4jp9 - Revision history

OCA at 15:46, 20 September 2023

2023-09-20T15:46:30Z

←Older revision		Revision as of 15:46, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4jp9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JP9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4jp9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JP9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1M5:(4R)-2-AMINO-6-(3-CHLOROPHENYL)-1,2,2-TRIMETHYL-2,3-DIHYDROSPIRO[CHROMENE-4,4-IMIDAZOL]-5(1H)-ONE'>1M5</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1M5:(4R)-2-AMINO-6-(3-CHLOROPHENYL)-1,2,2-TRIMETHYL-2,3-DIHYDROSPIRO[CHROMENE-4,4-IMIDAZOL]-5(1H)-ONE'>1M5</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jp9 OCA], [https://pdbe.org/4jp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jp9 RCSB], [https://www.ebi.ac.uk/pdbsum/4jp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jp9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jp9 OCA], [https://pdbe.org/4jp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jp9 RCSB], [https://www.ebi.ac.uk/pdbsum/4jp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jp9 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:28, 24 November 2022

2022-11-24T11:28:59Z

←Older revision		Revision as of 11:28, 24 November 2022
Line 1:		Line 1:

	==Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors==		==Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors==
-	<StructureSection load='4jp9' size='340' side='right' caption='[[4jp9]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4jp9' size='340' side='right'caption='[[4jp9]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jp9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JP9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4JP9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jp9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JP9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1M5:(4R)-2-AMINO-6-(3-CHLOROPHENYL)-1,2,2-TRIMETHYL-2,3-DIHYDROSPIRO[CHROMENE-4,4-IMIDAZOL]-5(1H)-ONE'>1M5</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1M5:(4R)-2-AMINO-6-(3-CHLOROPHENYL)-1,2,2-TRIMETHYL-2,3-DIHYDROSPIRO[CHROMENE-4,4-IMIDAZOL]-5(1H)-ONE'>1M5</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4joo\|4joo]], [[4jpc\|4jpc]], [[4jpe\|4jpe]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jp9 OCA], [https://pdbe.org/4jp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jp9 RCSB], [https://www.ebi.ac.uk/pdbsum/4jp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jp9 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4jp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jp9 OCA], [~~http~~://pdbe.org/4jp9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4jp9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4jp9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4jp9 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>	+	[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Beta secretase\|Beta secretase]]	+	*[[Beta secretase 3D structures\|Beta secretase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Memapsin 2~~]]	+	[[Category: Large Structures]]
-	[[Category: Smith, D]]	+	[[Category: Smith D]]
-	[[Category: Vigers~~, G P.A]]~~	+	[[Category: Vigers GPA]]
-	~~[[Category: Aspartyl protease]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 18:03, 4 August 2016

2016-08-04T18:03:38Z

←Older revision		Revision as of 18:03, 4 August 2016
Line 1:		Line 1:
		+
	==Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors==		==Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors==
	<StructureSection load='4jp9' size='340' side='right' caption='[[4jp9]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4jp9' size='340' side='right' caption='[[4jp9]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jp9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JP9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jp9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JP9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1M5:(4R)-2-AMINO-6-(3-CHLOROPHENYL)-1,2,2-TRIMETHYL-2,3-DIHYDROSPIRO[CHROMENE-4,4-IMIDAZOL]-5(1H)-ONE'>1M5</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1M5:(4R)-2-AMINO-6-(3-CHLOROPHENYL)-1,2,2-TRIMETHYL-2,3-DIHYDROSPIRO[CHROMENE-4,4-IMIDAZOL]-5(1H)-ONE'>1M5</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4joo\|4joo]], [[4jpc\|4jpc]], [[4jpe\|4jpe]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4joo\|4joo]], [[4jpc\|4jpc]], [[4jpe\|4jpe]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jp9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jp9 RCSB], [http://www.ebi.ac.uk/pdbsum/4jp9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jp9 OCA], [http://pdbe.org/4jp9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jp9 RCSB], [http://www.ebi.ac.uk/pdbsum/4jp9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jp9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4jp9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Smith, D]]		[[Category: Smith, D]]

OCA at 17:58, 24 December 2014

2014-12-24T17:58:40Z

←Older revision		Revision as of 17:58, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jp9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jp9 RCSB], [http://www.ebi.ac.uk/pdbsum/4jp9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jp9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jp9 RCSB], [http://www.ebi.ac.uk/pdbsum/4jp9 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 15:09, 21 December 2014

2014-12-21T15:09:36Z

←Older revision		Revision as of 15:09, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4jp9\| PDB=4jp9 \| SCENE= }}~~	+	==Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors==
-	===Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors===	+	<StructureSection load='4jp9' size='340' side='right' caption='[[4jp9]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23537249}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4jp9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JP9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1M5:(4R)-2-AMINO-6-(3-CHLOROPHENYL)-1,2,2-TRIMETHYL-2,3-DIHYDROSPIRO[CHROMENE-4,4-IMIDAZOL]-5(1H)-ONE'>1M5</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4joo\|4joo]], [[4jpc\|4jpc]], [[4jpe\|4jpe]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jp9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jp9 RCSB], [http://www.ebi.ac.uk/pdbsum/4jp9 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A hallmark of Alzheimer's disease is the brain deposition of amyloid beta (Ass), a peptide of 36-43 amino acids that is likely a primary driver of neurodegeneration. Ass is produced by the sequential cleavage of APP by BACE1 and gamma-secretase; therefore, inhibition of BACE1 represents an attractive therapeutic target to slow or prevent Alzheimer's disease. Herein we describe BACE1 inhibitors with limited molecular flexibility and molecular weight that decrease CSF Ass in vivo, despite efflux. Starting with spirocycle 1a, we explore structure activity relationships of core changes, P3 moieties and Asp binding functional groups in order to optimize BACE1 affinity, cathepsin D selectivity, and blood-brain barrier (BBB) penetration. Using wild type guinea pig and rat, we demonstrate a PK/PD relationship between free drug concentrations in the brain and CSF Ass lowering. Optimization of brain exposure led to the discovery of (R)-50 which reduced CSF Ass in rodents and in monkey.

-	~~==Function==~~	+	Spirocyclic ss-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid Beta in a Higher Species.,Hunt KW, Cook AW, Watts RJ, Clark CT, Vigers G, Smith D, Metcalf AT, Gunawardana IW, Burkard M, Cox AA, Geck-Do M, Dutcher D, Thomas AA, Rana S, Kallan NC, Delisle RK, Rizzi JP, Regal K, Sammond D, Groneberg R, Siu M, Purkey H, Lyssikatos JP, Marlow A, Liu X, Tang TP J Med Chem. 2013 Mar 28. PMID:23537249<ref>PMID:23537249</ref>
-	~~[[http~~:~~//www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing~~ of ~~the amyloid precursor protein~~ (~~APP~~). ~~Cleaves at the N-terminus of the A-beta peptide sequence~~, ~~between residues 671 and 672 of APP~~, ~~leads to the generation and extracellular release of beta-cleaved soluble APP~~, ~~and a corresponding cell~~-~~associated C-terminal fragment which is later released by gamma-secretase~~.~~<ref>~~PMID:~~10677483</ref>~~ <ref>PMID:~~20354142~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4jp9]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4JP9 OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Beta secretase\|Beta secretase]]		*[[Beta secretase\|Beta secretase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023537249</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
-	[[Category: Smith, D.]]	+	[[Category: Smith, D]]
-	[[Category: Vigers, G P.A.]]	+	[[Category: Vigers, G P.A]]
	[[Category: Aspartyl protease]]		[[Category: Aspartyl protease]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 05:13, 23 October 2013

2013-10-23T05:13:51Z

←Older revision		Revision as of 05:13, 23 October 2013
Line 8:		Line 8:
	==About this Structure==		==About this Structure==
	[[4jp9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JP9 OCA].		[[4jp9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JP9 OCA].
		+
		+	==See Also==
		+	*[[Beta secretase\|Beta secretase]]

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:023537249</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]

OCA at 22:51, 10 April 2013

2013-04-10T22:51:08Z

←Older revision		Revision as of 22:51, 10 April 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4jp9\| PDB=4jp9 \| SCENE= }}
		+	===Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors===
		+	{{ABSTRACT_PUBMED_23537249}}

-	~~The entry 4jp9~~ is ~~ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>

-	~~Authors~~: ~~Vigers, G~~.P.A.~~, Smith, D~~.	+	==About this Structure==
		+	[[4jp9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JP9 OCA].

-	~~Description~~: ~~Spirocyclic Beta~~-~~Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Memapsin 2]]
		+	[[Category: Smith, D.]]
		+	[[Category: Vigers, G P.A.]]
		+	[[Category: Aspartyl protease]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 00:57, 4 April 2013

2013-04-04T00:57:09Z

←Older revision		Revision as of 00:57, 4 April 2013
Line 3:		Line 3:
	The entry 4jp9 is ON HOLD		The entry 4jp9 is ON HOLD

-	Authors: Vigers, G.P.A, Smith, D.	+	Authors: Vigers, G.P.A., Smith, D.

	Description: Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors		Description: Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors

OCA: Protected "4jp9" [edit=sysop:move=sysop]

2013-03-27T08:21:28Z

Protected "4jp9" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:21, 27 March 2013

OCA: New page: '''Unreleased structure''' The entry 4jp9 is ON HOLD Authors: Vigers, G.P.A, Smith, D. Description: Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors

2013-03-27T08:21:27Z

New page: '''Unreleased structure''' The entry 4jp9 is ON HOLD Authors: Vigers, G.P.A, Smith, D. Description: Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors

New page

'''Unreleased structure'''

The entry 4jp9 is ON HOLD

Authors: Vigers, G.P.A, Smith, D.

Description: Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors