4ke0 - Revision history

OCA at 11:53, 30 November 2022

2022-11-30T11:53:51Z

←Older revision		Revision as of 11:53, 30 November 2022
Line 1:		Line 1:

	==Crystal structure of BACE1 in complex with hydroxyethylamine-macrocyclic inhibitor 13==		==Crystal structure of BACE1 in complex with hydroxyethylamine-macrocyclic inhibitor 13==
-	<StructureSection load='4ke0' size='340' side='right' caption='[[4ke0]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4ke0' size='340' side='right'caption='[[4ke0]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ke0]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KE0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KE0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ke0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KE0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1R8:(3S)-3-[(1R)-2-{[(4S)-6-ETHYL-3,4-DIHYDROSPIRO[CHROMENE-2,1-CYCLOBUTAN]-4-YL]AMINO}-1-HYDROXYETHYL]-4-AZABICYCLO[10.3.1]HEXADECA-1(16),12,14-TRIEN-5-ONE'>1R8</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1R8:(3S)-3-[(1R)-2-{[(4S)-6-ETHYL-3,4-DIHYDROSPIRO[CHROMENE-2,1-CYCLOBUTAN]-4-YL]AMINO}-1-HYDROXYETHYL]-4-AZABICYCLO[10.3.1]HEXADECA-1(16),12,14-TRIEN-5-ONE'>1R8</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k9h\|4k9h]], [[4k8s\|4k8s]], [[4ke1\|4ke1]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ke0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ke0 OCA], [https://pdbe.org/4ke0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ke0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ke0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ke0 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ke0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ke0 OCA], [~~http~~://pdbe.org/4ke0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ke0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ke0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ke0 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>	+	[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Beta secretase\|Beta secretase]]	+	*[[Beta secretase 3D structures\|Beta secretase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Memapsin 2~~]]	+	[[Category: Large Structures]]
-	[[Category: Li, V]]	+	[[Category: Li V]]
-	[[Category: Long~~, A M~~]]	+	[[Category: Long AM]]
-	[[Category: Whittington~~, D A]]~~	+	[[Category: Whittington DA]]
-	~~[[Category: Alzheimer's disease]]~~	+
-	~~[[Category: Aspartic protease]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 02:55, 5 August 2016

2016-08-05T02:55:43Z

←Older revision		Revision as of 02:55, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of BACE1 in complex with hydroxyethylamine-macrocyclic inhibitor 13==		==Crystal structure of BACE1 in complex with hydroxyethylamine-macrocyclic inhibitor 13==
	<StructureSection load='4ke0' size='340' side='right' caption='[[4ke0]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4ke0' size='340' side='right' caption='[[4ke0]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ke0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KE0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KE0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ke0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KE0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KE0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1R8:(3S)-3-[(1R)-2-{[(4S)-6-ETHYL-3,4-DIHYDROSPIRO[CHROMENE-2,1-CYCLOBUTAN]-4-YL]AMINO}-1-HYDROXYETHYL]-4-AZABICYCLO[10.3.1]HEXADECA-1(16),12,14-TRIEN-5-ONE'>1R8</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1R8:(3S)-3-[(1R)-2-{[(4S)-6-ETHYL-3,4-DIHYDROSPIRO[CHROMENE-2,1-CYCLOBUTAN]-4-YL]AMINO}-1-HYDROXYETHYL]-4-AZABICYCLO[10.3.1]HEXADECA-1(16),12,14-TRIEN-5-ONE'>1R8</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k9h\|4k9h]], [[4k8s\|4k8s]], [[4ke1\|4ke1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k9h\|4k9h]], [[4k8s\|4k8s]], [[4ke1\|4ke1]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ke0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ke0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ke0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ke0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ke0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ke0 OCA], [http://pdbe.org/4ke0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ke0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ke0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ke0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ke0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Li, V]]		[[Category: Li, V]]

OCA at 22:14, 24 December 2014

2014-12-24T22:14:25Z

←Older revision		Revision as of 22:14, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ke0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ke0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ke0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ke0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ke0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ke0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ke0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ke0 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:40, 21 December 2014

2014-12-21T14:40:58Z

←Older revision		Revision as of 14:40, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ke0\| PDB=4ke0 \| SCENE= }}~~	+	==Crystal structure of BACE1 in complex with hydroxyethylamine-macrocyclic inhibitor 13==
-	===Crystal structure of BACE1 in complex with hydroxyethylamine-macrocyclic inhibitor 13===	+	<StructureSection load='4ke0' size='340' side='right' caption='[[4ke0]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23769639}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ke0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KE0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KE0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1R8:(3S)-3-[(1R)-2-{[(4S)-6-ETHYL-3,4-DIHYDROSPIRO[CHROMENE-2,1-CYCLOBUTAN]-4-YL]AMINO}-1-HYDROXYETHYL]-4-AZABICYCLO[10.3.1]HEXADECA-1(16),12,14-TRIEN-5-ONE'>1R8</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k9h\|4k9h]], [[4k8s\|4k8s]], [[4ke1\|4ke1]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ke0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ke0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ke0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ke0 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We describe a systematic study of how macrocyclization in the P1-P3 region of hydroxyethylamine-based inhibitors of beta-site amyloid precursor protein (APP)-cleaving enzyme (BACE1) modulates in vitro activity. This study reveals that in a number of instances macrocyclization of bis-terminal dienes leads to improved potency toward BACE1 and selectivity against cathepsin D (CatD), as well as greater amyloid beta-peptide (Abeta)-lowering activity in HEK293T cells stably expressing APPSW. However, for several closely related analogs the benefits of macrocyclization are attenuated by the effects of other structural features in different regions of the molecules. X-ray crystal structures of three of these novel macrocyclic inhibitors bound to BACE1 revealed their binding conformations and interactions with the enzyme.

-	~~==Function==~~	+	Hydroxyethylamine-based inhibitors of BACE1: P1-P3 macrocyclization can improve potency, selectivity, and cell activity.,Pennington LD, Whittington DA, Bartberger MD, Jordan SR, Monenschein H, Nguyen TT, Yang BH, Xue QM, Vounatsos F, Wahl RC, Chen K, Wood S, Citron M, Patel VF, Hitchcock SA, Zhong W Bioorg Med Chem Lett. 2013 Aug 1;23(15):4459-64. doi: 10.1016/j.bmcl.2013.05.028., Epub 2013 May 16. PMID:23769639<ref>PMID:23769639</ref>
-	~~[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N~~-~~terminus~~ of ~~the A~~-~~beta peptide sequence~~, ~~between residues 671 and 672 of APP~~, ~~leads to the generation~~ and ~~extracellular release of beta-cleaved soluble APP, and a corresponding~~ cell-~~associated C-terminal fragment which is later released by gamma-secretase~~.~~<ref>PMID~~:~~10677483<~~/~~ref>~~ <ref>PMID:~~20354142~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4ke0]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4KE0 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023769639</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Beta secretase\|Beta secretase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
-	[[Category: Li, V.]]	+	[[Category: Li, V]]
-	[[Category: Long, A M.]]	+	[[Category: Long, A M]]
-	[[Category: Whittington, D A.]]	+	[[Category: Whittington, D A]]
	[[Category: Alzheimer's disease]]		[[Category: Alzheimer's disease]]
	[[Category: Aspartic protease]]		[[Category: Aspartic protease]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 14:01, 3 July 2013

2013-07-03T14:01:23Z

←Older revision		Revision as of 14:01, 3 July 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4ke0\| PDB=4ke0 \| SCENE= }}
		+	===Crystal structure of BACE1 in complex with hydroxyethylamine-macrocyclic inhibitor 13===
		+	{{ABSTRACT_PUBMED_23769639}}

-	~~The entry 4ke0~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>

-	~~Authors~~: ~~Whittington, D~~.A.~~, Long, A~~.M.~~, Li, V~~.	+	==About this Structure==
		+	[[4ke0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KE0 OCA].

-	~~Description~~: ~~Crystal structure of BACE1 in complex with hydroxyethylamine~~-~~macrocyclic~~ inhibitor 13	+	==Reference==
		+	<ref group="xtra">PMID:023769639</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Memapsin 2]]
		+	[[Category: Li, V.]]
		+	[[Category: Long, A M.]]
		+	[[Category: Whittington, D A.]]
		+	[[Category: Alzheimer's disease]]
		+	[[Category: Aspartic protease]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 11:34, 19 June 2013

2013-06-19T11:34:37Z

←Older revision		Revision as of 11:34, 19 June 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ke0 is ON HOLD	+	The entry 4ke0 is ON HOLD until Paper Publication

	Authors: Whittington, D.A., Long, A.M., Li, V.		Authors: Whittington, D.A., Long, A.M., Li, V.

	Description: Crystal structure of BACE1 in complex with hydroxyethylamine-macrocyclic inhibitor 13		Description: Crystal structure of BACE1 in complex with hydroxyethylamine-macrocyclic inhibitor 13

OCA: Protected "4ke0" [edit=sysop:move=sysop]

2013-05-02T07:18:02Z

Protected "4ke0" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:18, 2 May 2013

OCA: New page: '''Unreleased structure''' The entry 4ke0 is ON HOLD Authors: Whittington, D.A., Long, A.M., Li, V. Description: Crystal structure of BACE1 in complex with hydroxyethylamine-macrocycli...

2013-05-02T07:18:01Z

New page: '''Unreleased structure''' The entry 4ke0 is ON HOLD Authors: Whittington, D.A., Long, A.M., Li, V. Description: Crystal structure of BACE1 in complex with hydroxyethylamine-macrocycli...

New page

'''Unreleased structure'''

The entry 4ke0 is ON HOLD

Authors: Whittington, D.A., Long, A.M., Li, V.

Description: Crystal structure of BACE1 in complex with hydroxyethylamine-macrocyclic inhibitor 13