochore biorientation.

-	~~==Function==~~	+	An Iml3-Chl4 Heterodimer Links the Core Centromere to Factors Required for Accurate Chromosome Segregation.,Hinshaw SM, Harrison SC Cell Rep. 2013 Sep 25. pii: S2211-1247(13)00477-4. doi:, 10.1016/j.celrep.2013.08.036. PMID:24075991<ref>PMID:24075991</ref>
-	~~[[http://www.uniprot.org/uniprot/IML3_YEAST IML3_YEAST]] Component of~~ the ~~central kinetochore, which mediates the attachment of the centromere~~ to ~~the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins.~~ Required for ~~establishing bipolar spindle~~-~~microtubule attachments and proper chromosome segregation~~.~~<ref>PMID~~:~~11361335</ref> <ref>PMID:15241623</ref> [[http:/~~/~~www~~.~~uniprot~~.org/uniprot/CHL4_YEAST CHL4_YEAST]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. ~~Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation~~.<ref>PMID:~~9339342~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4je3]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4JE3 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:024075991</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Harrison, S C.]]	+	[[Category: Harrison, S C]]
-	[[Category: Hinshaw, S M.]]	+	[[Category: Hinshaw, S M]]
	[[Category: Beta sheet]]		[[Category: Beta sheet]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]

OCA at 08:00, 16 October 2013

2013-10-16T08:00:30Z

←Older revision		Revision as of 08:00, 16 October 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4je3\| PDB=4je3 \| SCENE= }}
		+	===An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation===
		+	{{ABSTRACT_PUBMED_24075991}}

-	~~The entry 4je3 is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/IML3_YEAST IML3_YEAST]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.<ref>PMID:11361335</ref> <ref>PMID:15241623</ref> [[http://www.uniprot.org/uniprot/CHL4_YEAST CHL4_YEAST]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.<ref>PMID:9339342</ref>

-	~~Authors~~: ~~Hinshaw, S~~.M.~~, Harrison, S~~.C.	+	==About this Structure==
		+	[[4je3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JE3 OCA].

-	~~Description~~: An Iml3-~~Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation~~	+	==Reference==
		+	<ref group="xtra">PMID:024075991</ref><references group="xtra"/><references/>
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Harrison, S C.]]
		+	[[Category: Hinshaw, S M.]]
		+	[[Category: Beta sheet]]
		+	[[Category: Cell cycle]]
		+	[[Category: Chromosome segregation]]
		+	[[Category: Iml3-chl4 dimer]]
		+	[[Category: Kinetochore]]
		+	[[Category: Nucleus]]

OCA at 07:06, 2 May 2013

2013-05-02T07:06:00Z

←Older revision		Revision as of 07:06, 2 May 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4je3 is ON HOLD	+	The entry 4je3 is ON HOLD until Paper Publication

	Authors: Hinshaw, S.M., Harrison, S.C.		Authors: Hinshaw, S.M., Harrison, S.C.

	Description: An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation		Description: An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation

OCA at 16:18, 20 March 2013

2013-03-20T16:18:19Z

←Older revision		Revision as of 16:18, 20 March 2013
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	The entry 4je3 is ON HOLD		The entry 4je3 is ON HOLD

-	Authors: Hinshaw, S. M., Harrison, S. C.	+	Authors: Hinshaw, S.M., Harrison, S.C.

	Description: An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation		Description: An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation

OCA: Protected "4je3" [edit=sysop:move=sysop]

2013-03-06T13:53:24Z

Protected "4je3" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:53, 6 March 2013

OCA: New page: '''Unreleased structure''' The entry 4je3 is ON HOLD Authors: Hinshaw, S. M., Harrison, S. C. Description: An Iml3-Chl4 heterodimer links the core centromere to factors required for ac...

2013-03-06T13:53:23Z

New page: '''Unreleased structure''' The entry 4je3 is ON HOLD Authors: Hinshaw, S. M., Harrison, S. C. Description: An Iml3-Chl4 heterodimer links the core centromere to factors required for ac...

New page

'''Unreleased structure'''

The entry 4je3 is ON HOLD

Authors: Hinshaw, S. M., Harrison, S. C.

Description: An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation