4ldl - Revision history

OCA at 16:17, 20 September 2023

2023-09-20T16:17:35Z

←Older revision		Revision as of 16:17, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ldl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LDL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ldl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LDL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1WV:(2S)-2,3-DIHYDROXYPROPYL+(7Z)-TETRADEC-7-ENOATE'>1WV</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XQC:4-[(1R)-1-HYDROXY-2-{[1-(4-HYDROXYPHENYL)-2-METHYLPROPAN-2-YL]AMINO}ETHYL]BENZENE-1,2-DIOL'>XQC</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1WV:(2S)-2,3-DIHYDROXYPROPYL+(7Z)-TETRADEC-7-ENOATE'>1WV</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XQC:4-[(1R)-1-HYDROXY-2-{[1-(4-HYDROXYPHENYL)-2-METHYLPROPAN-2-YL]AMINO}ETHYL]BENZENE-1,2-DIOL'>XQC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ldl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldl OCA], [https://pdbe.org/4ldl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ldl RCSB], [https://www.ebi.ac.uk/pdbsum/4ldl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ldl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldl OCA], [https://pdbe.org/4ldl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ldl RCSB], [https://www.ebi.ac.uk/pdbsum/4ldl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldl ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:53, 14 December 2022

2022-12-14T10:53:33Z

←Older revision		Revision as of 10:53, 14 December 2022
Line 1:		Line 1:

	==Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody==		==Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody==
-	<StructureSection load='4ldl' size='340' side='right' caption='[[4ldl]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='4ldl' size='340' side='right'caption='[[4ldl]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ldl]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/ ] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4LDL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ldl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LDL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1WV:(2S)-2,3-DIHYDROXYPROPYL+(7Z)-TETRADEC-7-ENOATE'>1WV</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XQC:4-[(1R)-1-HYDROXY-2-{[1-(4-HYDROXYPHENYL)-2-METHYLPROPAN-2-YL]AMINO}ETHYL]BENZENE-1,2-DIOL'>XQC</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1WV:(2S)-2,3-DIHYDROXYPROPYL+(7Z)-TETRADEC-7-ENOATE'>1WV</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XQC:4-[(1R)-1-HYDROXY-2-{[1-(4-HYDROXYPHENYL)-2-METHYLPROPAN-2-YL]AMINO}ETHYL]BENZENE-1,2-DIOL'>XQC</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lde\|4lde]], [[4ldo\|4ldo]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ldl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldl OCA], [https://pdbe.org/4ldl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ldl RCSB], [https://www.ebi.ac.uk/pdbsum/4ldl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldl ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADRB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ldl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldl OCA], [~~http~~://pdbe.org/4ldl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ldl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ldl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldl ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/~~LYS_BPT4 LYS_BPT4~~]~~] Helps~~ to ~~release~~ the mature ~~phage~~ particles ~~from~~ the cell ~~wall by breaking~~ down the peptidoglycan.	+	[https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Adrenergic receptor\|Adrenergic receptor]]	+	*[[Adrenergic receptor 3D structures\|Adrenergic receptor 3D structures]]
-	*[[~~Beta-2 adrenergic receptor~~\|~~Beta-2 adrenergic receptor~~]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
-	*[[3D structures of antibody\|3D structures of antibody]]	+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Escherichia virus T4]]
-	[[Category: ~~Lysozyme~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Enos, M D~~]]	+	[[Category: Lama glama]]
-	[[Category: ~~Garcia, K C~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Kobilka, B K~~]]	+	[[Category: Enos MD]]
-	[[Category: ~~Kruse, A C~~]]	+	[[Category: Garcia KC]]
-	[[Category: ~~Manglik, A~~]]	+	[[Category: Kobilka BK]]
-	[[Category: ~~Ring, A M~~]]	+	[[Category: Kruse AC]]
-	[[Category: ~~Weis, W I~~]]	+	[[Category: Manglik A]]
-	[[Category: ~~G protein coupled receptor~~]]	+	[[Category: Ring AM]]
-	[[Category: ~~Membrane protein-hydrolase complex~~]]	+	[[Category: Weis WI]]

OCA at 15:15, 5 August 2016

2016-08-05T15:15:19Z

←Older revision		Revision as of 15:15, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody==		==Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody==
	<StructureSection load='4ldl' size='340' side='right' caption='[[4ldl]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='4ldl' size='340' side='right' caption='[[4ldl]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ldl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human Human~~] and [http://en.wikipedia.org/wiki/~~Lama_glama Lama glama~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LDL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ldl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LDL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1WV:(2S)-2,3-DIHYDROXYPROPYL+(7Z)-TETRADEC-7-ENOATE'>1WV</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XQC:4-[(1R)-1-HYDROXY-2-{[1-(4-HYDROXYPHENYL)-2-METHYLPROPAN-2-YL]AMINO}ETHYL]BENZENE-1,2-DIOL'>XQC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1WV:(2S)-2,3-DIHYDROXYPROPYL+(7Z)-TETRADEC-7-ENOATE'>1WV</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XQC:4-[(1R)-1-HYDROXY-2-{[1-(4-HYDROXYPHENYL)-2-METHYLPROPAN-2-YL]AMINO}ETHYL]BENZENE-1,2-DIOL'>XQC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lde\|4lde]], [[4ldo\|4ldo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lde\|4lde]], [[4ldo\|4ldo]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADRB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADRB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ldl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ldl RCSB], [http://www.ebi.ac.uk/pdbsum/4ldl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ldl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldl OCA], [http://pdbe.org/4ldl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ldl RCSB], [http://www.ebi.ac.uk/pdbsum/4ldl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ldl" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Adrenergic receptor\|Adrenergic receptor]]		*[[Adrenergic receptor\|Adrenergic receptor]]
-	*[[~~Antibody~~\|~~Antibody~~]]	+	*[[Beta-2 adrenergic receptor\|Beta-2 adrenergic receptor]]
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
		+	*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Lama glama]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Enos, M D]]		[[Category: Enos, M D]]

OCA at 03:33, 25 December 2014

2014-12-25T03:33:00Z

←Older revision		Revision as of 03:33, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ldl\| PDB=4ldl \| SCENE= }}~~	+	==Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody==
-	===Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody===	+	<StructureSection load='4ldl' size='340' side='right' caption='[[4ldl]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	{~~{ABSTRACT_PUBMED_24056936}~~}	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4ldl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LDL FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1WV:(2S)-2,3-DIHYDROXYPROPYL+(7Z)-TETRADEC-7-ENOATE'>1WV</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XQC:4-[(1R)-1-HYDROXY-2-{[1-(4-HYDROXYPHENYL)-2-METHYLPROPAN-2-YL]AMINO}ETHYL]BENZENE-1,2-DIOL'>XQC</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lde\|4lde]], [[4ldo\|4ldo]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADRB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ldl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ldl RCSB], [http://www.ebi.ac.uk/pdbsum/4ldl PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/LYS_BPT4 LYS_BPT4]] Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.		[[http://www.uniprot.org/uniprot/LYS_BPT4 LYS_BPT4]] Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	G-protein-coupled receptors (GPCRs) are integral membrane proteins that have an essential role in human physiology, yet the molecular processes through which they bind to their endogenous agonists and activate effector proteins remain poorly understood. So far, it has not been possible to capture an active-state GPCR bound to its native neurotransmitter. Crystal structures of agonist-bound GPCRs have relied on the use of either exceptionally high-affinity agonists or receptor stabilization by mutagenesis. Many natural agonists such as adrenaline, which activates the beta2-adrenoceptor (beta2AR), bind with relatively low affinity, and they are often chemically unstable. Using directed evolution, we engineered a high-affinity camelid antibody fragment that stabilizes the active state of the beta2AR, and used this to obtain crystal structures of the activated receptor bound to multiple ligands. Here we present structures of the active-state human beta2AR bound to three chemically distinct agonists: the ultrahigh-affinity agonist BI167107, the high-affinity catecholamine agonist hydroxybenzyl isoproterenol, and the low-affinity endogenous agonist adrenaline. The crystal structures reveal a highly conserved overall ligand recognition and activation mode despite diverse ligand chemical structures and affinities that range from 100 nM to approximately 80 pM. Overall, the adrenaline-bound receptor structure is similar to the others, but it has substantial rearrangements in extracellular loop three and the extracellular tip of transmembrane helix 6. These structures also reveal a water-mediated hydrogen bond between two conserved tyrosines, which appears to stabilize the active state of the beta2AR and related GPCRs.
		+
		+	Adrenaline-activated structure of beta2-adrenoceptor stabilized by an engineered nanobody.,Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK Nature. 2013 Oct 24;502(7472):575-9. doi: 10.1038/nature12572. Epub 2013 Sep 22. PMID:24056936<ref>PMID:24056936</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4ldl]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/ ] and [http://en~~.~~wikipedia.org~~/~~wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDL OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024056936</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Adrenergic receptor\|Adrenergic receptor]]
		+	*[[Antibody\|Antibody]]
		+	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
	[[Category: Lama glama]]		[[Category: Lama glama]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
-	[[Category: Enos, M D.]]	+	[[Category: Enos, M D]]
-	[[Category: Garcia, K C.]]	+	[[Category: Garcia, K C]]
-	[[Category: Kobilka, B K.]]	+	[[Category: Kobilka, B K]]
-	[[Category: Kruse, A C.]]	+	[[Category: Kruse, A C]]
-	[[Category: Manglik, A.]]	+	[[Category: Manglik, A]]
-	[[Category: Ring, A M.]]	+	[[Category: Ring, A M]]
-	[[Category: Weis, W I.]]	+	[[Category: Weis, W I]]
	[[Category: G protein coupled receptor]]		[[Category: G protein coupled receptor]]
	[[Category: Membrane protein-hydrolase complex]]		[[Category: Membrane protein-hydrolase complex]]

OCA at 08:28, 30 October 2013

2013-10-30T08:28:40Z

←Older revision		Revision as of 08:28, 30 October 2013
Line 1:		Line 1:
	{{STRUCTURE_4ldl\| PDB=4ldl \| SCENE= }}		{{STRUCTURE_4ldl\| PDB=4ldl \| SCENE= }}
	===Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody===		===Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody===
		+	{{ABSTRACT_PUBMED_24056936}}

	==Function==		==Function==
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	==About this Structure==		==About this Structure==
	[[4ldl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDL OCA].		[[4ldl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024056936</ref><references group="xtra"/><references/>
	[[Category: Lama glama]]		[[Category: Lama glama]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]

OCA at 08:20, 29 September 2013

2013-09-29T08:20:00Z

←Older revision		Revision as of 08:20, 29 September 2013
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-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4ldl\| PDB=4ldl \| SCENE= }}
		+	===Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody===

-	~~The entry 4ldl is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/LYS_BPT4 LYS_BPT4]] Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.

-	~~Authors~~: ~~Ring, A~~.M.~~, Manglik, A~~.~~, Kruse, A~~.C., Enos, M.D., ~~Weis, W.I~~., ~~Garcia,~~ K.C., ~~Kobilka~~, B.K.	+	==About this Structure==
-		+	[[4ldl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDL OCA].
-	~~Description~~: ~~Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody~~	+	[[Category: Lama glama]]
		+	[[Category: Lysozyme]]
		+	[[Category: Enos, M D.]]
		+	[[Category: Garcia, K C.]]
		+	[[Category: Kobilka, B K.]]
		+	[[Category: Kruse, A C.]]
		+	[[Category: Manglik, A.]]
		+	[[Category: Ring, A M.]]
		+	[[Category: Weis, W I.]]
		+	[[Category: G protein coupled receptor]]
		+	[[Category: Membrane protein-hydrolase complex]]

OCA at 20:07, 7 August 2013

2013-08-07T20:07:42Z

←Older revision		Revision as of 20:07, 7 August 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ldl is ON HOLD	+	The entry 4ldl is ON HOLD until Paper Publication

	Authors: Ring, A.M., Manglik, A., Kruse, A.C., Enos, M.D., Weis, W.I., Garcia, K.C., Kobilka, B.K.		Authors: Ring, A.M., Manglik, A., Kruse, A.C., Enos, M.D., Weis, W.I., Garcia, K.C., Kobilka, B.K.

	Description: Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody		Description: Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody

OCA: Protected "4ldl" [edit=sysop:move=sysop]

2013-07-03T13:25:30Z

Protected "4ldl" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:25, 3 July 2013

OCA: New page: '''Unreleased structure''' The entry 4ldl is ON HOLD Authors: Ring, A.M., Manglik, A., Kruse, A.C., Enos, M.D., Weis, W.I., Garcia, K.C., Kobilka, B.K. Description: Structure of beta2 ...

2013-07-03T13:25:29Z

New page: '''Unreleased structure''' The entry 4ldl is ON HOLD Authors: Ring, A.M., Manglik, A., Kruse, A.C., Enos, M.D., Weis, W.I., Garcia, K.C., Kobilka, B.K. Description: Structure of beta2 ...

New page

'''Unreleased structure'''

The entry 4ldl is ON HOLD

Authors: Ring, A.M., Manglik, A., Kruse, A.C., Enos, M.D., Weis, W.I., Garcia, K.C., Kobilka, B.K.

Description: Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody