4krh - Revision history

OCA at 09:09, 7 December 2022

2022-12-07T09:09:38Z

←Older revision		Revision as of 09:09, 7 December 2022
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	<StructureSection load='4krh' size='340' side='right'caption='[[4krh]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4krh' size='340' side='right'caption='[[4krh]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4krh]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Barber_pole_worm Barber pole worm~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KRH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4krh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemonchus_contortus Haemonchus contortus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KRH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
-	~~<tr~~ id~~='NonStdRes'><td class~~="~~sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat~~"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene><~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4krh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4krh OCA], [https://pdbe.org/4krh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4krh RCSB], [https://www.ebi.ac.uk/pdbsum/4krh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4krh ProSAT]</span></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td>~~<td class="sblockDat">[[4krg\|4krg]], [[4kri\|4kri]]~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4krh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4krh OCA], [~~http~~://pdbe.org/4krh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4krh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4krh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4krh ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/U5HK48_HAECO U5HK48_HAECO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Barber pole worm~~]]	+	[[Category: Haemonchus contortus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jez~~, J M~~]]	+	[[Category: Jez JM]]
-	[[Category: Lee~~, S G]]~~	+	[[Category: Lee SG]]
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:34, 3 April 2019

2019-04-03T08:34:24Z

←Older revision		Revision as of 08:34, 3 April 2019
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	==SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 2 in complex with S-adenosyl-L-methionine==		==SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 2 in complex with S-adenosyl-L-methionine==
-	<StructureSection load='4krh' size='340' side='right' caption='[[4krh]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4krh' size='340' side='right'caption='[[4krh]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4krh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Barber_pole_worm Barber pole worm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KRH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4krh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Barber_pole_worm Barber pole worm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KRH FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Barber pole worm]]		[[Category: Barber pole worm]]
		+	[[Category: Large Structures]]
	[[Category: Jez, J M]]		[[Category: Jez, J M]]
	[[Category: Lee, S G]]		[[Category: Lee, S G]]
	[[Category: Methyltransferase]]		[[Category: Methyltransferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 22:38, 4 August 2016

2016-08-04T22:38:57Z

←Older revision		Revision as of 22:38, 4 August 2016
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		+
	==SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 2 in complex with S-adenosyl-L-methionine==		==SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 2 in complex with S-adenosyl-L-methionine==
	<StructureSection load='4krh' size='340' side='right' caption='[[4krh]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4krh' size='340' side='right' caption='[[4krh]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4krh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Haemonchus_contortus Haemonchus contortus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KRH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4krh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Barber_pole_worm Barber pole worm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KRH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4krg\|4krg]], [[4kri\|4kri]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4krg\|4krg]], [[4kri\|4kri]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4krh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4krh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4krh RCSB], [http://www.ebi.ac.uk/pdbsum/4krh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4krh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4krh OCA], [http://pdbe.org/4krh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4krh RCSB], [http://www.ebi.ac.uk/pdbsum/4krh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4krh ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4krh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Haemonchus contortus~~]]	+	[[Category: Barber pole worm]]
	[[Category: Jez, J M]]		[[Category: Jez, J M]]
	[[Category: Lee, S G]]		[[Category: Lee, S G]]
	[[Category: Methyltransferase]]		[[Category: Methyltransferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 15:07, 21 December 2014

2014-12-21T15:07:08Z

←Older revision		Revision as of 15:07, 21 December 2014
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-	~~{{STRUCTURE_4krh\| PDB=4krh \| SCENE= }}~~	+	==SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 2 in complex with S-adenosyl-L-methionine==
-	===SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 2 in complex with S-adenosyl-L-methionine===	+	<StructureSection load='4krh' size='340' side='right' caption='[[4krh]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24012478}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4krh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemonchus_contortus Haemonchus contortus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KRH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4krg\|4krg]], [[4kri\|4kri]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4krh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4krh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4krh RCSB], [http://www.ebi.ac.uk/pdbsum/4krh PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The phosphobase methylation pathway is the major route for supplying phosphocholine to phospholipid biosynthesis in plants, nematodes, and Plasmodium. In this pathway, phosphoethanolamine N-methyltransferase (PMT) catalyzes the sequential methylation of phosphoethanolamine to phosphocholine. In the PMT, one domain (MT1) catalyzes methylation of phosphoethanolamine to phosphomonomethylethanolamine and a second domain (MT2) completes the synthesis of phosphocholine. The X-ray crystal structures of the di-domain PMT from the parasitic nematode Haemonchus contortus (HcPMT1 and HcPMT2) reveal that the catalytic domains of these proteins are structurally distinct and allow for selective methylation of phosphobase substrates using different active site architectures. These structures also reveal changes leading to loss of function in the vestigial domains of the nematode PMT. Divergence of function in the two nematode PMTs provides two distinct antiparasitic inhibitor targets within the same essential metabolic pathway. The PMTs from nematodes, plants, and Plasmodium also highlight adaptable metabolic modularity in evolutionarily diverse organisms.

-	~~==About this~~ Structure==	+	Evolution of Structure and Mechanistic Divergence in Di-Domain Methyltransferases from Nematode Phosphocholine Biosynthesis.,Lee SG, Jez JM Structure. 2013 Sep 4. pii: S0969-2126(13)00291-8. doi:, 10.1016/j.str.2013.07.023. PMID:24012478<ref>PMID:24012478</ref>
-	~~[[4krh]] is a 2 chain structure with sequence~~ from ~~[http://en~~.~~wikipedia~~.~~org/wiki/Haemonchus_contortus Haemonchus contortus]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=4KRH OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024012478</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Haemonchus contortus]]		[[Category: Haemonchus contortus]]
-	[[Category: Jez, J M.]]	+	[[Category: Jez, J M]]
-	[[Category: Lee, S G.]]	+	[[Category: Lee, S G]]
	[[Category: Methyltransferase]]		[[Category: Methyltransferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:09, 29 September 2013

2013-09-29T08:09:41Z

←Older revision		Revision as of 08:09, 29 September 2013
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-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4krh\| PDB=4krh \| SCENE= }}
		+	===SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 2 in complex with S-adenosyl-L-methionine===
		+	{{ABSTRACT_PUBMED_24012478}}

-	~~The entry~~ 4krh is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4krh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemonchus_contortus Haemonchus contortus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRH OCA].

-	~~Authors~~: ~~Lee, S.G.,~~ Jez, J.M.	+	==Reference==
-		+	<ref group="xtra">PMID:024012478</ref><references group="xtra"/><references/>
-	~~Description~~: ~~SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 2 in complex with~~ S~~-adenosyl-L-methionine~~	+	[[Category: Haemonchus contortus]]
		+	[[Category: Jez, J M.]]
		+	[[Category: Lee, S G.]]
		+	[[Category: Methyltransferase]]
		+	[[Category: Transferase]]

OCA: Protected "4krh" [edit=sysop:move=sysop]

2013-06-19T11:57:00Z

Protected "4krh" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:57, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 4krh is ON HOLD until Paper Publication Authors: Lee, S.G., Jez, J.M. Description: SeMet Haemonchus contortus Phosphoethanolamine N-methyltransfera...

2013-06-19T11:56:58Z

New page: '''Unreleased structure''' The entry 4krh is ON HOLD until Paper Publication Authors: Lee, S.G., Jez, J.M. Description: SeMet Haemonchus contortus Phosphoethanolamine N-methyltransfera...

New page

'''Unreleased structure'''

The entry 4krh is ON HOLD until Paper Publication

Authors: Lee, S.G., Jez, J.M.

Description: SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 2 in complex with S-adenosyl-L-methionine