4kf1 - Revision history

OCA at 07:25, 18 May 2023

2023-05-18T07:25:08Z

←Older revision		Revision as of 07:25, 18 May 2023
Line 3:		Line 3:
	<StructureSection load='4kf1' size='340' side='right'caption='[[4kf1]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4kf1' size='340' side='right'caption='[[4kf1]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kf1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_35091 Atcc 35091~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KF1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KF1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kf1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KF1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KF1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HT5:(4S)-4-(DECANOYLAMINO)-5-HYDROXY-3,4-DIHYDRO-2H-THIOPHENIUM'>HT5</scene>, ~~<scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HT5:(4S)-4-(DECANOYLAMINO)-5-HYDROXY-3,4-DIHYDRO-2H-THIOPHENIUM'>HT5</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>~~</td></tr>~~	+
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vc5\|2vc5]]~~, ~~[[2vc7\|2vc7]], [[3uf9\|3uf9]], [[4ker\|4ker]], [[4kes\|4kes]], [[4ket\|4ket]], [[4keu\|4keu]], [[4kev\|4kev]], [[4kez\|4kez]]~~<~~/div></td></tr>~~	+
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b></td><td class="sblockDat">php, php SSO2522, SSO2522 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091])</td></tr>~~	+
-	~~<tr id='activity~~'>~~<td class="sblockLbl"><b>Activity:~~</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aryldialkylphosphatase Aryldialkylphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.1 3.1.8.1] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kf1 OCA], [https://pdbe.org/4kf1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kf1 RCSB], [https://www.ebi.ac.uk/pdbsum/4kf1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kf1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kf1 OCA], [https://pdbe.org/4kf1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kf1 RCSB], [https://www.ebi.ac.uk/pdbsum/4kf1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kf1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~PHP_SULSO PHP_SULSO]~~] Has a low paraoxonase activity. Also active, but with a lower activity, against other ~~oregano~~-phosphorus insecticides such as Dursban, Coumaphos, pNP-butanoate or parathion.<ref>PMID:15909078</ref>	+	[https://www.uniprot.org/uniprot/PHP_SACS2 PHP_SACS2] Has a low paraoxonase activity. Also active, but with a lower activity, against other organo-phosphorus insecticides such as Dursban, Coumaphos, pNP-butanoate or parathion.<ref>PMID:15909078</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 30:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aryldialkylphosphatase]]
-	[[Category: Atcc 35091]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chabriere, E]]	+	[[Category: Saccharolobus solfataricus]]
-	[[Category: Elias, M]]	+	[[Category: Chabriere E]]
-	[[Category: Gotthard, G]]	+	[[Category: Elias M]]
-	[[Category: Hiblot, J]]	+	[[Category: Gotthard G]]
-	~~[[Category: Hydrolase]]~~	+	[[Category: Hiblot J]]
-	~~[[Category: Lactonase~~]]	+

OCA at 06:09, 11 August 2021

2021-08-11T06:09:38Z

OCA at 16:27, 22 January 2020

2020-01-22T16:27:40Z

←Older revision		Revision as of 16:27, 22 January 2020
Line 1:		Line 1:

	==Crystal structure of SsoPox W263I in complex with C10HTL==		==Crystal structure of SsoPox W263I in complex with C10HTL==
-	<StructureSection load='4kf1' size='340' side='right' caption='[[4kf1]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4kf1' size='340' side='right'caption='[[4kf1]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kf1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KF1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KF1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kf1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KF1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KF1 FirstGlance]. <br>
Line 24:		Line 24:

	==See Also==		==See Also==
-	*[[Phosphotriesterase\|Phosphotriesterase]]	+	*[[Phosphotriesterase 3D structures\|Phosphotriesterase 3D structures]]
		+	*[[Serum Paraoxonase\|Serum Paraoxonase]]
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 32:
	[[Category: Aryldialkylphosphatase]]		[[Category: Aryldialkylphosphatase]]
	[[Category: Atcc 35091]]		[[Category: Atcc 35091]]
		+	[[Category: Large Structures]]
	[[Category: Chabriere, E]]		[[Category: Chabriere, E]]
	[[Category: Elias, M]]		[[Category: Elias, M]]

OCA at 18:04, 5 August 2016

2016-08-05T18:04:03Z

←Older revision		Revision as of 18:04, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of SsoPox W263I in complex with C10HTL==		==Crystal structure of SsoPox W263I in complex with C10HTL==
	<StructureSection load='4kf1' size='340' side='right' caption='[[4kf1]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4kf1' size='340' side='right' caption='[[4kf1]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 8:		Line 9:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">php, php SSO2522, SSO2522 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">php, php SSO2522, SSO2522 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aryldialkylphosphatase Aryldialkylphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.1 3.1.8.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aryldialkylphosphatase Aryldialkylphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.1 3.1.8.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kf1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kf1 RCSB], [http://www.ebi.ac.uk/pdbsum/4kf1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kf1 OCA], [http://pdbe.org/4kf1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kf1 RCSB], [http://www.ebi.ac.uk/pdbsum/4kf1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kf1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kf1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphotriesterase\|Phosphotriesterase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:40, 25 December 2014

2014-12-25T04:40:22Z

←Older revision		Revision as of 04:40, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4kf1\| PDB=4kf1 \| SCENE= }}~~	+	==Crystal structure of SsoPox W263I in complex with C10HTL==
-	===Crystal structure of SsoPox W263I in complex with C10HTL===	+	<StructureSection load='4kf1' size='340' side='right' caption='[[4kf1]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24086491}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4kf1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KF1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KF1 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HT5:(4S)-4-(DECANOYLAMINO)-5-HYDROXY-3,4-DIHYDRO-2H-THIOPHENIUM'>HT5</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vc5\|2vc5]], [[2vc7\|2vc7]], [[3uf9\|3uf9]], [[4ker\|4ker]], [[4kes\|4kes]], [[4ket\|4ket]], [[4keu\|4keu]], [[4kev\|4kev]], [[4kez\|4kez]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">php, php SSO2522, SSO2522 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aryldialkylphosphatase Aryldialkylphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.1 3.1.8.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kf1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kf1 RCSB], [http://www.ebi.ac.uk/pdbsum/4kf1 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/PHP_SULSO PHP_SULSO]] Has a low paraoxonase activity. Also active, but with a lower activity, against other oregano-phosphorus insecticides such as Dursban, Coumaphos, pNP-butanoate or parathion.<ref>PMID:15909078</ref>		[[http://www.uniprot.org/uniprot/PHP_SULSO PHP_SULSO]] Has a low paraoxonase activity. Also active, but with a lower activity, against other oregano-phosphorus insecticides such as Dursban, Coumaphos, pNP-butanoate or parathion.<ref>PMID:15909078</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Enzymes are proficient catalysts that enable fast rates of Michaelis-complex formation, the chemical step and products release. These different steps may require different conformational states of the active site that have distinct binding properties. Moreover, the conformational flexibility of the active site mediates alternative, promiscuous functions. Here we focused on the lactonase SsoPox from Sulfolobus solfataricus. SsoPox is a native lactonase endowed with promiscuous phosphotriesterase activity. We identified a position in the active site loop (W263) that governs its flexibility, and thereby affects the substrate specificity of the enzyme. We isolated two different sets of substitutions at position 263 that induce two distinct conformational sampling of the active loop and characterized the structural and kinetic effects of these substitutions. These sets of mutations selectively and distinctly mediate the improvement of the promiscuous phosphotriesterase and oxo-lactonase activities of SsoPox by increasing active-site loop flexibility. These observations corroborate the idea that conformational diversity governs enzymatic promiscuity and is a key feature of protein evolvability.

-	~~==About this Structure==~~	+	Differential Active Site Loop Conformations Mediate Promiscuous Activities in the Lactonase SsoPox.,Hiblot J, Gotthard G, Elias M, Chabriere E PLoS One. 2013 Sep 23;8(9):e75272. doi: 10.1371/journal.pone.0075272. PMID:24086491<ref>PMID:24086491</ref>
-	~~[[4kf1]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Atcc_35091 Atcc 35091]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4KF1 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024086491</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Aryldialkylphosphatase]]		[[Category: Aryldialkylphosphatase]]
	[[Category: Atcc 35091]]		[[Category: Atcc 35091]]
-	[[Category: Chabriere, E.]]	+	[[Category: Chabriere, E]]
-	[[Category: Elias, M.]]	+	[[Category: Elias, M]]
-	[[Category: Gotthard, G.]]	+	[[Category: Gotthard, G]]
-	[[Category: Hiblot, J.]]	+	[[Category: Hiblot, J]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Lactonase]]		[[Category: Lactonase]]

OCA at 12:17, 20 November 2013

2013-11-20T12:17:58Z

←Older revision		Revision as of 12:17, 20 November 2013
Line 1:		Line 1:
	{{STRUCTURE_4kf1\| PDB=4kf1 \| SCENE= }}		{{STRUCTURE_4kf1\| PDB=4kf1 \| SCENE= }}
	===Crystal structure of SsoPox W263I in complex with C10HTL===		===Crystal structure of SsoPox W263I in complex with C10HTL===
		+	{{ABSTRACT_PUBMED_24086491}}

	==Function==		==Function==
Line 6:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4kf1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sulfolobus_solfataricus Sulfolobus solfataricus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KF1 OCA].	+	[[4kf1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KF1 OCA].

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:024086491</ref><references group="xtra"/><references/>
	[[Category: Aryldialkylphosphatase]]		[[Category: Aryldialkylphosphatase]]
-	[[Category: ~~Sulfolobus solfataricus~~]]	+	[[Category: Atcc 35091]]
	[[Category: Chabriere, E.]]		[[Category: Chabriere, E.]]
	[[Category: Elias, M.]]		[[Category: Elias, M.]]

OCA at 07:35, 2 October 2013

2013-10-02T07:35:53Z

←Older revision		Revision as of 07:35, 2 October 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4kf1\| PDB=4kf1 \| SCENE= }}
		+	===Crystal structure of SsoPox W263I in complex with C10HTL===

-	~~The entry 4kf1 is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PHP_SULSO PHP_SULSO]] Has a low paraoxonase activity. Also active, but with a lower activity, against other oregano-phosphorus insecticides such as Dursban, Coumaphos, pNP-butanoate or parathion.<ref>PMID:15909078</ref>

-	~~Authors~~: ~~Gotthard, G~~.~~, Hiblot, J~~.~~, Chabriere, E~~.~~, Elias, M~~.	+	==About this Structure==
		+	[[4kf1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KF1 OCA].

-	~~Description~~: ~~Crystal structure of SsoPox W263I in complex with C10HTL~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Aryldialkylphosphatase]]
		+	[[Category: Sulfolobus solfataricus]]
		+	[[Category: Chabriere, E.]]
		+	[[Category: Elias, M.]]
		+	[[Category: Gotthard, G.]]
		+	[[Category: Hiblot, J.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Lactonase]]

OCA at 07:10, 14 August 2013

2013-08-14T07:10:48Z

←Older revision		Revision as of 07:10, 14 August 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kf1 is ON HOLD	+	The entry 4kf1 is ON HOLD until Paper Publication

	Authors: Gotthard, G., Hiblot, J., Chabriere, E., Elias, M.		Authors: Gotthard, G., Hiblot, J., Chabriere, E., Elias, M.

	Description: Crystal structure of SsoPox W263I in complex with C10HTL		Description: Crystal structure of SsoPox W263I in complex with C10HTL

OCA at 14:59, 10 July 2013

2013-07-10T14:59:55Z

←Older revision		Revision as of 14:59, 10 July 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kf1 is ON HOLD ~~until Paper Publication~~	+	The entry 4kf1 is ON HOLD

	Authors: Gotthard, G., Hiblot, J., Chabriere, E., Elias, M.		Authors: Gotthard, G., Hiblot, J., Chabriere, E., Elias, M.

	Description: Crystal structure of SsoPox W263I in complex with C10HTL		Description: Crystal structure of SsoPox W263I in complex with C10HTL

OCA at 13:11, 3 July 2013

2013-07-03T13:11:17Z

←Older revision		Revision as of 13:11, 3 July 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kf1 is ON HOLD	+	The entry 4kf1 is ON HOLD until Paper Publication

	Authors: Gotthard, G., Hiblot, J., Chabriere, E., Elias, M.		Authors: Gotthard, G., Hiblot, J., Chabriere, E., Elias, M.

	Description: Crystal structure of SsoPox W263I in complex with C10HTL		Description: Crystal structure of SsoPox W263I in complex with C10HTL

←Older revision		Revision as of 06:09, 11 August 2021
Line 3:		Line 3:
	<StructureSection load='4kf1' size='340' side='right'caption='[[4kf1]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4kf1' size='340' side='right'caption='[[4kf1]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kf1]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KF1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KF1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kf1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KF1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KF1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HT5:(4S)-4-(DECANOYLAMINO)-5-HYDROXY-3,4-DIHYDRO-2H-THIOPHENIUM'>HT5</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HT5:(4S)-4-(DECANOYLAMINO)-5-HYDROXY-3,4-DIHYDRO-2H-THIOPHENIUM'>HT5</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vc5\|2vc5]], [[2vc7\|2vc7]], [[3uf9\|3uf9]], [[4ker\|4ker]], [[4kes\|4kes]], [[4ket\|4ket]], [[4keu\|4keu]], [[4kev\|4kev]], [[4kez\|4kez]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vc5\|2vc5]], [[2vc7\|2vc7]], [[3uf9\|3uf9]], [[4ker\|4ker]], [[4kes\|4kes]], [[4ket\|4ket]], [[4keu\|4keu]], [[4kev\|4kev]], [[4kez\|4kez]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">php, php SSO2522, SSO2522 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">php, php SSO2522, SSO2522 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Aryldialkylphosphatase Aryldialkylphosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.1 3.1.8.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aryldialkylphosphatase Aryldialkylphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.1 3.1.8.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kf1 OCA], [~~http~~://pdbe.org/4kf1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kf1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kf1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kf1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kf1 OCA], [https://pdbe.org/4kf1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kf1 RCSB], [https://www.ebi.ac.uk/pdbsum/4kf1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kf1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PHP_SULSO PHP_SULSO]] Has a low paraoxonase activity. Also active, but with a lower activity, against other oregano-phosphorus insecticides such as Dursban, Coumaphos, pNP-butanoate or parathion.<ref>PMID:15909078</ref>	+	[[https://www.uniprot.org/uniprot/PHP_SULSO PHP_SULSO]] Has a low paraoxonase activity. Also active, but with a lower activity, against other oregano-phosphorus insecticides such as Dursban, Coumaphos, pNP-butanoate or parathion.<ref>PMID:15909078</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==