4k6n - Revision history

OCA at 11:42, 30 November 2022

2022-11-30T11:42:20Z

←Older revision		Revision as of 11:42, 30 November 2022
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	==Crystal structure of yeast 4-amino-4-deoxychorismate lyase==		==Crystal structure of yeast 4-amino-4-deoxychorismate lyase==
-	<StructureSection load='4k6n' size='340' side='right' caption='[[4k6n]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4k6n' size='340' side='right'caption='[[4k6n]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4k6n]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4K6N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4k6n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K6N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABZ2, YMR289W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k6n OCA], [https://pdbe.org/4k6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k6n RCSB], [https://www.ebi.ac.uk/pdbsum/4k6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k6n ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminodeoxychorismate_lyase Aminodeoxychorismate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.38 4.1.3.38] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4k6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k6n OCA], [~~http~~://pdbe.org/4k6n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4k6n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4k6n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4k6n ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PABC_YEAST PABC_YEAST]] Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate (By similarity).	+	[https://www.uniprot.org/uniprot/PABC_YEAST PABC_YEAST] Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aminodeoxychorismate lyase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Baker's yeast~~]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: Chen, Y]]	+	[[Category: Chen Y]]
-	[[Category: Cheng, W]]	+	[[Category: Cheng W]]
-	[[Category: Chi, C B]]	+	[[Category: Chi C-B]]
-	[[Category: Dai, Y N]]	+	[[Category: Dai Y-N]]
-	[[Category: Jiang, Y L]]	+	[[Category: Jiang Y-L]]
-	[[Category: Ren, Y M]]	+	[[Category: Ren Y-M]]
-	[[Category: Zhou, C Z]]	+	[[Category: Zhou C-Z]]
-	[[Category: Zhou, K]]	+	[[Category: Zhou K]]
-	~~[[Category: 4-amino-4-deoxychorismate]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Plp]]~~	+
-	~~[[Category: Plp-dependent fold type iv enzyme]]~~	+
-	~~[[Category: Pyruvate~~]]	+

OCA at 16:19, 5 August 2016

2016-08-05T16:19:14Z

←Older revision		Revision as of 16:19, 5 August 2016
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		+
	==Crystal structure of yeast 4-amino-4-deoxychorismate lyase==		==Crystal structure of yeast 4-amino-4-deoxychorismate lyase==
	<StructureSection load='4k6n' size='340' side='right' caption='[[4k6n]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4k6n' size='340' side='right' caption='[[4k6n]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4k6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K6N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4k6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K6N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABZ2, YMR289W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 ~~Saccharomyces cerevisiae S288c~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABZ2, YMR289W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminodeoxychorismate_lyase Aminodeoxychorismate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.38 4.1.3.38] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminodeoxychorismate_lyase Aminodeoxychorismate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.38 4.1.3.38] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k6n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k6n RCSB], [http://www.ebi.ac.uk/pdbsum/4k6n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k6n OCA], [http://pdbe.org/4k6n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k6n RCSB], [http://www.ebi.ac.uk/pdbsum/4k6n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4k6n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4k6n" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Aminodeoxychorismate lyase]]		[[Category: Aminodeoxychorismate lyase]]
-	[[Category: ~~Saccharomyces cerevisiae s288c~~]]	+	[[Category: Baker's yeast]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Cheng, W]]		[[Category: Cheng, W]]

OCA at 03:55, 25 December 2014

2014-12-25T03:55:35Z

←Older revision		Revision as of 03:55, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4k6n\| PDB=4k6n \| SCENE= }}~~	+	==Crystal structure of yeast 4-amino-4-deoxychorismate lyase==
-	===Crystal structure of yeast 4-amino-4-deoxychorismate lyase===	+	<StructureSection load='4k6n' size='340' side='right' caption='[[4k6n]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23818518}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4k6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K6N FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABZ2, YMR289W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminodeoxychorismate_lyase Aminodeoxychorismate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.38 4.1.3.38] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k6n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k6n RCSB], [http://www.ebi.ac.uk/pdbsum/4k6n PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/PABC_YEAST PABC_YEAST]] Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate (By similarity).		[[http://www.uniprot.org/uniprot/PABC_YEAST PABC_YEAST]] Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Saccharomyces cerevisiae Abz2 is a pyridoxal 5'-phosphate (PLP)-dependent lyase that converts 4-amino-4-deoxychorismate (ADC) to para-aminobenzoate and pyruvate. To investigate the catalytic mechanism, we determined the 1.9 A resolution crystal structure of Abz2 complexed with PLP, representing the first eukaryotic ADC lyase structure. Unlike Escherichia coli ADC lyase, whose dimerization is critical to the formation of the active site, the overall structure of Abz2 displays as a monomer of two domains. At the interdomain cleft, a molecule of cofactor PLP forms a Schiff base with residue Lys-251. Computational simulations defined a basic clamp to orientate the substrate ADC in a proper pose, which was validated by site-directed mutageneses combined with enzymatic activity assays. Altogether, we propose a putative catalytic mechanism of a unique class of monomeric ADC lyases led by yeast Abz2.

-	~~==About this~~ Structure==	+	Structure and catalytic mechanism of yeast 4-amino-4-deoxychorismate lyase.,Dai YN, Chi CB, Zhou K, Cheng W, Jiang YL, Ren YM, Ruan K, Chen Y, Zhou CZ J Biol Chem. 2013 Aug 9;288(32):22985-92. doi: 10.1074/jbc.M113.480335. Epub 2013, Jul 1. PMID:23818518<ref>PMID:23818518</ref>
-	~~[[4k6n]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=4K6N OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023818518</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Aminodeoxychorismate lyase]]		[[Category: Aminodeoxychorismate lyase]]
	[[Category: Saccharomyces cerevisiae s288c]]		[[Category: Saccharomyces cerevisiae s288c]]
-	[[Category: Chen, Y.]]	+	[[Category: Chen, Y]]
-	[[Category: Cheng, W.]]	+	[[Category: Cheng, W]]
-	[[Category: Chi, C B.]]	+	[[Category: Chi, C B]]
-	[[Category: Dai, Y N.]]	+	[[Category: Dai, Y N]]
-	[[Category: Jiang, Y L.]]	+	[[Category: Jiang, Y L]]
-	[[Category: Ren, Y M.]]	+	[[Category: Ren, Y M]]
-	[[Category: Zhou, C Z.]]	+	[[Category: Zhou, C Z]]
-	[[Category: Zhou, K.]]	+	[[Category: Zhou, K]]
	[[Category: 4-amino-4-deoxychorismate]]		[[Category: 4-amino-4-deoxychorismate]]
	[[Category: Lyase]]		[[Category: Lyase]]

OCA at 06:45, 16 October 2013

2013-10-16T06:45:04Z

←Older revision		Revision as of 06:45, 16 October 2013
Line 1:		Line 1:
	{{STRUCTURE_4k6n\| PDB=4k6n \| SCENE= }}		{{STRUCTURE_4k6n\| PDB=4k6n \| SCENE= }}
	===Crystal structure of yeast 4-amino-4-deoxychorismate lyase===		===Crystal structure of yeast 4-amino-4-deoxychorismate lyase===
		+	{{ABSTRACT_PUBMED_23818518}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[4k6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6N OCA].		[[4k6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6N OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023818518</ref><references group="xtra"/><references/>
	[[Category: Aminodeoxychorismate lyase]]		[[Category: Aminodeoxychorismate lyase]]
	[[Category: Saccharomyces cerevisiae s288c]]		[[Category: Saccharomyces cerevisiae s288c]]

OCA at 15:53, 10 July 2013

2013-07-10T15:53:57Z

←Older revision		Revision as of 15:53, 10 July 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4k6n\| PDB=4k6n \| SCENE= }}
		+	===Crystal structure of yeast 4-amino-4-deoxychorismate lyase===

-	~~The entry 4k6n is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PABC_YEAST PABC_YEAST]] Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate (By similarity).

-	~~Authors~~: ~~Dai, Y~~.-N.~~, Chi, C~~.-B., ~~Zhou, K~~., Cheng, W., ~~Jiang~~, Y.-L., Ren, Y.-M.~~, Chen, Y.,~~ Zhou, C.-Z.	+	==About this Structure==
-		+	[[4k6n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6N OCA].
-	~~Description~~: ~~Crystal structure of yeast~~ 4-amino-4-deoxychorismate ~~lyase~~	+	[[Category: Aminodeoxychorismate lyase]]
		+	[[Category: Saccharomyces cerevisiae s288c]]
		+	[[Category: Chen, Y.]]
		+	[[Category: Cheng, W.]]
		+	[[Category: Chi, C B.]]
		+	[[Category: Dai, Y N.]]
		+	[[Category: Jiang, Y L.]]
		+	[[Category: Ren, Y M.]]
		+	[[Category: Zhou, C Z.]]
		+	[[Category: Zhou, K.]]
		+	[[Category: 4-amino-4-deoxychorismate]]
		+	[[Category: Lyase]]
		+	[[Category: Plp]]
		+	[[Category: Plp-dependent fold type iv enzyme]]
		+	[[Category: Pyruvate]]

OCA at 08:47, 30 June 2013

2013-06-30T08:47:34Z

←Older revision		Revision as of 08:47, 30 June 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4k6n is ON HOLD	+	The entry 4k6n is ON HOLD until Paper Publication

	Authors: Dai, Y.-N., Chi, C.-B., Zhou, K., Cheng, W., Jiang, Y.-L., Ren, Y.-M., Chen, Y., Zhou, C.-Z.		Authors: Dai, Y.-N., Chi, C.-B., Zhou, K., Cheng, W., Jiang, Y.-L., Ren, Y.-M., Chen, Y., Zhou, C.-Z.

	Description: Crystal structure of yeast 4-amino-4-deoxychorismate lyase		Description: Crystal structure of yeast 4-amino-4-deoxychorismate lyase

OCA at 07:11, 2 May 2013

2013-05-02T07:11:59Z

←Older revision		Revision as of 07:11, 2 May 2013
Line 3:		Line 3:
	The entry 4k6n is ON HOLD		The entry 4k6n is ON HOLD

-	Authors: ~~Ya-Nan~~ Dai, ~~Chang~~-~~Biao~~ Chi, ~~Kang~~ Zhou, ~~Wang~~ Cheng, ~~Yong-Liang~~ Jiang, ~~Yan~~-~~Min~~ Ren, ~~Yuxing~~ Chen, ~~Cong-Zhao~~ Zhou	+	Authors: Dai, Y.-N., Chi, C.-B., Zhou, K., Cheng, W., Jiang, Y.-L., Ren, Y.-M., Chen, Y., Zhou, C.-Z.

	Description: Crystal structure of yeast 4-amino-4-deoxychorismate lyase		Description: Crystal structure of yeast 4-amino-4-deoxychorismate lyase

OCA: Protected "4k6n" [edit=sysop:move=sysop]

2013-04-24T11:00:58Z

Protected "4k6n" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:00, 24 April 2013

OCA: New page: '''Unreleased structure''' The entry 4k6n is ON HOLD Authors: Ya-Nan Dai, Chang-Biao Chi, Kang Zhou, Wang Cheng, Yong-Liang Jiang, Yan-Min Ren, Yuxing Chen, Cong-Zhao Zhou Description:...

2013-04-24T11:00:57Z

New page: '''Unreleased structure''' The entry 4k6n is ON HOLD Authors: Ya-Nan Dai, Chang-Biao Chi, Kang Zhou, Wang Cheng, Yong-Liang Jiang, Yan-Min Ren, Yuxing Chen, Cong-Zhao Zhou Description:...

New page

'''Unreleased structure'''

The entry 4k6n is ON HOLD

Authors: Ya-Nan Dai, Chang-Biao Chi, Kang Zhou, Wang Cheng, Yong-Liang Jiang, Yan-Min Ren, Yuxing Chen, Cong-Zhao Zhou

Description: Crystal structure of yeast 4-amino-4-deoxychorismate lyase