4kll - Revision history

OCA at 16:01, 20 September 2023

2023-09-20T16:01:14Z

←Older revision		Revision as of 16:01, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kll]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KLL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kll]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KLL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.841Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kll OCA], [https://pdbe.org/4kll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kll RCSB], [https://www.ebi.ac.uk/pdbsum/4kll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kll ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kll OCA], [https://pdbe.org/4kll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kll RCSB], [https://www.ebi.ac.uk/pdbsum/4kll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kll ProSAT]</span></td></tr>
	</table>		</table>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4kll" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4kll" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:58, 7 December 2022

2022-12-07T08:58:33Z

←Older revision		Revision as of 08:58, 7 December 2022
Line 1:		Line 1:

	==DNA polymerase beta matched product complex with Mg2+, 45 min==		==DNA polymerase beta matched product complex with Mg2+, 45 min==
-	<StructureSection load='4kll' size='340' side='right' caption='[[4kll]], [[Resolution\|resolution]] 1.84Å' scene=''>	+	<StructureSection load='4kll' size='340' side='right'caption='[[4kll]], [[Resolution\|resolution]] 1.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kll]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KLL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kll]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KLL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kld\|4kld]], [[4kle\|4kle]], [[4klf\|4klf]], [[4klg\|4klg]], [[4klh\|4klh]], [[4kli\|4kli]], [[4klj\|4klj]], [[4klm\|4klm]], [[4klo\|4klo]], [[4klp\|4klp]], [[4klq\|4klq]], [[4kls\|4kls]], [[4klt\|4klt]], [[4klu\|4klu]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kll OCA], [https://pdbe.org/4kll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kll RCSB], [https://www.ebi.ac.uk/pdbsum/4kll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kll ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Polb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kll OCA], [~~http~~://pdbe.org/4kll PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kll RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kll PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kll ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>	+	[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Beard, W A~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Freudenthal, B D~~]]	+	[[Category: Beard WA]]
-	[[Category: ~~Shock, D D~~]]	+	[[Category: Freudenthal BD]]
-	[[Category: ~~Wilson, S H~~]]	+	[[Category: Shock DD]]
-	[[Category: ~~Dna polymerase]]~~	+	[[Category: Wilson SH]]
-	~~[[Category: Lyase-dna complex]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:23, 15 November 2017

2017-11-15T09:23:08Z

←Older revision		Revision as of 09:23, 15 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4kll" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4kll" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[DNA polymerase\|DNA polymerase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:20, 4 August 2016

2016-08-04T19:20:42Z

←Older revision		Revision as of 19:20, 4 August 2016
Line 1:		Line 1:
		+
	==DNA polymerase beta matched product complex with Mg2+, 45 min==		==DNA polymerase beta matched product complex with Mg2+, 45 min==
	<StructureSection load='4kll' size='340' side='right' caption='[[4kll]], [[Resolution\|resolution]] 1.84Å' scene=''>		<StructureSection load='4kll' size='340' side='right' caption='[[4kll]], [[Resolution\|resolution]] 1.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kll]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KLL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kll]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KLL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kld\|4kld]], [[4kle\|4kle]], [[4klf\|4klf]], [[4klg\|4klg]], [[4klh\|4klh]], [[4kli\|4kli]], [[4klj\|4klj]], [[4klm\|4klm]], [[4klo\|4klo]], [[4klp\|4klp]], [[4klq\|4klq]], [[4kls\|4kls]], [[4klt\|4klt]], [[4klu\|4klu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kld\|4kld]], [[4kle\|4kle]], [[4klf\|4klf]], [[4klg\|4klg]], [[4klh\|4klh]], [[4kli\|4kli]], [[4klj\|4klj]], [[4klm\|4klm]], [[4klo\|4klo]], [[4klp\|4klp]], [[4klq\|4klq]], [[4kls\|4kls]], [[4klt\|4klt]], [[4klu\|4klu]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Polb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Polb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kll OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kll RCSB], [http://www.ebi.ac.uk/pdbsum/4kll PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kll OCA], [http://pdbe.org/4kll PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kll RCSB], [http://www.ebi.ac.uk/pdbsum/4kll PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kll ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kll" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Beard, W A]]		[[Category: Beard, W A]]
	[[Category: Freudenthal, B D]]		[[Category: Freudenthal, B D]]

OCA at 18:40, 24 December 2014

2014-12-24T18:40:37Z

←Older revision		Revision as of 18:40, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kll OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kll RCSB], [http://www.ebi.ac.uk/pdbsum/4kll PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kll OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kll RCSB], [http://www.ebi.ac.uk/pdbsum/4kll PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:41, 21 December 2014

2014-12-21T14:41:03Z

←Older revision		Revision as of 14:41, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4kll\| PDB=4kll \| SCENE= }}~~	+	==DNA polymerase beta matched product complex with Mg2+, 45 min==
-	===DNA polymerase beta matched product complex with Mg2+, 45 min===	+	<StructureSection load='4kll' size='340' side='right' caption='[[4kll]], [[Resolution\|resolution]] 1.84Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23827680}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4kll]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KLL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kld\|4kld]], [[4kle\|4kle]], [[4klf\|4klf]], [[4klg\|4klg]], [[4klh\|4klh]], [[4kli\|4kli]], [[4klj\|4klj]], [[4klm\|4klm]], [[4klo\|4klo]], [[4klp\|4klp]], [[4klq\|4klq]], [[4kls\|4kls]], [[4klt\|4klt]], [[4klu\|4klu]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Polb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kll OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kll RCSB], [http://www.ebi.ac.uk/pdbsum/4kll PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	DNA polymerase (pol) beta is a model polymerase involved in gap-filling DNA synthesis utilizing two metals to facilitate nucleotidyl transfer. Previous structural studies have trapped catalytic intermediates by utilizing substrate analogs (dideoxy-terminated primer or nonhydrolysable incoming nucleotide). To identify additional intermediates during catalysis, we now employ natural substrates (correct and incorrect nucleotides) and follow product formation in real time with 15 different crystal structures. We are able to observe molecular adjustments at the active site that hasten correct nucleotide insertion and deter incorrect insertion not appreciated previously. A third metal binding site is transiently formed during correct, but not incorrect, nucleotide insertion. Additionally, long incubations indicate that pyrophosphate more easily dissociates after incorrect, compared to correct, nucleotide insertion. This appears to be coupled to subdomain repositioning that is required for catalytic activation/deactivation. The structures provide insights into a fundamental chemical reaction that impacts polymerase fidelity and genome stability.

-	~~==Function==~~	+	Observing a DNA polymerase choose right from wrong.,Freudenthal BD, Beard WA, Shock DD, Wilson SH Cell. 2013 Jul 3;154(1):157-68. doi: 10.1016/j.cell.2013.05.048. PMID:23827680<ref>PMID:23827680</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase~~ (~~dRP lyase~~) ~~activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single~~-~~nucleotide gap~~. ~~Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases~~.~~<ref>PMID:9207062<~~/~~ref> <ref>~~PMID:~~9572863</ref> <ref>PMID:11805079</ref>~~ <ref>PMID:~~21362556~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4kll]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4KLL OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023827680</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[DNA polymerase\|DNA polymerase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Beard, W A.]]	+	[[Category: Beard, W A]]
-	[[Category: Freudenthal, B D.]]	+	[[Category: Freudenthal, B D]]
-	[[Category: Shock, D D.]]	+	[[Category: Shock, D D]]
-	[[Category: Wilson, S H.]]	+	[[Category: Wilson, S H]]
	[[Category: Dna polymerase]]		[[Category: Dna polymerase]]
	[[Category: Lyase-dna complex]]		[[Category: Lyase-dna complex]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 04:58, 18 July 2013

2013-07-18T04:58:32Z

←Older revision		Revision as of 04:58, 18 July 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4kll\| PDB=4kll \| SCENE= }}
		+	===DNA polymerase beta matched product complex with Mg2+, 45 min===
		+	{{ABSTRACT_PUBMED_23827680}}

-	~~The entry 4kll is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>

-	~~Authors~~: ~~Freudenthal, B~~.D.~~, Beard, W~~.~~A., Shock, D~~.D.~~, Wilson, S~~.H.	+	==About this Structure==
		+	[[4kll]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLL OCA].

-	~~Description~~: ~~DNA~~ polymerase ~~beta matched product~~ complex ~~with Mg2+, 45 min~~	+	==Reference==
		+	<ref group="xtra">PMID:023827680</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Beard, W A.]]
		+	[[Category: Freudenthal, B D.]]
		+	[[Category: Shock, D D.]]
		+	[[Category: Wilson, S H.]]
		+	[[Category: Dna polymerase]]
		+	[[Category: Lyase-dna complex]]
		+	[[Category: Transferase]]

OCA at 11:43, 19 June 2013

2013-06-19T11:43:57Z

←Older revision		Revision as of 11:43, 19 June 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kll is ON HOLD	+	The entry 4kll is ON HOLD until Paper Publication

	Authors: Freudenthal, B.D., Beard, W.A., Shock, D.D., Wilson, S.H.		Authors: Freudenthal, B.D., Beard, W.A., Shock, D.D., Wilson, S.H.

	Description: DNA polymerase beta matched product complex with Mg2+, 45 min		Description: DNA polymerase beta matched product complex with Mg2+, 45 min

OCA: Protected "4kll" [edit=sysop:move=sysop]

2013-05-16T06:59:04Z

Protected "4kll" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:59, 16 May 2013

OCA: New page: '''Unreleased structure''' The entry 4kll is ON HOLD Authors: Freudenthal, B.D., Beard, W.A., Shock, D.D., Wilson, S.H. Description: DNA polymerase beta matched product complex with Mg...

2013-05-16T06:59:03Z

New page: '''Unreleased structure''' The entry 4kll is ON HOLD Authors: Freudenthal, B.D., Beard, W.A., Shock, D.D., Wilson, S.H. Description: DNA polymerase beta matched product complex with Mg...

New page

'''Unreleased structure'''

The entry 4kll is ON HOLD

Authors: Freudenthal, B.D., Beard, W.A., Shock, D.D., Wilson, S.H.

Description: DNA polymerase beta matched product complex with Mg2+, 45 min