4l3n - Revision history

OCA at 09:29, 7 December 2022

2022-12-07T09:29:53Z

←Older revision		Revision as of 09:29, 7 December 2022
Line 1:		Line 1:

	==Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus==		==Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus==
-	<StructureSection load='4l3n' size='340' side='right' caption='[[4l3n]], [[Resolution\|resolution]] 2.13Å' scene=''>	+	<StructureSection load='4l3n' size='340' side='right'caption='[[4l3n]], [[Resolution\|resolution]] 2.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4l3n]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human_betacoronavirus_2c_jordan~~-n3/2012 Human betacoronavirus 2c ~~jordan~~-n3/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L3N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4L3N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4l3n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_betacoronavirus_2c_Jordan-N3/2012 Human betacoronavirus 2c Jordan-N3/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L3N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1306931 Human betacoronavirus 2c Jordan-N3/2012])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l3n OCA], [https://pdbe.org/4l3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l3n RCSB], [https://www.ebi.ac.uk/pdbsum/4l3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l3n ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4l3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l3n OCA], [~~http~~://pdbe.org/4l3n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4l3n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4l3n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4l3n ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/M4SVE7_MERS M4SVE7_MERS] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human betacoronavirus 2c ~~jordan~~-n3/2012]]	+	[[Category: Human betacoronavirus 2c Jordan-N3/2012]]
-	[[Category: Agnihothram~~, S S~~]]	+	[[Category: Large Structures]]
-	[[Category: Baric~~, R S~~]]	+	[[Category: Agnihothram SS]]
-	[[Category: Chen, Y]]	+	[[Category: Baric RS]]
-	[[Category: Li, F]]	+	[[Category: Chen Y]]
-	[[Category: Lin, Y L]]	+	[[Category: Li F]]
-	[[Category: Liu, C]]	+	[[Category: Lin Y-L]]
-	[[Category: Rajashankar~~, K R~~]]	+	[[Category: Liu C]]
-	[[Category: Yang, Y]]	+	[[Category: Rajashankar KR]]
-	~~[[Category: Beta-sheet fold]]~~	+	[[Category: Yang Y]]
-	~~[[Category: Viral protein~~]]	+

OCA at 09:44, 5 August 2016

2016-08-05T09:44:23Z

←Older revision		Revision as of 09:44, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus==		==Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus==
	<StructureSection load='4l3n' size='340' side='right' caption='[[4l3n]], [[Resolution\|resolution]] 2.13Å' scene=''>		<StructureSection load='4l3n' size='340' side='right' caption='[[4l3n]], [[Resolution\|resolution]] 2.13Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1306931 Human betacoronavirus 2c Jordan-N3/2012])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1306931 Human betacoronavirus 2c Jordan-N3/2012])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l3n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l3n RCSB], [http://www.ebi.ac.uk/pdbsum/4l3n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l3n OCA], [http://pdbe.org/4l3n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l3n RCSB], [http://www.ebi.ac.uk/pdbsum/4l3n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l3n ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4l3n" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:18, 21 December 2014

2014-12-21T15:18:50Z

←Older revision		Revision as of 15:18, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4l3n\| PDB=4l3n \| SCENE= }}~~	+	==Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus==
-	===Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus===	+	<StructureSection load='4l3n' size='340' side='right' caption='[[4l3n]], [[Resolution\|resolution]] 2.13Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23903833}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4l3n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_betacoronavirus_2c_jordan-n3/2012 Human betacoronavirus 2c jordan-n3/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L3N FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1306931 Human betacoronavirus 2c Jordan-N3/2012])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l3n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l3n RCSB], [http://www.ebi.ac.uk/pdbsum/4l3n PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) has infected at least 77 people with a fatality rate of more than 50%. Alarmingly, the virus demonstrates a capability of human-to-human transmission, raising the possibility of global spread and endangering world health and economy. Here we have identified the receptor-binding domain (RBD) from the MERS-CoV spike protein and determined its crystal structure. This study also presents the structural comparison of MERS-CoV RBD with other coronavirus RBDs, successfully positioning MERS-CoV on the landscape of coronavirus evolution and providing insights into receptor binding by MERS-CoV. Furthermore, we found that MERS-CoV RBD functions as an effective entry inhibitor of MERS-CoV. The identified MERS-CoV RBD may also serve as a potential candidate for MERS-CoV subunit vaccines. Overall, this study enhances our understanding of the evolution of coronavirus RBDs, provides insights into receptor recognition by MERS-CoV, and may help control the transmission of MERS-CoV in humans.

-	~~==About this Structure==~~	+	Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus.,Chen Y, Rajashankar KR, Yang Y, Agnihothram SS, Liu C, Lin YL, Baric RS, Li F J Virol. 2013 Jul 31. PMID:23903833<ref>PMID:23903833</ref>
-	~~[[4l3n]] is a 2 chain~~ structure ~~with sequence~~ from ~~[http://en~~.~~wikipedia~~.~~org/wiki/Human_betacoronavirus_2c_jordan-n3/2012 Human betacoronavirus 2c jordan-n3/2012]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4L3N OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023903833</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Human betacoronavirus 2c jordan-n3/2012]]		[[Category: Human betacoronavirus 2c jordan-n3/2012]]
-	[[Category: Agnihothram, S S.]]	+	[[Category: Agnihothram, S S]]
-	[[Category: Baric, R S.]]	+	[[Category: Baric, R S]]
-	[[Category: Chen, Y.]]	+	[[Category: Chen, Y]]
-	[[Category: Li, F.]]	+	[[Category: Li, F]]
-	[[Category: Lin, Y L.]]	+	[[Category: Lin, Y L]]
-	[[Category: Liu, C.]]	+	[[Category: Liu, C]]
-	[[Category: Rajashankar, K R.]]	+	[[Category: Rajashankar, K R]]
-	[[Category: Yang, Y.]]	+	[[Category: Yang, Y]]
	[[Category: Beta-sheet fold]]		[[Category: Beta-sheet fold]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 06:39, 14 August 2013

2013-08-14T06:39:33Z

←Older revision		Revision as of 06:39, 14 August 2013
Line 1:		Line 1:
	{{STRUCTURE_4l3n\| PDB=4l3n \| SCENE= }}		{{STRUCTURE_4l3n\| PDB=4l3n \| SCENE= }}
	===Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus===		===Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus===
		+	{{ABSTRACT_PUBMED_23903833}}

	==About this Structure==		==About this Structure==
	[[4l3n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_betacoronavirus_2c_jordan-n3/2012 Human betacoronavirus 2c jordan-n3/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L3N OCA].		[[4l3n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_betacoronavirus_2c_jordan-n3/2012 Human betacoronavirus 2c jordan-n3/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L3N OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023903833</ref><references group="xtra"/><references/>
	[[Category: Human betacoronavirus 2c jordan-n3/2012]]		[[Category: Human betacoronavirus 2c jordan-n3/2012]]
	[[Category: Agnihothram, S S.]]		[[Category: Agnihothram, S S.]]

OCA at 05:24, 1 August 2013

2013-08-01T05:24:36Z

←Older revision		Revision as of 05:24, 1 August 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4l3n\| PDB=4l3n \| SCENE= }}
		+	===Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus===

-	~~The entry~~ 4l3n is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4l3n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_betacoronavirus_2c_jordan-n3/2012 Human betacoronavirus 2c jordan-n3/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L3N OCA].
-	~~Authors~~: ~~Chen, Y~~.~~, Rajashankar, K~~.R.~~, Yang, Y~~., Agnihothram, S.S., ~~Liu, C~~., Lin, Y.-L., ~~Baric~~, R.S., ~~Li, F~~.	+	[[Category: Human betacoronavirus 2c jordan-n3/2012]]
-		+	[[Category: Agnihothram, S S.]]
-	~~Description~~: ~~Crystal structure of the receptor~~-~~binding domain from newly emerged Middle East respiratory syndrome coronavirus~~	+	[[Category: Baric, R S.]]
		+	[[Category: Chen, Y.]]
		+	[[Category: Li, F.]]
		+	[[Category: Lin, Y L.]]
		+	[[Category: Liu, C.]]
		+	[[Category: Rajashankar, K R.]]
		+	[[Category: Yang, Y.]]
		+	[[Category: Beta-sheet fold]]
		+	[[Category: Viral protein]]

OCA at 13:19, 3 July 2013

2013-07-03T13:19:18Z

←Older revision		Revision as of 13:19, 3 July 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4l3n is ON HOLD	+	The entry 4l3n is ON HOLD until Paper Publication

	Authors: Chen, Y., Rajashankar, K.R., Yang, Y., Agnihothram, S.S., Liu, C., Lin, Y.-L., Baric, R.S., Li, F.		Authors: Chen, Y., Rajashankar, K.R., Yang, Y., Agnihothram, S.S., Liu, C., Lin, Y.-L., Baric, R.S., Li, F.

	Description: Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus		Description: Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus

OCA at 08:59, 30 June 2013

2013-06-30T08:59:45Z

←Older revision		Revision as of 08:59, 30 June 2013
Line 3:		Line 3:
	The entry 4l3n is ON HOLD		The entry 4l3n is ON HOLD

-	Authors: ~~Yaoqing~~ Chen, ~~Kanagalaghatta R~~. Rajashankar, ~~Yang~~ Yang , ~~Sudhakar S~~. Agnihothram , ~~Chang~~ Liu , ~~Yi-Lun~~ Lin , ~~Ralph S~~. Baric , ~~Fang~~ Li	+	Authors: Chen, Y., Rajashankar, K.R., Yang, Y., Agnihothram, S.S., Liu, C., Lin, Y.-L., Baric, R.S., Li, F.

	Description: Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus		Description: Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus

OCA: Protected "4l3n" [edit=sysop:move=sysop]

2013-06-19T12:27:51Z

Protected "4l3n" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:27, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 4l3n is ON HOLD Authors: Yaoqing Chen, Kanagalaghatta R. Rajashankar, Yang Yang , Sudhakar S. Agnihothram , Chang Liu , Yi-Lun Lin , Ralph S. Baric ...

2013-06-19T12:27:50Z

New page: '''Unreleased structure''' The entry 4l3n is ON HOLD Authors: Yaoqing Chen, Kanagalaghatta R. Rajashankar, Yang Yang , Sudhakar S. Agnihothram , Chang Liu , Yi-Lun Lin , Ralph S. Baric ...

New page

'''Unreleased structure'''

The entry 4l3n is ON HOLD

Authors: Yaoqing Chen, Kanagalaghatta R. Rajashankar, Yang Yang , Sudhakar S. Agnihothram , Chang Liu , Yi-Lun Lin , Ralph S. Baric , Fang Li

Description: Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus