4kie - Revision history

OCA at 16:00, 20 September 2023

2023-09-20T16:00:03Z

←Older revision		Revision as of 16:00, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kie]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KIE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kie]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KIE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kie OCA], [https://pdbe.org/4kie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kie RCSB], [https://www.ebi.ac.uk/pdbsum/4kie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kie ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kie OCA], [https://pdbe.org/4kie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kie RCSB], [https://www.ebi.ac.uk/pdbsum/4kie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kie ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:53, 7 December 2022

2022-12-07T08:53:45Z

←Older revision		Revision as of 08:53, 7 December 2022
Line 1:		Line 1:

	==Crystal structure of the EAL domain of c-di-GMP specific phosphodiesterase YahA==		==Crystal structure of the EAL domain of c-di-GMP specific phosphodiesterase YahA==
-	<StructureSection load='4kie' size='340' side='right' caption='[[4kie]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4kie' size='340' side='right'caption='[[4kie]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kie]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KIE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kie]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KIE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lj3\|4lj3]], [[4lyk\|4lyk]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kie OCA], [https://pdbe.org/4kie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kie RCSB], [https://www.ebi.ac.uk/pdbsum/4kie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kie ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yahA, b0315, JW0307 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kie OCA], [~~http~~://pdbe.org/4kie PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kie RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kie PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kie ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~YAHA_ECOLI YAHA_ECOLI~~]~~] Hydrolyzes~~ c-di-GMP (cyclic ~~bis~~(3'-~~5') dimeric~~ GMP) to 5'-pGpG, ~~known as PDE-A activity. PDE-B activity~~, ~~that is hydrolysis of 5'-pGpG~~ to ~~GMP, proceeds only very slowly~~.	+	[https://www.uniprot.org/uniprot/PDEL_ECOLI PDEL_ECOLI] Acts both as an enzyme and as a c-di-GMP sensor to couple transcriptional activity to the c-di-GMP status of the cell (PubMed:26553851). Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG (PubMed:15995192, PubMed:24451384, PubMed:26553851). Also acts as a transcription factor to control its own expression (PubMed:26553851).<ref>PMID:15995192</ref> <ref>PMID:24451384</ref> <ref>PMID:26553851</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Phosphodiesterase\|Phosphodiesterase]]	+	*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
-	[[Category: ~~Schirmer, T~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Sundriyal, A~~]]	+	[[Category: Schirmer T]]
-	[[Category: ~~Hydrolase]]~~	+	[[Category: Sundriyal A]]
-	~~[[Category: Pgpg]]~~	+
-	~~[[Category: Phosphodiesterase]]~~	+
-	~~[[Category: Tim-barrel~~]]	+

OCA at 08:33, 5 August 2016

2016-08-05T08:33:52Z

←Older revision		Revision as of 08:33, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the EAL domain of c-di-GMP specific phosphodiesterase YahA==		==Crystal structure of the EAL domain of c-di-GMP specific phosphodiesterase YahA==
	<StructureSection load='4kie' size='340' side='right' caption='[[4kie]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4kie' size='340' side='right' caption='[[4kie]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lj3\|4lj3]], [[4lyk\|4lyk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lj3\|4lj3]], [[4lyk\|4lyk]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yahA, b0315, JW0307 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yahA, b0315, JW0307 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kie OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kie RCSB], [http://www.ebi.ac.uk/pdbsum/4kie PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kie OCA], [http://pdbe.org/4kie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kie RCSB], [http://www.ebi.ac.uk/pdbsum/4kie PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kie ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kie" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:18, 25 December 2014

2014-12-25T17:18:48Z

←Older revision		Revision as of 17:18, 25 December 2014
Line 2:		Line 2:
	<StructureSection load='4kie' size='340' side='right' caption='[[4kie]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4kie' size='340' side='right' caption='[[4kie]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kie]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIE OCA]. <br>	+	<table><tr><td colspan='2'>[[4kie]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KIE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lj3\|4lj3]], [[4lyk\|4lyk]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lj3\|4lj3]], [[4lyk\|4lyk]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yahA, b0315, JW0307 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yahA, b0315, JW0307 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kie OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kie RCSB], [http://www.ebi.ac.uk/pdbsum/4kie PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kie OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kie RCSB], [http://www.ebi.ac.uk/pdbsum/4kie PDBsum]</span></td></tr>	+	</table>
-	<table>	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/YAHA_ECOLI YAHA_ECOLI]] Hydrolyzes c-di-GMP (cyclic bis(3'-5') dimeric GMP) to 5'-pGpG, known as PDE-A activity. PDE-B activity, that is hydrolysis of 5'-pGpG to GMP, proceeds only very slowly.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 16:
	Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger c-di-GMP.,Sundriyal A, Massa C, Samoray D, Zehender F, Sharpe T, Jenal U, Schirmer T J Biol Chem. 2014 Jan 22. PMID:24451384<ref>PMID:24451384</ref>		Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger c-di-GMP.,Sundriyal A, Massa C, Samoray D, Zehender F, Sharpe T, Jenal U, Schirmer T J Biol Chem. 2014 Jan 22. PMID:24451384<ref>PMID:24451384</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Phosphodiesterase\|Phosphodiesterase]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
-	[[Category: Schirmer, T.]]	+	[[Category: Schirmer, T]]
-	[[Category: Sundriyal, A.]]	+	[[Category: Sundriyal, A]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Pgpg]]		[[Category: Pgpg]]
	[[Category: Phosphodiesterase]]		[[Category: Phosphodiesterase]]
	[[Category: Tim-barrel]]		[[Category: Tim-barrel]]

OCA at 06:40, 14 May 2014

2014-05-14T06:40:13Z

←Older revision		Revision as of 06:40, 14 May 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4kie\| PDB=4kie \| SCENE= }}~~	+	==Crystal structure of the EAL domain of c-di-GMP specific phosphodiesterase YahA==
-	===Crystal structure of the EAL domain of c-di-GMP specific phosphodiesterase YahA===	+	<StructureSection load='4kie' size='340' side='right' caption='[[4kie]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24451384}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4kie]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIE OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lj3\|4lj3]], [[4lyk\|4lyk]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yahA, b0315, JW0307 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kie OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kie RCSB], [http://www.ebi.ac.uk/pdbsum/4kie PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The universal second messenger cyclic di-GMP (cdG) is involved in the regulation of a diverse range of cellular processes in bacteria. The intracellular concentration of the dinucleotide is determined by the opposing actions of diguanylate cyclases (DGCs) and cdG specific phosphodiesterases (PDEs). While most PDEs have accessory domains that are involved in the regulation of their activity, the regulatory mechanism of this class of enzymes has remained unclear. Here, we use biophysical and functional analyses to show that the isolated EAL domain of a PDE from E. coli (YahA) is in a fast thermodynamic monomer - dimer equilibrium, and that the domain is active only in its dimeric state. Furthermore, our data indicate thermodynamic coupling between substrate binding and EAL dimerization with the dimerization affinity being increased about 100-fold upon substrate binding. Crystal structures of the YahA-EAL domain determined under various conditions (apo, Mg2+, c-di-GMP/Mg2+ complex) confirm structural coupling between the dimer interface and the catalytic center. The in-built regulatory properties of the EAL domain probably facilitates its modular, functional combination with the diverse repertoire of accessory domains.

-	~~==Function==~~	+	Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger c-di-GMP.,Sundriyal A, Massa C, Samoray D, Zehender F, Sharpe T, Jenal U, Schirmer T J Biol Chem. 2014 Jan 22. PMID:24451384<ref>PMID:24451384</ref>
-	~~[[http://www.uniprot.org/uniprot/YAHA_ECOLI YAHA_ECOLI]] Hydrolyzes~~ c-di-GMP ~~(cyclic bis(3'-5') dimeric GMP) to 5'-pGpG~~, ~~known as PDE-~~A ~~activity. PDE-B activity~~, ~~that is hydrolysis of 5'-pGpG to GMP~~, ~~proceeds only very slowly~~.	+

-	~~==About this Structure==~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4kie]] is~~ a ~~1 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4KIE OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:024451384</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
		+	[[Category: Ecoli]]
	[[Category: Schirmer, T.]]		[[Category: Schirmer, T.]]
	[[Category: Sundriyal, A.]]		[[Category: Sundriyal, A.]]

OCA at 03:16, 13 February 2014

2014-02-13T03:16:03Z

←Older revision		Revision as of 03:16, 13 February 2014
Line 1:		Line 1:
	{{STRUCTURE_4kie\| PDB=4kie \| SCENE= }}		{{STRUCTURE_4kie\| PDB=4kie \| SCENE= }}
	===Crystal structure of the EAL domain of c-di-GMP specific phosphodiesterase YahA===		===Crystal structure of the EAL domain of c-di-GMP specific phosphodiesterase YahA===
		+	{{ABSTRACT_PUBMED_24451384}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[4kie]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIE OCA].		[[4kie]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIE OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024451384</ref><references group="xtra"/><references/>
	[[Category: Schirmer, T.]]		[[Category: Schirmer, T.]]
	[[Category: Sundriyal, A.]]		[[Category: Sundriyal, A.]]

OCA at 07:48, 29 January 2014

2014-01-29T07:48:11Z

←Older revision		Revision as of 07:48, 29 January 2014
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4kie\| PDB=4kie \| SCENE= }}
		+	===Crystal structure of the EAL domain of c-di-GMP specific phosphodiesterase YahA===

-	~~The entry 4kie~~ is ~~ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/YAHA_ECOLI YAHA_ECOLI]] Hydrolyzes c-di-GMP (cyclic bis(3'-5') dimeric GMP) to 5'-pGpG, known as PDE-A activity. PDE-B activity, that is hydrolysis of 5'-pGpG to GMP, proceeds only very slowly.

-	~~Authors~~: ~~Sundriyal, A~~., Schirmer, T.	+	==About this Structure==
-		+	[[4kie]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIE OCA].
-	~~Description~~: ~~Crystal structure of the EAL domain of c-di~~-~~GMP specific phosphodiesterase YahA~~	+	[[Category: Schirmer, T.]]
		+	[[Category: Sundriyal, A.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Pgpg]]
		+	[[Category: Phosphodiesterase]]
		+	[[Category: Tim-barrel]]

OCA at 11:39, 19 June 2013

2013-06-19T11:39:49Z

←Older revision		Revision as of 11:39, 19 June 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kie is ON HOLD	+	The entry 4kie is ON HOLD until Paper Publication

	Authors: Sundriyal, A., Schirmer, T.		Authors: Sundriyal, A., Schirmer, T.

	Description: Crystal structure of the EAL domain of c-di-GMP specific phosphodiesterase YahA		Description: Crystal structure of the EAL domain of c-di-GMP specific phosphodiesterase YahA

OCA: Protected "4kie" [edit=sysop:move=sysop]

2013-05-08T07:24:45Z

Protected "4kie" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:24, 8 May 2013

OCA: New page: '''Unreleased structure''' The entry 4kie is ON HOLD Authors: Sundriyal, A., Schirmer, T. Description: Crystal structure of the EAL domain of c-di-GMP specific phosphodiesterase YahA

2013-05-08T07:24:44Z

New page: '''Unreleased structure''' The entry 4kie is ON HOLD Authors: Sundriyal, A., Schirmer, T. Description: Crystal structure of the EAL domain of c-di-GMP specific phosphodiesterase YahA

New page

'''Unreleased structure'''

The entry 4kie is ON HOLD

Authors: Sundriyal, A., Schirmer, T.

Description: Crystal structure of the EAL domain of c-di-GMP specific phosphodiesterase YahA