4k41 - Revision history

OCA at 12:08, 1 March 2024

2024-03-01T12:08:21Z

←Older revision		Revision as of 12:08, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4k41]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K41 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4k41]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K41 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KAB:KABIRAMIDE+C'>KAB</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KAB:KABIRAMIDE+C'>KAB</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k41 OCA], [https://pdbe.org/4k41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k41 RCSB], [https://www.ebi.ac.uk/pdbsum/4k41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k41 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k41 OCA], [https://pdbe.org/4k41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k41 RCSB], [https://www.ebi.ac.uk/pdbsum/4k41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k41 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.		[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The actin filament-binding and filament-severing activities of the aplyronine, kabiramide, and reidispongiolide families of marine macrolides are located within the hydrophobic tail region of the molecule. Two synthetic tail analogues of aplyronine C (SF-01 and GC-04) are shown to bind to G-actin with dissociation constants of (285+/-33) and (132+/-13) nM, respectively. The crystal structures of actin complexes with GC-04, SF-01, and kabiramide C reveal a conserved mode of tail binding within the cleft that forms between subdomains (SD) 1 and 3. Our studies support the view that filament severing is brought about by specific binding of the tail region to the SD1/SD3 cleft on the upper protomer, which displaces loop-D from the lower protomer on the same half-filament. With previous studies showing that the GC-04 analogue can sever actin filaments, it is argued that the shorter complex lifetime of tail analogues with F-actin would make them more effective at severing filaments compared with plasma gelsolin. Structure-based analyses are used to suggest more reactive or targetable forms of GC-04 and SF-01, which may serve to boost the capacity of the serum actin scavenging system, to generate antibody conjugates against tumor cell antigens, and to decrease sputum viscosity in children with cystic fibrosis.
-
-	Structural and biochemical studies of actin in complex with synthetic macrolide tail analogues.,Pereira JH, Petchprayoon C, Hoepker AC, Moriarty NW, Fink SJ, Cecere G, Paterson I, Adams PD, Marriott G ChemMedChem. 2014 Oct;9(10):2286-93. doi: 10.1002/cmdc.201402150. Epub 2014 Jul, 22. PMID:25047814<ref>PMID:25047814</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4k41" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Actin 3D structures\|Actin 3D structures]]		*[[Actin 3D structures\|Actin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:39, 30 November 2022

2022-11-30T11:39:01Z

←Older revision		Revision as of 11:39, 30 November 2022
Line 3:		Line 3:
	<StructureSection load='4k41' size='340' side='right'caption='[[4k41]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='4k41' size='340' side='right'caption='[[4k41]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4k41]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K41 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4K41 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4k41]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K41 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KAB:KABIRAMIDE+C'>KAB</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KAB:KABIRAMIDE+C'>KAB</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k43\|4k43]], [[4k42\|4k42]], [[1qz5\|1qz5]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k41 OCA], [https://pdbe.org/4k41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k41 RCSB], [https://www.ebi.ac.uk/pdbsum/4k41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k41 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4k41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k41 OCA], [~~http~~://pdbe.org/4k41 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4k41 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4k41 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4k41 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	+	[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Adams~~, P D~~]]	+	[[Category: Adams PD]]
-	[[Category: Cecere, G]]	+	[[Category: Cecere G]]
-	[[Category: Fink~~, S J~~]]	+	[[Category: Fink SJ]]
-	[[Category: Marriott, G]]	+	[[Category: Marriott G]]
-	[[Category: Moriarty~~, N W~~]]	+	[[Category: Moriarty NW]]
-	[[Category: Paterson, I]]	+	[[Category: Paterson I]]
-	[[Category: Pereira~~, J H~~]]	+	[[Category: Pereira JH]]
-	[[Category: Petchprayoon, C]]	+	[[Category: Petchprayoon C]]
-	~~[[Category: Actin filament]]~~	+
-	~~[[Category: Cell motility]]~~	+
-	~~[[Category: Citoplasm]]~~	+
-	~~[[Category: Contractile protein]]~~	+
-	~~[[Category: Gelsolin~~]]	+

OCA at 09:30, 3 April 2019

2019-04-03T09:30:12Z

←Older revision		Revision as of 09:30, 3 April 2019
Line 1:		Line 1:

	==Crystal structure of actin in complex with marine macrolide kabiramide C==		==Crystal structure of actin in complex with marine macrolide kabiramide C==
-	<StructureSection load='4k41' size='340' side='right' caption='[[4k41]], [[Resolution\|resolution]] 1.40Å' scene=''>	+	<StructureSection load='4k41' size='340' side='right'caption='[[4k41]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4k41]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K41 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K41 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4k41]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K41 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K41 FirstGlance]. <br>
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Actin\|Actin]]	+	*[[Actin 3D structures\|Actin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Adams, P D]]		[[Category: Adams, P D]]

OCA at 22:12, 4 August 2016

2016-08-04T22:12:08Z

←Older revision		Revision as of 22:12, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of actin in complex with marine macrolide kabiramide C==		==Crystal structure of actin in complex with marine macrolide kabiramide C==
	<StructureSection load='4k41' size='340' side='right' caption='[[4k41]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='4k41' size='340' side='right' caption='[[4k41]], [[Resolution\|resolution]] 1.40Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KAB:KABIRAMIDE+C'>KAB</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KAB:KABIRAMIDE+C'>KAB</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k43\|4k43]], [[4k42\|4k42]], [[1qz5\|1qz5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k43\|4k43]], [[4k42\|4k42]], [[1qz5\|1qz5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k41 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k41 RCSB], [http://www.ebi.ac.uk/pdbsum/4k41 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k41 OCA], [http://pdbe.org/4k41 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k41 RCSB], [http://www.ebi.ac.uk/pdbsum/4k41 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4k41 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4k41" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Actin\|Actin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:34, 25 December 2014

2014-12-25T13:34:26Z

←Older revision		Revision as of 13:34, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k41 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k41 RCSB], [http://www.ebi.ac.uk/pdbsum/4k41 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k41 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k41 RCSB], [http://www.ebi.ac.uk/pdbsum/4k41 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Adams, P D.]]	+	[[Category: Adams, P D]]
-	[[Category: Cecere, G.]]	+	[[Category: Cecere, G]]
-	[[Category: Fink, S J.]]	+	[[Category: Fink, S J]]
-	[[Category: Marriott, G.]]	+	[[Category: Marriott, G]]
-	[[Category: Moriarty, N W.]]	+	[[Category: Moriarty, N W]]
-	[[Category: Paterson, I.]]	+	[[Category: Paterson, I]]
-	[[Category: Pereira, J H.]]	+	[[Category: Pereira, J H]]
-	[[Category: Petchprayoon, C.]]	+	[[Category: Petchprayoon, C]]
	[[Category: Actin filament]]		[[Category: Actin filament]]
	[[Category: Cell motility]]		[[Category: Cell motility]]

OCA at 05:58, 8 October 2014

2014-10-08T05:58:17Z

←Older revision		Revision as of 05:58, 8 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4k41]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K41 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K41 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4k41]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K41 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K41 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KAB:KABIRAMIDE+C'>KAB</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KAB:KABIRAMIDE+C'>KAB</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k43\|4k43]], [[4k42\|4k42]], [[1qz5\|1qz5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k43\|4k43]], [[4k42\|4k42]], [[1qz5\|1qz5]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k41 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k41 RCSB], [http://www.ebi.ac.uk/pdbsum/4k41 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k41 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k41 RCSB], [http://www.ebi.ac.uk/pdbsum/4k41 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 00:18, 2 October 2014

2014-10-02T00:18:42Z

←Older revision		Revision as of 00:18, 2 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of actin in complex with marine macrolide kabiramide C==
		+	<StructureSection load='4k41' size='340' side='right' caption='[[4k41]], [[Resolution\|resolution]] 1.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4k41]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K41 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K41 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KAB:KABIRAMIDE+C'>KAB</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k43\|4k43]], [[4k42\|4k42]], [[1qz5\|1qz5]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k41 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k41 RCSB], [http://www.ebi.ac.uk/pdbsum/4k41 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The actin filament-binding and filament-severing activities of the aplyronine, kabiramide, and reidispongiolide families of marine macrolides are located within the hydrophobic tail region of the molecule. Two synthetic tail analogues of aplyronine C (SF-01 and GC-04) are shown to bind to G-actin with dissociation constants of (285+/-33) and (132+/-13) nM, respectively. The crystal structures of actin complexes with GC-04, SF-01, and kabiramide C reveal a conserved mode of tail binding within the cleft that forms between subdomains (SD) 1 and 3. Our studies support the view that filament severing is brought about by specific binding of the tail region to the SD1/SD3 cleft on the upper protomer, which displaces loop-D from the lower protomer on the same half-filament. With previous studies showing that the GC-04 analogue can sever actin filaments, it is argued that the shorter complex lifetime of tail analogues with F-actin would make them more effective at severing filaments compared with plasma gelsolin. Structure-based analyses are used to suggest more reactive or targetable forms of GC-04 and SF-01, which may serve to boost the capacity of the serum actin scavenging system, to generate antibody conjugates against tumor cell antigens, and to decrease sputum viscosity in children with cystic fibrosis.

-	~~The entry 4k41 is ON HOLD until Paper Publication~~	+	Structural and biochemical studies of actin in complex with synthetic macrolide tail analogues.,Pereira JH, Petchprayoon C, Hoepker AC, Moriarty NW, Fink SJ, Cecere G, Paterson I, Adams PD, Marriott G ChemMedChem. 2014 Oct;9(10):2286-93. doi: 10.1002/cmdc.201402150. Epub 2014 Jul, 22. PMID:25047814<ref>PMID:25047814</ref>

-	~~Authors: Pereira~~, J.H.~~, Petchprayoon, C~~., ~~Moriarty, N.W~~., Fink, S.J.~~, Cecere~~, G., Paterson, I., ~~Adams, P.D~~., ~~Marriott, G~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of actin in complex with marine macrolide kabiramide C~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Oryctolagus cuniculus]]
		+	[[Category: Adams, P D.]]
		+	[[Category: Cecere, G.]]
		+	[[Category: Fink, S J.]]
		+	[[Category: Marriott, G.]]
		+	[[Category: Moriarty, N W.]]
		+	[[Category: Paterson, I.]]
		+	[[Category: Pereira, J H.]]
		+	[[Category: Petchprayoon, C.]]
		+	[[Category: Actin filament]]
		+	[[Category: Cell motility]]
		+	[[Category: Citoplasm]]
		+	[[Category: Contractile protein]]
		+	[[Category: Gelsolin]]

OCA at 05:54, 30 April 2014

2014-04-30T05:54:17Z

←Older revision		Revision as of 05:54, 30 April 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4k41 is ON HOLD until ~~Apr 28 2015~~	+	The entry 4k41 is ON HOLD until Paper Publication

	Authors: Pereira, J.H., Petchprayoon, C., Moriarty, N.W., Fink, S.J., Cecere, G., Paterson, I., Adams, P.D., Marriott, G.		Authors: Pereira, J.H., Petchprayoon, C., Moriarty, N.W., Fink, S.J., Cecere, G., Paterson, I., Adams, P.D., Marriott, G.

	Description: Crystal structure of actin in complex with marine macrolide kabiramide C		Description: Crystal structure of actin in complex with marine macrolide kabiramide C

OCA at 07:07, 23 April 2014

2014-04-23T07:07:40Z

←Older revision		Revision as of 07:07, 23 April 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4k41 is ON HOLD until ~~Paper Publication~~	+	The entry 4k41 is ON HOLD until Apr 28 2015

	Authors: Pereira, J.H., Petchprayoon, C., Moriarty, N.W., Fink, S.J., Cecere, G., Paterson, I., Adams, P.D., Marriott, G.		Authors: Pereira, J.H., Petchprayoon, C., Moriarty, N.W., Fink, S.J., Cecere, G., Paterson, I., Adams, P.D., Marriott, G.

	Description: Crystal structure of actin in complex with marine macrolide kabiramide C		Description: Crystal structure of actin in complex with marine macrolide kabiramide C

OCA at 08:46, 30 June 2013

2013-06-30T08:46:48Z

←Older revision		Revision as of 08:46, 30 June 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4k41 is ON HOLD	+	The entry 4k41 is ON HOLD until Paper Publication

	Authors: Pereira, J.H., Petchprayoon, C., Moriarty, N.W., Fink, S.J., Cecere, G., Paterson, I., Adams, P.D., Marriott, G.		Authors: Pereira, J.H., Petchprayoon, C., Moriarty, N.W., Fink, S.J., Cecere, G., Paterson, I., Adams, P.D., Marriott, G.

	Description: Crystal structure of actin in complex with marine macrolide kabiramide C		Description: Crystal structure of actin in complex with marine macrolide kabiramide C