4kik - Revision history

OCA at 08:54, 7 December 2022

2022-12-07T08:54:01Z

←Older revision		Revision as of 08:54, 7 December 2022
Line 1:		Line 1:

	==Human IkB kinase beta==		==Human IkB kinase beta==
-	<StructureSection load='4kik' size='340' side='right' caption='[[4kik]], [[Resolution\|resolution]] 2.83Å' scene=''>	+	<StructureSection load='4kik' size='340' side='right'caption='[[4kik]], [[Resolution\|resolution]] 2.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kik]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KIK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kik]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KIK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KSA:K-252A'>KSA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KSA:K-252A'>KSA</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene~~></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kik OCA], [https://pdbe.org/4kik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kik RCSB], [https://www.ebi.ac.uk/pdbsum/4kik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kik ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IKBKB, IKKB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/I-kappa-B_kinase I-kappa-B kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.10 2.7.11.10] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kik OCA], [~~http~~://pdbe.org/4kik PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kik RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kik PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kik ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/IKKB_HUMAN IKKB_HUMAN]] Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.<ref>PMID:11297557</ref> <ref>PMID:17213322</ref> <ref>PMID:20434986</ref> <ref>PMID:20410276</ref> <ref>PMID:20797629</ref> <ref>PMID:21138416</ref>	+	[https://www.uniprot.org/uniprot/IKKB_HUMAN IKKB_HUMAN] Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.<ref>PMID:11297557</ref> <ref>PMID:17213322</ref> <ref>PMID:20434986</ref> <ref>PMID:20410276</ref> <ref>PMID:20797629</ref> <ref>PMID:21138416</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~I-kappa-B kinase~~]]	+	[[Category: Large Structures]]
-	[[Category: Liu, S]]	+	[[Category: Liu S]]
-	[[Category: Mosyak, L]]	+	[[Category: Mosyak L]]
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Nkb signaling]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 14:37, 5 August 2016

2016-08-05T14:37:20Z

←Older revision		Revision as of 14:37, 5 August 2016
Line 1:		Line 1:
		+
	==Human IkB kinase beta==		==Human IkB kinase beta==
	<StructureSection load='4kik' size='340' side='right' caption='[[4kik]], [[Resolution\|resolution]] 2.83Å' scene=''>		<StructureSection load='4kik' size='340' side='right' caption='[[4kik]], [[Resolution\|resolution]] 2.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kik]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rhizobium_loessense Rhizobium loessense~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KIK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kik]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KIK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KSA:K-252A'>KSA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KSA:K-252A'>KSA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IKBKB, IKKB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens]), IKBKB, IKKB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158890 Rhizobium loessense~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IKBKB, IKKB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/I-kappa-B_kinase I-kappa-B kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.10 2.7.11.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/I-kappa-B_kinase I-kappa-B kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.10 2.7.11.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kik OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kik RCSB], [http://www.ebi.ac.uk/pdbsum/4kik PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kik OCA], [http://pdbe.org/4kik PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kik RCSB], [http://www.ebi.ac.uk/pdbsum/4kik PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kik ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kik" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: I-kappa-B kinase]]		[[Category: I-kappa-B kinase]]
-	[[Category: Rhizobium loessense]]
	[[Category: Liu, S]]		[[Category: Liu, S]]
	[[Category: Mosyak, L]]		[[Category: Mosyak, L]]

OCA at 03:18, 25 December 2014

2014-12-25T03:18:14Z

←Older revision		Revision as of 03:18, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4kik~~\| ~~PDB~~=4kik \| ~~SCENE~~= }}	+	==Human IkB kinase beta==
-	===~~Human IkB kinase beta~~===	+	<StructureSection load='4kik' size='340' side='right' caption='[[4kik]], [[Resolution\|resolution]] 2.83Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23792959}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4kik]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rhizobium_loessense Rhizobium loessense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KIK FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KSA:K-252A'>KSA</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IKBKB, IKKB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), IKBKB, IKKB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158890 Rhizobium loessense])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/I-kappa-B_kinase I-kappa-B kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.10 2.7.11.10] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kik OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kik RCSB], [http://www.ebi.ac.uk/pdbsum/4kik PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/IKKB_HUMAN IKKB_HUMAN]] Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.<ref>PMID:11297557</ref> <ref>PMID:17213322</ref> <ref>PMID:20434986</ref> <ref>PMID:20410276</ref> <ref>PMID:20797629</ref> <ref>PMID:21138416</ref>		[[http://www.uniprot.org/uniprot/IKKB_HUMAN IKKB_HUMAN]] Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.<ref>PMID:11297557</ref> <ref>PMID:17213322</ref> <ref>PMID:20434986</ref> <ref>PMID:20410276</ref> <ref>PMID:20797629</ref> <ref>PMID:21138416</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Phosphorylation of inhibitor of nuclear transcription factor kappaB (IkappaB) by IkappaB kinase (IKK) triggers the degradation of IkappaB and migration of cytoplasmic kappaB to the nucleus where it promotes the transcription of its target genes. Activation of IKK is achieved by phosphorylation of its main subunit, IKKbeta, at the activation loop sites. Here, we report the 2.8 A resolution crystal structure of human IKKbeta (hIKKbeta), which is partially phosphorylated and bound to the staurosporine analog K252a. The hIKKbeta protomer adopts a trimodular structure that closely resembles that from Xenopus laevis (xIKKbeta): an N-terminal kinase domain (KD), a central ubiquitin-like domain (ULD), and a C-terminal scaffold/dimerization domain (SDD). Although hIKKbeta and xIKKbeta utilize a similar dimerization mode, their overall geometries are distinct. In contrast to the structure resembling closed shears reported previously for xIKKbeta, hIKKbeta exists as an open asymmetric dimer in which the two KDs are further apart, with one in an active and the other in an inactive conformation. Dimer interactions are limited to the C-terminal six-helix bundle that acts as a hinge between the two subunits. The observed domain movements in the structures of IKKbeta may represent trans-phosphorylation steps that accompany IKKbeta activation.

-	~~==About this~~ Structure==	+	Crystal Structure of a Human IkappaB Kinase beta Asymmetric Dimer.,Liu S, Misquitta YR, Olland A, Johnson MA, Kelleher KS, Kriz R, Lin LL, Stahl M, Mosyak L J Biol Chem. 2013 Aug 2;288(31):22758-67. doi: 10.1074/jbc.M113.482596. Epub 2013, Jun 21. PMID:23792959<ref>PMID:23792959</ref>
-	~~[[4kik]] is~~ a 2 ~~chain structure with sequence from [http~~:~~//en~~.~~wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http~~:~~//en~~.~~wikipedia.org/wiki~~/~~Rhizobium_loessense Rhizobium loessense]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4KIK OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023792959</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: I-kappa-B kinase]]		[[Category: I-kappa-B kinase]]
	[[Category: Rhizobium loessense]]		[[Category: Rhizobium loessense]]
-	[[Category: Liu, S.]]	+	[[Category: Liu, S]]
-	[[Category: Mosyak, L.]]	+	[[Category: Mosyak, L]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Nkb signaling]]		[[Category: Nkb signaling]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 05:30, 28 August 2013

2013-08-28T05:30:17Z

←Older revision		Revision as of 05:30, 28 August 2013
Line 1:		Line 1:
	{{STRUCTURE_4kik\| PDB=4kik \| SCENE= }}		{{STRUCTURE_4kik\| PDB=4kik \| SCENE= }}
	===Human IkB kinase beta===		===Human IkB kinase beta===
		+	{{ABSTRACT_PUBMED_23792959}}

	==Function==		==Function==
Line 9:		Line 10:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:023792959</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: I-kappa-B kinase]]		[[Category: I-kappa-B kinase]]

OCA at 10:32, 30 June 2013

2013-06-30T10:32:34Z

←Older revision		Revision as of 10:32, 30 June 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4kik\| PDB=4kik \| SCENE= }}
		+	===Human IkB kinase beta===

-	~~The entry 4kik~~ is ~~ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/IKKB_HUMAN IKKB_HUMAN]] Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.<ref>PMID:11297557</ref> <ref>PMID:17213322</ref> <ref>PMID:20434986</ref> <ref>PMID:20410276</ref> <ref>PMID:20797629</ref> <ref>PMID:21138416</ref>

-	~~Authors~~: ~~Liu, S~~.~~, Mosyak, L~~.	+	==About this Structure==
		+	[[4kik]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rhizobium_loessense Rhizobium loessense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIK OCA].

-	~~Description~~: ~~Human IkB~~ kinase ~~beta~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: I-kappa-B kinase]]
		+	[[Category: Rhizobium loessense]]
		+	[[Category: Liu, S.]]
		+	[[Category: Mosyak, L.]]
		+	[[Category: Kinase]]
		+	[[Category: Nkb signaling]]
		+	[[Category: Transferase]]

OCA at 11:40, 19 June 2013

2013-06-19T11:40:15Z

←Older revision		Revision as of 11:40, 19 June 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kik is ON HOLD ~~until Paper Publication~~	+	The entry 4kik is ON HOLD

	Authors: Liu, S., Mosyak, L.		Authors: Liu, S., Mosyak, L.

	Description: Human IkB kinase beta		Description: Human IkB kinase beta

OCA at 06:56, 16 May 2013

2013-05-16T06:56:05Z

←Older revision		Revision as of 06:56, 16 May 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kik is ON HOLD	+	The entry 4kik is ON HOLD until Paper Publication

-	Authors: Liu,S, Mosyak,L	+	Authors: Liu, S., Mosyak, L.

	Description: Human IkB kinase beta		Description: Human IkB kinase beta

OCA: Protected "4kik" [edit=sysop:move=sysop]

2013-05-08T07:24:56Z

Protected "4kik" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:24, 8 May 2013

OCA: New page: '''Unreleased structure''' The entry 4kik is ON HOLD Authors: Liu,S, Mosyak,L Description: Human IkB kinase beta

2013-05-08T07:24:55Z

New page: '''Unreleased structure''' The entry 4kik is ON HOLD Authors: Liu,S, Mosyak,L Description: Human IkB kinase beta

New page

'''Unreleased structure'''

The entry 4kik is ON HOLD

Authors: Liu,S, Mosyak,L

Description: Human IkB kinase beta