4mss - Revision history

OCA at 16:41, 20 September 2023

2023-09-20T16:41:48Z

←Older revision		Revision as of 16:41, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mss]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_cenocepacia_J2315 Burkholderia cenocepacia J2315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MSS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mss]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_cenocepacia_J2315 Burkholderia cenocepacia J2315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MSS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CZ:N-[(3S,4R,5R,6S)-4,5,6-TRIHYDROXYAZEPAN-3-YL]ACETAMIDE'>2CZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CZ:N-[(3S,4R,5R,6S)-4,5,6-TRIHYDROXYAZEPAN-3-YL]ACETAMIDE'>2CZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mss OCA], [https://pdbe.org/4mss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mss RCSB], [https://www.ebi.ac.uk/pdbsum/4mss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mss ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mss OCA], [https://pdbe.org/4mss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mss RCSB], [https://www.ebi.ac.uk/pdbsum/4mss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mss ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:06, 28 December 2022

2022-12-28T10:06:04Z

←Older revision		Revision as of 10:06, 28 December 2022
Line 1:		Line 1:

	==Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to (3S,4R,5R,6S)-3-acetamido-4,5,6-trihydroxyazepane==		==Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to (3S,4R,5R,6S)-3-acetamido-4,5,6-trihydroxyazepane==
-	<StructureSection load='4mss' size='340' side='right' caption='[[4mss]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4mss' size='340' side='right'caption='[[4mss]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4mss]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Burcj Burcj~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4MSS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4mss]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_cenocepacia_J2315 Burkholderia cenocepacia J2315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MSS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CZ:N-[(3S,4R,5R,6S)-4,5,6-TRIHYDROXYAZEPAN-3-YL]ACETAMIDE'>2CZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CZ:N-[(3S,4R,5R,6S)-4,5,6-TRIHYDROXYAZEPAN-3-YL]ACETAMIDE'>2CZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gnv\|4gnv]], [[4g6c\|4g6c]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mss OCA], [https://pdbe.org/4mss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mss RCSB], [https://www.ebi.ac.uk/pdbsum/4mss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mss ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCAL1010, BCAL2860, BceJ2315_10000, BceJ2315_27960, nagZ, nagZ1, nagZ2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216591 BURCJ])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4mss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mss OCA], [~~http~~://pdbe.org/4mss PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4mss RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4mss PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4mss ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B4EA43_BURCJ B4EA43_BURCJ]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	==See Also==		==See Also==
	*[[Beta-Hexosaminidase\|Beta-Hexosaminidase]]		*[[Beta-Hexosaminidase\|Beta-Hexosaminidase]]
		+	*[[Beta-Hexosaminidase 3D structures\|Beta-Hexosaminidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Beta-N-acetylhexosaminidase~~]]	+	[[Category: Burkholderia cenocepacia J2315]]
-	[[Category: ~~Burcj~~]]	+	[[Category: Large Structures]]
-	[[Category: Mark~~, B L~~]]	+	[[Category: Mark BL]]
-	[[Category: Vadlamani, G]]	+	[[Category: Vadlamani G]]
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Tim barrel~~]]	+

OCA at 08:54, 11 August 2016

2016-08-11T08:54:35Z

←Older revision		Revision as of 08:54, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to (3S,4R,5R,6S)-3-acetamido-4,5,6-trihydroxyazepane==		==Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to (3S,4R,5R,6S)-3-acetamido-4,5,6-trihydroxyazepane==
	<StructureSection load='4mss' size='340' side='right' caption='[[4mss]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4mss' size='340' side='right' caption='[[4mss]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCAL1010, BCAL2860, BceJ2315_10000, BceJ2315_27960, nagZ, nagZ1, nagZ2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216591 BURCJ])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCAL1010, BCAL2860, BceJ2315_10000, BceJ2315_27960, nagZ, nagZ1, nagZ2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216591 BURCJ])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mss OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mss RCSB], [http://www.ebi.ac.uk/pdbsum/4mss PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mss OCA], [http://pdbe.org/4mss PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mss RCSB], [http://www.ebi.ac.uk/pdbsum/4mss PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mss ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4mss" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 09:50, 5 January 2015

2015-01-05T09:50:03Z

←Older revision		Revision as of 09:50, 5 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4mss\| PDB=4mss \| SCENE= }}~~	+	==Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to (3S,4R,5R,6S)-3-acetamido-4,5,6-trihydroxyazepane==
-	===Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to (3S,4R,5R,6S)-3-acetamido-4,5,6-trihydroxyazepane===	+	<StructureSection load='4mss' size='340' side='right' caption='[[4mss]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24136176}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4mss]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burcj Burcj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MSS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CZ:N-[(3S,4R,5R,6S)-4,5,6-TRIHYDROXYAZEPAN-3-YL]ACETAMIDE'>2CZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gnv\|4gnv]], [[4g6c\|4g6c]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCAL1010, BCAL2860, BceJ2315_10000, BceJ2315_27960, nagZ, nagZ1, nagZ2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216591 BURCJ])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mss OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mss RCSB], [http://www.ebi.ac.uk/pdbsum/4mss PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	AmpC beta-lactamase confers resistance to beta-lactam antibiotics in many Gram negative bacteria. Inducible expression of AmpC requires an N-acetylglucosaminidase termed NagZ. Here we describe the synthesis and characterization of hydroxyazepane inhibitors of NagZ. We find that these inhibitors enhance the susceptibility of clinically relevant Pseudomonas aeruginosa to beta-lactams.

-	~~==About this Structure==~~	+	Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to beta-lactams.,Mondon M, Hur S, Vadlamani G, Rodrigues P, Tsybina P, Oliver A, Mark BL, Vocadlo DJ, Bleriot Y Chem Commun (Camb). 2013 Oct 29;49(93):10983-5. doi: 10.1039/c3cc46646a. PMID:24136176<ref>PMID:24136176</ref>
-	~~[[4mss]] is a 2 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Burcj Burcj]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4MSS OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group~~=~~"xtra">PMID:024136176</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+
		+	==See Also==
		+	*[[Beta-Hexosaminidase\|Beta-Hexosaminidase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Beta-N-acetylhexosaminidase]]		[[Category: Beta-N-acetylhexosaminidase]]
	[[Category: Burcj]]		[[Category: Burcj]]
-	[[Category: Mark, B L.]]	+	[[Category: Mark, B L]]
-	[[Category: Vadlamani, G.]]	+	[[Category: Vadlamani, G]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]

OCA at 06:47, 13 November 2013

2013-11-13T06:47:31Z

←Older revision		Revision as of 06:47, 13 November 2013
Line 4:		Line 4:

	==About this Structure==		==About this Structure==
-	[[4mss]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Burkholderia_cenocepacia_j2315 Burkholderia cenocepacia j2315~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSS OCA].	+	[[4mss]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burcj Burcj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSS OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:024136176</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024136176</ref><references group="xtra"/><references/>
	[[Category: Beta-N-acetylhexosaminidase]]		[[Category: Beta-N-acetylhexosaminidase]]
-	[[Category: ~~Burkholderia cenocepacia j2315~~]]	+	[[Category: Burcj]]
	[[Category: Mark, B L.]]		[[Category: Mark, B L.]]
	[[Category: Vadlamani, G.]]		[[Category: Vadlamani, G.]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]

OCA at 09:42, 30 October 2013

2013-10-30T09:42:57Z

←Older revision		Revision as of 09:42, 30 October 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4mss\| PDB=4mss \| SCENE= }}
		+	===Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to (3S,4R,5R,6S)-3-acetamido-4,5,6-trihydroxyazepane===
		+	{{ABSTRACT_PUBMED_24136176}}

-	~~The entry~~ 4mss is ~~ON HOLD~~	+	==About this Structure==
		+	[[4mss]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_cenocepacia_j2315 Burkholderia cenocepacia j2315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSS OCA].

-	~~Authors~~: ~~Vadlamani, G.,~~ Mark, B.L.	+	==Reference==
-		+	<ref group="xtra">PMID:024136176</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to (3S,4R,5R~~,~~6S)-3-acetamido~~-~~4,5,6-trihydroxyazepane~~	+	[[Category: Beta-N-acetylhexosaminidase]]
		+	[[Category: Burkholderia cenocepacia j2315]]
		+	[[Category: Mark, B L.]]
		+	[[Category: Vadlamani, G.]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Tim barrel]]

OCA at 06:53, 2 October 2013

2013-10-02T06:53:07Z

←Older revision		Revision as of 06:53, 2 October 2013
Line 3:		Line 3:
	The entry 4mss is ON HOLD		The entry 4mss is ON HOLD

-	Authors: Vadlamani, G., Mark, B. L.	+	Authors: Vadlamani, G., Mark, B.L.

	Description: Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to (3S,4R,5R,6S)-3-acetamido-4,5,6-trihydroxyazepane		Description: Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to (3S,4R,5R,6S)-3-acetamido-4,5,6-trihydroxyazepane

OCA: Protected "4mss" [edit=sysop:move=sysop]

2013-09-29T07:44:12Z

Protected "4mss" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:44, 29 September 2013

OCA: New page: '''Unreleased structure''' The entry 4mss is ON HOLD Authors: Vadlamani, G., Mark, B. L. Description: Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) ...

2013-09-29T07:44:10Z

New page: '''Unreleased structure''' The entry 4mss is ON HOLD Authors: Vadlamani, G., Mark, B. L. Description: Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) ...

New page

'''Unreleased structure'''

The entry 4mss is ON HOLD

Authors: Vadlamani, G., Mark, B. L.

Description: Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to (3S,4R,5R,6S)-3-acetamido-4,5,6-trihydroxyazepane