4l02 - Revision history

OCA at 12:16, 1 March 2024

2024-03-01T12:16:27Z

←Older revision		Revision as of 12:16, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4l02]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L02 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4l02]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L02 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1V2:(2R,4S)-1-[2-(4-{[4-(3,4-DICHLOROPHENYL)-1,3-THIAZOL-2-YL]AMINO}PHENYL)ETHYL]-2-(HYDROXYMETHYL)PIPERIDIN-4-OL'>1V2</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.75Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1V2:(2R,4S)-1-[2-(4-{[4-(3,4-DICHLOROPHENYL)-1,3-THIAZOL-2-YL]AMINO}PHENYL)ETHYL]-2-(HYDROXYMETHYL)PIPERIDIN-4-OL'>1V2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l02 OCA], [https://pdbe.org/4l02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l02 RCSB], [https://www.ebi.ac.uk/pdbsum/4l02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l02 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l02 OCA], [https://pdbe.org/4l02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l02 RCSB], [https://www.ebi.ac.uk/pdbsum/4l02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l02 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref>		[https://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Sphingosine-1-phosphate (S1P) signaling plays a vital role in mitogenesis, cell migration and angiogenesis. Sphingosine kinases (SphKs) catalyze a key step in sphingomyelin metabolism that leads to the production of S1P. There are two isoforms of SphK and observations made with SphK deficient mice show the two isoforms can compensate for each other's loss. Thus, inhibition of both isoforms is likely required to block SphK dependent angiogenesis. A structure based approach was used to design and synthesize a series of SphK inhibitors resulting in the identification of the first potent inhibitors of both isoforms of human SphK. Additionally, to our knowledge, this series of inhibitors contains the only sufficiently potent inhibitors of murine SphK1 with suitable physico-chemical properties to pharmacologically interrogate the role of SphK1 in rodent models and to reproduce the phenotype of SphK1 (-/-) mice.

-	Structure guided design of a series of sphingosine kinase (SphK) inhibitors.,Gustin DJ, Li Y, Brown ML, Min X, Schmitt MJ, Wanska M, Wang X, Connors R, Johnstone S, Cardozo M, Cheng AC, Jeffries S, Franks B, Li S, Shen S, Wong M, Wesche H, Xu G, Carlson TJ, Plant M, Morgenstern K, Rex K, Schmitt J, Coxon A, Walker N, Kayser F, Wang Z Bioorg Med Chem Lett. 2013 Jun 20. pii: S0960-894X(13)00739-7. doi:, 10.1016/j.bmcl.2013.06.030. PMID:23845219<ref>PMID:23845219</ref>	+	==See Also==
-		+	*[[Sphingosine kinase\|Sphingosine kinase]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class~~=~~"pdbe-citations 4l02" style~~=~~"background-color:#fffaf0;"></div>~~	+
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:23, 7 December 2022

2022-12-07T09:23:33Z

←Older revision		Revision as of 09:23, 7 December 2022
Line 1:		Line 1:

	==Crystal Structure of SphK1 with inhibitor==		==Crystal Structure of SphK1 with inhibitor==
-	<StructureSection load='4l02' size='340' side='right' caption='[[4l02]], [[Resolution\|resolution]] 2.75Å' scene=''>	+	<StructureSection load='4l02' size='340' side='right'caption='[[4l02]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4l02]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L02 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4L02 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4l02]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L02 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1V2:(2R,4S)-1-[2-(4-{[4-(3,4-DICHLOROPHENYL)-1,3-THIAZOL-2-YL]AMINO}PHENYL)ETHYL]-2-(HYDROXYMETHYL)PIPERIDIN-4-OL'>1V2</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1V2:(2R,4S)-1-[2-(4-{[4-(3,4-DICHLOROPHENYL)-1,3-THIAZOL-2-YL]AMINO}PHENYL)ETHYL]-2-(HYDROXYMETHYL)PIPERIDIN-4-OL'>1V2</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vzb\|3vzb]], [[3vzc\|3vzc]], [[3vzd\|3vzd]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l02 OCA], [https://pdbe.org/4l02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l02 RCSB], [https://www.ebi.ac.uk/pdbsum/4l02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l02 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sphingosine kinase 1, SPHK, SPHK1, SPK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sphinganine_kinase Sphinganine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.91 2.7.1.91] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4l02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l02 OCA], [~~http~~://pdbe.org/4l02 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4l02 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4l02 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4l02 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN]] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref>	+	[https://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Sphinganine kinase~~]]	+	[[Category: Large Structures]]
-	[[Category: Min, X]]	+	[[Category: Min X]]
-	[[Category: Walker, N]]	+	[[Category: Walker N]]
-	[[Category: Wang, Z]]	+	[[Category: Wang Z]]
-	~~[[Category: Lipid kinase]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 23:30, 5 August 2016

2016-08-05T23:30:51Z

←Older revision		Revision as of 23:30, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of SphK1 with inhibitor==		==Crystal Structure of SphK1 with inhibitor==
	<StructureSection load='4l02' size='340' side='right' caption='[[4l02]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='4l02' size='340' side='right' caption='[[4l02]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4l02]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L02 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4l02]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L02 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1V2:(2R,4S)-1-[2-(4-{[4-(3,4-DICHLOROPHENYL)-1,3-THIAZOL-2-YL]AMINO}PHENYL)ETHYL]-2-(HYDROXYMETHYL)PIPERIDIN-4-OL'>1V2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1V2:(2R,4S)-1-[2-(4-{[4-(3,4-DICHLOROPHENYL)-1,3-THIAZOL-2-YL]AMINO}PHENYL)ETHYL]-2-(HYDROXYMETHYL)PIPERIDIN-4-OL'>1V2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vzb\|3vzb]], [[3vzc\|3vzc]], [[3vzd\|3vzd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vzb\|3vzb]], [[3vzc\|3vzc]], [[3vzd\|3vzd]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sphingosine kinase 1, SPHK, SPHK1, SPK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sphingosine kinase 1, SPHK, SPHK1, SPK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sphinganine_kinase Sphinganine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.91 2.7.1.91] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sphinganine_kinase Sphinganine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.91 2.7.1.91] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l02 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l02 RCSB], [http://www.ebi.ac.uk/pdbsum/4l02 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l02 OCA], [http://pdbe.org/4l02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l02 RCSB], [http://www.ebi.ac.uk/pdbsum/4l02 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l02 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4l02" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Sphinganine kinase]]		[[Category: Sphinganine kinase]]
	[[Category: Min, X]]		[[Category: Min, X]]

OCA at 06:48, 25 December 2014

2014-12-25T06:48:30Z

←Older revision		Revision as of 06:48, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4l02\| PDB=4l02 \| SCENE= }}~~	+	==Crystal Structure of SphK1 with inhibitor==
-	===Crystal Structure of SphK1 with inhibitor===	+	<StructureSection load='4l02' size='340' side='right' caption='[[4l02]], [[Resolution\|resolution]] 2.75Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23845219}~~}	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4l02]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L02 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1V2:(2R,4S)-1-[2-(4-{[4-(3,4-DICHLOROPHENYL)-1,3-THIAZOL-2-YL]AMINO}PHENYL)ETHYL]-2-(HYDROXYMETHYL)PIPERIDIN-4-OL'>1V2</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3vzb\|3vzb]], [[3vzc\|3vzc]], [[3vzd\|3vzd]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sphingosine kinase 1, SPHK, SPHK1, SPK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sphinganine_kinase Sphinganine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.91 2.7.1.91] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l02 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l02 RCSB], [http://www.ebi.ac.uk/pdbsum/4l02 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN]] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref>		[[http://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN]] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sphingosine-1-phosphate (S1P) signaling plays a vital role in mitogenesis, cell migration and angiogenesis. Sphingosine kinases (SphKs) catalyze a key step in sphingomyelin metabolism that leads to the production of S1P. There are two isoforms of SphK and observations made with SphK deficient mice show the two isoforms can compensate for each other's loss. Thus, inhibition of both isoforms is likely required to block SphK dependent angiogenesis. A structure based approach was used to design and synthesize a series of SphK inhibitors resulting in the identification of the first potent inhibitors of both isoforms of human SphK. Additionally, to our knowledge, this series of inhibitors contains the only sufficiently potent inhibitors of murine SphK1 with suitable physico-chemical properties to pharmacologically interrogate the role of SphK1 in rodent models and to reproduce the phenotype of SphK1 (-/-) mice.

-	~~==About this~~ Structure==	+	Structure guided design of a series of sphingosine kinase (SphK) inhibitors.,Gustin DJ, Li Y, Brown ML, Min X, Schmitt MJ, Wanska M, Wang X, Connors R, Johnstone S, Cardozo M, Cheng AC, Jeffries S, Franks B, Li S, Shen S, Wong M, Wesche H, Xu G, Carlson TJ, Plant M, Morgenstern K, Rex K, Schmitt J, Coxon A, Walker N, Kayser F, Wang Z Bioorg Med Chem Lett. 2013 Jun 20. pii: S0960-894X(13)00739-7. doi:, 10.1016/j.bmcl.2013.06.030. PMID:23845219<ref>PMID:23845219</ref>
-	~~[[4l02]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=4L02 OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023845219</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Sphinganine kinase]]		[[Category: Sphinganine kinase]]
-	[[Category: Min, X.]]	+	[[Category: Min, X]]
-	[[Category: Walker, N.]]	+	[[Category: Walker, N]]
-	[[Category: Wang, Z.]]	+	[[Category: Wang, Z]]
	[[Category: Lipid kinase]]		[[Category: Lipid kinase]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 12:59, 24 July 2013

2013-07-24T12:59:33Z

←Older revision		Revision as of 12:59, 24 July 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4l02\| PDB=4l02 \| SCENE= }}
		+	===Crystal Structure of SphK1 with inhibitor===
		+	{{ABSTRACT_PUBMED_23845219}}

-	~~The entry 4l02 is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN]] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref>

-	~~Authors~~: ~~Min, X~~.~~, Walker, N~~.~~, Wang, Z~~.	+	==About this Structure==
		+	[[4l02]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L02 OCA].

-	~~Description~~: ~~Crystal Structure of SphK1 with~~ inhibitor	+	==Reference==
		+	<ref group="xtra">PMID:023845219</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Sphinganine kinase]]
		+	[[Category: Min, X.]]
		+	[[Category: Walker, N.]]
		+	[[Category: Wang, Z.]]
		+	[[Category: Lipid kinase]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 15:04, 10 July 2013

2013-07-10T15:04:10Z

←Older revision		Revision as of 15:04, 10 July 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4l02 is ON HOLD	+	The entry 4l02 is ON HOLD until Paper Publication

	Authors: Min, X., Walker, N., Wang, Z.		Authors: Min, X., Walker, N., Wang, Z.

	Description: Crystal Structure of SphK1 with inhibitor		Description: Crystal Structure of SphK1 with inhibitor

OCA at 08:57, 30 June 2013

2013-06-30T08:57:14Z

←Older revision		Revision as of 08:57, 30 June 2013
Line 3:		Line 3:
	The entry 4l02 is ON HOLD		The entry 4l02 is ON HOLD

-	Authors: ~~Xiaoshan~~ Min, ~~Nigel~~ Walker, ~~Zhulun~~ Wang	+	Authors: Min, X., Walker, N., Wang, Z.

	Description: Crystal Structure of SphK1 with inhibitor		Description: Crystal Structure of SphK1 with inhibitor

OCA: Protected "4l02" [edit=sysop:move=sysop]

2013-06-19T12:18:03Z

Protected "4l02" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:18, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 4l02 is ON HOLD Authors: Xiaoshan Min, Nigel Walker, Zhulun Wang Description: Crystal Structure of SphK1 with inhibitor

2013-06-19T12:18:01Z

New page: '''Unreleased structure''' The entry 4l02 is ON HOLD Authors: Xiaoshan Min, Nigel Walker, Zhulun Wang Description: Crystal Structure of SphK1 with inhibitor

New page

'''Unreleased structure'''

The entry 4l02 is ON HOLD

Authors: Xiaoshan Min, Nigel Walker, Zhulun Wang

Description: Crystal Structure of SphK1 with inhibitor