4kcn - Revision history

OCA at 15:57, 20 September 2023

2023-09-20T15:57:51Z

←Older revision		Revision as of 15:57, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kcn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KCN FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kcn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KCN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5H3:N-[3-({[2-(3-FLUOROPHENYL)ETHYL]AMINO}METHYL)PHENYL]THIOPHENE-2-CARBOXIMIDAMIDE'>5H3</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MTL:D-MANNITOL'>MTL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5H3:N-[3-({[2-(3-FLUOROPHENYL)ETHYL]AMINO}METHYL)PHENYL]THIOPHENE-2-CARBOXIMIDAMIDE'>5H3</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MTL:D-MANNITOL'>MTL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kcn OCA], [https://pdbe.org/4kcn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kcn RCSB], [https://www.ebi.ac.uk/pdbsum/4kcn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kcn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kcn OCA], [https://pdbe.org/4kcn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kcn RCSB], [https://www.ebi.ac.uk/pdbsum/4kcn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kcn ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:52, 30 November 2022

2022-11-30T11:52:16Z

←Older revision		Revision as of 11:52, 30 November 2022
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	==Structure of neuronal nitric oxide synthase heme domain in complex with N-(3-(((3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide==		==Structure of neuronal nitric oxide synthase heme domain in complex with N-(3-(((3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide==
-	<StructureSection load='4kcn' size='340' side='right' caption='[[4kcn]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='4kcn' size='340' side='right'caption='[[4kcn]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kcn]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KCN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KCN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kcn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KCN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5H3:N-[3-({[2-(3-FLUOROPHENYL)ETHYL]AMINO}METHYL)PHENYL]THIOPHENE-2-CARBOXIMIDAMIDE'>5H3</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MTL:D-MANNITOL'>MTL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5H3:N-[3-({[2-(3-FLUOROPHENYL)ETHYL]AMINO}METHYL)PHENYL]THIOPHENE-2-CARBOXIMIDAMIDE'>5H3</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MTL:D-MANNITOL'>MTL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kch\|4kch]], [[4kci\|4kci]], [[4kcj\|4kcj]], [[4kck\|4kck]], [[4kcl\|4kcl]], [[4kcm\|4kcm]], [[4kco\|4kco]], [[4kcp\|4kcp]], [[4kcq\|4kcq]], [[4kcr\|4kcr]], [[4kcs\|4kcs]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kcn OCA], [https://pdbe.org/4kcn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kcn RCSB], [https://www.ebi.ac.uk/pdbsum/4kcn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kcn ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Nos1, Bnos ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kcn OCA], [~~http~~://pdbe.org/4kcn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kcn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kcn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kcn ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.	+	[https://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4kcn" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4kcn" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Nitric Oxide Synthase 3D structures\|Nitric Oxide Synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Buffalo rat~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Li, H~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Poulos, T L~~]]	+	[[Category: Li H]]
-	[[Category: ~~Nitric oxide synthase]]~~	+	[[Category: Poulos TL]]
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex~~]]	+

OCA at 09:20, 15 November 2017

2017-11-15T09:20:11Z

←Older revision		Revision as of 09:20, 15 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4kcn" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4kcn" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:09, 4 August 2016

2016-08-04T12:09:58Z

←Older revision		Revision as of 12:09, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of neuronal nitric oxide synthase heme domain in complex with N-(3-(((3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide==		==Structure of neuronal nitric oxide synthase heme domain in complex with N-(3-(((3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide==
	<StructureSection load='4kcn' size='340' side='right' caption='[[4kcn]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4kcn' size='340' side='right' caption='[[4kcn]], [[Resolution\|resolution]] 1.85Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Nos1, Bnos ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Nos1, Bnos ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kcn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kcn RCSB], [http://www.ebi.ac.uk/pdbsum/4kcn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kcn OCA], [http://pdbe.org/4kcn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kcn RCSB], [http://www.ebi.ac.uk/pdbsum/4kcn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kcn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kcn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 14:19, 24 December 2014

2014-12-24T14:19:44Z

←Older revision		Revision as of 14:19, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4kcn\| PDB=4kcn \| SCENE= }}~~	+	==Structure of neuronal nitric oxide synthase heme domain in complex with N-(3-(((3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide==
-	===Structure of neuronal nitric oxide synthase heme domain in complex with N-(3-(((3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide===	+	<StructureSection load='4kcn' size='340' side='right' caption='[[4kcn]], [[Resolution\|resolution]] 1.85Å' scene=''>
-	{~~{ABSTRACT_PUBMED_24447275}~~}	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4kcn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KCN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KCN FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5H3:N-[3-({[2-(3-FLUOROPHENYL)ETHYL]AMINO}METHYL)PHENYL]THIOPHENE-2-CARBOXIMIDAMIDE'>5H3</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MTL:D-MANNITOL'>MTL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kch\|4kch]], [[4kci\|4kci]], [[4kcj\|4kcj]], [[4kck\|4kck]], [[4kcl\|4kcl]], [[4kcm\|4kcm]], [[4kco\|4kco]], [[4kcp\|4kcp]], [[4kcq\|4kcq]], [[4kcr\|4kcr]], [[4kcs\|4kcs]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Nos1, Bnos ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kcn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kcn RCSB], [http://www.ebi.ac.uk/pdbsum/4kcn PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.		[[http://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Selective inhibitors of neuronal nitric oxide synthase (nNOS) are regarded as valuable and powerful agents with therapeutic potential for the treatment of chronic neurodegenerative pathologies and human melanoma. Here, we describe a novel hybrid strategy that combines the pharmacokinetically promising thiophene-2-carboximidamide fragment and structural features of our previously reported potent and selective aminopyridine inhibitors. Two inhibitors, 13 and 14, show low nanomolar inhibitory potency (Ki = 5 nM for nNOS) and good isoform selectivities (nNOS over eNOS [440- and 540-fold, respectively] and over iNOS [260- and 340-fold, respectively]). The crystal structures of these nNOS-inhibitor complexes reveal a new hot spot that explains the selectivity of 14 and why converting the secondary to tertiary amine leads to enhanced selectivity. More importantly, these compounds are the first highly potent and selective nNOS inhibitory agents that exhibit excellent in vitro efficacy in melanoma cell lines.
		+
		+	Potent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma.,Huang H, Li H, Yang S, Chreifi G, Martasek P, Roman LJ, Meyskens FL, Poulos TL, Silverman RB J Med Chem. 2014 Jan 30. PMID:24447275<ref>PMID:24447275</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4kcn]] is~~ a ~~2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4KCN OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024447275</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]
-	[[Category: Li, H.]]	+	== References ==
-	[[Category: Poulos, T L.]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Buffalo rat]]
		+	[[Category: Li, H]]
		+	[[Category: Poulos, T L]]
	[[Category: Nitric oxide synthase]]		[[Category: Nitric oxide synthase]]
	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]		[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 05:03, 13 February 2014

2014-02-13T05:03:14Z

←Older revision		Revision as of 05:03, 13 February 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4kcn\| PDB=4kcn \| SCENE= }}
		+	===Structure of neuronal nitric oxide synthase heme domain in complex with N-(3-(((3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide===
		+	{{ABSTRACT_PUBMED_24447275}}

-	~~The entry 4kcn~~ is ~~ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.

-	~~Authors~~: ~~Li, H~~.~~, Poulos, T~~.L.	+	==About this Structure==
		+	[[4kcn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KCN OCA].

-	~~Description~~: ~~Structure of neuronal nitric~~ oxide synthase ~~heme domain in complex with N~~-~~(3-(((3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide~~	+	==Reference==
		+	<ref group="xtra">PMID:024447275</ref><references group="xtra"/><references/>
		+	[[Category: Li, H.]]
		+	[[Category: Poulos, T L.]]
		+	[[Category: Nitric oxide synthase]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 11:32, 19 June 2013

2013-06-19T11:32:26Z

←Older revision		Revision as of 11:32, 19 June 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kcn is ON HOLD	+	The entry 4kcn is ON HOLD until Paper Publication

	Authors: Li, H., Poulos, T.L.		Authors: Li, H., Poulos, T.L.

	Description: Structure of neuronal nitric oxide synthase heme domain in complex with N-(3-(((3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide		Description: Structure of neuronal nitric oxide synthase heme domain in complex with N-(3-(((3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide

OCA at 07:20, 8 May 2013

2013-05-08T07:20:21Z

←Older revision		Revision as of 07:20, 8 May 2013
Line 3:		Line 3:
	The entry 4kcn is ON HOLD		The entry 4kcn is ON HOLD

-	Authors: Hi, L. , Poulos, T.L.	+	Authors: Li, H., Poulos, T.L.

	Description: Structure of neuronal nitric oxide synthase heme domain in complex with N-(3-(((3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide		Description: Structure of neuronal nitric oxide synthase heme domain in complex with N-(3-(((3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide

OCA: Protected "4kcn" [edit=sysop:move=sysop]

2013-05-02T07:16:26Z

Protected "4kcn" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:16, 2 May 2013

OCA: New page: '''Unreleased structure''' The entry 4kcn is ON HOLD Authors: Hi, L. , Poulos, T.L. Description: Structure of neuronal nitric oxide synthase heme domain in complex with N-(3-(((3-fluor...

2013-05-02T07:16:25Z

New page: '''Unreleased structure''' The entry 4kcn is ON HOLD Authors: Hi, L. , Poulos, T.L. Description: Structure of neuronal nitric oxide synthase heme domain in complex with N-(3-(((3-fluor...

New page

'''Unreleased structure'''

The entry 4kcn is ON HOLD

Authors: Hi, L. , Poulos, T.L.

Description: Structure of neuronal nitric oxide synthase heme domain in complex with N-(3-(((3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide