4lsx - Revision history

OCA at 16:24, 20 September 2023

2023-09-20T16:24:52Z

←Older revision		Revision as of 16:24, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4lsx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LSX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4lsx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LSX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BLD:BRASSINOLIDE'>BLD</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.302Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BLD:BRASSINOLIDE'>BLD</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lsx OCA], [https://pdbe.org/4lsx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lsx RCSB], [https://www.ebi.ac.uk/pdbsum/4lsx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lsx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lsx OCA], [https://pdbe.org/4lsx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lsx RCSB], [https://www.ebi.ac.uk/pdbsum/4lsx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lsx ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:30, 21 December 2022

2022-12-21T10:30:01Z

←Older revision		Revision as of 10:30, 21 December 2022
Line 1:		Line 1:

	==Plant steroid receptor ectodomain bound to brassinolide and SERK1 co-receptor ectodomain==		==Plant steroid receptor ectodomain bound to brassinolide and SERK1 co-receptor ectodomain==
-	<StructureSection load='4lsx' size='340' side='right' caption='[[4lsx]], [[Resolution\|resolution]] 3.30Å' scene=''>	+	<StructureSection load='4lsx' size='340' side='right'caption='[[4lsx]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4lsx]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LSX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4LSX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4lsx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LSX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BLD:BRASSINOLIDE'>BLD</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-~~MANNOSE~~'>~~MAN~~</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BLD:BRASSINOLIDE'>BLD</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3riz\|3riz]], [[3rj0\|3rj0]], [[4lsa\|4lsa]], [[4lsc\|4lsc]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lsx OCA], [https://pdbe.org/4lsx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lsx RCSB], [https://www.ebi.ac.uk/pdbsum/4lsx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lsx ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At4g39400, BRI1, F23K16.30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH]), At1g71830, F14O23.21, F14O23_24, SERK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4lsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lsx OCA], [~~http~~://pdbe.org/4lsx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4lsx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4lsx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4lsx ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BRI1_ARATH BRI1_ARATH]] Receptor with a dual specificity kinase activity acting on both serine/threonine- and tyrosine-containing substrates. Regulates, in response to brassinosteroid binding, a signaling cascade involved in plant development, including expression of light- and stress-regulated genes, promotion of cell elongation, normal leaf and chloroplast senescence, and flowering. Binds brassinolide, and less effectively castasterone, but not 2,3,22,23-O-tetramethylbrassinolide or ecdysone. May be involved in a feedback regulation of brassinosteroid biosynthesis. Phosphorylates BRI1-associated receptor kinase 1 (BAK1), Transthyretin-Like protein (TTL) and SERK1 on 'Ser-299' and 'Thr-462' in vitro. May have a guanylyl cyclase activity.<ref>PMID:10557222</ref> <ref>PMID:10938344</ref> <ref>PMID:17138891</ref> <ref>PMID:17520012</ref> <ref>PMID:18694562</ref> <ref>PMID:19124768</ref> [[http://www.uniprot.org/uniprot/SERK1_ARATH SERK1_ARATH]] Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Phosphorylates BRI1 on 'Ser-887' and CDC48 on at least one threonine residue and on 'Ser-41'. Confers embryogenic competence. Acts redundantly with SERK2 as a control point for sporophytic development controlling male gametophyte production. Involved in the brassinolide signaling pathway.<ref>PMID:11509554</ref> <ref>PMID:17693538</ref>	+	[https://www.uniprot.org/uniprot/BRI1_ARATH BRI1_ARATH] Receptor with a dual specificity kinase activity acting on both serine/threonine- and tyrosine-containing substrates. Regulates, in response to brassinosteroid binding, a signaling cascade involved in plant development, including expression of light- and stress-regulated genes, promotion of cell elongation, normal leaf and chloroplast senescence, and flowering. Binds brassinolide, and less effectively castasterone, but not 2,3,22,23-O-tetramethylbrassinolide or ecdysone. May be involved in a feedback regulation of brassinosteroid biosynthesis. Phosphorylates BRI1-associated receptor kinase 1 (BAK1), Transthyretin-Like protein (TTL) and SERK1 on 'Ser-299' and 'Thr-462' in vitro. May have a guanylyl cyclase activity.<ref>PMID:10557222</ref> <ref>PMID:10938344</ref> <ref>PMID:17138891</ref> <ref>PMID:17520012</ref> <ref>PMID:18694562</ref> <ref>PMID:19124768</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
-	[[Category: ~~Henzler, C~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Hothorn, M~~]]	+	[[Category: Henzler C]]
-	[[Category: ~~Santiago, J~~]]	+	[[Category: Hothorn M]]
-	[[Category: ~~Brassinosteroid binding]]~~	+	[[Category: Santiago J]]
-	~~[[Category: Lrr-domain]]~~	+
-	~~[[Category: Membrane signaling complex receptor co-receptor complex]]~~	+
-	~~[[Category: N-glycosylation]]~~	+
-	~~[[Category: Steroid binding protein-protein binding complex~~]]	+

OCA at 00:19, 5 August 2016

2016-08-05T00:19:20Z

←Older revision		Revision as of 00:19, 5 August 2016
Line 1:		Line 1:
		+
	==Plant steroid receptor ectodomain bound to brassinolide and SERK1 co-receptor ectodomain==		==Plant steroid receptor ectodomain bound to brassinolide and SERK1 co-receptor ectodomain==
	<StructureSection load='4lsx' size='340' side='right' caption='[[4lsx]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='4lsx' size='340' side='right' caption='[[4lsx]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4lsx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LSX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LSX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4lsx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LSX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LSX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BLD:BRASSINOLIDE'>BLD</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BLD:BRASSINOLIDE'>BLD</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3riz\|3riz]], [[3rj0\|3rj0]], [[4lsa\|4lsa]], [[4lsc\|4lsc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3riz\|3riz]], [[3rj0\|3rj0]], [[4lsa\|4lsa]], [[4lsc\|4lsc]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At4g39400, BRI1, F23K16.30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ~~Arabidopsis thaliana~~]), At1g71830, F14O23.21, F14O23_24, SERK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ~~Arabidopsis thaliana~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At4g39400, BRI1, F23K16.30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH]), At1g71830, F14O23.21, F14O23_24, SERK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lsx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lsx RCSB], [http://www.ebi.ac.uk/pdbsum/4lsx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lsx OCA], [http://pdbe.org/4lsx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lsx RCSB], [http://www.ebi.ac.uk/pdbsum/4lsx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lsx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/SERK1_ARATH SERK1_ARATH]] Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Phosphorylates BRI1 on 'Ser-887' and CDC48 on at least one threonine residue and on 'Ser-41'. Confers embryogenic competence. Acts redundantly with SERK2 as a control point for sporophytic development controlling male gametophyte production. Involved in the brassinolide signaling pathway.<ref>PMID:11509554</ref> <ref>PMID:17693538</ref>	+	[[http://www.uniprot.org/uniprot/BRI1_ARATH BRI1_ARATH]] Receptor with a dual specificity kinase activity acting on both serine/threonine- and tyrosine-containing substrates. Regulates, in response to brassinosteroid binding, a signaling cascade involved in plant development, including expression of light- and stress-regulated genes, promotion of cell elongation, normal leaf and chloroplast senescence, and flowering. Binds brassinolide, and less effectively castasterone, but not 2,3,22,23-O-tetramethylbrassinolide or ecdysone. May be involved in a feedback regulation of brassinosteroid biosynthesis. Phosphorylates BRI1-associated receptor kinase 1 (BAK1), Transthyretin-Like protein (TTL) and SERK1 on 'Ser-299' and 'Thr-462' in vitro. May have a guanylyl cyclase activity.<ref>PMID:10557222</ref> <ref>PMID:10938344</ref> <ref>PMID:17138891</ref> <ref>PMID:17520012</ref> <ref>PMID:18694562</ref> <ref>PMID:19124768</ref> [[http://www.uniprot.org/uniprot/SERK1_ARATH SERK1_ARATH]] Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Phosphorylates BRI1 on 'Ser-887' and CDC48 on at least one threonine residue and on 'Ser-41'. Confers embryogenic competence. Acts redundantly with SERK2 as a control point for sporophytic development controlling male gametophyte production. Involved in the brassinolide signaling pathway.<ref>PMID:11509554</ref> <ref>PMID:17693538</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4lsx" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arabidopsis thaliana~~]]	+	[[Category: Arath]]
	[[Category: Henzler, C]]		[[Category: Henzler, C]]
	[[Category: Hothorn, M]]		[[Category: Hothorn, M]]

OCA at 14:19, 25 December 2014

2014-12-25T14:19:33Z

←Older revision		Revision as of 14:19, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lsx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lsx RCSB], [http://www.ebi.ac.uk/pdbsum/4lsx PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lsx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lsx RCSB], [http://www.ebi.ac.uk/pdbsum/4lsx PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SERK1_ARATH SERK1_ARATH]] Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Phosphorylates BRI1 on 'Ser-887' and CDC48 on at least one threonine residue and on 'Ser-41'. Confers embryogenic competence. Acts redundantly with SERK2 as a control point for sporophytic development controlling male gametophyte production. Involved in the brassinolide signaling pathway.<ref>PMID:11509554</ref> <ref>PMID:17693538</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:42, 21 December 2014

2014-12-21T14:42:47Z

←Older revision		Revision as of 14:42, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4lsx\| PDB=4lsx \| SCENE= }}~~	+	==Plant steroid receptor ectodomain bound to brassinolide and SERK1 co-receptor ectodomain==
-	===Plant steroid receptor ectodomain bound to brassinolide and SERK1 co-receptor ectodomain===	+	<StructureSection load='4lsx' size='340' side='right' caption='[[4lsx]], [[Resolution\|resolution]] 3.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23929946}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4lsx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LSX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LSX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BLD:BRASSINOLIDE'>BLD</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3riz\|3riz]], [[3rj0\|3rj0]], [[4lsa\|4lsa]], [[4lsc\|4lsc]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At4g39400, BRI1, F23K16.30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana]), At1g71830, F14O23.21, F14O23_24, SERK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lsx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lsx RCSB], [http://www.ebi.ac.uk/pdbsum/4lsx PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Brassinosteroids, which control plant growth and development, are sensed by the leucine-rich repeat (LRR) domain of the membrane receptor kinase BRASSINOSTEROID INSENSITIVE 1 (BRI1), but it is unknown how steroid binding at the cell surface activates the cytoplasmic kinase domain of the receptor. A family of somatic embryogenesis receptor kinases (SERKs) has been genetically implicated in mediating early brassinosteroid signaling events. We found a direct and steroid-dependent interaction between the BRI1 and SERK1 LRR domains by analysis of their complex crystal structure at 3.3 angstrom resolution. We show that the SERK1 LRR domain is involved in steroid sensing and, through receptor-co-receptor heteromerization, in the activation of the BRI1 signaling pathway. Our work reveals how known missense mutations in BRI1 and in SERKs modulate brassinosteroid signaling and the targeting mechanism of BRI1 receptor antagonists.

-	~~==Function==~~	+	Molecular mechanism for plant steroid receptor activation by somatic embryogenesis co-receptor kinases.,Santiago J, Henzler C, Hothorn M Science. 2013 Aug 23;341(6148):889-92. doi: 10.1126/science.1242468. Epub 2013, Aug 8. PMID:23929946<ref>PMID:23929946</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/SERK1_ARATH SERK1_ARATH]] Dual specificity kinase acting on both serine/threonine~~- ~~and tyrosine-containing substrates~~. ~~Phosphorylates BRI1 on 'Ser-887' and CDC48 on at least one threonine residue and on 'Ser-41'~~. ~~Confers embryogenic competence~~. ~~Acts redundantly with SERK2 as a control point for sporophytic development controlling male gametophyte production~~. ~~Involved in the brassinolide signaling pathway~~.~~<ref>~~PMID:~~11509554</ref>~~ <ref>PMID:~~17693538~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4lsx]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4LSX OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023929946</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
-	[[Category: Henzler, C.]]	+	[[Category: Henzler, C]]
-	[[Category: Hothorn, M.]]	+	[[Category: Hothorn, M]]
-	[[Category: Santiago, J.]]	+	[[Category: Santiago, J]]
	[[Category: Brassinosteroid binding]]		[[Category: Brassinosteroid binding]]
	[[Category: Lrr-domain]]		[[Category: Lrr-domain]]

OCA at 10:45, 4 September 2013

2013-09-04T10:45:54Z

←Older revision		Revision as of 10:45, 4 September 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4lsx\| PDB=4lsx \| SCENE= }}
		+	===Plant steroid receptor ectodomain bound to brassinolide and SERK1 co-receptor ectodomain===
		+	{{ABSTRACT_PUBMED_23929946}}

-	~~The entry 4lsx is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/SERK1_ARATH SERK1_ARATH]] Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Phosphorylates BRI1 on 'Ser-887' and CDC48 on at least one threonine residue and on 'Ser-41'. Confers embryogenic competence. Acts redundantly with SERK2 as a control point for sporophytic development controlling male gametophyte production. Involved in the brassinolide signaling pathway.<ref>PMID:11509554</ref> <ref>PMID:17693538</ref>

-	~~Authors~~: ~~Santiago, J~~.~~, Henzler, C~~.~~, Hothorn, M~~.	+	==About this Structure==
		+	[[4lsx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LSX OCA].

-	~~Description~~:	+	==Reference==
		+	<ref group="xtra">PMID:023929946</ref><references group="xtra"/><references/>
		+	[[Category: Arabidopsis thaliana]]
		+	[[Category: Henzler, C.]]
		+	[[Category: Hothorn, M.]]
		+	[[Category: Santiago, J.]]
		+	[[Category: Brassinosteroid binding]]
		+	[[Category: Lrr-domain]]
		+	[[Category: Membrane signaling complex receptor co-receptor complex]]
		+	[[Category: N-glycosylation]]
		+	[[Category: Steroid binding protein-protein binding complex]]

OCA at 07:52, 21 August 2013

2013-08-21T07:52:16Z

←Older revision		Revision as of 07:52, 21 August 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4lsx is ON HOLD	+	The entry 4lsx is ON HOLD until Paper Publication

	Authors: Santiago, J., Henzler, C., Hothorn, M.		Authors: Santiago, J., Henzler, C., Hothorn, M.

	Description:		Description:

OCA at 07:19, 14 August 2013

2013-08-14T07:19:06Z

←Older revision		Revision as of 07:19, 14 August 2013
Line 5:		Line 5:
	Authors: Santiago, J., Henzler, C., Hothorn, M.		Authors: Santiago, J., Henzler, C., Hothorn, M.

-	Description: ..	+	Description:

OCA: Protected "4lsx" [edit=sysop:move=sysop]

2013-08-01T04:22:26Z

Protected "4lsx" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:22, 1 August 2013

OCA: New page: '''Unreleased structure''' The entry 4lsx is ON HOLD Authors: Santiago, J., Henzler, C., Hothorn, M. Description: ..

2013-08-01T04:22:25Z

New page: '''Unreleased structure''' The entry 4lsx is ON HOLD Authors: Santiago, J., Henzler, C., Hothorn, M. Description: ..

New page

'''Unreleased structure'''

The entry 4lsx is ON HOLD

Authors: Santiago, J., Henzler, C., Hothorn, M.

Description: ..