4mxw - Revision history

OCA at 16:44, 20 September 2023

2023-09-20T16:44:31Z

←Older revision		Revision as of 16:44, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mxw]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MXW FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mxw]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MXW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mxw OCA], [https://pdbe.org/4mxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mxw RCSB], [https://www.ebi.ac.uk/pdbsum/4mxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mxw ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.6Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mxw OCA], [https://pdbe.org/4mxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mxw RCSB], [https://www.ebi.ac.uk/pdbsum/4mxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mxw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 10:18, 28 December 2022

2022-12-28T10:18:09Z

←Older revision		Revision as of 10:18, 28 December 2022
Line 1:		Line 1:

	==Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab==		==Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab==
-	<StructureSection load='4mxw' size='340' side='right' caption='[[4mxw]], [[Resolution\|resolution]] 3.60Å' scene=''>	+	<StructureSection load='4mxw' size='340' side='right'caption='[[4mxw]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4mxw]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4MXW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4mxw]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MXW FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mxv\|4mxv]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mxw OCA], [https://pdbe.org/4mxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mxw RCSB], [https://www.ebi.ac.uk/pdbsum/4mxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mxw ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTBR, D12S370, TNFCR, TNFR3, TNFRSF3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LTA, TNFB, TNFSF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LTB, TNFC, TNFSF3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4mxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mxw OCA], [~~http~~://pdbe.org/4mxw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4mxw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4mxw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4mxw ProSAT]</span></td></tr>	+
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/TNFB_HUMAN TNFB_HUMAN]] Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:[http://omim.org/entry/607507 607507]]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TNR3_HUMAN TNR3_HUMAN]] Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.<ref>PMID:8171323</ref> <ref>PMID:10799510</ref> [[http://www.uniprot.org/uniprot/TNFC_HUMAN TNFC_HUMAN]] Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional. [[http://www.uniprot.org/uniprot/TNFB_HUMAN TNFB_HUMAN]] Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.	+	[https://www.uniprot.org/uniprot/TNR3_HUMAN TNR3_HUMAN] Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.<ref>PMID:8171323</ref> <ref>PMID:10799510</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 19:

	==See Also==		==See Also==
-	*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
-	*[[3D structures of ~~monoclonal~~ antibody\|3D structures of ~~monoclonal~~ antibody]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
		+	*[[Tumor necrosis factor receptor 3D structures\|Tumor necrosis factor receptor 3D structures]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Hymowitz, S G~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Sudhamsu, J~~]]	+	[[Category: Hymowitz SG]]
-	[[Category: ~~Yin,~~ J P]]	+	[[Category: Sudhamsu J]]
-	[[Category: ~~Auto-immunity]]~~	+	[[Category: Yin JP]]
-	~~[[Category: Cytokine-immune system complex]]~~	+
-	~~[[Category: Lymphoid development]]~~	+
-	~~[[Category: Lymphotoxin alpha]]~~	+
-	~~[[Category: Lymphotoxin beta receptor]]~~	+
-	~~[[Category: Tnf]]~~	+
-	~~[[Category: Tnfr receptor]]~~	+
-	~~[[Category: Tumor immunity]]~~	+
-	~~[[Category: Tumor necrosis factor~~]]	+

OCA at 22:26, 4 August 2016

2016-08-04T22:26:51Z

←Older revision		Revision as of 22:26, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab==		==Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab==
	<StructureSection load='4mxw' size='340' side='right' caption='[[4mxw]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='4mxw' size='340' side='right' caption='[[4mxw]], [[Resolution\|resolution]] 3.60Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mxv\|4mxv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mxv\|4mxv]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTBR, D12S370, TNFCR, TNFR3, TNFRSF3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LTA, TNFB, TNFSF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LTB, TNFC, TNFSF3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTBR, D12S370, TNFCR, TNFR3, TNFRSF3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LTA, TNFB, TNFSF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LTB, TNFC, TNFSF3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mxw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mxw RCSB], [http://www.ebi.ac.uk/pdbsum/4mxw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mxw OCA], [http://pdbe.org/4mxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mxw RCSB], [http://www.ebi.ac.uk/pdbsum/4mxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mxw ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4mxw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[~~Monoclonal Antibody~~\|~~Monoclonal Antibody~~]]	+	*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]
		+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:33, 21 December 2014

2014-12-21T17:33:34Z

←Older revision		Revision as of 17:33, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4mxw\| PDB=4mxw \| SCENE= }}~~	+	==Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab==
-	===Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab===	+	<StructureSection load='4mxw' size='340' side='right' caption='[[4mxw]], [[Resolution\|resolution]] 3.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24248355}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4mxw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MXW FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mxv\|4mxv]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTBR, D12S370, TNFCR, TNFR3, TNFRSF3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LTA, TNFB, TNFSF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LTB, TNFC, TNFSF3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mxw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mxw RCSB], [http://www.ebi.ac.uk/pdbsum/4mxw PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/TNFB_HUMAN TNFB_HUMAN]] Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:[http://omim.org/entry/607507 607507]]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).		[[http://www.uniprot.org/uniprot/TNFB_HUMAN TNFB_HUMAN]] Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:[http://omim.org/entry/607507 607507]]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TNR3_HUMAN TNR3_HUMAN]] Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.<ref>PMID:8171323</ref> <ref>PMID:10799510</ref> [[http://www.uniprot.org/uniprot/TNFC_HUMAN TNFC_HUMAN]] Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional. [[http://www.uniprot.org/uniprot/TNFB_HUMAN TNFB_HUMAN]] Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Homotrimeric TNF superfamily ligands signal by inducing trimers of their cognate receptors. As a biologically active heterotrimer, Lymphotoxin(LT)alpha1beta2 is unique in the TNF superfamily. How the three unique potential receptor-binding interfaces in LTalpha1beta2 trigger signaling via LTbeta Receptor (LTbetaR) resulting in lymphoid organogenesis and propagation of inflammatory signals is poorly understood. Here we show that LTalpha1beta2 possesses two binding sites for LTbetaR with distinct affinities and that dimerization of LTbetaR by LTalpha1beta2 is necessary and sufficient for signal transduction. The crystal structure of a complex formed by LTalpha1beta2, LTbetaR, and the fab fragment of an antibody that blocks LTbetaR activation reveals the lower affinity receptor-binding site. Mutations targeting each potential receptor-binding site in an engineered single-chain variant of LTalpha1beta2 reveal the high-affinity site. NF-kappaB reporter assays further validate that disruption of receptor interactions at either site is sufficient to prevent signaling via LTbetaR.

-	~~==Function==~~	+	Dimerization of LTbetaR by LTalpha1beta2 is necessary and sufficient for signal transduction.,Sudhamsu J, Yin J, Chiang EY, Starovasnik MA, Grogan JL, Hymowitz SG Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19896-901. doi:, 10.1073/pnas.1310838110. Epub 2013 Nov 18. PMID:24248355<ref>PMID:24248355</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/TNR3_HUMAN TNR3_HUMAN]] Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT~~. ~~Promotes apoptosis via TRAF3 and TRAF5~~. ~~May play a role in the development of lymphoid organs~~.~~<ref>~~PMID:~~8171323</ref>~~ <ref>PMID:~~10799510~~</ref> [[http://www.uniprot.org/uniprot/TNFC_HUMAN TNFC_HUMAN]] Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional. [[http://www.uniprot.org/uniprot/TNFB_HUMAN TNFB_HUMAN]] Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4mxw]] is~~ a ~~12 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4MXW OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024248355</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Hymowitz, S G.]]	+	[[Category: Hymowitz, S G]]
-	[[Category: Sudhamsu, J.]]	+	[[Category: Sudhamsu, J]]
-	[[Category: Yin, J P.]]	+	[[Category: Yin, J P]]
	[[Category: Auto-immunity]]		[[Category: Auto-immunity]]
	[[Category: Cytokine-immune system complex]]		[[Category: Cytokine-immune system complex]]

OCA at 12:28, 11 December 2013

2013-12-11T12:28:50Z

←Older revision		Revision as of 12:28, 11 December 2013
Line 1:		Line 1:
	{{STRUCTURE_4mxw\| PDB=4mxw \| SCENE= }}		{{STRUCTURE_4mxw\| PDB=4mxw \| SCENE= }}
	===Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab===		===Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab===
		+	{{ABSTRACT_PUBMED_24248355}}

	==Disease==		==Disease==
Line 9:		Line 10:

	==About this Structure==		==About this Structure==
-	[[4mxw]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXW OCA].	+	[[4mxw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXW OCA].

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:024248355</ref><references group="xtra"/><references/>
		+	[[Category: Human]]
	[[Category: Hymowitz, S G.]]		[[Category: Hymowitz, S G.]]
	[[Category: Sudhamsu, J.]]		[[Category: Sudhamsu, J.]]

OCA at 08:32, 13 November 2013

2013-11-13T08:32:58Z

←Older revision		Revision as of 08:32, 13 November 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4mxw\| PDB=4mxw \| SCENE= }}
		+	===Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab===

-	~~The~~ entry ~~4mxw~~ is ~~ON HOLD~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/TNFB_HUMAN TNFB_HUMAN]] Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:[http://omim.org/entry/607507 607507]]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).

-	~~Authors~~: ~~Sudhamsu, J~~., ~~Yin, J~~.P., ~~Hymowitz, S~~.G.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/TNR3_HUMAN TNR3_HUMAN]] Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.<ref>PMID:8171323</ref> <ref>PMID:10799510</ref> [[http://www.uniprot.org/uniprot/TNFC_HUMAN TNFC_HUMAN]] Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional. [[http://www.uniprot.org/uniprot/TNFB_HUMAN TNFB_HUMAN]] Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.

-	~~Description:~~ Structure ~~of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin~~ beta receptor ~~LTbR and anti-LTa Fab~~	+	==About this Structure==
		+	[[4mxw]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXW OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Hymowitz, S G.]]
		+	[[Category: Sudhamsu, J.]]
		+	[[Category: Yin, J P.]]
		+	[[Category: Auto-immunity]]
		+	[[Category: Cytokine-immune system complex]]
		+	[[Category: Lymphoid development]]
		+	[[Category: Lymphotoxin alpha]]
		+	[[Category: Lymphotoxin beta receptor]]
		+	[[Category: Tnf]]
		+	[[Category: Tnfr receptor]]
		+	[[Category: Tumor immunity]]
		+	[[Category: Tumor necrosis factor]]

OCA at 07:29, 16 October 2013

2013-10-16T07:29:40Z

←Older revision		Revision as of 07:29, 16 October 2013
Line 3:		Line 3:
	The entry 4mxw is ON HOLD		The entry 4mxw is ON HOLD

-	Authors: Sudhamsu, J., Yin, J. P., Hymowitz, S. G.	+	Authors: Sudhamsu, J., Yin, J.P., Hymowitz, S.G.

-	Description: Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa ~~fab.~~	+	Description: Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab

OCA: Protected "4mxw" [edit=sysop:move=sysop]

2013-10-02T06:59:18Z

Protected "4mxw" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:59, 2 October 2013

OCA: New page: '''Unreleased structure''' The entry 4mxw is ON HOLD Authors: Sudhamsu, J., Yin, J. P., Hymowitz, S. G. Description: Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin...

2013-10-02T06:59:17Z

New page: '''Unreleased structure''' The entry 4mxw is ON HOLD Authors: Sudhamsu, J., Yin, J. P., Hymowitz, S. G. Description: Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin...

New page

'''Unreleased structure'''

The entry 4mxw is ON HOLD

Authors: Sudhamsu, J., Yin, J. P., Hymowitz, S. G.

Description: Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa fab.