4ksh - Revision history

OCA at 12:15, 1 March 2024

2024-03-01T12:15:10Z

←Older revision		Revision as of 12:15, 1 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ksh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KSH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ksh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KSH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HTT:7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1,5-NAPHTHYRIDIN-1(4H)-OL'>HTT</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HTT:7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1,5-NAPHTHYRIDIN-1(4H)-OL'>HTT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ksh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksh OCA], [https://pdbe.org/4ksh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ksh RCSB], [https://www.ebi.ac.uk/pdbsum/4ksh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ksh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ksh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksh OCA], [https://pdbe.org/4ksh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ksh RCSB], [https://www.ebi.ac.uk/pdbsum/4ksh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ksh ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:11, 7 December 2022

2022-12-07T09:11:15Z

←Older revision		Revision as of 09:11, 7 December 2022
Line 1:		Line 1:

	==Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1,5-NAPHTHYRIDIN-1(4H)-OL)==		==Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1,5-NAPHTHYRIDIN-1(4H)-OL)==
-	<StructureSection load='4ksh' size='340' side='right' caption='[[4ksh]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4ksh' size='340' side='right'caption='[[4ksh]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ksh]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Entfa Entfa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KSH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ksh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KSH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HTT:7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1,5-NAPHTHYRIDIN-1(4H)-OL'>HTT</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HTT:7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1,5-NAPHTHYRIDIN-1(4H)-OL'>HTT</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gee\|4gee]], [[4ktn\|4ktn]], [[4ksg\|4ksg]], [[4k4o\|4k4o]], [[4kfg\|4kfg]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ksh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksh OCA], [https://pdbe.org/4ksh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ksh RCSB], [https://www.ebi.ac.uk/pdbsum/4ksh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ksh ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EF_0005, gyrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226185 ENTFA])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ksh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksh OCA], [~~http~~://pdbe.org/4ksh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ksh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ksh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ksh ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/Q839Z1_ENTFA Q839Z1_ENTFA]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).[HAMAP-Rule:MF_01898]	+	[https://www.uniprot.org/uniprot/GYRB_ENTFA GYRB_ENTFA]

	==See Also==		==See Also==
-	*[[Gyrase\|Gyrase]]	+	*[[Gyrase 3D Structures\|Gyrase 3D Structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Entfa~~]]	+	[[Category: Enterococcus faecalis V583]]
-	[[Category: ~~Akers-Rodriguez, S~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Bensen, D C]]~~	+	[[Category: Akers-Rodriguez S]]
-	~~[[Category: Tari, L W]]~~	+	[[Category: Bensen DC]]
-	~~[[Category: Atp~~-~~binding~~]]	+	[[Category: Tari LW]]
-	[[Category: ~~Atp-binding domain~~]]	+
-	[[Category: ~~Dna gyrase negatively supercoils closed circular double-stranded dna in an atp-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded dna ring]]~~	+
-	~~[[Category: Isomerase-isomerase inhibitor complex]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Topoisomerase~~]]	+

OCA at 05:26, 5 August 2016

2016-08-05T05:26:52Z

←Older revision		Revision as of 05:26, 5 August 2016
Line 1:		Line 1:
		+
	==Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1,5-NAPHTHYRIDIN-1(4H)-OL)==		==Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1,5-NAPHTHYRIDIN-1(4H)-OL)==
	<StructureSection load='4ksh' size='340' side='right' caption='[[4ksh]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4ksh' size='340' side='right' caption='[[4ksh]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EF_0005, gyrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226185 ENTFA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EF_0005, gyrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226185 ENTFA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ksh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ksh RCSB], [http://www.ebi.ac.uk/pdbsum/4ksh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ksh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksh OCA], [http://pdbe.org/4ksh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ksh RCSB], [http://www.ebi.ac.uk/pdbsum/4ksh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ksh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 23:23, 24 December 2014

2014-12-24T23:23:25Z

←Older revision		Revision as of 23:23, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ksh\| PDB=4ksh \| SCENE= }}~~	+	==Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1,5-NAPHTHYRIDIN-1(4H)-OL)==
-	===Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1,5-NAPHTHYRIDIN-1(4H)-OL)===	+	<StructureSection load='4ksh' size='340' side='right' caption='[[4ksh]], [[Resolution\|resolution]] 1.70Å' scene=''>
-		+	== Structural highlights ==
-	==Function==	+	<table><tr><td colspan='2'>[[4ksh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Entfa Entfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KSH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HTT:7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1,5-NAPHTHYRIDIN-1(4H)-OL'>HTT</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gee\|4gee]], [[4ktn\|4ktn]], [[4ksg\|4ksg]], [[4k4o\|4k4o]], [[4kfg\|4kfg]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EF_0005, gyrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226185 ENTFA])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ksh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ksh RCSB], [http://www.ebi.ac.uk/pdbsum/4ksh PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/Q839Z1_ENTFA Q839Z1_ENTFA]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).[HAMAP-Rule:MF_01898]		[[http://www.uniprot.org/uniprot/Q839Z1_ENTFA Q839Z1_ENTFA]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).[HAMAP-Rule:MF_01898]

-	==~~About this Structure~~==	+	==See Also==
-	[[~~4ksh~~]] ~~is a 1 chain structure. Full crystallographic information is available from~~ [~~http~~:~~//oca.weizmann.ac.il/oca-bin/ocashort?id=4KSH OCA~~].	+	*[[Gyrase\|Gyrase]]
-	[[Category: Akers-Rodriguez, S.]]	+	__TOC__
-	[[Category: Bensen, D C.]]	+	</StructureSection>
-	[[Category: Tari, L W.]]	+	[[Category: Entfa]]
		+	[[Category: Akers-Rodriguez, S]]
		+	[[Category: Bensen, D C]]
		+	[[Category: Tari, L W]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Atp-binding domain]]		[[Category: Atp-binding domain]]

OCA at 08:23, 15 January 2014

2014-01-15T08:23:50Z

←Older revision		Revision as of 08:23, 15 January 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4ksh\| PDB=4ksh \| SCENE= }}
		+	===Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1,5-NAPHTHYRIDIN-1(4H)-OL)===

-	~~The entry 4ksh is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/Q839Z1_ENTFA Q839Z1_ENTFA]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).[HAMAP-Rule:MF_01898]

-	~~Authors~~: ~~Bensen, D~~.C., Akers-Rodriguez, S., Tari, L.W.	+	==About this Structure==
-		+	[[4ksh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSH OCA].
-	~~Description~~: Dna gyrase atp ~~binding domain~~ of ~~enterococcus faecalis in complex with a small molecule~~ inhibitor	+	[[Category: Akers-Rodriguez, S.]]
		+	[[Category: Bensen, D C.]]
		+	[[Category: Tari, L W.]]
		+	[[Category: Atp-binding]]
		+	[[Category: Atp-binding domain]]
		+	[[Category: Dna gyrase negatively supercoils closed circular double-stranded dna in an atp-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded dna ring]]
		+	[[Category: Isomerase-isomerase inhibitor complex]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Topoisomerase]]

OCA: Protected "4ksh" [edit=sysop:move=sysop]

2013-06-19T11:59:13Z

Protected "4ksh" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:59, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 4ksh is ON HOLD until Paper Publication Authors: Bensen, D.C., Akers-Rodriguez, S., Tari, L.W. Description: Dna gyrase atp binding domain of entero...

2013-06-19T11:59:11Z

New page: '''Unreleased structure''' The entry 4ksh is ON HOLD until Paper Publication Authors: Bensen, D.C., Akers-Rodriguez, S., Tari, L.W. Description: Dna gyrase atp binding domain of entero...

New page

'''Unreleased structure'''

The entry 4ksh is ON HOLD until Paper Publication

Authors: Bensen, D.C., Akers-Rodriguez, S., Tari, L.W.

Description: Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor