4lga - Revision history

OCA at 16:18, 20 September 2023

2023-09-20T16:18:53Z

←Older revision		Revision as of 16:18, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4lga]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LGA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4lga]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LGA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2O:N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE'>A2O</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2O:N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE'>A2O</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lga OCA], [https://pdbe.org/4lga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lga RCSB], [https://www.ebi.ac.uk/pdbsum/4lga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lga ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lga OCA], [https://pdbe.org/4lga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lga RCSB], [https://www.ebi.ac.uk/pdbsum/4lga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lga ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:59, 14 December 2022

2022-12-14T10:59:25Z

←Older revision		Revision as of 10:59, 14 December 2022
Line 3:		Line 3:
	<StructureSection load='4lga' size='340' side='right'caption='[[4lga]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4lga' size='340' side='right'caption='[[4lga]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4lga]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LGA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4LGA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4lga]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LGA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2O:N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE'>A2O</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2O:N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE'>A2O</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lg5\|4lg5]], [[4lgb\|4lgb]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lga OCA], [https://pdbe.org/4lga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lga RCSB], [https://www.ebi.ac.uk/pdbsum/4lga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lga ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYL2, RCAR14, At2g26040, T19L18.15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH]), HAB1, P2C-HA, At1g72770, F28P22.4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4lga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lga OCA], [~~http~~://pdbe.org/4lga PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4lga RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4lga PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4lga ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref> [[http://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref>	+	[https://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 21:
	==See Also==		==See Also==
	*[[Abscisic acid receptor 3D structures\|Abscisic acid receptor 3D structures]]		*[[Abscisic acid receptor 3D structures\|Abscisic acid receptor 3D structures]]
-	*[[PYR/PYL/RCAR family of ABA receptors\|PYR/PYL/RCAR family of ABA receptors]]	+	*[[Protein phosphatase 3D structures\|Protein phosphatase 3D structures]]
-	*[[Protein phosphatase\|Protein phosphatase]]	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Phosphoprotein phosphatase]]~~	+	[[Category: Deng P]]
-	[[Category: Deng, P]]	+	[[Category: Gao M]]
-	[[Category: Gao, M]]	+	[[Category: Gao P]]
-	[[Category: Gao, P]]	+	[[Category: Liu X]]
-	[[Category: Liu, X]]	+	[[Category: Melcher K]]
-	[[Category: Melcher, K]]	+	[[Category: Wang F]]
-	[[Category: Wang, F]]	+	[[Category: Xu HE]]
-	[[Category: Xu~~, H E~~]]	+	[[Category: Xu Y]]
-	[[Category: Xu, Y]]	+	[[Category: Xue X]]
-	[[Category: Xue, X]]	+	[[Category: Zeng L]]
-	[[Category: Zeng, L]]	+	[[Category: Zhang Y]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhao Y]]
-	[[Category: Zhao, Y]]	+	[[Category: Zhong D]]
-	[[Category: Zhong, D]]	+	[[Category: Zhou XE]]
-	[[Category: Zhou~~, X E~~]]	+	[[Category: Zhu J-K]]
-	[[Category: Zhu, J K]]	+
-	~~[[Category: Abscisic acid mimicking compound]]~~	+
-	~~[[Category: Hydrolase-receptor complex]]~~	+
-	~~[[Category: Pp2c]]~~	+
-	~~[[Category: Pyr/pyl/rcar~~]]	+

OCA at 12:05, 17 July 2019

2019-07-17T12:05:59Z

←Older revision		Revision as of 12:05, 17 July 2019
Line 1:		Line 1:

	==ABA-mimicking ligand N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE in complex with ABA receptor PYL2 and PP2C HAB1==		==ABA-mimicking ligand N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE in complex with ABA receptor PYL2 and PP2C HAB1==
-	<StructureSection load='4lga' size='340' side='right' caption='[[4lga]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4lga' size='340' side='right'caption='[[4lga]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4lga]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LGA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4lga]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LGA FirstGlance]. <br>
Line 23:		Line 23:

	==See Also==		==See Also==
		+	*[[Abscisic acid receptor 3D structures\|Abscisic acid receptor 3D structures]]
	*[[PYR/PYL/RCAR family of ABA receptors\|PYR/PYL/RCAR family of ABA receptors]]		*[[PYR/PYL/RCAR family of ABA receptors\|PYR/PYL/RCAR family of ABA receptors]]
		+	*[[Protein phosphatase\|Protein phosphatase]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Arath]]		[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
	[[Category: Deng, P]]		[[Category: Deng, P]]

OCA at 22:55, 4 August 2016

2016-08-04T22:55:27Z

←Older revision		Revision as of 22:55, 4 August 2016
Line 1:		Line 1:
		+
	==ABA-mimicking ligand N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE in complex with ABA receptor PYL2 and PP2C HAB1==		==ABA-mimicking ligand N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE in complex with ABA receptor PYL2 and PP2C HAB1==
	<StructureSection load='4lga' size='340' side='right' caption='[[4lga]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4lga' size='340' side='right' caption='[[4lga]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4lga]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LGA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4lga]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LGA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2O:N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE'>A2O</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2O:N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE'>A2O</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lg5\|4lg5]], [[4lgb\|4lgb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lg5\|4lg5]], [[4lgb\|4lgb]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYL2, RCAR14, At2g26040, T19L18.15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ~~Arabidopsis thaliana~~]), HAB1, P2C-HA, At1g72770, F28P22.4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ~~Arabidopsis thaliana~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYL2, RCAR14, At2g26040, T19L18.15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH]), HAB1, P2C-HA, At1g72770, F28P22.4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lga OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lga RCSB], [http://www.ebi.ac.uk/pdbsum/4lga PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lga OCA], [http://pdbe.org/4lga PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lga RCSB], [http://www.ebi.ac.uk/pdbsum/4lga PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lga ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4lga" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arabidopsis thaliana~~]]	+	[[Category: Arath]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
	[[Category: Deng, P]]		[[Category: Deng, P]]

OCA at 20:25, 24 December 2014

2014-12-24T20:25:37Z

←Older revision		Revision as of 20:25, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lga OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lga RCSB], [http://www.ebi.ac.uk/pdbsum/4lga PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lga OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lga RCSB], [http://www.ebi.ac.uk/pdbsum/4lga PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref> [[http://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 15:13, 21 December 2014

2014-12-21T15:13:28Z

←Older revision		Revision as of 15:13, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4lga\| PDB=4lga \| SCENE= }}~~	+	==ABA-mimicking ligand N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE in complex with ABA receptor PYL2 and PP2C HAB1==
-	===ABA-mimicking ligand N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE in complex with ABA receptor PYL2 and PP2C HAB1===	+	<StructureSection load='4lga' size='340' side='right' caption='[[4lga]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23835477}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4lga]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LGA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2O:N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE'>A2O</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lg5\|4lg5]], [[4lgb\|4lgb]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PYL2, RCAR14, At2g26040, T19L18.15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana]), HAB1, P2C-HA, At1g72770, F28P22.4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lga OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lga RCSB], [http://www.ebi.ac.uk/pdbsum/4lga PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Abscisic acid (ABA) is the most important hormone for plants to resist drought and other abiotic stresses. ABA binds directly to the PYR/PYL family of ABA receptors, resulting in inhibition of type 2C phosphatases (PP2C) and activation of downstream ABA signaling. It is envisioned that intervention of ABA signaling by small molecules could help plants to overcome abiotic stresses such as drought, cold and soil salinity. However, chemical instability and rapid catabolism by plant enzymes limit the practical application of ABA itself. Here we report the identification of a small molecule ABA mimic (AM1) that acts as a potent activator of multiple members of the family of ABA receptors. In Arabidopsis, AM1 activates a gene network that is highly similar to that induced by ABA. Treatments with AM1 inhibit seed germination, prevent leaf water loss, and promote drought resistance. We solved the crystal structure of AM1 in complex with the PYL2 ABA receptor and the HAB1 PP2C, which revealed that AM1 mediates a gate-latch-lock interacting network, a structural feature that is conserved in the ABA-bound receptor/PP2C complex. Together, these results demonstrate that a single small molecule ABA mimic can activate multiple ABA receptors and protect plants from water loss and drought stress. Moreover, the AM1 complex crystal structure provides a structural basis for designing the next generation of ABA-mimicking small molecules.

-	~~==Function==~~	+	An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants.,Cao M, Liu X, Zhang Y, Xue X, Zhou XE, Melcher K, Gao P, Wang F, Zeng L, Zhao Y, Zhao Y, Deng P, Zhong D, Zhu JK, Xu HE, Xu Y Cell Res. 2013 Aug;23(8):1043-54. doi: 10.1038/cr.2013.95. Epub 2013 Jul 9. PMID:23835477<ref>PMID:23835477</ref>
-	~~[[http://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH]] Receptor for abscisic acid (ABA) required for~~ ABA-~~mediated responses such as stomatal closure~~ and ~~germination inhibition~~. ~~Inhibits the activity of group-A protein phosphatases type 2C~~ (~~PP2Cs~~) ~~when activated by ABA~~.~~<ref>PMID~~:~~19898420</ref> <ref>PMID:19893533</ref> [[http:/~~/~~www~~.~~uniprot~~.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. ~~Confers enhanced sensitivity to drought~~.~~<ref>~~PMID:~~14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref>~~ <ref>PMID:~~19033529~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4lga]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4LGA OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023835477</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[PYR/PYL/RCAR family of ABA receptors\|PYR/PYL/RCAR family of ABA receptors]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
-	[[Category: Deng, P.]]	+	[[Category: Deng, P]]
-	[[Category: Gao, M.]]	+	[[Category: Gao, M]]
-	[[Category: Gao, P.]]	+	[[Category: Gao, P]]
-	[[Category: Liu, X.]]	+	[[Category: Liu, X]]
-	[[Category: Melcher, K.]]	+	[[Category: Melcher, K]]
-	[[Category: Wang, F.]]	+	[[Category: Wang, F]]
-	[[Category: Xu, H E.]]	+	[[Category: Xu, H E]]
-	[[Category: Xu, Y.]]	+	[[Category: Xu, Y]]
-	[[Category: Xue, X.]]	+	[[Category: Xue, X]]
-	[[Category: Zeng, L.]]	+	[[Category: Zeng, L]]
-	[[Category: Zhang, Y.]]	+	[[Category: Zhang, Y]]
-	[[Category: Zhao, Y.]]	+	[[Category: Zhao, Y]]
-	[[Category: Zhong, D.]]	+	[[Category: Zhong, D]]
-	[[Category: Zhou, X E.]]	+	[[Category: Zhou, X E]]
-	[[Category: Zhu, J K.]]	+	[[Category: Zhu, J K]]
	[[Category: Abscisic acid mimicking compound]]		[[Category: Abscisic acid mimicking compound]]
	[[Category: Hydrolase-receptor complex]]		[[Category: Hydrolase-receptor complex]]
	[[Category: Pp2c]]		[[Category: Pp2c]]
	[[Category: Pyr/pyl/rcar]]		[[Category: Pyr/pyl/rcar]]

OCA at 07:55, 14 August 2013

2013-08-14T07:55:45Z

←Older revision		Revision as of 07:55, 14 August 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4lga\| PDB=4lga \| SCENE= }}
		+	===ABA-mimicking ligand N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE in complex with ABA receptor PYL2 and PP2C HAB1===
		+	{{ABSTRACT_PUBMED_23835477}}

-	~~The entry 4lga is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref> [[http://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref>

-	~~Authors~~: ~~Zhou, X~~.E.~~, Gao, M~~.~~, Liu, X~~.~~, Zhang, Y~~.~~, Xue, X., Melcher, K., Gao, P., Wang, F., Zeng, L., Zhao, Y., Zhao, Y., Deng, P., Zhong, D., Zhu, J~~.-~~K., Xu, Y., Xu, H.E~~.	+	==About this Structure==
		+	[[4lga]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LGA OCA].

-	~~Description~~: ~~ABA-~~mimicking ~~ligand number 2 in complex with ABA~~ receptor ~~PYL2 and PP2C HAB1~~	+	==Reference==
		+	<ref group="xtra">PMID:023835477</ref><references group="xtra"/><references/>
		+	[[Category: Arabidopsis thaliana]]
		+	[[Category: Phosphoprotein phosphatase]]
		+	[[Category: Deng, P.]]
		+	[[Category: Gao, M.]]
		+	[[Category: Gao, P.]]
		+	[[Category: Liu, X.]]
		+	[[Category: Melcher, K.]]
		+	[[Category: Wang, F.]]
		+	[[Category: Xu, H E.]]
		+	[[Category: Xu, Y.]]
		+	[[Category: Xue, X.]]
		+	[[Category: Zeng, L.]]
		+	[[Category: Zhang, Y.]]
		+	[[Category: Zhao, Y.]]
		+	[[Category: Zhong, D.]]
		+	[[Category: Zhou, X E.]]
		+	[[Category: Zhu, J K.]]
		+	[[Category: Abscisic acid mimicking compound]]
		+	[[Category: Hydrolase-receptor complex]]
		+	[[Category: Pp2c]]
		+	[[Category: Pyr/pyl/rcar]]

OCA at 15:09, 10 July 2013

2013-07-10T15:09:14Z

←Older revision		Revision as of 15:09, 10 July 2013
Line 3:		Line 3:
	The entry 4lga is ON HOLD		The entry 4lga is ON HOLD

-	Authors: Zhou, X.E., Gao, M., Liu X., Zhang Y., Xue X., Melcher K., Gao P., Wang F., Zeng L., Zhao Y., Zhao Y., Deng P., Zhong D., Zhu J.-K., Xu Y., Xu H. E.	+	Authors: Zhou, X.E., Gao, M., Liu, X., Zhang, Y., Xue, X., Melcher, K., Gao, P., Wang, F., Zeng, L., Zhao, Y., Zhao, Y., Deng, P., Zhong, D., Zhu, J.-K., Xu, Y., Xu, H.E.

	Description: ABA-mimicking ligand number 2 in complex with ABA receptor PYL2 and PP2C HAB1		Description: ABA-mimicking ligand number 2 in complex with ABA receptor PYL2 and PP2C HAB1

OCA: Protected "4lga" [edit=sysop:move=sysop]

2013-07-03T13:29:56Z

Protected "4lga" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:29, 3 July 2013

OCA: New page: '''Unreleased structure''' The entry 4lga is ON HOLD Authors: Zhou, X.E., Gao, M., Liu X., Zhang Y., Xue X., Melcher K., Gao P., Wang F., Zeng L., Zhao Y., Zhao Y., Deng P., Zhong D., Z...

2013-07-03T13:29:55Z

New page: '''Unreleased structure''' The entry 4lga is ON HOLD Authors: Zhou, X.E., Gao, M., Liu X., Zhang Y., Xue X., Melcher K., Gao P., Wang F., Zeng L., Zhao Y., Zhao Y., Deng P., Zhong D., Z...

New page

'''Unreleased structure'''

The entry 4lga is ON HOLD

Authors: Zhou, X.E., Gao, M., Liu X., Zhang Y., Xue X., Melcher K., Gao P., Wang F., Zeng L., Zhao Y., Zhao Y., Deng P., Zhong D., Zhu J.-K., Xu Y., Xu H. E.

Description: ABA-mimicking ligand number 2 in complex with ABA receptor PYL2 and PP2C HAB1