4mn4 - Revision history

OCA at 16:39, 20 September 2023

2023-09-20T16:39:42Z

←Older revision		Revision as of 16:39, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mn4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_str._K-12_substr._MG1655 Escherichia coli str. K-12 substr. MG1655]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MN4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mn4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_str._K-12_substr._MG1655 Escherichia coli str. K-12 substr. MG1655]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MN4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mn4 OCA], [https://pdbe.org/4mn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mn4 RCSB], [https://www.ebi.ac.uk/pdbsum/4mn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mn4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mn4 OCA], [https://pdbe.org/4mn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mn4 RCSB], [https://www.ebi.ac.uk/pdbsum/4mn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mn4 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:52, 28 December 2022

2022-12-28T09:52:10Z

←Older revision		Revision as of 09:52, 28 December 2022
Line 1:		Line 1:

	==Structural Basis for the MukB-topoisomerase IV Interaction==		==Structural Basis for the MukB-topoisomerase IV Interaction==
-	<StructureSection load='4mn4' size='340' side='right' caption='[[4mn4]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4mn4' size='340' side='right'caption='[[4mn4]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4mn4]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Escherichia_coli_mg1655~~ Escherichia coli ~~mg1655~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MN4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4MN4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4mn4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_str._K-12_substr._MG1655 Escherichia coli str. K-12 substr. MG1655]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MN4 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">parC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=511145 Escherichia coli MG1655]), mukB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=511145 Escherichia coli MG1655])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mn4 OCA], [https://pdbe.org/4mn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mn4 RCSB], [https://www.ebi.ac.uk/pdbsum/4mn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mn4 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4mn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mn4 OCA], [~~http~~://pdbe.org/4mn4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4mn4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4mn4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4mn4 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PARC_ECOLI PARC_ECOLI]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation.<ref>PMID:20921377</ref> <ref>PMID:12269820</ref> <ref>PMID:21300644</ref> <ref>PMID:16023670</ref> [[http://www.uniprot.org/uniprot/MUKB_ECOLI MUKB_ECOLI]] Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organizes and compacts chromosomes. May achieve or facilitate chromosome segregation by condensation of DNA from both sides of a centrally located replisome during cell division. Stimulates both DNA relaxation and to a lesser extent decatenation activity of topoisomerase IV.<ref>PMID:20921377</ref> <ref>PMID:10660686</ref>	+	[https://www.uniprot.org/uniprot/PARC_ECOLI PARC_ECOLI] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation.<ref>PMID:20921377</ref> <ref>PMID:12269820</ref> <ref>PMID:21300644</ref> <ref>PMID:16023670</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Topoisomerase\|Topoisomerase]]	+	*[[Condensin\|Condensin]]
		+	*[[Topoisomerase 3D structures\|Topoisomerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Escherichia coli ~~mg1655~~]]	+	[[Category: Escherichia coli str. K-12 substr. MG1655]]
-	[[Category: ~~Berger, J M~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Oakley, M G~~]]	+	[[Category: Berger JM]]
-	[[Category: ~~Stewart, N K~~]]	+	[[Category: Oakley MG]]
-	[[Category: ~~Vos, S M~~]]	+	[[Category: Stewart NK]]
-	[[Category: ~~Beta-pinwheel]]~~	+	[[Category: Vos SM]]
-	~~[[Category: Chromosome partitioning]]~~	+
-	~~[[Category: Isomerase-cell cycle complex~~]]	+

OCA at 08:09, 5 August 2016

2016-08-05T08:09:49Z

←Older revision		Revision as of 08:09, 5 August 2016
Line 1:		Line 1:
		+
	==Structural Basis for the MukB-topoisomerase IV Interaction==		==Structural Basis for the MukB-topoisomerase IV Interaction==
	<StructureSection load='4mn4' size='340' side='right' caption='[[4mn4]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4mn4' size='340' side='right' caption='[[4mn4]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">parC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=511145 Escherichia coli MG1655]), mukB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=511145 Escherichia coli MG1655])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">parC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=511145 Escherichia coli MG1655]), mukB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=511145 Escherichia coli MG1655])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mn4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mn4 RCSB], [http://www.ebi.ac.uk/pdbsum/4mn4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mn4 OCA], [http://pdbe.org/4mn4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mn4 RCSB], [http://www.ebi.ac.uk/pdbsum/4mn4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mn4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4mn4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:09, 25 December 2014

2014-12-25T17:09:30Z

←Older revision		Revision as of 17:09, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4mn4\| PDB=4mn4 \| SCENE= }}~~	+	==Structural Basis for the MukB-topoisomerase IV Interaction==
-	===Structural Basis for the MukB-topoisomerase IV Interaction===	+	<StructureSection load='4mn4' size='340' side='right' caption='[[4mn4]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24097060}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4mn4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_mg1655 Escherichia coli mg1655]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MN4 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">parC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=511145 Escherichia coli MG1655]), mukB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=511145 Escherichia coli MG1655])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mn4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mn4 RCSB], [http://www.ebi.ac.uk/pdbsum/4mn4 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/PARC_ECOLI PARC_ECOLI]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation.<ref>PMID:20921377</ref> <ref>PMID:12269820</ref> <ref>PMID:21300644</ref> <ref>PMID:16023670</ref> [[http://www.uniprot.org/uniprot/MUKB_ECOLI MUKB_ECOLI]] Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organizes and compacts chromosomes. May achieve or facilitate chromosome segregation by condensation of DNA from both sides of a centrally located replisome during cell division. Stimulates both DNA relaxation and to a lesser extent decatenation activity of topoisomerase IV.<ref>PMID:20921377</ref> <ref>PMID:10660686</ref>		[[http://www.uniprot.org/uniprot/PARC_ECOLI PARC_ECOLI]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation.<ref>PMID:20921377</ref> <ref>PMID:12269820</ref> <ref>PMID:21300644</ref> <ref>PMID:16023670</ref> [[http://www.uniprot.org/uniprot/MUKB_ECOLI MUKB_ECOLI]] Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organizes and compacts chromosomes. May achieve or facilitate chromosome segregation by condensation of DNA from both sides of a centrally located replisome during cell division. Stimulates both DNA relaxation and to a lesser extent decatenation activity of topoisomerase IV.<ref>PMID:20921377</ref> <ref>PMID:10660686</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Chromosome partitioning in Escherichia coli is assisted by two interacting proteins, topoisomerase (topo) IV and MukB. MukB stimulates the relaxation of negative supercoils by topo IV; to understand the mechanism of their action and to define this functional interplay, we determined the crystal structure of a minimal MukB-topo IV complex to 2.3 A resolution. The structure shows that the so-called 'hinge' region of MukB forms a heterotetrameric assembly with a C-terminal DNA binding domain (CTD) on topo IV's ParC subunit. Biochemical studies show that the hinge stimulates topo IV by competing for a site on the CTD that normally represses activity on negatively supercoiled DNA, while complementation tests using mutants implicated in the interaction reveal that the cellular dependency on topo IV derives from a joint need for both strand passage and MukB binding. Interestingly, the configuration of the MukB.topo IV complex sterically disfavours intradimeric interactions, indicating that the proteins may form oligomeric arrays with one another, and suggesting a framework by which MukB and topo IV may collaborate during daughter chromosome disentanglement.
		+
		+	Structural basis for the MukB-topoisomerase IV interaction and its functional implications in vivo.,Vos SM, Stewart NK, Oakley MG, Berger JM EMBO J. 2013 Oct 4. doi: 10.1038/emboj.2013.218. PMID:24097060<ref>PMID:24097060</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4mn4]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli_mg1655 Escherichia coli mg1655]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4MN4 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024097060</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Topoisomerase\|Topoisomerase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli mg1655]]		[[Category: Escherichia coli mg1655]]
-	[[Category: Berger, J M.]]	+	[[Category: Berger, J M]]
-	[[Category: Oakley, M G.]]	+	[[Category: Oakley, M G]]
-	[[Category: Stewart, N K.]]	+	[[Category: Stewart, N K]]
-	[[Category: Vos, S M.]]	+	[[Category: Vos, S M]]
	[[Category: Beta-pinwheel]]		[[Category: Beta-pinwheel]]
	[[Category: Chromosome partitioning]]		[[Category: Chromosome partitioning]]
	[[Category: Isomerase-cell cycle complex]]		[[Category: Isomerase-cell cycle complex]]

OCA at 05:58, 22 January 2014

2014-01-22T05:58:33Z

←Older revision		Revision as of 05:58, 22 January 2014
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4mn4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli_str._k-12_substr._mg1655~~ Escherichia coli ~~str. k-12 substr.~~ mg1655]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MN4 OCA].	+	[[4mn4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_mg1655 Escherichia coli mg1655]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MN4 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:024097060</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024097060</ref><references group="xtra"/><references/>
-	[[Category: Escherichia coli ~~str. k-12 substr.~~ mg1655]]	+	[[Category: Escherichia coli mg1655]]
	[[Category: Berger, J M.]]		[[Category: Berger, J M.]]
	[[Category: Oakley, M G.]]		[[Category: Oakley, M G.]]

OCA at 06:45, 23 October 2013

2013-10-23T06:45:54Z

←Older revision		Revision as of 06:45, 23 October 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4mn4\| PDB=4mn4 \| SCENE= }}
		+	===Structural Basis for the MukB-topoisomerase IV Interaction===
		+	{{ABSTRACT_PUBMED_24097060}}

-	~~The entry 4mn4~~ is ~~ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PARC_ECOLI PARC_ECOLI]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation.<ref>PMID:20921377</ref> <ref>PMID:12269820</ref> <ref>PMID:21300644</ref> <ref>PMID:16023670</ref> [[http://www.uniprot.org/uniprot/MUKB_ECOLI MUKB_ECOLI]] Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organizes and compacts chromosomes. May achieve or facilitate chromosome segregation by condensation of DNA from both sides of a centrally located replisome during cell division. Stimulates both DNA relaxation and to a lesser extent decatenation activity of topoisomerase IV.<ref>PMID:20921377</ref> <ref>PMID:10660686</ref>

-	~~Authors~~: ~~Vos, S~~.M.~~, Stewart, N~~.K.~~, Oakley, M~~.G.~~, Berger, J~~.M.	+	==About this Structure==
		+	[[4mn4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_str._k-12_substr._mg1655 Escherichia coli str. k-12 substr. mg1655]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MN4 OCA].

-	~~Description~~: ~~Structural Basis for the MukB~~-~~topoisomerase IV Interaction~~	+	==Reference==
		+	<ref group="xtra">PMID:024097060</ref><references group="xtra"/><references/>
		+	[[Category: Escherichia coli str. k-12 substr. mg1655]]
		+	[[Category: Berger, J M.]]
		+	[[Category: Oakley, M G.]]
		+	[[Category: Stewart, N K.]]
		+	[[Category: Vos, S M.]]
		+	[[Category: Beta-pinwheel]]
		+	[[Category: Chromosome partitioning]]
		+	[[Category: Isomerase-cell cycle complex]]

OCA: Protected "4mn4" [edit=sysop:move=sysop]

2013-09-20T03:42:58Z

Protected "4mn4" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:42, 20 September 2013

OCA: New page: '''Unreleased structure''' The entry 4mn4 is ON HOLD Authors: Vos, S.M., Stewart, N.K., Oakley, M.G., Berger, J.M. Description: Structural Basis for the MukB-topoisomerase IV Interacti...

2013-09-20T03:42:57Z

New page: '''Unreleased structure''' The entry 4mn4 is ON HOLD Authors: Vos, S.M., Stewart, N.K., Oakley, M.G., Berger, J.M. Description: Structural Basis for the MukB-topoisomerase IV Interacti...

New page

'''Unreleased structure'''

The entry 4mn4 is ON HOLD

Authors: Vos, S.M., Stewart, N.K., Oakley, M.G., Berger, J.M.

Description: Structural Basis for the MukB-topoisomerase IV Interaction