4m9k - Revision history

OCA at 16:34, 20 September 2023

2023-09-20T16:34:38Z

←Older revision		Revision as of 16:34, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4m9k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M9K FirstGlance]. <br>		<table><tr><td colspan='2'>[[4m9k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M9K FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m9k OCA], [https://pdbe.org/4m9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m9k RCSB], [https://www.ebi.ac.uk/pdbsum/4m9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m9k ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.46Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m9k OCA], [https://pdbe.org/4m9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m9k RCSB], [https://www.ebi.ac.uk/pdbsum/4m9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m9k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:04, 21 December 2022

2022-12-21T11:04:22Z

←Older revision		Revision as of 11:04, 21 December 2022
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	==NS2B-NS3 protease from dengue virus at pH 5.5==		==NS2B-NS3 protease from dengue virus at pH 5.5==
-	<StructureSection load='4m9k' size='340' side='right' caption='[[4m9k]], [[Resolution\|resolution]] 1.46Å' scene=''>	+	<StructureSection load='4m9k' size='340' side='right'caption='[[4m9k]], [[Resolution\|resolution]] 1.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4m9k]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M9K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4M9K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4m9k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M9K FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fom\|2fom]], [[3u1i\|3u1i]], [[3u1j\|3u1j]], [[4m9f\|4m9f]], [[4m9i\|4m9i]], [[4m9m\|4m9m]], [[4m9t\|4m9t]]</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m9k OCA], [https://pdbe.org/4m9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m9k RCSB], [https://www.ebi.ac.uk/pdbsum/4m9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m9k ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dengue virus serotype 2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11060 Dengue virus 2])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4m9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m9k OCA], [~~http~~://pdbe.org/4m9k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4m9k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4m9k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4m9k ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~Q91H74_9FLAV Q91H74_9FLAV]~~] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).~~[SAAS~~:~~SAAS026470_004_099774]~~	+	[https://www.uniprot.org/uniprot/POLG_DEN2P POLG_DEN2P] Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA (By similarity). prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity). Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity). Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity). Non-structural protein 2A may be involved viral RNA replication and capsid assembly (Potential). Non-structural protein 2B is a required cofactor for the serine protease function of NS3 (By similarity). Serine protease NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS2B, performs its autocleavage and cleaves the polyprotein at dibasic sites in the cytoplasm: C-prM, NS2A-NS2B, NS2B-NS3, NS3-NS4A, NS4A-2K and NS4B-NS5. NS3 RNA helicase binds RNA and unwinds dsRNA in the 3' to 5' direction (By similarity). Non-structural protein 4A induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the NS3 helicase (By similarity). Peptide 2k functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter (By similarity). Non-structural protein 4B inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway (By similarity). RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome, and performs the capping of genomes in the cytoplasm. NS5 methylates viral RNA cap at guanine N-7 and ribose 2'-O positions. Besides its role in genome replication, also prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) signaling pathway. Inhibits host TYK2 and STAT2 phosphorylation, thereby preventing activation of JAK-STAT signaling pathway (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4m9k" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4m9k" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Virus protease 3D structures\|Virus protease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
-	[[Category: ~~Hardy, J A~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Yildiz, M~~]]	+	[[Category: Hardy JA]]
-	[[Category: ~~Allosteric inhibition]]~~	+	[[Category: Yildiz M]]
-	~~[[Category: Conformational flexibility]]~~	+
-	~~[[Category: Dengue virus protease]]~~	+
-	~~[[Category: Serine protease]]~~	+
-	~~[[Category: Trypsin-like protease]]~~	+
-	~~[[Category: Viral protease]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 23:22, 5 August 2016

2016-08-05T23:22:01Z

←Older revision		Revision as of 23:22, 5 August 2016
Line 1:		Line 1:
		+
	==NS2B-NS3 protease from dengue virus at pH 5.5==		==NS2B-NS3 protease from dengue virus at pH 5.5==
	<StructureSection load='4m9k' size='340' side='right' caption='[[4m9k]], [[Resolution\|resolution]] 1.46Å' scene=''>		<StructureSection load='4m9k' size='340' side='right' caption='[[4m9k]], [[Resolution\|resolution]] 1.46Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fom\|2fom]], [[3u1i\|3u1i]], [[3u1j\|3u1j]], [[4m9f\|4m9f]], [[4m9i\|4m9i]], [[4m9m\|4m9m]], [[4m9t\|4m9t]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fom\|2fom]], [[3u1i\|3u1i]], [[3u1j\|3u1j]], [[4m9f\|4m9f]], [[4m9i\|4m9i]], [[4m9m\|4m9m]], [[4m9t\|4m9t]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dengue virus serotype 2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11060 Dengue virus 2])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dengue virus serotype 2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11060 Dengue virus 2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m9k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m9k RCSB], [http://www.ebi.ac.uk/pdbsum/4m9k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m9k OCA], [http://pdbe.org/4m9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m9k RCSB], [http://www.ebi.ac.uk/pdbsum/4m9k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m9k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4m9k" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:49, 25 December 2014

2014-12-25T22:49:02Z

←Older revision		Revision as of 22:49, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m9k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m9k RCSB], [http://www.ebi.ac.uk/pdbsum/4m9k PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m9k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m9k RCSB], [http://www.ebi.ac.uk/pdbsum/4m9k PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q91H74_9FLAV Q91H74_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 18:50, 21 December 2014

2014-12-21T18:50:36Z

←Older revision		Revision as of 18:50, 21 December 2014
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-	~~{{STRUCTURE_4m9k\| PDB=4m9k \| SCENE= }}~~	+	==NS2B-NS3 protease from dengue virus at pH 5.5==
-	===NS2B-NS3 protease from dengue virus at pH 5.5===	+	<StructureSection load='4m9k' size='340' side='right' caption='[[4m9k]], [[Resolution\|resolution]] 1.46Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24164286}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4m9k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M9K FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fom\|2fom]], [[3u1i\|3u1i]], [[3u1j\|3u1j]], [[4m9f\|4m9f]], [[4m9i\|4m9i]], [[4m9m\|4m9m]], [[4m9t\|4m9t]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dengue virus serotype 2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11060 Dengue virus 2])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m9k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m9k RCSB], [http://www.ebi.ac.uk/pdbsum/4m9k PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dengue virus is the flavivirus that causes dengue fever, dengue hemorrhagic disease, and dengue shock syndrome, which are currently increasing in incidence worldwide. Dengue virus protease (NS2B-NS3pro) is essential for dengue virus infection and is thus a target of therapeutic interest. To date, attention has focused on developing active-site inhibitors of NS2B-NS3pro. The flat and charged nature of the NS2B-NS3pro active site may contribute to difficulties in developing inhibitors and suggests that a strategy of identifying allosteric sites may be useful. We report an approach that allowed us to scan the NS2B-NS3pro surface by cysteine mutagenesis and use cysteine reactive probes to identify regions of the protein that are susceptible to allosteric inhibition. This method identified a new allosteric site utilizing a circumscribed panel of just eight cysteine variants and only five cysteine reactive probes. The allosterically sensitive site is centered at Ala125, between the 120s loop and the 150s loop. The crystal structures of WT and modified NS2B-NS3pro demonstrate that the 120s loop is flexible. Our work suggests that binding at this site prevents a conformational rearrangement of the NS2B region of the protein, which is required for activation. Preventing this movement locks the protein into the open, inactive conformation, suggesting that this site may be useful in the future development of therapeutic allosteric inhibitors.

-	~~==Function==~~	+	Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus.,Yildiz M, Ghosh S, Bell JA, Sherman W, Hardy JA ACS Chem Biol. 2013 Oct 28. PMID:24164286<ref>PMID:24164286</ref>
-	~~[[http://www.uniprot.org/uniprot/Q91H74_9FLAV Q91H74_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin~~-~~mediated endocytosis~~. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, ~~envelope protein E dissociate from small envelope protein~~ M ~~and homodimerizes (By similarity)~~.~~[SAAS~~:~~SAAS026470_004_099774]~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4m9k]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Dengue_virus_2 Dengue virus 2]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4M9K OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:024164286</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
-	[[Category: Hardy, J A.]]	+	[[Category: Hardy, J A]]
-	[[Category: Yildiz, M.]]	+	[[Category: Yildiz, M]]
	[[Category: Allosteric inhibition]]		[[Category: Allosteric inhibition]]
	[[Category: Conformational flexibility]]		[[Category: Conformational flexibility]]

OCA at 09:08, 5 February 2014

2014-02-05T09:08:46Z

←Older revision		Revision as of 09:08, 5 February 2014
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4m9k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M9K OCA].	+	[[4m9k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M9K OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:024164286</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024164286</ref><references group="xtra"/><references/>
		+	[[Category: Dengue virus 2]]
	[[Category: Hardy, J A.]]		[[Category: Hardy, J A.]]
	[[Category: Yildiz, M.]]		[[Category: Yildiz, M.]]

OCA at 10:22, 27 November 2013

2013-11-27T10:22:27Z

←Older revision		Revision as of 10:22, 27 November 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4m9k\| PDB=4m9k \| SCENE= }}
		+	===NS2B-NS3 protease from dengue virus at pH 5.5===
		+	{{ABSTRACT_PUBMED_24164286}}

-	~~The entry 4m9k~~ is ~~ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/Q91H74_9FLAV Q91H74_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]

-	~~Authors~~: ~~Yildiz, M~~.~~, Hardy, J~~.A.	+	==About this Structure==
		+	[[4m9k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M9K OCA].

-	~~Description~~: ~~NS2B~~-~~NS3~~ protease ~~from dengue virus at pH 5.5~~	+	==Reference==
		+	<ref group="xtra">PMID:024164286</ref><references group="xtra"/><references/>
		+	[[Category: Hardy, J A.]]
		+	[[Category: Yildiz, M.]]
		+	[[Category: Allosteric inhibition]]
		+	[[Category: Conformational flexibility]]
		+	[[Category: Dengue virus protease]]
		+	[[Category: Serine protease]]
		+	[[Category: Trypsin-like protease]]
		+	[[Category: Viral protease]]
		+	[[Category: Viral protein]]

OCA at 06:54, 6 November 2013

2013-11-06T06:54:57Z

←Older revision		Revision as of 06:54, 6 November 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4m9k is ON HOLD	+	The entry 4m9k is ON HOLD until Paper Publication

	Authors: Yildiz, M., Hardy, J.A.		Authors: Yildiz, M., Hardy, J.A.

	Description: NS2B-NS3 protease from dengue virus at pH 5.5		Description: NS2B-NS3 protease from dengue virus at pH 5.5

OCA at 07:34, 29 September 2013

2013-09-29T07:34:43Z

←Older revision		Revision as of 07:34, 29 September 2013
Line 3:		Line 3:
	The entry 4m9k is ON HOLD		The entry 4m9k is ON HOLD

-	Authors: Yildiz M., Hardy J.A.	+	Authors: Yildiz, M., Hardy, J.A.

	Description: NS2B-NS3 protease from dengue virus at pH 5.5		Description: NS2B-NS3 protease from dengue virus at pH 5.5

OCA: Protected "4m9k" [edit=sysop:move=sysop]

2013-08-21T08:00:05Z

Protected "4m9k" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:00, 21 August 2013