4kxa - Revision history

OCA at 09:19, 7 December 2022

2022-12-07T09:19:57Z

←Older revision		Revision as of 09:19, 7 December 2022
Line 1:		Line 1:

	==Crystal structure of human aminopeptidase A complexed with aspartate and calcium==		==Crystal structure of human aminopeptidase A complexed with aspartate and calcium==
-	<StructureSection load='4kxa' size='340' side='right' caption='[[4kxa]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='4kxa' size='340' side='right'caption='[[4kxa]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kxa]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KXA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kxa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KXA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:~~ZINC+ION~~'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900017:triacetyl-beta-chitotriose'>PRD_900017</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kx7\|4kx7]]~~, ~~[[4kx8\|4kx8]], [[4kx9\|4kx9]], [[4kxb\|4kxb]], [[4kxc\|4kxc]], [[4kxd\|4kxd]]~~<~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxa OCA], [https://pdbe.org/4kxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kxa RCSB], [https://www.ebi.ac.uk/pdbsum/4kxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kxa ProSAT]</span></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b></td><td class="sblockDat">ENPEP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	~~<tr id='activity~~'>~~<td class="sblockLbl"><b>Activity:~~</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_aminopeptidase Glutamyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.7 3.4.11.7] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxa OCA], [~~http~~://pdbe.org/4kxa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kxa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kxa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kxa ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/AMPE_HUMAN AMPE_HUMAN]] Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.	+	[https://www.uniprot.org/uniprot/AMPE_HUMAN AMPE_HUMAN] Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Aminopeptidase\|Aminopeptidase]]	+	*[[Aminopeptidase 3D structures\|Aminopeptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Glutamyl aminopeptidase~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Li, F]]	+	[[Category: Li F]]
-	[[Category: Lin~~, Y Y~~]]	+	[[Category: Lin YY]]
-	[[Category: Liu, C]]	+	[[Category: Liu C]]
-	[[Category: Yang, Y]]	+	[[Category: Yang Y]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Zinc-aminopeptidase~~]]	+

OCA at 19:05, 5 August 2016

2016-08-05T19:05:56Z

←Older revision		Revision as of 19:05, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human aminopeptidase A complexed with aspartate and calcium==		==Crystal structure of human aminopeptidase A complexed with aspartate and calcium==
	<StructureSection load='4kxa' size='340' side='right' caption='[[4kxa]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4kxa' size='340' side='right' caption='[[4kxa]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kxa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KXA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kxa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KXA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kx7\|4kx7]], [[4kx8\|4kx8]], [[4kx9\|4kx9]], [[4kxb\|4kxb]], [[4kxc\|4kxc]], [[4kxd\|4kxd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kx7\|4kx7]], [[4kx8\|4kx8]], [[4kx9\|4kx9]], [[4kxb\|4kxb]], [[4kxc\|4kxc]], [[4kxd\|4kxd]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ENPEP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ENPEP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_aminopeptidase Glutamyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.7 3.4.11.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_aminopeptidase Glutamyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.7 3.4.11.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kxa RCSB], [http://www.ebi.ac.uk/pdbsum/4kxa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxa OCA], [http://pdbe.org/4kxa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kxa RCSB], [http://www.ebi.ac.uk/pdbsum/4kxa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kxa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kxa" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Glutamyl aminopeptidase]]		[[Category: Glutamyl aminopeptidase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Li, F]]		[[Category: Li, F]]
	[[Category: Lin, Y Y]]		[[Category: Lin, Y Y]]

OCA at 21:11, 25 December 2014

2014-12-25T21:11:48Z

←Older revision		Revision as of 21:11, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4kxa\| PDB=4kxa \| SCENE= }}~~	+	==Crystal structure of human aminopeptidase A complexed with aspartate and calcium==
-	===Crystal structure of human aminopeptidase A complexed with aspartate and calcium===	+	<StructureSection load='4kxa' size='340' side='right' caption='[[4kxa]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23888046}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4kxa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KXA FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kx7\|4kx7]], [[4kx8\|4kx8]], [[4kx9\|4kx9]], [[4kxb\|4kxb]], [[4kxc\|4kxc]], [[4kxd\|4kxd]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ENPEP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_aminopeptidase Glutamyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.7 3.4.11.7] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kxa RCSB], [http://www.ebi.ac.uk/pdbsum/4kxa PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/AMPE_HUMAN AMPE_HUMAN]] Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.		[[http://www.uniprot.org/uniprot/AMPE_HUMAN AMPE_HUMAN]] Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hypertension is regulated through both the central and systemic renin-angiotensin systems. In the central renin-angiotensin system, zinc-dependent aminopeptidase A (APA) up-regulates blood pressure by specifically cleaving the N-terminal aspartate, but not the adjacent arginine, from angiotensin II, a process facilitated by calcium. Here, we determined the crystal structures of human APA and its complexes with different ligands and identified a calcium-binding site in the S1 pocket of APA. Without calcium, the S1 pocket can bind both acidic and basic residues through formation of salt bridges with the charged side chains. In the presence of calcium, the binding of acidic residues is enhanced as they ligate the cation, whereas the binding of basic residues is no longer favorable due to charge repulsion. Of the peptidomimetic inhibitors of APA, amastatin has higher potency than bestatin by fitting better in the S1 pocket and interacting additionally with the S3' subsite. These results explain the calcium-modulated substrate specificity of APA in central hypertension regulation and can guide the design and development of brain-targeting antihypertensive APA inhibitors.

-	~~==About this Structure==~~	+	Structural insights into central hypertension regulation by human aminopeptidase a.,Yang Y, Liu C, Lin YL, Li F J Biol Chem. 2013 Aug 30;288(35):25638-45. doi: 10.1074/jbc.M113.494955. Epub, 2013 Jul 25. PMID:23888046<ref>PMID:23888046</ref>
-	~~[[4kxa]] is~~ a ~~1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4KXA OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Aminopeptidase\|Aminopeptidase]]		*[[Aminopeptidase\|Aminopeptidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023888046</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Glutamyl aminopeptidase]]		[[Category: Glutamyl aminopeptidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Li, F.]]	+	[[Category: Li, F]]
-	[[Category: Lin, Y Y.]]	+	[[Category: Lin, Y Y]]
-	[[Category: Liu, C.]]	+	[[Category: Liu, C]]
-	[[Category: Yang, Y.]]	+	[[Category: Yang, Y]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Zinc-aminopeptidase]]		[[Category: Zinc-aminopeptidase]]

OCA at 08:53, 4 September 2013

2013-09-04T08:53:12Z

←Older revision		Revision as of 08:53, 4 September 2013
Line 1:		Line 1:
	{{STRUCTURE_4kxa\| PDB=4kxa \| SCENE= }}		{{STRUCTURE_4kxa\| PDB=4kxa \| SCENE= }}
	===Crystal structure of human aminopeptidase A complexed with aspartate and calcium===		===Crystal structure of human aminopeptidase A complexed with aspartate and calcium===
		+	{{ABSTRACT_PUBMED_23888046}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[4kxa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXA OCA].		[[4kxa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXA OCA].
		+
		+	==See Also==
		+	*[[Aminopeptidase\|Aminopeptidase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023888046</ref><references group="xtra"/><references/>
	[[Category: Glutamyl aminopeptidase]]		[[Category: Glutamyl aminopeptidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 05:24, 1 August 2013

2013-08-01T05:24:08Z

←Older revision		Revision as of 05:24, 1 August 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4kxa\| PDB=4kxa \| SCENE= }}
		+	===Crystal structure of human aminopeptidase A complexed with aspartate and calcium===

-	~~The entry 4kxa is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/AMPE_HUMAN AMPE_HUMAN]] Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.

-	~~Authors~~: ~~Yang, Y~~.~~, Liu, C~~., Lin, Y.Y., Li, F.	+	==About this Structure==
-		+	[[4kxa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXA OCA].
-	~~Description~~: ~~Crystal structure of human~~ aminopeptidase ~~A complexed with aspartate and calcium~~	+	[[Category: Glutamyl aminopeptidase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Li, F.]]
		+	[[Category: Lin, Y Y.]]
		+	[[Category: Liu, C.]]
		+	[[Category: Yang, Y.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Zinc-aminopeptidase]]

OCA at 12:22, 24 July 2013

2013-07-24T12:22:31Z

←Older revision		Revision as of 12:22, 24 July 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kxa is ON HOLD	+	The entry 4kxa is ON HOLD until Paper Publication

	Authors: Yang, Y., Liu, C., Lin, Y.Y., Li, F.		Authors: Yang, Y., Liu, C., Lin, Y.Y., Li, F.

	Description: Crystal structure of human aminopeptidase A complexed with aspartate and calcium		Description: Crystal structure of human aminopeptidase A complexed with aspartate and calcium

OCA: Protected "4kxa" [edit=sysop:move=sysop]

2013-06-19T12:10:34Z

Protected "4kxa" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:10, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 4kxa is ON HOLD Authors: Yang, Y., Liu, C., Lin, Y.Y., Li, F. Description: Crystal structure of human aminopeptidase A complexed with aspartate and...

2013-06-19T12:10:32Z

New page: '''Unreleased structure''' The entry 4kxa is ON HOLD Authors: Yang, Y., Liu, C., Lin, Y.Y., Li, F. Description: Crystal structure of human aminopeptidase A complexed with aspartate and...

New page

'''Unreleased structure'''

The entry 4kxa is ON HOLD

Authors: Yang, Y., Liu, C., Lin, Y.Y., Li, F.

Description: Crystal structure of human aminopeptidase A complexed with aspartate and calcium