4kx8 - Revision history

OCA at 09:19, 15 November 2023

2023-11-15T09:19:08Z

←Older revision		Revision as of 09:19, 15 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kx8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptomyces_sp. Streptomyces sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KX8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kx8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptomyces_sp. Streptomyces sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KX8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L2O:(2S,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC+ACID'>L2O</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900017:triacetyl-beta-chitotriose'>PRD_900017</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L2O:(2S,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC+ACID'>L2O</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900017:triacetyl-beta-chitotriose'>PRD_900017</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kx8 OCA], [https://pdbe.org/4kx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kx8 RCSB], [https://www.ebi.ac.uk/pdbsum/4kx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kx8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kx8 OCA], [https://pdbe.org/4kx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kx8 RCSB], [https://www.ebi.ac.uk/pdbsum/4kx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kx8 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:19, 7 December 2022

2022-12-07T09:19:51Z

←Older revision		Revision as of 09:19, 7 December 2022
Line 1:		Line 1:

	==Crystal structure of human aminopeptidase A complexed with amastatin==		==Crystal structure of human aminopeptidase A complexed with amastatin==
-	<StructureSection load='4kx8' size='340' side='right' caption='[[4kx8]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='4kx8' size='340' side='right'caption='[[4kx8]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kx8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KX8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KX8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kx8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptomyces_sp. Streptomyces sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KX8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L2O:(2S,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC+ACID'>L2O</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900017:triacetyl-beta-chitotriose'>PRD_900017</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr~~ id~~='NonStdRes'><td class~~="~~sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat~~"><scene name='pdbligand=L2O:(2S,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC+ACID'>L2O</scene><~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kx8 OCA], [https://pdbe.org/4kx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kx8 RCSB], [https://www.ebi.ac.uk/pdbsum/4kx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kx8 ProSAT]</span></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td>~~<td class="sblockDat">[[4kx7\|4kx7]]~~, ~~[[4kx9\|4kx9]], [[4kxa\|4kxa]], [[4kxb\|4kxb]], [[4kxc\|4kxc]], [[4kxd\|4kxd]]~~<~~/td></tr>~~	+
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><~~td class="sblockDat">ENPEP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Glutamyl_aminopeptidase Glutamyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.7 3.4.11.7]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kx8 OCA], [~~http~~://pdbe.org/4kx8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kx8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kx8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kx8 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/AMPE_HUMAN AMPE_HUMAN]] Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.	+	[https://www.uniprot.org/uniprot/AMPE_HUMAN AMPE_HUMAN] Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 20:

	==See Also==		==See Also==
-	*[[Aminopeptidase\|Aminopeptidase]]	+	*[[Aminopeptidase 3D structures\|Aminopeptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Glutamyl aminopeptidase~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Li, F]]	+	[[Category: Streptomyces sp]]
-	[[Category: Lin~~, Y Y~~]]	+	[[Category: Li F]]
-	[[Category: Liu, C]]	+	[[Category: Lin YY]]
-	[[Category: Yang, Y]]	+	[[Category: Liu C]]
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+	[[Category: Yang Y]]
-	~~[[Category: Zinc-aminopeptidase~~]]	+

OCA at 11:31, 5 August 2016

2016-08-05T11:31:11Z

←Older revision		Revision as of 11:31, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human aminopeptidase A complexed with amastatin==		==Crystal structure of human aminopeptidase A complexed with amastatin==
	<StructureSection load='4kx8' size='340' side='right' caption='[[4kx8]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4kx8' size='340' side='right' caption='[[4kx8]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kx8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KX8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KX8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kx8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KX8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KX8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=L2O:(2S,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC+ACID'>L2O</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=L2O:(2S,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC+ACID'>L2O</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kx7\|4kx7]], [[4kx9\|4kx9]], [[4kxa\|4kxa]], [[4kxb\|4kxb]], [[4kxc\|4kxc]], [[4kxd\|4kxd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kx7\|4kx7]], [[4kx9\|4kx9]], [[4kxa\|4kxa]], [[4kxb\|4kxb]], [[4kxc\|4kxc]], [[4kxd\|4kxd]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ENPEP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ENPEP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_aminopeptidase Glutamyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.7 3.4.11.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_aminopeptidase Glutamyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.7 3.4.11.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kx8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kx8 RCSB], [http://www.ebi.ac.uk/pdbsum/4kx8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kx8 OCA], [http://pdbe.org/4kx8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kx8 RCSB], [http://www.ebi.ac.uk/pdbsum/4kx8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kx8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kx8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Glutamyl aminopeptidase]]		[[Category: Glutamyl aminopeptidase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Li, F]]		[[Category: Li, F]]
	[[Category: Lin, Y Y]]		[[Category: Lin, Y Y]]

OCA at 02:02, 25 December 2014

2014-12-25T02:02:49Z

←Older revision		Revision as of 02:02, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4kx8\| PDB=4kx8 \| SCENE= }}~~	+	==Crystal structure of human aminopeptidase A complexed with amastatin==
-	===Crystal structure of human aminopeptidase A complexed with amastatin===	+	<StructureSection load='4kx8' size='340' side='right' caption='[[4kx8]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23888046}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4kx8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KX8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KX8 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=L2O:(2S,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC+ACID'>L2O</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kx7\|4kx7]], [[4kx9\|4kx9]], [[4kxa\|4kxa]], [[4kxb\|4kxb]], [[4kxc\|4kxc]], [[4kxd\|4kxd]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ENPEP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_aminopeptidase Glutamyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.7 3.4.11.7] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kx8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kx8 RCSB], [http://www.ebi.ac.uk/pdbsum/4kx8 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/AMPE_HUMAN AMPE_HUMAN]] Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.		[[http://www.uniprot.org/uniprot/AMPE_HUMAN AMPE_HUMAN]] Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hypertension is regulated through both the central and systemic renin-angiotensin systems. In the central renin-angiotensin system, zinc-dependent aminopeptidase A (APA) up-regulates blood pressure by specifically cleaving the N-terminal aspartate, but not the adjacent arginine, from angiotensin II, a process facilitated by calcium. Here, we determined the crystal structures of human APA and its complexes with different ligands and identified a calcium-binding site in the S1 pocket of APA. Without calcium, the S1 pocket can bind both acidic and basic residues through formation of salt bridges with the charged side chains. In the presence of calcium, the binding of acidic residues is enhanced as they ligate the cation, whereas the binding of basic residues is no longer favorable due to charge repulsion. Of the peptidomimetic inhibitors of APA, amastatin has higher potency than bestatin by fitting better in the S1 pocket and interacting additionally with the S3' subsite. These results explain the calcium-modulated substrate specificity of APA in central hypertension regulation and can guide the design and development of brain-targeting antihypertensive APA inhibitors.

-	~~==About this Structure==~~	+	Structural insights into central hypertension regulation by human aminopeptidase a.,Yang Y, Liu C, Lin YL, Li F J Biol Chem. 2013 Aug 30;288(35):25638-45. doi: 10.1074/jbc.M113.494955. Epub, 2013 Jul 25. PMID:23888046<ref>PMID:23888046</ref>
-	~~[[4kx8]] is~~ a ~~2 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4KX8 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Aminopeptidase\|Aminopeptidase]]		*[[Aminopeptidase\|Aminopeptidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023888046</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Glutamyl aminopeptidase]]		[[Category: Glutamyl aminopeptidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Li, F.]]	+	[[Category: Li, F]]
-	[[Category: Lin, Y Y.]]	+	[[Category: Lin, Y Y]]
-	[[Category: Liu, C.]]	+	[[Category: Liu, C]]
-	[[Category: Yang, Y.]]	+	[[Category: Yang, Y]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Zinc-aminopeptidase]]		[[Category: Zinc-aminopeptidase]]

OCA at 09:02, 4 September 2013

2013-09-04T09:02:22Z

←Older revision		Revision as of 09:02, 4 September 2013
Line 1:		Line 1:
	{{STRUCTURE_4kx8\| PDB=4kx8 \| SCENE= }}		{{STRUCTURE_4kx8\| PDB=4kx8 \| SCENE= }}
	===Crystal structure of human aminopeptidase A complexed with amastatin===		===Crystal structure of human aminopeptidase A complexed with amastatin===
		+	{{ABSTRACT_PUBMED_23888046}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[4kx8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KX8 OCA].		[[4kx8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KX8 OCA].
		+
		+	==See Also==
		+	*[[Aminopeptidase\|Aminopeptidase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023888046</ref><references group="xtra"/><references/>
	[[Category: Glutamyl aminopeptidase]]		[[Category: Glutamyl aminopeptidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 19:19, 7 August 2013

2013-08-07T19:19:54Z

←Older revision		Revision as of 19:19, 7 August 2013
Line 13:		Line 13:
	[[Category: Liu, C.]]		[[Category: Liu, C.]]
	[[Category: Yang, Y.]]		[[Category: Yang, Y.]]
-	[[Category: Hydrolase-inhibitor complex]]	+	[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Zinc-aminopeptidase]]		[[Category: Zinc-aminopeptidase]]

OCA at 05:23, 1 August 2013

2013-08-01T05:23:58Z

←Older revision		Revision as of 05:23, 1 August 2013
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-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4kx8\| PDB=4kx8 \| SCENE= }}
		+	===Crystal structure of human aminopeptidase A complexed with amastatin===

-	~~The entry 4kx8 is ON HOLD until sometime~~ in the ~~future~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/AMPE_HUMAN AMPE_HUMAN]] Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.

-	~~Authors~~: ~~Yang, Y~~.~~, Liu, C~~., Lin, Y.Y., Li, F.	+	==About this Structure==
-		+	[[4kx8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KX8 OCA].
-	~~Description~~: ~~Crystal structure of human~~ aminopeptidase ~~A complexed with amastatin~~	+	[[Category: Glutamyl aminopeptidase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Li, F.]]
		+	[[Category: Lin, Y Y.]]
		+	[[Category: Liu, C.]]
		+	[[Category: Yang, Y.]]
		+	[[Category: Hydrolase-inhibitor complex]]
		+	[[Category: Zinc-aminopeptidase]]

OCA: Protected "4kx8" [edit=sysop:move=sysop]

2013-06-19T12:10:30Z

Protected "4kx8" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:10, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 4kx8 is ON HOLD until sometime in the future Authors: Yang, Y., Liu, C., Lin, Y.Y., Li, F. Description: Crystal structure of human aminopeptidase A...

2013-06-19T12:10:29Z

New page: '''Unreleased structure''' The entry 4kx8 is ON HOLD until sometime in the future Authors: Yang, Y., Liu, C., Lin, Y.Y., Li, F. Description: Crystal structure of human aminopeptidase A...

New page

'''Unreleased structure'''

The entry 4kx8 is ON HOLD until sometime in the future

Authors: Yang, Y., Liu, C., Lin, Y.Y., Li, F.

Description: Crystal structure of human aminopeptidase A complexed with amastatin