4mbs - Revision history

OCA at 16:35, 20 September 2023

2023-09-20T16:35:28Z

←Older revision		Revision as of 16:35, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mbs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_pasteurianum Clostridium pasteurianum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MBS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mbs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_pasteurianum Clostridium pasteurianum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MBS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MRV:4,4-DIFLUORO-N-[(1S)-3-{(3-EXO)-3-[3-METHYL-5-(PROPAN-2-YL)-4H-1,2,4-TRIAZOL-4-YL]-8-AZABICYCLO[3.2.1]OCT-8-YL}-1-PHENYLPROPYL]CYCLOHEXANECARBOXAMIDE'>MRV</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.71Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MRV:4,4-DIFLUORO-N-[(1S)-3-{(3-EXO)-3-[3-METHYL-5-(PROPAN-2-YL)-4H-1,2,4-TRIAZOL-4-YL]-8-AZABICYCLO[3.2.1]OCT-8-YL}-1-PHENYLPROPYL]CYCLOHEXANECARBOXAMIDE'>MRV</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mbs OCA], [https://pdbe.org/4mbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mbs RCSB], [https://www.ebi.ac.uk/pdbsum/4mbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mbs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mbs OCA], [https://pdbe.org/4mbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mbs RCSB], [https://www.ebi.ac.uk/pdbsum/4mbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mbs ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:07, 21 December 2022

2022-12-21T11:07:44Z

←Older revision		Revision as of 11:07, 21 December 2022
Line 1:		Line 1:

	==Crystal Structure of the CCR5 Chemokine Receptor==		==Crystal Structure of the CCR5 Chemokine Receptor==
-	<StructureSection load='4mbs' size='340' side='right' caption='[[4mbs]], [[Resolution\|resolution]] 2.71Å' scene=''>	+	<StructureSection load='4mbs' size='340' side='right'caption='[[4mbs]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4mbs]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_pasteurianus"_(winogradsky_1895)_lehmann_and_neumann_1907 "bacillus pasteurianus" (winogradsky 1895) lehmann~~ and ~~neumann 1907~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MBS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4MBS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4mbs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_pasteurianum Clostridium pasteurianum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MBS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MRV:4,4-DIFLUORO-N-[(1S)-3-{(3-EXO)-3-[3-METHYL-5-(PROPAN-2-YL)-4H-1,2,4-TRIAZOL-4-YL]-8-AZABICYCLO[3.2.1]OCT-8-YL}-1-PHENYLPROPYL]CYCLOHEXANECARBOXAMIDE'>MRV</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MRV:4,4-DIFLUORO-N-[(1S)-3-{(3-EXO)-3-[3-METHYL-5-(PROPAN-2-YL)-4H-1,2,4-TRIAZOL-4-YL]-8-AZABICYCLO[3.2.1]OCT-8-YL}-1-PHENYLPROPYL]CYCLOHEXANECARBOXAMIDE'>MRV</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCR5, CCR5_HUMAN, CMKBR5, Rd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1501 "Bacillus pasteurianus" (Winogradsky 1895) Lehmann and Neumann 1907])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mbs OCA], [https://pdbe.org/4mbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mbs RCSB], [https://www.ebi.ac.uk/pdbsum/4mbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mbs ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4mbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mbs OCA], [~~http~~://pdbe.org/4mbs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4mbs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4mbs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4mbs ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Genetic variation in CCR5 is associated with susceptibility to diabetes mellitus insulin-dependent type 22 (IDDM22) [MIM:[~~http~~://omim.org/entry/612522 612522]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:19073967</ref>	+	[https://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN] Genetic variation in CCR5 is associated with susceptibility to diabetes mellitus insulin-dependent type 22 (IDDM22) [MIM:[https://omim.org/entry/612522 612522]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:19073967</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.<ref>PMID:8639485</ref> <ref>PMID:8663314</ref> <ref>PMID:8699119</ref> <ref>PMID:8649511</ref> <ref>PMID:8649512</ref> <ref>PMID:11323418</ref>	+	[https://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN] Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.<ref>PMID:8639485</ref> <ref>PMID:8663314</ref> <ref>PMID:8699119</ref> <ref>PMID:8649511</ref> <ref>PMID:8649512</ref> <ref>PMID:11323418</ref> [https://www.uniprot.org/uniprot/RUBR_CLOPA RUBR_CLOPA] Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cherezov, V~~]]	+	[[Category: Clostridium pasteurianum]]
-	[[Category: ~~Fenalti, G~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~GPCR, GPCR Network~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Han, G W~~]]	+	[[Category: Cherezov V]]
-	[[Category: ~~Li, J~~]]	+	[[Category: Fenalti G]]
-	[[Category: ~~Liu, H~~]]	+	[[Category: Han GW]]
-	[[Category: ~~Stevens, R C~~]]	+	[[Category: Li J]]
-	[[Category: ~~Tan, Q~~]]	+	[[Category: Liu H]]
-	[[Category: ~~Wu, B~~]]	+	[[Category: Stevens RC]]
-	[[Category: ~~Zhao,~~ Q]]	+	[[Category: Tan Q]]
-	[[Category: ~~Zhu, Y~~]]	+	[[Category: Wu B]]
-	[[Category: ~~Anti-hiv agent~~]]	+	[[Category: Zhao Q]]
-	[[Category: ~~G protein-coupled receptor]]~~	+	[[Category: Zhu Y]]
-	~~[[Category: Gpcr network]]~~	+
-	~~[[Category: Human ccr5 chemokine receptor]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Novel protein engineering]]~~	+
-	~~[[Category: Psi-biology]]~~	+
-	~~[[Category: Seven transmembrane helice]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Structural genomic~~]]	+

OCA at 13:10, 4 August 2016

2016-08-04T13:10:40Z

←Older revision		Revision as of 13:10, 4 August 2016
Line 1:		Line 1:
-	{{STRUCTURE_4mbs\| PDB=4mbs \| SCENE= }}
-	===Crystal Structure of the CCR5 Chemokine Receptor===
-	{{ABSTRACT_PUBMED_24030490}}

-	==Disease==	+	==Crystal Structure of the CCR5 Chemokine Receptor==
		+	<StructureSection load='4mbs' size='340' side='right' caption='[[4mbs]], [[Resolution\|resolution]] 2.71Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4mbs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pasteurianus"_(winogradsky_1895)_lehmann_and_neumann_1907 "bacillus pasteurianus" (winogradsky 1895) lehmann and neumann 1907]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MBS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MRV:4,4-DIFLUORO-N-[(1S)-3-{(3-EXO)-3-[3-METHYL-5-(PROPAN-2-YL)-4H-1,2,4-TRIAZOL-4-YL]-8-AZABICYCLO[3.2.1]OCT-8-YL}-1-PHENYLPROPYL]CYCLOHEXANECARBOXAMIDE'>MRV</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCR5, CCR5_HUMAN, CMKBR5, Rd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1501 "Bacillus pasteurianus" (Winogradsky 1895) Lehmann and Neumann 1907])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mbs OCA], [http://pdbe.org/4mbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mbs RCSB], [http://www.ebi.ac.uk/pdbsum/4mbs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mbs ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Genetic variation in CCR5 is associated with susceptibility to diabetes mellitus insulin-dependent type 22 (IDDM22) [MIM:[http://omim.org/entry/612522 612522]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:19073967</ref>		[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Genetic variation in CCR5 is associated with susceptibility to diabetes mellitus insulin-dependent type 22 (IDDM22) [MIM:[http://omim.org/entry/612522 612522]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:19073967</ref>
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.<ref>PMID:8639485</ref> <ref>PMID:8663314</ref> <ref>PMID:8699119</ref> <ref>PMID:8649511</ref> <ref>PMID:8649512</ref> <ref>PMID:11323418</ref>		[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.<ref>PMID:8639485</ref> <ref>PMID:8663314</ref> <ref>PMID:8699119</ref> <ref>PMID:8649511</ref> <ref>PMID:8649512</ref> <ref>PMID:11323418</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The CCR5 chemokine receptor acts as a co-receptor for HIV-1 viral entry. Here we report the 2.7 angstrom-resolution crystal structure of human CCR5 bound to the marketed HIV drug maraviroc. The structure reveals a ligand-binding site that is distinct from the proposed major recognition sites for chemokines and the viral glycoprotein gp120, providing insights into the mechanism of allosteric inhibition of chemokine signaling and viral entry. A comparison between CCR5 and CXCR4 crystal structures, along with models of co-receptor-gp120-V3 complexes, suggests that different charge distributions and steric hindrances caused by residue substitutions may be major determinants of HIV-1 co-receptor selectivity. These high-resolution insights into CCR5 can enable structure-based drug discovery for the treatment of HIV-1 infection.

-	~~==About this~~ Structure==	+	Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex.,Tan Q, Zhu Y, Li J, Chen Z, Han GW, Kufareva I, Li T, Ma L, Fenalti G, Li J, Zhang W, Xie X, Yang H, Jiang H, Cherezov V, Liu H, Stevens RC, Zhao Q, Wu B Science. 2013 Sep 20;341(6152):1387-90. doi: 10.1126/science.1241475. Epub 2013, Sep 12. PMID:24030490<ref>PMID:24030490</ref>
-	~~[[4mbs]] is a 2 chain structure~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4MBS OCA].~~	+

-	~~==Reference==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	<~~ref group~~="~~xtra~~"~~>PMID~~:~~024030490~~</~~ref~~><references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Cherezov, V.]]	+	<div class="pdbe-citations 4mbs" style="background-color:#fffaf0;"></div>
-	[[Category: Fenalti, G.]]	+	== References ==
-	[[Category: GPCR, GPCR Network.]]	+	<references/>
-	[[Category: Han, G W.]]	+	__TOC__
-	[[Category: Li, J.]]	+	</StructureSection>
-	[[Category: Liu, H.]]	+	[[Category: Cherezov, V]]
-	[[Category: Stevens, R C.]]	+	[[Category: Fenalti, G]]
-	[[Category: Tan, Q.]]	+	[[Category: GPCR, GPCR Network]]
-	[[Category: Wu, B.]]	+	[[Category: Han, G W]]
-	[[Category: Zhao, Q.]]	+	[[Category: Li, J]]
-	[[Category: Zhu, Y.]]	+	[[Category: Liu, H]]
		+	[[Category: Stevens, R C]]
		+	[[Category: Tan, Q]]
		+	[[Category: Wu, B]]
		+	[[Category: Zhao, Q]]
		+	[[Category: Zhu, Y]]
	[[Category: Anti-hiv agent]]		[[Category: Anti-hiv agent]]
	[[Category: G protein-coupled receptor]]		[[Category: G protein-coupled receptor]]

OCA at 06:50, 29 September 2013

2013-09-29T06:50:40Z

←Older revision		Revision as of 06:50, 29 September 2013
Line 1:		Line 1:
	{{STRUCTURE_4mbs\| PDB=4mbs \| SCENE= }}		{{STRUCTURE_4mbs\| PDB=4mbs \| SCENE= }}
	===Crystal Structure of the CCR5 Chemokine Receptor===		===Crystal Structure of the CCR5 Chemokine Receptor===
		+	{{ABSTRACT_PUBMED_24030490}}

	==Disease==		==Disease==
Line 12:		Line 13:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:024030490</ref><references group="xtra"/><references/>
	[[Category: Cherezov, V.]]		[[Category: Cherezov, V.]]
	[[Category: Fenalti, G.]]		[[Category: Fenalti, G.]]

OCA at 05:34, 12 September 2013

2013-09-12T05:34:27Z

←Older revision		Revision as of 05:34, 12 September 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4mbs\| PDB=4mbs \| SCENE= }}
		+	===Crystal Structure of the CCR5 Chemokine Receptor===

-	~~The~~ entry ~~4mbs~~ is ~~ON HOLD~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Genetic variation in CCR5 is associated with susceptibility to diabetes mellitus insulin-dependent type 22 (IDDM22) [MIM:[http://omim.org/entry/612522 612522]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:19073967</ref>

-	~~Authors~~: ~~Tan, Q~~.~~, Zhu, Y~~., ~~Han, G~~. W.~~, Li, J., Fenalti, G., Liu, H., Cherezov, V., Stevens, R. C., Zhao, Q., Wu, B., GPCR Network~~ (~~GPCR~~)	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.<ref>PMID:8639485</ref> <ref>PMID:8663314</ref> <ref>PMID:8699119</ref> <ref>PMID:8649511</ref> <ref>PMID:8649512</ref> <ref>PMID:11323418</ref>

-	~~Description: Crystal~~ Structure ~~of the CCR5 Chemokine Receptor~~	+	==About this Structure==
		+	[[4mbs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MBS OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Cherezov, V.]]
		+	[[Category: Fenalti, G.]]
		+	[[Category: GPCR, GPCR Network.]]
		+	[[Category: Han, G W.]]
		+	[[Category: Li, J.]]
		+	[[Category: Liu, H.]]
		+	[[Category: Stevens, R C.]]
		+	[[Category: Tan, Q.]]
		+	[[Category: Wu, B.]]
		+	[[Category: Zhao, Q.]]
		+	[[Category: Zhu, Y.]]
		+	[[Category: Anti-hiv agent]]
		+	[[Category: G protein-coupled receptor]]
		+	[[Category: Gpcr network]]
		+	[[Category: Human ccr5 chemokine receptor]]
		+	[[Category: Membrane]]
		+	[[Category: Membrane protein]]
		+	[[Category: Novel protein engineering]]
		+	[[Category: Psi-biology]]
		+	[[Category: Seven transmembrane helice]]
		+	[[Category: Signaling protein]]
		+	[[Category: Structural genomic]]

OCA: Protected "4mbs" [edit=sysop:move=sysop]

2013-08-28T06:57:06Z

Protected "4mbs" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:57, 28 August 2013

OCA: New page: '''Unreleased structure''' The entry 4mbs is ON HOLD Authors: Tan, Q., Zhu, Y., Han, G. W., Li, J., Fenalti, G., Liu, H., Cherezov, V., Stevens, R. C., Zhao, Q., Wu, B., GPCR Network (G...

2013-08-28T06:57:05Z

New page: '''Unreleased structure''' The entry 4mbs is ON HOLD Authors: Tan, Q., Zhu, Y., Han, G. W., Li, J., Fenalti, G., Liu, H., Cherezov, V., Stevens, R. C., Zhao, Q., Wu, B., GPCR Network (G...

New page

'''Unreleased structure'''

The entry 4mbs is ON HOLD

Authors: Tan, Q., Zhu, Y., Han, G. W., Li, J., Fenalti, G., Liu, H., Cherezov, V., Stevens, R. C., Zhao, Q., Wu, B., GPCR Network (GPCR)

Description: Crystal Structure of the CCR5 Chemokine Receptor