4kkv - Revision history

OCA at 16:00, 20 September 2023

2023-09-20T16:00:50Z

←Older revision		Revision as of 16:00, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kkv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata_CBS_138 Candida glabrata CBS 138]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KKV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kkv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata_CBS_138 Candida glabrata CBS 138]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KKV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.74Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kkv OCA], [https://pdbe.org/4kkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kkv RCSB], [https://www.ebi.ac.uk/pdbsum/4kkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kkv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kkv OCA], [https://pdbe.org/4kkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kkv RCSB], [https://www.ebi.ac.uk/pdbsum/4kkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kkv ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:57, 7 December 2022

2022-12-07T08:57:04Z

←Older revision		Revision as of 08:57, 7 December 2022
Line 1:		Line 1:

	==Crystal structure of candida glabrata FMN adenylyltransferase D181A Mutant==		==Crystal structure of candida glabrata FMN adenylyltransferase D181A Mutant==
-	<StructureSection load='4kkv' size='340' side='right' caption='[[4kkv]], [[Resolution\|resolution]] 1.74Å' scene=''>	+	<StructureSection load='4kkv' size='340' side='right'caption='[[4kkv]], [[Resolution\|resolution]] 1.74Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kkv]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Canga Canga~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KKV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KKV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kkv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata_CBS_138 Candida glabrata CBS 138]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KKV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fwk\|3fwk]], [[3g59\|3g59]], [[3g5a\|3g5a]], [[3g6k\|3g6k]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kkv OCA], [https://pdbe.org/4kkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kkv RCSB], [https://www.ebi.ac.uk/pdbsum/4kkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kkv ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAGL0K01397g, FAD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284593 CANGA])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/FAD_synthetase FAD synthetase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.2 2.7.7.2] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kkv OCA], [~~http~~://pdbe.org/4kkv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kkv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kkv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kkv ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6FNA9_CANGA Q6FNA9_CANGA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Canga]]~~	+	[[Category: Large Structures]]
-	~~[[Category: FAD synthetase~~]]	+	[[Category: Huerta C]]
-	[[Category: Huerta, C]]	+	[[Category: Zhang H]]
-	[[Category: Zhang, H]]	+
-	~~[[Category: Alpha/beta protein]]~~	+
-	~~[[Category: Fad biosynthesis]]~~	+
-	~~[[Category: Rossmann-like fold]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 19:42, 5 August 2016

2016-08-05T19:42:28Z

←Older revision		Revision as of 19:42, 5 August 2016
Line 1:		Line 1:
-	{{STRUCTURE_4kkv\| PDB=4kkv \| SCENE= }}
-	===Crystal structure of candida glabrata FMN adenylyltransferase D181A Mutant===
-	{{ABSTRACT_PUBMED_23663086}}

-	==~~About this Structure~~==	+	==Crystal structure of candida glabrata FMN adenylyltransferase D181A Mutant==
-	[[4kkv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canga Canga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KKV OCA].	+	<StructureSection load='4kkv' size='340' side='right' caption='[[4kkv]], [[Resolution\|resolution]] 1.74Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4kkv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canga Canga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KKV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fwk\|3fwk]], [[3g59\|3g59]], [[3g5a\|3g5a]], [[3g6k\|3g6k]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAGL0K01397g, FAD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284593 CANGA])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/FAD_synthetase FAD synthetase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.2 2.7.7.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kkv OCA], [http://pdbe.org/4kkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kkv RCSB], [http://www.ebi.ac.uk/pdbsum/4kkv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kkv ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	FMN adenylyltransferase (FMNAT) is an essential enzyme catalyzing the last step of a two-step pathway converting riboflavin (vitamin B2) to FAD, the ubiquitous flavocoenzyme. A structure-based mutagenesis and steady-state kinetic analysis of yeast FMNAT unexpectedly revealed that mutant D181A had a much faster turnover rate than the wild-type enzyme. Product inhibition analysis showed that wild-type FMNAT is strongly inhibited by FAD, whereas the D181A mutant has an attenuated product inhibition. These results provide a structural basis for the product inhibition of the enzyme and suggest that product release may be the rate-limiting step of the reaction.

-	~~==Reference==~~	+	The "Super Mutant" of Yeast FMN Adenylyltransferase Enhances the Enzyme Turnover Rate by Attenuating Product Inhibition.,Huerta C, Grishin NV, Zhang H Biochemistry. 2013 May 15. PMID:23663086<ref>PMID:23663086</ref>
-	~~<ref group=~~"~~xtra~~">PMID:~~023663086~~</ref><~~references group~~="~~xtra~~"/><references/>	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4kkv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Canga]]		[[Category: Canga]]
	[[Category: FAD synthetase]]		[[Category: FAD synthetase]]
-	[[Category: Huerta, C.]]	+	[[Category: Huerta, C]]
-	[[Category: Zhang, H.]]	+	[[Category: Zhang, H]]
	[[Category: Alpha/beta protein]]		[[Category: Alpha/beta protein]]
	[[Category: Fad biosynthesis]]		[[Category: Fad biosynthesis]]
	[[Category: Rossmann-like fold]]		[[Category: Rossmann-like fold]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:46, 25 December 2013

2013-12-25T08:46:02Z

←Older revision		Revision as of 08:46, 25 December 2013
Line 4:		Line 4:

	==About this Structure==		==About this Structure==
-	[[4kkv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Candida_glabrata_cbs_138 Candida glabrata cbs 138~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KKV OCA].	+	[[4kkv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canga Canga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KKV OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:023663086</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:023663086</ref><references group="xtra"/><references/>
-	[[Category: ~~Candida glabrata cbs 138~~]]	+	[[Category: Canga]]
	[[Category: FAD synthetase]]		[[Category: FAD synthetase]]
	[[Category: Huerta, C.]]		[[Category: Huerta, C.]]

OCA at 15:16, 19 June 2013

2013-06-19T15:16:47Z

←Older revision		Revision as of 15:16, 19 June 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4kkv\| PDB=4kkv \| SCENE= }}
		+	===Crystal structure of candida glabrata FMN adenylyltransferase D181A Mutant===
		+	{{ABSTRACT_PUBMED_23663086}}

-	~~The entry~~ 4kkv is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4kkv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_glabrata_cbs_138 Candida glabrata cbs 138]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KKV OCA].

-	~~Authors~~: Huerta, C., Zhang, H.	+	==Reference==
-		+	<ref group="xtra">PMID:023663086</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Crystal structure of candida glabrata FMN adenylyltransferase D181A Mutant~~	+	[[Category: Candida glabrata cbs 138]]
		+	[[Category: FAD synthetase]]
		+	[[Category: Huerta, C.]]
		+	[[Category: Zhang, H.]]
		+	[[Category: Alpha/beta protein]]
		+	[[Category: Fad biosynthesis]]
		+	[[Category: Rossmann-like fold]]
		+	[[Category: Transferase]]

OCA: Protected "4kkv" [edit=sysop:move=sysop]

2013-05-16T06:58:16Z

Protected "4kkv" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:58, 16 May 2013

OCA: New page: '''Unreleased structure''' The entry 4kkv is ON HOLD until Paper Publication Authors: Huerta, C., Zhang, H. Description: Crystal structure of candida glabrata FMN adenylyltransferase D...

2013-05-16T06:58:15Z

New page: '''Unreleased structure''' The entry 4kkv is ON HOLD until Paper Publication Authors: Huerta, C., Zhang, H. Description: Crystal structure of candida glabrata FMN adenylyltransferase D...

New page

'''Unreleased structure'''

The entry 4kkv is ON HOLD until Paper Publication

Authors: Huerta, C., Zhang, H.

Description: Crystal structure of candida glabrata FMN adenylyltransferase D181A Mutant