4m6j - Revision history

OCA at 16:32, 20 September 2023

2023-09-20T16:32:40Z

←Older revision		Revision as of 16:32, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4m6j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M6J FirstGlance]. <br>		<table><tr><td colspan='2'>[[4m6j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M6J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.201Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m6j OCA], [https://pdbe.org/4m6j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m6j RCSB], [https://www.ebi.ac.uk/pdbsum/4m6j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m6j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m6j OCA], [https://pdbe.org/4m6j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m6j RCSB], [https://www.ebi.ac.uk/pdbsum/4m6j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m6j ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:59, 21 December 2022

2022-12-21T10:59:28Z

←Older revision		Revision as of 10:59, 21 December 2022
Line 1:		Line 1:

	==Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH==		==Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH==
-	<StructureSection load='4m6j' size='340' side='right' caption='[[4m6j]], [[Resolution\|resolution]] 1.20Å' scene=''>	+	<StructureSection load='4m6j' size='340' side='right'caption='[[4m6j]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4m6j]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4M6J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4m6j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M6J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4m6k\|4m6k]], [[4m6l\|4m6l]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m6j OCA], [https://pdbe.org/4m6j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m6j RCSB], [https://www.ebi.ac.uk/pdbsum/4m6j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m6j ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4m6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m6j OCA], [~~http~~://pdbe.org/4m6j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4m6j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4m6j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4m6j ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[~~http~~://omim.org/entry/613839 613839]]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>	+	[https://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[https://omim.org/entry/613839 613839]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>	+	[https://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:

	==See Also==		==See Also==
-	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]	+	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dihydrofolate reductase~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Bhabha, G]]	+	[[Category: Bhabha G]]
-	[[Category: Ekiert~~, D C~~]]	+	[[Category: Ekiert DC]]
-	[[Category: Wilson~~, I A~~]]	+	[[Category: Wilson IA]]
-	[[Category: Wright~~, P E]]~~	+	[[Category: Wright PE]]
-	~~[[Category: Folate binding]]~~	+
-	~~[[Category: Nadph binding]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Rossmann fold~~]]	+

OCA at 11:16, 4 August 2016

2016-08-04T11:16:17Z

←Older revision		Revision as of 11:16, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH==		==Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH==
	<StructureSection load='4m6j' size='340' side='right' caption='[[4m6j]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='4m6j' size='340' side='right' caption='[[4m6j]], [[Resolution\|resolution]] 1.20Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m6j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m6j RCSB], [http://www.ebi.ac.uk/pdbsum/4m6j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m6j OCA], [http://pdbe.org/4m6j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m6j RCSB], [http://www.ebi.ac.uk/pdbsum/4m6j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m6j ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 22:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4m6j" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 15:16, 21 December 2014

2014-12-21T15:16:18Z

←Older revision		Revision as of 15:16, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4m6j\| PDB=4m6j \| SCENE= }}~~	+	==Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH==
-	===Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH===	+	<StructureSection load='4m6j' size='340' side='right' caption='[[4m6j]], [[Resolution\|resolution]] 1.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24077226}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4m6j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M6J FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4m6k\|4m6k]], [[4m6l\|4m6l]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m6j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m6j RCSB], [http://www.ebi.ac.uk/pdbsum/4m6j PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[http://omim.org/entry/613839 613839]]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>		[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[http://omim.org/entry/613839 613839]]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Molecular evolution is driven by mutations, which may affect the fitness of an organism and are then subject to natural selection or genetic drift. Analysis of primary protein sequences and tertiary structures has yielded valuable insights into the evolution of protein function, but little is known about the evolution of functional mechanisms, protein dynamics and conformational plasticity essential for activity. We characterized the atomic-level motions across divergent members of the dihydrofolate reductase (DHFR) family. Despite structural similarity, Escherichia coli and human DHFRs use different dynamic mechanisms to perform the same function, and human DHFR cannot complement DHFR-deficient E. coli cells. Identification of the primary-sequence determinants of flexibility in DHFRs from several species allowed us to propose a likely scenario for the evolution of functionally important DHFR dynamics following a pattern of divergent evolution that is tuned by cellular environment.

-	~~==Function==~~	+	Divergent evolution of protein conformational dynamics in dihydrofolate reductase.,Bhabha G, Ekiert DC, Jennewein M, Zmasek CM, Tuttle LM, Kroon G, Dyson HJ, Godzik A, Wilson IA, Wright PE Nat Struct Mol Biol. 2013 Sep 29. doi: 10.1038/nsmb.2676. PMID:24077226<ref>PMID:24077226</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism~~. ~~Contributes to the de novo mitochondrial thymidylate biosynthesis pathway~~. ~~Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis~~. ~~Binds its own mRNA and that of DHFRL1~~.~~<ref>~~PMID:~~21876188</ref>~~ <ref>PMID:~~12096917~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4m6j]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4M6J OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024077226</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Bhabha, G.]]	+	[[Category: Bhabha, G]]
-	[[Category: Ekiert, D C.]]	+	[[Category: Ekiert, D C]]
-	[[Category: Wilson, I A.]]	+	[[Category: Wilson, I A]]
-	[[Category: Wright, P E.]]	+	[[Category: Wright, P E]]
	[[Category: Folate binding]]		[[Category: Folate binding]]
	[[Category: Nadph binding]]		[[Category: Nadph binding]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]

OCA at 12:12, 20 November 2013

2013-11-20T12:12:10Z

←Older revision		Revision as of 12:12, 20 November 2013
Line 10:		Line 10:

	==About this Structure==		==About this Structure==
-	[[4m6j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6J OCA].	+	[[4m6j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6J OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:024077226</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024077226</ref><references group="xtra"/><references/>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bhabha, G.]]		[[Category: Bhabha, G.]]
	[[Category: Ekiert, D C.]]		[[Category: Ekiert, D C.]]

OCA at 06:50, 16 October 2013

2013-10-16T06:50:33Z

←Older revision		Revision as of 06:50, 16 October 2013
Line 1:		Line 1:
	{{STRUCTURE_4m6j\| PDB=4m6j \| SCENE= }}		{{STRUCTURE_4m6j\| PDB=4m6j \| SCENE= }}
	===Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH===		===Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH===
		+	{{ABSTRACT_PUBMED_24077226}}

	==Disease==		==Disease==
Line 12:		Line 13:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:024077226</ref><references group="xtra"/><references/>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 08:21, 29 September 2013

2013-09-29T08:21:21Z

←Older revision		Revision as of 08:21, 29 September 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4m6j\| PDB=4m6j \| SCENE= }}
		+	===Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH===

-	~~The~~ entry ~~4m6j~~ is ~~ON HOLD~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[http://omim.org/entry/613839 613839]]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>

-	~~Authors~~: ~~Bhabha, G~~.~~, Ekiert, D~~.C.~~, Wright, P.E~~., ~~Wilson, I~~.A.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>

-	~~Description: Crystal~~ structure ~~of human dihydrofolate~~ reductase ~~(DHFR) bound to NADPH~~	+	==About this Structure==
		+	[[4m6j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6J OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Dihydrofolate reductase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Bhabha, G.]]
		+	[[Category: Ekiert, D C.]]
		+	[[Category: Wilson, I A.]]
		+	[[Category: Wright, P E.]]
		+	[[Category: Folate binding]]
		+	[[Category: Nadph binding]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Rossmann fold]]

OCA: Protected "4m6j" [edit=sysop:move=sysop]

2013-08-21T07:56:31Z

Protected "4m6j" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:56, 21 August 2013

OCA: New page: '''Unreleased structure''' The entry 4m6j is ON HOLD Authors: Bhabha, G., Ekiert, D.C., Wright, P.E., Wilson, I.A. Description: Crystal structure of human dihydrofolate reductase (DHFR...

2013-08-21T07:56:30Z

New page: '''Unreleased structure''' The entry 4m6j is ON HOLD Authors: Bhabha, G., Ekiert, D.C., Wright, P.E., Wilson, I.A. Description: Crystal structure of human dihydrofolate reductase (DHFR...

New page

'''Unreleased structure'''

The entry 4m6j is ON HOLD

Authors: Bhabha, G., Ekiert, D.C., Wright, P.E., Wilson, I.A.

Description: Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH