4llo - Revision history

OCA at 16:21, 20 September 2023

2023-09-20T16:21:06Z

←Older revision		Revision as of 16:21, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4llo]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LLO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4llo]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LLO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4llo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4llo OCA], [https://pdbe.org/4llo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4llo RCSB], [https://www.ebi.ac.uk/pdbsum/4llo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4llo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.995Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4llo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4llo OCA], [https://pdbe.org/4llo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4llo RCSB], [https://www.ebi.ac.uk/pdbsum/4llo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4llo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:09, 14 December 2022

2022-12-14T11:09:17Z

←Older revision		Revision as of 11:09, 14 December 2022
Line 1:		Line 1:

	==Structure of the eag domain-CNBHD complex of the mouse EAG1 channel==		==Structure of the eag domain-CNBHD complex of the mouse EAG1 channel==
-	<StructureSection load='4llo' size='340' side='right' caption='[[4llo]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4llo' size='340' side='right'caption='[[4llo]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4llo]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4LLO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4llo]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LLO FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Eag, Kcnh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4llo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4llo OCA], [https://pdbe.org/4llo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4llo RCSB], [https://www.ebi.ac.uk/pdbsum/4llo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4llo ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4llo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4llo OCA], [~~http~~://pdbe.org/4llo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4llo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4llo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4llo ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KCNH1_MOUSE KCNH1_MOUSE]] Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts (By similarity).	+	[https://www.uniprot.org/uniprot/KCNH1_MOUSE KCNH1_MOUSE] Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4llo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4llo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Carlson, A E~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Haitin, Y~~]]	+	[[Category: Carlson AE]]
-	[[Category: ~~Zagotta, W N~~]]	+	[[Category: Haitin Y]]
-	[[Category: ~~Transport protein]]~~	+	[[Category: Zagotta WN]]
-	~~[[Category: Voltage-gated potassium channel~~]]	+

OCA at 20:12, 4 August 2016

2016-08-04T20:12:11Z

←Older revision		Revision as of 20:12, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of the eag domain-CNBHD complex of the mouse EAG1 channel==		==Structure of the eag domain-CNBHD complex of the mouse EAG1 channel==
	<StructureSection load='4llo' size='340' side='right' caption='[[4llo]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4llo' size='340' side='right' caption='[[4llo]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4llo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LLO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4llo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LLO FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Eag, Kcnh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Eag, Kcnh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4llo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4llo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4llo RCSB], [http://www.ebi.ac.uk/pdbsum/4llo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4llo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4llo OCA], [http://pdbe.org/4llo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4llo RCSB], [http://www.ebi.ac.uk/pdbsum/4llo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4llo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4llo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Carlson, A E]]		[[Category: Carlson, A E]]
	[[Category: Haitin, Y]]		[[Category: Haitin, Y]]

OCA at 19:10, 24 December 2014

2014-12-24T19:10:58Z

←Older revision		Revision as of 19:10, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4llo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4llo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4llo RCSB], [http://www.ebi.ac.uk/pdbsum/4llo PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4llo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4llo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4llo RCSB], [http://www.ebi.ac.uk/pdbsum/4llo PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KCNH1_MOUSE KCNH1_MOUSE]] Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 15:10, 21 December 2014

2014-12-21T15:10:48Z

←Older revision		Revision as of 15:10, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4llo~~\| ~~PDB~~=4llo \| ~~SCENE~~= }}	+	==Structure of the eag domain-CNBHD complex of the mouse EAG1 channel==
-	===~~Structure~~ of the eag domain-CNBHD complex of the mouse EAG1 channel~~===~~	+	<StructureSection load='4llo' size='340' side='right' caption='[[4llo]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23975098}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4llo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LLO FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Eag, Kcnh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4llo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4llo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4llo RCSB], [http://www.ebi.ac.uk/pdbsum/4llo PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The KCNH voltage-dependent potassium channels (ether-a-go-go, EAG; EAG-related gene, ERG; EAG-like channels, ELK) are important regulators of cellular excitability and have key roles in diseases such as cardiac long QT syndrome type 2 (LQT2), epilepsy, schizophrenia and cancer. The intracellular domains of KCNH channels are structurally distinct from other voltage-gated channels. The amino-terminal region contains an eag domain, which is composed of a Per-Arnt-Sim (PAS) domain and a PAS-cap domain, whereas the carboxy-terminal region contains a cyclic nucleotide-binding homology domain (CNBHD), which is connected to the pore through a C-linker domain. Many disease-causing mutations localize to these specialized intracellular domains, which underlie the unique gating and regulation of KCNH channels. It has been suggested that the eag domain may regulate the channel by interacting with either the S4-S5 linker or the CNBHD. Here we present a 2 A resolution crystal structure of the eag domain-CNBHD complex of the mouse EAG1 (also known as KCNH1) channel. It displays extensive interactions between the eag domain and the CNBHD, indicating that the regulatory mechanism of the eag domain primarily involves the CNBHD. Notably, the structure reveals that a number of LQT2 mutations at homologous positions in human ERG, in addition to cancer-associated mutations in EAG channels, localize to the eag domain-CNBHD interface. Furthermore, mutations at the interface produced marked effects on channel gating, demonstrating the important physiological role of the eag domain-CNBHD interaction. Our structure of the eag domain-CNBHD complex of mouse EAG1 provides unique insights into the physiological and pathophysiological mechanisms of KCNH channels.

-	~~==Function==~~	+	The structural mechanism of KCNH-channel regulation by the eag domain.,Haitin Y, Carlson AE, Zagotta WN Nature. 2013 Sep 19;501(7467):444-8. doi: 10.1038/nature12487. Epub 2013 Aug 25. PMID:23975098<ref>PMID:23975098</ref>
-	~~[[http://www.uniprot.org/uniprot/KCNH1_MOUSE KCNH1_MOUSE]] Pore-forming (alpha) subunit~~ of ~~voltage-gated non~~-~~inactivating delayed rectifier potassium~~ channel~~. Channel properties may be modulated~~ by ~~cAMP and subunit assembly~~. ~~Mediates IK~~(~~NI) current in myoblasts (By similarity~~).	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4llo]] is~~ a ~~8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4LLO OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023975098</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Carlson, A E.]]	+	[[Category: Carlson, A E]]
-	[[Category: Haitin, Y.]]	+	[[Category: Haitin, Y]]
-	[[Category: Zagotta, W N.]]	+	[[Category: Zagotta, W N]]
	[[Category: Transport protein]]		[[Category: Transport protein]]
	[[Category: Voltage-gated potassium channel]]		[[Category: Voltage-gated potassium channel]]

OCA at 06:48, 29 September 2013

2013-09-29T06:48:25Z

←Older revision		Revision as of 06:48, 29 September 2013
Line 1:		Line 1:
	{{STRUCTURE_4llo\| PDB=4llo \| SCENE= }}		{{STRUCTURE_4llo\| PDB=4llo \| SCENE= }}
	===Structure of the eag domain-CNBHD complex of the mouse EAG1 channel===		===Structure of the eag domain-CNBHD complex of the mouse EAG1 channel===
		+	{{ABSTRACT_PUBMED_23975098}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[4llo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLO OCA].		[[4llo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLO OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023975098</ref><references group="xtra"/><references/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Carlson, A E.]]		[[Category: Carlson, A E.]]

OCA at 07:40, 28 August 2013

2013-08-28T07:40:18Z

←Older revision		Revision as of 07:40, 28 August 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4llo\| PDB=4llo \| SCENE= }}
		+	===Structure of the eag domain-CNBHD complex of the mouse EAG1 channel===

-	~~The entry 4llo is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/KCNH1_MOUSE KCNH1_MOUSE]] Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts (By similarity).

-	~~Authors~~: ~~Haitin, Y~~., Carlson, A.E., Zagotta, W.N.	+	==About this Structure==
-		+	[[4llo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLO OCA].
-	~~Description~~: ~~Structure of the eag domain~~-~~CNBHD complex of the mouse EAG1~~ channel	+	[[Category: Mus musculus]]
		+	[[Category: Carlson, A E.]]
		+	[[Category: Haitin, Y.]]
		+	[[Category: Zagotta, W N.]]
		+	[[Category: Transport protein]]
		+	[[Category: Voltage-gated potassium channel]]

OCA at 12:28, 24 July 2013

2013-07-24T12:28:30Z

←Older revision		Revision as of 12:28, 24 July 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4llo is ON HOLD	+	The entry 4llo is ON HOLD until Paper Publication

	Authors: Haitin, Y., Carlson, A.E., Zagotta, W.N.		Authors: Haitin, Y., Carlson, A.E., Zagotta, W.N.

	Description: Structure of the eag domain-CNBHD complex of the mouse EAG1 channel		Description: Structure of the eag domain-CNBHD complex of the mouse EAG1 channel

OCA: Protected "4llo" [edit=sysop:move=sysop]

2013-07-18T04:47:56Z

Protected "4llo" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:47, 18 July 2013

OCA: New page: '''Unreleased structure''' The entry 4llo is ON HOLD Authors: Haitin, Y., Carlson, A.E., Zagotta, W.N. Description: Structure of the eag domain-CNBHD complex of the mouse EAG1 channel

2013-07-18T04:47:55Z

New page: '''Unreleased structure''' The entry 4llo is ON HOLD Authors: Haitin, Y., Carlson, A.E., Zagotta, W.N. Description: Structure of the eag domain-CNBHD complex of the mouse EAG1 channel

New page

'''Unreleased structure'''

The entry 4llo is ON HOLD

Authors: Haitin, Y., Carlson, A.E., Zagotta, W.N.

Description: Structure of the eag domain-CNBHD complex of the mouse EAG1 channel