4kfz - Revision history

OCA at 15:58, 20 September 2023

2023-09-20T15:58:53Z

←Older revision		Revision as of 15:58, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kfz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KFZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kfz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KFZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kfz OCA], [https://pdbe.org/4kfz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kfz RCSB], [https://www.ebi.ac.uk/pdbsum/4kfz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kfz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kfz OCA], [https://pdbe.org/4kfz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kfz RCSB], [https://www.ebi.ac.uk/pdbsum/4kfz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kfz ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:56, 30 November 2022

2022-11-30T11:56:31Z

←Older revision		Revision as of 11:56, 30 November 2022
Line 1:		Line 1:

	==Crystal structure of LMO2 and anti-LMO2 VH complex==		==Crystal structure of LMO2 and anti-LMO2 VH complex==
-	<StructureSection load='4kfz' size='340' side='right' caption='[[4kfz]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='4kfz' size='340' side='right'caption='[[4kfz]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kfz]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KFZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kfz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KFZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LMO2, RBTN2, RBTNL1, RHOM2, TTG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Anti-LMO2 VH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kfz OCA], [https://pdbe.org/4kfz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kfz RCSB], [https://www.ebi.ac.uk/pdbsum/4kfz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kfz ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kfz OCA], [~~http~~://pdbe.org/4kfz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kfz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kfz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kfz ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN]] A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.	+	[https://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN] A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN]] Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.	+	[https://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN] Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Chambers, J]]	+	[[Category: Large Structures]]
-	[[Category: Cruz-Migoni, A]]	+	[[Category: Chambers J]]
-	[[Category: ~~Fuentes-Fernandez, N~~]]	+	[[Category: Cruz-Migoni A]]
-	[[Category: ~~Mancini, E J~~]]	+	[[Category: El Omari K]]
-	[[Category: ~~Omari, K El~~]]	+	[[Category: Fuentes-Fernandez N]]
-	[[Category: Rabbitts~~, T H~~]]	+	[[Category: Mancini EJ]]
-	[[Category: Sewell, H]]	+	[[Category: Rabbitts TH]]
-	[[Category: Tanaka, T]]	+	[[Category: Sewell H]]
-	~~[[Category: Developmental protein]]~~	+	[[Category: Tanaka T]]
-	~~[[Category: Lim domain]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Oncoprotein]]~~	+
-	~~[[Category: Proto-oncogene]]~~	+
-	~~[[Category: T-cell leukemia]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription factor~~]]	+

OCA at 09:37, 4 August 2016

2016-08-04T09:37:56Z

←Older revision		Revision as of 09:37, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of LMO2 and anti-LMO2 VH complex==		==Crystal structure of LMO2 and anti-LMO2 VH complex==
	<StructureSection load='4kfz' size='340' side='right' caption='[[4kfz]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4kfz' size='340' side='right' caption='[[4kfz]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LMO2, RBTN2, RBTNL1, RHOM2, TTG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Anti-LMO2 VH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LMO2, RBTN2, RBTNL1, RHOM2, TTG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Anti-LMO2 VH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kfz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kfz RCSB], [http://www.ebi.ac.uk/pdbsum/4kfz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kfz OCA], [http://pdbe.org/4kfz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kfz RCSB], [http://www.ebi.ac.uk/pdbsum/4kfz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kfz ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kfz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:56, 21 December 2014

2014-12-21T18:56:23Z

←Older revision		Revision as of 18:56, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4kfz\| PDB~~=4kfz \| ~~SCENE~~= }}	+	==Crystal structure of LMO2 and anti-LMO2 VH complex==
-	===~~Crystal~~ structure of LMO2 ~~and anti~~-LMO2 VH ~~complex~~===	+	<StructureSection load='4kfz' size='340' side='right' caption='[[4kfz]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24407558}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4kfz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KFZ FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LMO2, RBTN2, RBTNL1, RHOM2, TTG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Anti-LMO2 VH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kfz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kfz RCSB], [http://www.ebi.ac.uk/pdbsum/4kfz PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN]] A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.		[[http://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN]] A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN]] Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.		[[http://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN]] Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	LMO2 was discovered via chromosomal translocations in T-cell leukaemia and shown normally to be essential for haematopoiesis. LMO2 is made up of two LIM only domains (thus it is a LIM-only protein) and forms a bridge in a multi-protein complex. We have studied the mechanism of formation of this complex using a single domain antibody fragment that inhibits LMO2 by sequestering it in a non-functional form. The crystal structure of LMO2 with this antibody fragment has been solved revealing a conformational difference in the positioning and angle between the two LIM domains compared with its normal binding. This contortion occurs by bending at a central helical region of LMO2. This is a unique mechanism for inhibiting an intracellular protein function and the structural contusion implies a model in which newly synthesized, intrinsically disordered LMO2 binds to a partner protein nucleating further interactions and suggests approaches for therapeutic targeting of LMO2.

-	~~==About this Structure==~~	+	Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex.,Sewell H, Tanaka T, Omari KE, Mancini EJ, Cruz A, Fernandez-Fuentes N, Chambers J, Rabbitts TH Sci Rep. 2014 Jan 10;4:3643. doi: 10.1038/srep03643. PMID:24407558<ref>PMID:24407558</ref>
-	~~[[4kfz]] is a~~ 4 ~~chain structure~~. ~~Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann.ac.il~~/~~oca-bin/ocashort?id=4KFZ OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024407558</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Chambers, J.]]	+	== References ==
-	[[Category: Cruz-Migoni, A.]]	+	<references/>
-	[[Category: Fuentes-Fernandez, N.]]	+	__TOC__
-	[[Category: Mancini, E J.]]	+	</StructureSection>
-	[[Category: Omari, K El.]]	+	[[Category: Human]]
-	[[Category: Rabbitts, T H.]]	+	[[Category: Chambers, J]]
-	[[Category: Sewell, H.]]	+	[[Category: Cruz-Migoni, A]]
-	[[Category: Tanaka, T.]]	+	[[Category: Fuentes-Fernandez, N]]
		+	[[Category: Mancini, E J]]
		+	[[Category: Omari, K El]]
		+	[[Category: Rabbitts, T H]]
		+	[[Category: Sewell, H]]
		+	[[Category: Tanaka, T]]
	[[Category: Developmental protein]]		[[Category: Developmental protein]]
	[[Category: Lim domain]]		[[Category: Lim domain]]

OCA at 06:58, 22 January 2014

2014-01-22T06:58:41Z

←Older revision		Revision as of 06:58, 22 January 2014
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4kfz\| PDB=4kfz \| SCENE= }}
		+	===Crystal structure of LMO2 and anti-LMO2 VH complex===
		+	{{ABSTRACT_PUBMED_24407558}}

-	~~The entry 4kfz is ON HOLD until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN]] A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.

-	~~Authors~~: ~~Sewell, H~~.~~, Tanaka, T~~.~~, El Omari, K~~.~~, Cruz-Migoni, A., Mancini, E.J., Fuentes-Fernandez, N., Chambers, J., Rabbitts, T.H~~.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN]] Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.

-	~~Description: Crystal~~ structure ~~of LMO2 and anti~~-~~LMO2 VH complex~~	+	==About this Structure==
		+	[[4kfz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFZ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024407558</ref><references group="xtra"/><references/>
		+	[[Category: Chambers, J.]]
		+	[[Category: Cruz-Migoni, A.]]
		+	[[Category: Fuentes-Fernandez, N.]]
		+	[[Category: Mancini, E J.]]
		+	[[Category: Omari, K El.]]
		+	[[Category: Rabbitts, T H.]]
		+	[[Category: Sewell, H.]]
		+	[[Category: Tanaka, T.]]
		+	[[Category: Developmental protein]]
		+	[[Category: Lim domain]]
		+	[[Category: Nucleus]]
		+	[[Category: Oncoprotein]]
		+	[[Category: Proto-oncogene]]
		+	[[Category: T-cell leukemia]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription factor]]

OCA at 06:55, 16 May 2013

2013-05-16T06:55:25Z

←Older revision		Revision as of 06:55, 16 May 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kfz is ON HOLD	+	The entry 4kfz is ON HOLD until Paper Publication

	Authors: Sewell, H., Tanaka, T., El Omari, K., Cruz-Migoni, A., Mancini, E.J., Fuentes-Fernandez, N., Chambers, J., Rabbitts, T.H.		Authors: Sewell, H., Tanaka, T., El Omari, K., Cruz-Migoni, A., Mancini, E.J., Fuentes-Fernandez, N., Chambers, J., Rabbitts, T.H.

	Description: Crystal structure of LMO2 and anti-LMO2 VH complex		Description: Crystal structure of LMO2 and anti-LMO2 VH complex

OCA: Protected "4kfz" [edit=sysop:move=sysop]

2013-05-08T07:22:17Z

Protected "4kfz" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:22, 8 May 2013

OCA: New page: '''Unreleased structure''' The entry 4kfz is ON HOLD Authors: Sewell, H., Tanaka, T., El Omari, K., Cruz-Migoni, A., Mancini, E.J., Fuentes-Fernandez, N., Chambers, J., Rabbitts, T.H. ...

2013-05-08T07:22:16Z

New page: '''Unreleased structure''' The entry 4kfz is ON HOLD Authors: Sewell, H., Tanaka, T., El Omari, K., Cruz-Migoni, A., Mancini, E.J., Fuentes-Fernandez, N., Chambers, J., Rabbitts, T.H. ...

New page

'''Unreleased structure'''

The entry 4kfz is ON HOLD

Authors: Sewell, H., Tanaka, T., El Omari, K., Cruz-Migoni, A., Mancini, E.J., Fuentes-Fernandez, N., Chambers, J., Rabbitts, T.H.

Description: Crystal structure of LMO2 and anti-LMO2 VH complex