4mqa - Revision history

OCA at 10:00, 28 December 2022

2022-12-28T10:00:49Z

←Older revision		Revision as of 10:00, 28 December 2022
Line 3:		Line 3:
	<StructureSection load='4mqa' size='340' side='right'caption='[[4mqa]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4mqa' size='340' side='right'caption='[[4mqa]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4mqa]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4MQA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4mqa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MQA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=X00:{(1,1,3,3-TETRAMETHYLDISILOXANE-1,3-DIYL)BIS[5-(METHYLSULFANYL)BENZENE-3,1-DIYL]}BIS({4-[3-(AMINOMETHYL)PHENYL]PIPERIDIN-1-YL}METHANONE)'>X00</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=X00:{(1,1,3,3-TETRAMETHYLDISILOXANE-1,3-DIYL)BIS[5-(METHYLSULFANYL)BENZENE-3,1-DIYL]}BIS({4-[3-(AMINOMETHYL)PHENYL]PIPERIDIN-1-YL}METHANONE)'>X00</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mpu\|4mpu]], [[4mpv\|4mpv]], [[4mpw\|4mpw]], [[4mpx\|4mpx]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mqa OCA], [https://pdbe.org/4mqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mqa RCSB], [https://www.ebi.ac.uk/pdbsum/4mqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mqa ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TPS1, TPS2, TPSAB1, TPSB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptase Tryptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.59 3.4.21.59] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mqa OCA], [~~http~~://pdbe.org/4mqa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4mqa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4mqa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4mqa ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TRYB1_HUMAN TRYB1_HUMAN]] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity).	+	[https://www.uniprot.org/uniprot/TRYB1_HUMAN TRYB1_HUMAN] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity).

	==See Also==		==See Also==
Line 17:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Tryptase]]~~	+	[[Category: Lakshminarasimhan D]]
-	[[Category: Lakshminarasimhan, D]]	+	[[Category: Suto R]]
-	[[Category: Suto, R]]	+	[[Category: White A]]
-	[[Category: White, A]]	+
-	~~[[Category: Alpha-hydroxyketone]]~~	+
-	~~[[Category: Coferon]]~~	+
-	~~[[Category: Crystal catalysis]]~~	+
-	~~[[Category: Drug discovery]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Self-assembly]]~~	+
-	~~[[Category: Silanol]]~~	+
-	~~[[Category: Small molecule inhibitor~~]]	+

OCA at 08:23, 10 April 2019

2019-04-10T08:23:21Z

←Older revision		Revision as of 08:23, 10 April 2019
Line 1:		Line 1:

	==Human beta-tryptase co-crystal structure with {(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis[5-(methylsulfanyl)benzene-3,1-diyl]}bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone)==		==Human beta-tryptase co-crystal structure with {(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis[5-(methylsulfanyl)benzene-3,1-diyl]}bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone)==
-	<StructureSection load='4mqa' size='340' side='right' caption='[[4mqa]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='4mqa' size='340' side='right'caption='[[4mqa]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4mqa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MQA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4mqa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MQA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=X00:{(1,1,3,3-TETRAMETHYLDISILOXANE-1,3-DIYL)BIS[5-(METHYLSULFANYL)BENZENE-3,1-DIYL]}BIS({4-[3-(AMINOMETHYL)PHENYL]PIPERIDIN-1-YL}METHANONE)'>X00</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=X00:{(1,1,3,3-TETRAMETHYLDISILOXANE-1,3-DIYL)BIS[5-(METHYLSULFANYL)BENZENE-3,1-DIYL]}BIS({4-[3-(AMINOMETHYL)PHENYL]PIPERIDIN-1-YL}METHANONE)'>X00</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mpu\|4mpu]], [[4mpv\|4mpv]], [[4mpw\|4mpw]], [[4mpx\|4mpx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mpu\|4mpu]], [[4mpv\|4mpv]], [[4mpw\|4mpw]], [[4mpx\|4mpx]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TPS1, TPS2, TPSAB1, TPSB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptase Tryptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.59 3.4.21.59] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptase Tryptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.59 3.4.21.59] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mqa OCA], [http://pdbe.org/4mqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mqa RCSB], [http://www.ebi.ac.uk/pdbsum/4mqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mqa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mqa OCA], [http://pdbe.org/4mqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mqa RCSB], [http://www.ebi.ac.uk/pdbsum/4mqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mqa ProSAT]</span></td></tr>
Line 16:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Tryptase]]		[[Category: Tryptase]]
	[[Category: Lakshminarasimhan, D]]		[[Category: Lakshminarasimhan, D]]

OCA at 07:22, 23 December 2016

2016-12-23T07:22:00Z

←Older revision		Revision as of 07:22, 23 December 2016
Line 1:		Line 1:
		+
	==Human beta-tryptase co-crystal structure with {(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis[5-(methylsulfanyl)benzene-3,1-diyl]}bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone)==		==Human beta-tryptase co-crystal structure with {(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis[5-(methylsulfanyl)benzene-3,1-diyl]}bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone)==
	<StructureSection load='4mqa' size='340' side='right' caption='[[4mqa]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4mqa' size='340' side='right' caption='[[4mqa]], [[Resolution\|resolution]] 2.25Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mpu\|4mpu]], [[4mpv\|4mpv]], [[4mpw\|4mpw]], [[4mpx\|4mpx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mpu\|4mpu]], [[4mpv\|4mpv]], [[4mpw\|4mpw]], [[4mpx\|4mpx]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptase Tryptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.59 3.4.21.59] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptase Tryptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.59 3.4.21.59] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mqa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mqa RCSB], [http://www.ebi.ac.uk/pdbsum/4mqa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mqa OCA], [http://pdbe.org/4mqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mqa RCSB], [http://www.ebi.ac.uk/pdbsum/4mqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mqa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TRYB1_HUMAN TRYB1_HUMAN]] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity).		[[http://www.uniprot.org/uniprot/TRYB1_HUMAN TRYB1_HUMAN]] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity).
		+
		+	==See Also==
		+	*[[Tryptase\|Tryptase]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:10, 18 March 2015

2015-03-18T12:10:23Z

←Older revision		Revision as of 12:10, 18 March 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Human beta-tryptase co-crystal structure with {(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis[5-(methylsulfanyl)benzene-3,1-diyl]}bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone)==
-		+	<StructureSection load='4mqa' size='340' side='right' caption='[[4mqa]], [[Resolution\|resolution]] 2.25Å' scene=''>
-	~~The entry~~ 4mqa is ~~ON HOLD until Mar 18 2016~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4mqa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MQA FirstGlance]. <br>
-	~~Authors~~: ~~White~~, A., ~~Lakshminarasimhan~~, D., ~~Suto~~, R.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=X00:{(1,1,3,3-TETRAMETHYLDISILOXANE-1,3-DIYL)BIS[5-(METHYLSULFANYL)BENZENE-3,1-DIYL]}BIS({4-[3-(AMINOMETHYL)PHENYL]PIPERIDIN-1-YL}METHANONE)'>X00</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mpu\|4mpu]], [[4mpv\|4mpv]], [[4mpw\|4mpw]], [[4mpx\|4mpx]]</td></tr>
-	~~Description~~:	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptase Tryptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.59 3.4.21.59] </span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mqa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mqa RCSB], [http://www.ebi.ac.uk/pdbsum/4mqa PDBsum]</span></td></tr>
-	[[~~Category~~: ~~White, A~~]]	+	</table>
-	[[Category: ~~Suto, R~~]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TRYB1_HUMAN TRYB1_HUMAN]] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Tryptase]]
	[[Category: Lakshminarasimhan, D]]		[[Category: Lakshminarasimhan, D]]
		+	[[Category: Suto, R]]
		+	[[Category: White, A]]
		+	[[Category: Alpha-hydroxyketone]]
		+	[[Category: Coferon]]
		+	[[Category: Crystal catalysis]]
		+	[[Category: Drug discovery]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Self-assembly]]
		+	[[Category: Silanol]]
		+	[[Category: Small molecule inhibitor]]

OCA at 14:07, 24 December 2014

2014-12-24T14:07:02Z

←Older revision		Revision as of 14:07, 24 December 2014
Line 5:		Line 5:
	Authors: White, A., Lakshminarasimhan, D., Suto, R.		Authors: White, A., Lakshminarasimhan, D., Suto, R.

-	Description:	+	Description:
		+	[[Category: Unreleased Structures]]
		+	[[Category: White, A]]
		+	[[Category: Suto, R]]
		+	[[Category: Lakshminarasimhan, D]]

OCA at 00:44, 7 August 2014

2014-08-07T00:44:51Z

←Older revision		Revision as of 00:44, 7 August 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4mqa is ON HOLD until ~~Paper Publication~~	+	The entry 4mqa is ON HOLD until Mar 18 2016

	Authors: White, A., Lakshminarasimhan, D., Suto, R.		Authors: White, A., Lakshminarasimhan, D., Suto, R.

	Description:		Description:

OCA at 10:11, 5 February 2014

2014-02-05T10:11:27Z

←Older revision		Revision as of 10:11, 5 February 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4mqa is ON HOLD	+	The entry 4mqa is ON HOLD until Paper Publication

	Authors: White, A., Lakshminarasimhan, D., Suto, R.		Authors: White, A., Lakshminarasimhan, D., Suto, R.

	Description:		Description:

OCA: Protected "4mqa" [edit=sysop:move=sysop]

2013-09-29T07:41:01Z

Protected "4mqa" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:41, 29 September 2013

OCA: New page: '''Unreleased structure''' The entry 4mqa is ON HOLD Authors: White, A., Lakshminarasimhan, D., Suto, R. Description:

2013-09-29T07:41:00Z

New page: '''Unreleased structure''' The entry 4mqa is ON HOLD Authors: White, A., Lakshminarasimhan, D., Suto, R. Description:

New page

'''Unreleased structure'''

The entry 4mqa is ON HOLD

Authors: White, A., Lakshminarasimhan, D., Suto, R.

Description: