4jni - Revision history

OCA: Redirecting to 5yc6

2018-10-03T07:34:14Z

Redirecting to 5yc6

←Older revision		Revision as of 07:34, 3 October 2018
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-		+	#REDIRECT [[5yc6]] This PDB entry is obsolete and replaced by 5yc6
-	~~==Crystal Structure of uPA in complex with its inhibitor 4-bromobenzylamine at pH 4.6==~~	+
-	~~<StructureSection load='4jni' size='340' side='right' caption='~~[[~~4jni~~]]~~, [[Resolution\|resolution]] 1.17Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	<table><tr><td colspan='2'>[[4jni]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JNI FirstGlance]. <br>	+
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PZH:1-(4-BROMOPHENYL)METHANAMINE'>PZH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jnl\|4jnl]]</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLAU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jni OCA], [http://pdbe.org/4jni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jni RCSB], [http://www.ebi.ac.uk/pdbsum/4jni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jni ProSAT]</span></td></tr>	+
-	~~</table>~~	+
-	~~== Disease ==~~	+
-	~~[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/~~entry~~/601709 601709]]. QPD~~ is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and ~~secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>~~	+
-	~~== Function ==~~	+
-	~~[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.~~	+
-		+
-	~~==See Also==~~	+
-	*[[Urokinase\|Urokinase]]	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Human]]~~	+
-	~~[[Category: U-plasminogen activator]]~~	+
-	~~[[Category: Huang, M]]~~	+
-	~~[[Category: Jiang, L]]~~	+
-	~~[[Category: Yuan, C]]~~	+
-	~~[[Category: Zhang, X]]~~	+
-	~~[[Category: Zhao, B]]~~	+
-	~~[[Category: Halogen]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Upa]]~~	+

OCA at 17:16, 11 August 2016

2016-08-11T17:16:12Z

←Older revision		Revision as of 17:16, 11 August 2016
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		+
	==Crystal Structure of uPA in complex with its inhibitor 4-bromobenzylamine at pH 4.6==		==Crystal Structure of uPA in complex with its inhibitor 4-bromobenzylamine at pH 4.6==
	<StructureSection load='4jni' size='340' side='right' caption='[[4jni]], [[Resolution\|resolution]] 1.17Å' scene=''>		<StructureSection load='4jni' size='340' side='right' caption='[[4jni]], [[Resolution\|resolution]] 1.17Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLAU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLAU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jni OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jni RCSB], [http://www.ebi.ac.uk/pdbsum/4jni PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jni OCA], [http://pdbe.org/4jni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jni RCSB], [http://www.ebi.ac.uk/pdbsum/4jni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jni ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.		[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
		+
		+	==See Also==
		+	*[[Urokinase\|Urokinase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:08, 4 January 2015

2015-01-04T14:08:38Z

←Older revision		Revision as of 14:08, 4 January 2015
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-	~~{{STRUCTURE_4jni\| PDB=4jni \| SCENE= }}~~	+	==Crystal Structure of uPA in complex with its inhibitor 4-bromobenzylamine at pH 4.6==
-	===Crystal Structure of uPA in complex with its inhibitor 4-bromobenzylamine at pH 4.6===	+	<StructureSection load='4jni' size='340' side='right' caption='[[4jni]], [[Resolution\|resolution]] 1.17Å' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[4jni]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JNI FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PZH:1-(4-BROMOPHENYL)METHANAMINE'>PZH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jnl\|4jnl]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLAU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jni OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jni RCSB], [http://www.ebi.ac.uk/pdbsum/4jni PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>		[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.		[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	~~[[4jni]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JNI OCA].~~	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+	[[Category: Human]]
-	<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]
-	[[Category: Huang, M.]]	+	[[Category: Huang, M]]
-	[[Category: Jiang, L.]]	+	[[Category: Jiang, L]]
-	[[Category: Yuan, C.]]	+	[[Category: Yuan, C]]
-	[[Category: Zhang, X.]]	+	[[Category: Zhang, X]]
-	[[Category: Zhao, B.]]	+	[[Category: Zhao, B]]
	[[Category: Halogen]]		[[Category: Halogen]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Upa]]		[[Category: Upa]]

OCA at 09:31, 19 March 2014

2014-03-19T09:31:01Z

←Older revision		Revision as of 09:31, 19 March 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4jni\| PDB=4jni \| SCENE= }}
		+	===Crystal Structure of uPA in complex with its inhibitor 4-bromobenzylamine at pH 4.6===

-	~~The~~ entry ~~4jni~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>

-	~~Authors~~: ~~Zhang, X~~.~~, Jiang, L~~.~~, Zhao, B., Yuan, C., Huang, M~~.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

-	~~Description: Crystal~~ Structure ~~of uPA in complex with its inhibitor 4~~-~~bromobenzylamine at pH 4~~.6	+	==About this Structure==
		+	[[4jni]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JNI OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: U-plasminogen activator]]
		+	[[Category: Huang, M.]]
		+	[[Category: Jiang, L.]]
		+	[[Category: Yuan, C.]]
		+	[[Category: Zhang, X.]]
		+	[[Category: Zhao, B.]]
		+	[[Category: Halogen]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Upa]]

OCA at 10:54, 24 April 2013

2013-04-24T10:54:40Z

←Older revision		Revision as of 10:54, 24 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4jni is ON HOLD	+	The entry 4jni is ON HOLD until Paper Publication

	Authors: Zhang, X., Jiang, L., Zhao, B., Yuan, C., Huang, M.		Authors: Zhang, X., Jiang, L., Zhao, B., Yuan, C., Huang, M.

	Description: Crystal Structure of uPA in complex with its inhibitor 4-bromobenzylamine at pH 4.6		Description: Crystal Structure of uPA in complex with its inhibitor 4-bromobenzylamine at pH 4.6

OCA: Protected "4jni" [edit=sysop:move=sysop]

2013-03-27T08:19:23Z

Protected "4jni" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:19, 27 March 2013

OCA: New page: '''Unreleased structure''' The entry 4jni is ON HOLD Authors: Zhang, X., Jiang, L., Zhao, B., Yuan, C., Huang, M. Description: Crystal Structure of uPA in complex with its inhibitor 4-...

2013-03-27T08:19:22Z

New page: '''Unreleased structure''' The entry 4jni is ON HOLD Authors: Zhang, X., Jiang, L., Zhao, B., Yuan, C., Huang, M. Description: Crystal Structure of uPA in complex with its inhibitor 4-...

New page

'''Unreleased structure'''

The entry 4jni is ON HOLD

Authors: Zhang, X., Jiang, L., Zhao, B., Yuan, C., Huang, M.

Description: Crystal Structure of uPA in complex with its inhibitor 4-bromobenzylamine at pH 4.6