4kgr - Revision history

OCA at 15:59, 20 September 2023

2023-09-20T15:59:23Z

←Older revision		Revision as of 15:59, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kgr]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_sp._'group_G' Streptococcus sp. 'group G']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KGR FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kgr]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_sp._'group_G' Streptococcus sp. 'group G']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KGR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3K:(3S)-3,7-DIAMINOHEPTANOIC+ACID'>B3K</scene>, <scene name='pdbligand=B3X:(3S)-3,5-DIAMINO-5-OXOPENTANOIC+ACID'>B3X</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3K:(3S)-3,7-DIAMINOHEPTANOIC+ACID'>B3K</scene>, <scene name='pdbligand=B3X:(3S)-3,5-DIAMINO-5-OXOPENTANOIC+ACID'>B3X</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kgr OCA], [https://pdbe.org/4kgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kgr RCSB], [https://www.ebi.ac.uk/pdbsum/4kgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kgr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kgr OCA], [https://pdbe.org/4kgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kgr RCSB], [https://www.ebi.ac.uk/pdbsum/4kgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kgr ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:58, 30 November 2022

2022-11-30T11:58:01Z

←Older revision		Revision as of 11:58, 30 November 2022
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	<StructureSection load='4kgr' size='340' side='right'caption='[[4kgr]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4kgr' size='340' side='right'caption='[[4kgr]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kgr]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KGR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kgr]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_sp._'group_G' Streptococcus sp. 'group G']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KGR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3K:(3S)-3,7-DIAMINOHEPTANOIC+ACID'>B3K</scene>, <scene name='pdbligand=B3X:(3S)-3,5-DIAMINO-5-OXOPENTANOIC+ACID'>B3X</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	~~<tr~~ id~~='NonStdRes'><td class~~="~~sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat~~"><scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3K:(3S)-3,7-DIAMINOHEPTANOIC+ACID'>B3K</scene>, <scene name='pdbligand=B3X:(3S)-3,5-DIAMINO-5-OXOPENTANOIC+ACID'>B3X</scene>, <scene name='pdbligand=~~NH2~~:~~AMINO+GROUP~~'>~~NH2~~</scene><~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kgr OCA], [https://pdbe.org/4kgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kgr RCSB], [https://www.ebi.ac.uk/pdbsum/4kgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kgr ProSAT]</span></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td>~~<td class="sblockDat">[[4kgs\|4kgs]], [[4kgt\|4kgt]]~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kgr OCA], [~~http~~://pdbe.org/4kgr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kgr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kgr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kgr ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPG1_STRSG SPG1_STRSG] Binds to the constant Fc region of IgG with high affinity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Horne, W S]]~~	+	[[Category: Streptococcus sp. 'group G']]
-	~~[[Category: Lengyel,~~ G A]]	+	[[Category: Horne WS]]
-	[[Category: ~~Reinert, Z E~~]]	+	[[Category: Lengyel GA]]
-	[[Category: ~~De novo protein~~]]	+	[[Category: Reinert ZE]]
-	[[Category: ~~Unnatural backbone~~]]	+

OCA at 09:31, 3 April 2019

2019-04-03T09:31:25Z

←Older revision		Revision as of 09:31, 3 April 2019
Line 1:		Line 1:

	==Backbone Modifications in the Protein GB1 Helix: beta-3-Ala24, beta-3-Lys28, beta-3-Lys31, beta-3-Asn35==		==Backbone Modifications in the Protein GB1 Helix: beta-3-Ala24, beta-3-Lys28, beta-3-Lys31, beta-3-Asn35==
-	<StructureSection load='4kgr' size='340' side='right' caption='[[4kgr]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4kgr' size='340' side='right'caption='[[4kgr]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kgr]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KGR FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kgr]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KGR FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Horne, W S]]		[[Category: Horne, W S]]
	[[Category: Lengyel, G A]]		[[Category: Lengyel, G A]]

OCA at 08:44, 11 August 2016

2016-08-11T08:44:59Z

←Older revision		Revision as of 08:44, 11 August 2016
Line 1:		Line 1:
		+
	==Backbone Modifications in the Protein GB1 Helix: beta-3-Ala24, beta-3-Lys28, beta-3-Lys31, beta-3-Asn35==		==Backbone Modifications in the Protein GB1 Helix: beta-3-Ala24, beta-3-Lys28, beta-3-Lys31, beta-3-Asn35==
	<StructureSection load='4kgr' size='340' side='right' caption='[[4kgr]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4kgr' size='340' side='right' caption='[[4kgr]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3K:(3S)-3,7-DIAMINOHEPTANOIC+ACID'>B3K</scene>, <scene name='pdbligand=B3X:(3S)-3,5-DIAMINO-5-OXOPENTANOIC+ACID'>B3X</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3K:(3S)-3,7-DIAMINOHEPTANOIC+ACID'>B3K</scene>, <scene name='pdbligand=B3X:(3S)-3,5-DIAMINO-5-OXOPENTANOIC+ACID'>B3X</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kgs\|4kgs]], [[4kgt\|4kgt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kgs\|4kgs]], [[4kgt\|4kgt]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kgr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kgr RCSB], [http://www.ebi.ac.uk/pdbsum/4kgr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kgr OCA], [http://pdbe.org/4kgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kgr RCSB], [http://www.ebi.ac.uk/pdbsum/4kgr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kgr ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kgr" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:03, 5 January 2015

2015-01-05T13:03:26Z

←Older revision		Revision as of 13:03, 5 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4kgr\| PDB=4kgr \| SCENE= }}~~	+	==Backbone Modifications in the Protein GB1 Helix: beta-3-Ala24, beta-3-Lys28, beta-3-Lys31, beta-3-Asn35==
-	===Backbone Modifications in the Protein GB1 Helix: beta-3-Ala24, beta-3-Lys28, beta-3-Lys31, beta-3-Asn35===	+	<StructureSection load='4kgr' size='340' side='right' caption='[[4kgr]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23937097}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4kgr]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KGR FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3K:(3S)-3,7-DIAMINOHEPTANOIC+ACID'>B3K</scene>, <scene name='pdbligand=B3X:(3S)-3,5-DIAMINO-5-OXOPENTANOIC+ACID'>B3X</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kgs\|4kgs]], [[4kgt\|4kgt]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kgr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kgr RCSB], [http://www.ebi.ac.uk/pdbsum/4kgr PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Because proteins play vital roles in life, much effort has been invested in their mimicry by synthetic agents. One approach is to design unnatural backbone oligomers ("foldamers") that fold like natural peptides. Despite success in secondary structure mimicry by such species, protein-like tertiary folds remain elusive. A fundamental challenge underlying this task is the design of a sequence of side chains that will specify a complex tertiary folding pattern on an unnatural backbone. We report here a sequence-based approach to convert a natural protein with a compact tertiary fold to an analogue with a backbone composed of approximately 20% unnatural building blocks but folding behavior similar to that of the parent protein.

-	~~==About this Structure==~~	+	Protein-like Tertiary Folding Behavior from Heterogeneous Backbones.,Reinert ZE, Lengyel GA, Horne WS J Am Chem Soc. 2013 Aug 28;135(34):12528-31. doi: 10.1021/ja405422v. Epub 2013, Aug 15. PMID:23937097<ref>PMID:23937097</ref>
-	~~[[4kgr]] is a 8 chain structure. Full crystallographic information is available~~ from ~~[http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4KGR OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023937097</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Horne, W S.]]	+	== References ==
-	[[Category: Lengyel, G A.]]	+	<references/>
-	[[Category: Reinert, Z E.]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Horne, W S]]
		+	[[Category: Lengyel, G A]]
		+	[[Category: Reinert, Z E]]
	[[Category: De novo protein]]		[[Category: De novo protein]]
	[[Category: Unnatural backbone]]		[[Category: Unnatural backbone]]

OCA at 10:40, 4 September 2013

2013-09-04T10:40:32Z

←Older revision		Revision as of 10:40, 4 September 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4kgr\| PDB=4kgr \| SCENE= }}
		+	===Backbone Modifications in the Protein GB1 Helix: beta-3-Ala24, beta-3-Lys28, beta-3-Lys31, beta-3-Asn35===
		+	{{ABSTRACT_PUBMED_23937097}}

-	~~The entry~~ 4kgr is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4kgr]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGR OCA].

-	~~Authors~~: ~~Reinert~~, Z.~~E.,~~ Lengyel, G.A., ~~Horne, W.S~~.	+	==Reference==
-		+	<ref group="xtra">PMID:023937097</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Backbone Modifications in the Protein GB1 Helix: beta-3-Ala24, beta-3-Lys28, beta-3-Lys31, beta-3-Asn35~~	+	[[Category: Horne, W S.]]
		+	[[Category: Lengyel, G A.]]
		+	[[Category: Reinert, Z E.]]
		+	[[Category: De novo protein]]
		+	[[Category: Unnatural backbone]]

OCA at 15:00, 10 July 2013

2013-07-10T15:00:16Z

←Older revision		Revision as of 15:00, 10 July 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kgr is ON HOLD	+	The entry 4kgr is ON HOLD until Paper Publication

	Authors: Reinert, Z.E., Lengyel, G.A., Horne, W.S.		Authors: Reinert, Z.E., Lengyel, G.A., Horne, W.S.

	Description: Backbone Modifications in the Protein GB1 Helix: beta-3-Ala24, beta-3-Lys28, beta-3-Lys31, beta-3-Asn35		Description: Backbone Modifications in the Protein GB1 Helix: beta-3-Ala24, beta-3-Lys28, beta-3-Lys31, beta-3-Asn35

OCA: Protected "4kgr" [edit=sysop:move=sysop]

2013-05-08T07:23:02Z

Protected "4kgr" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:23, 8 May 2013

OCA: New page: '''Unreleased structure''' The entry 4kgr is ON HOLD Authors: Reinert, Z.E., Lengyel, G.A., Horne, W.S. Description: Backbone Modifications in the Protein GB1 Helix: beta-3-Ala24, beta...

2013-05-08T07:23:00Z

New page: '''Unreleased structure''' The entry 4kgr is ON HOLD Authors: Reinert, Z.E., Lengyel, G.A., Horne, W.S. Description: Backbone Modifications in the Protein GB1 Helix: beta-3-Ala24, beta...

New page

'''Unreleased structure'''

The entry 4kgr is ON HOLD

Authors: Reinert, Z.E., Lengyel, G.A., Horne, W.S.

Description: Backbone Modifications in the Protein GB1 Helix: beta-3-Ala24, beta-3-Lys28, beta-3-Lys31, beta-3-Asn35