4kq4 - Revision history

OCA at 16:03, 20 September 2023

2023-09-20T16:03:33Z

←Older revision		Revision as of 16:03, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kq4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KQ4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kq4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KQ4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kq4 OCA], [https://pdbe.org/4kq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kq4 RCSB], [https://www.ebi.ac.uk/pdbsum/4kq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kq4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kq4 OCA], [https://pdbe.org/4kq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kq4 RCSB], [https://www.ebi.ac.uk/pdbsum/4kq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kq4 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:06, 7 December 2022

2022-12-07T09:06:48Z

←Older revision		Revision as of 09:06, 7 December 2022
Line 3:		Line 3:
	<StructureSection load='4kq4' size='340' side='right'caption='[[4kq4]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='4kq4' size='340' side='right'caption='[[4kq4]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kq4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KQ4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kq4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KQ4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kq3\|4kq3]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kq4 OCA], [https://pdbe.org/4kq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kq4 RCSB], [https://www.ebi.ac.uk/pdbsum/4kq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kq4 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kq4 OCA], [~~http~~://pdbe.org/4kq4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kq4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kq4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kq4 ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Gilliland~~, G L~~]]	+	[[Category: Gilliland GL]]
-	[[Category: Malia, T]]	+	[[Category: Malia T]]
-	[[Category: Obmolova, G]]	+	[[Category: Obmolova G]]
-	[[Category: Teplyakov, A]]	+	[[Category: Teplyakov A]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin fold~~]]	+

OCA at 09:02, 3 April 2019

2019-04-03T09:02:21Z

←Older revision		Revision as of 09:02, 3 April 2019
Line 1:		Line 1:

	==Crystal structure of Anti-IL-17A antibody CNTO7357==		==Crystal structure of Anti-IL-17A antibody CNTO7357==
-	<StructureSection load='4kq4' size='340' side='right' caption='[[4kq4]], [[Resolution\|resolution]] 2.45Å' scene=''>	+	<StructureSection load='4kq4' size='340' side='right'caption='[[4kq4]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kq4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KQ4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kq4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KQ4 FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Gilliland, G L]]		[[Category: Gilliland, G L]]

OCA at 11:47, 11 August 2016

2016-08-11T11:47:35Z

←Older revision		Revision as of 11:47, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Anti-IL-17A antibody CNTO7357==		==Crystal structure of Anti-IL-17A antibody CNTO7357==
	<StructureSection load='4kq4' size='340' side='right' caption='[[4kq4]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='4kq4' size='340' side='right' caption='[[4kq4]], [[Resolution\|resolution]] 2.45Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kq3\|4kq3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kq3\|4kq3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kq4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kq4 RCSB], [http://www.ebi.ac.uk/pdbsum/4kq4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kq4 OCA], [http://pdbe.org/4kq4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kq4 RCSB], [http://www.ebi.ac.uk/pdbsum/4kq4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kq4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kq4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:32, 5 January 2015

2015-01-05T14:32:07Z

←Older revision		Revision as of 14:32, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kq4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KQ4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kq4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KQ4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kq3\|4kq3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kq3\|4kq3]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kq4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kq4 RCSB], [http://www.ebi.ac.uk/pdbsum/4kq4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kq4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kq4 RCSB], [http://www.ebi.ac.uk/pdbsum/4kq4 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
-	[[Category: Gilliland, G L.]]	+	[[Category: Gilliland, G L]]
-	[[Category: Malia, T.]]	+	[[Category: Malia, T]]
-	[[Category: Obmolova, G.]]	+	[[Category: Obmolova, G]]
-	[[Category: Teplyakov, A.]]	+	[[Category: Teplyakov, A]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin fold]]		[[Category: Immunoglobulin fold]]

OCA at 02:55, 7 August 2014

2014-08-07T02:55:51Z

←Older revision		Revision as of 02:55, 7 August 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4kq4\| PDB=4kq4 \| SCENE= }}~~	+	==Crystal structure of Anti-IL-17A antibody CNTO7357==
-	===Crystal structure of Anti-IL-17A antibody CNTO7357===	+	<StructureSection load='4kq4' size='340' side='right' caption='[[4kq4]], [[Resolution\|resolution]] 2.45Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24633955}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4kq4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KQ4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kq3\|4kq3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kq4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kq4 RCSB], [http://www.ebi.ac.uk/pdbsum/4kq4 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To assess the state-of-the-art in antibody structure modeling, a blinded study was conducted. Eleven unpublished Fab crystal structures were used as a benchmark to compare Fv models generated by seven structure prediction methodologies. In the first round, each participant submitted three non-ranked complete Fv models for each target. In the second round, CDR-H3 modeling was performed in the context of the correct environment provided by the crystal structures with CDR-H3 removed. In this report we describe the reference structures and present our assessment of the models. Some of the essential sources of errors in the predictions were traced to the selection of the structure template, both in terms of the CDR canonical structures and VL/VH packing. On top of this, the errors present in the Protein Data Bank structures were sometimes propagated in the current models, which emphasized the need for the curated structural database devoid of errors. Modeling non-canonical structures, including CDR-H3, remains the biggest challenge for antibody structure prediction. Proteins 2014. (c) 2014 Wiley Periodicals, Inc.

-	~~==About this Structure==~~	+	Antibody modeling assessment II. Structures and models.,Teplyakov A, Luo J, Obmolova G, Malia TJ, Sweet R, Stanfield RL, Kodangattil S, Almagro JC, Gilliland GL Proteins. 2014 Mar 14. doi: 10.1002/prot.24554. PMID:24633955<ref>PMID:24633955</ref>
-	~~[[4kq4]] is a 2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4KQ4 OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024633955</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Gilliland, G L.]]		[[Category: Gilliland, G L.]]
	[[Category: Malia, T.]]		[[Category: Malia, T.]]

OCA at 07:28, 2 April 2014

2014-04-02T07:28:45Z

←Older revision		Revision as of 07:28, 2 April 2014
Line 1:		Line 1:
	{{STRUCTURE_4kq4\| PDB=4kq4 \| SCENE= }}		{{STRUCTURE_4kq4\| PDB=4kq4 \| SCENE= }}
	===Crystal structure of Anti-IL-17A antibody CNTO7357===		===Crystal structure of Anti-IL-17A antibody CNTO7357===
		+	{{ABSTRACT_PUBMED_24633955}}

	==About this Structure==		==About this Structure==
	[[4kq4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ4 OCA].		[[4kq4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ4 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024633955</ref><references group="xtra"/><references/>
	[[Category: Gilliland, G L.]]		[[Category: Gilliland, G L.]]
	[[Category: Malia, T.]]		[[Category: Malia, T.]]

OCA at 09:33, 26 March 2014

2014-03-26T09:33:42Z

←Older revision		Revision as of 09:33, 26 March 2014
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4kq4\| PDB=4kq4 \| SCENE= }}
		+	===Crystal structure of Anti-IL-17A antibody CNTO7357===

-	~~The entry~~ 4kq4 is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4kq4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ4 OCA].
-	~~Authors~~: ~~Teplyakov, A., Obmolova~~, G., Malia, T.~~, Gilliland~~, G.L.	+	[[Category: Gilliland, G L.]]
-		+	[[Category: Malia, T.]]
-	~~Description~~: ~~Crystal structure of Anti-IL-17A antibody CNTO7357~~	+	[[Category: Obmolova, G.]]
		+	[[Category: Teplyakov, A.]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin fold]]

OCA at 06:48, 6 November 2013

2013-11-06T06:48:11Z

←Older revision		Revision as of 06:48, 6 November 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kq4 is ON HOLD	+	The entry 4kq4 is ON HOLD until Paper Publication

	Authors: Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.		Authors: Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.

	Description: Crystal structure of Anti-IL-17A antibody CNTO7357		Description: Crystal structure of Anti-IL-17A antibody CNTO7357

OCA: Protected "4kq4" [edit=sysop:move=sysop]

2013-06-19T11:53:49Z

Protected "4kq4" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:53, 19 June 2013