4mzv - Revision history

OCA at 10:22, 28 December 2022

2022-12-28T10:22:34Z

←Older revision		Revision as of 10:22, 28 December 2022
Line 3:		Line 3:
	<StructureSection load='4mzv' size='340' side='right'caption='[[4mzv]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='4mzv' size='340' side='right'caption='[[4mzv]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4mzv]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4MZV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4mzv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MZV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mzv OCA], [https://pdbe.org/4mzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mzv RCSB], [https://www.ebi.ac.uk/pdbsum/4mzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mzv ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4mzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mzv OCA], [~~http~~://pdbe.org/4mzv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4mzv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4mzv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4mzv ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/EPCAM_HUMAN EPCAM_HUMAN]] Intestinal epithelial dysplasia;Hereditary nonpolyposis colon cancer. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:18572020</ref> The disease is caused by mutations affecting the gene represented in this entry. HNPCC8 results from heterozygous deletion of 3-prime exons of EPCAM and intergenic regions directly upstream of MSH2, resulting in transcriptional read-through and epigenetic silencing of MSH2 in tissues expressing EPCAM.<ref>PMID:19098912</ref>	+	[https://www.uniprot.org/uniprot/EPCAM_HUMAN EPCAM_HUMAN] Intestinal epithelial dysplasia;Hereditary nonpolyposis colon cancer. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:18572020</ref> The disease is caused by mutations affecting the gene represented in this entry. HNPCC8 results from heterozygous deletion of 3-prime exons of EPCAM and intergenic regions directly upstream of MSH2, resulting in transcriptional read-through and epigenetic silencing of MSH2 in tissues expressing EPCAM.<ref>PMID:19098912</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/EPCAM_HUMAN EPCAM_HUMAN]] May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.<ref>PMID:15195135</ref> <ref>PMID:15922867</ref> <ref>PMID:20064925</ref> <ref>PMID:19785009</ref>	+	[https://www.uniprot.org/uniprot/EPCAM_HUMAN EPCAM_HUMAN] May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.<ref>PMID:15195135</ref> <ref>PMID:15922867</ref> <ref>PMID:20064925</ref> <ref>PMID:19785009</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Djinovic-Carugo, K]]	+	[[Category: Djinovic-Carugo K]]
-	[[Category: Guncar, G]]	+	[[Category: Guncar G]]
-	[[Category: Lenarcic, B]]	+	[[Category: Lenarcic B]]
-	[[Category: Pavsic, M]]	+	[[Category: Pavsic M]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Dimer]]~~	+
-	~~[[Category: Ectodomain]]~~	+
-	~~[[Category: Extracellular space~~]]	+

OCA at 08:23, 10 April 2019

2019-04-10T08:23:37Z

←Older revision		Revision as of 08:23, 10 April 2019
Line 1:		Line 1:

	==Crystal structure of extracellular part of human EpCAM==		==Crystal structure of extracellular part of human EpCAM==
-	<StructureSection load='4mzv' size='340' side='right' caption='[[4mzv]], [[Resolution\|resolution]] 1.86Å' scene=''>	+	<StructureSection load='4mzv' size='340' side='right'caption='[[4mzv]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4mzv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MZV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4mzv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MZV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mzv OCA], [http://pdbe.org/4mzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mzv RCSB], [http://www.ebi.ac.uk/pdbsum/4mzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mzv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mzv OCA], [http://pdbe.org/4mzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mzv RCSB], [http://www.ebi.ac.uk/pdbsum/4mzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mzv ProSAT]</span></td></tr>
	</table>		</table>
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Djinovic-Carugo, K]]		[[Category: Djinovic-Carugo, K]]
	[[Category: Guncar, G]]		[[Category: Guncar, G]]

OCA at 10:02, 11 August 2016

2016-08-11T10:02:35Z

←Older revision		Revision as of 10:02, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of extracellular part of human EpCAM==		==Crystal structure of extracellular part of human EpCAM==
	<StructureSection load='4mzv' size='340' side='right' caption='[[4mzv]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='4mzv' size='340' side='right' caption='[[4mzv]], [[Resolution\|resolution]] 1.86Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mzv RCSB], [http://www.ebi.ac.uk/pdbsum/4mzv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mzv OCA], [http://pdbe.org/4mzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mzv RCSB], [http://www.ebi.ac.uk/pdbsum/4mzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mzv ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4mzv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:15, 20 January 2015

2015-01-20T11:15:49Z

←Older revision		Revision as of 11:15, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mzv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MZV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mzv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MZV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mzv RCSB], [http://www.ebi.ac.uk/pdbsum/4mzv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mzv RCSB], [http://www.ebi.ac.uk/pdbsum/4mzv PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/EPCAM_HUMAN EPCAM_HUMAN]] Intestinal epithelial dysplasia;Hereditary nonpolyposis colon cancer. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:18572020</ref> The disease is caused by mutations affecting the gene represented in this entry. HNPCC8 results from heterozygous deletion of 3-prime exons of EPCAM and intergenic regions directly upstream of MSH2, resulting in transcriptional read-through and epigenetic silencing of MSH2 in tissues expressing EPCAM.<ref>PMID:19098912</ref>		[[http://www.uniprot.org/uniprot/EPCAM_HUMAN EPCAM_HUMAN]] Intestinal epithelial dysplasia;Hereditary nonpolyposis colon cancer. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:18572020</ref> The disease is caused by mutations affecting the gene represented in this entry. HNPCC8 results from heterozygous deletion of 3-prime exons of EPCAM and intergenic regions directly upstream of MSH2, resulting in transcriptional read-through and epigenetic silencing of MSH2 in tissues expressing EPCAM.<ref>PMID:19098912</ref>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Djinovic-Carugo, K.]]	+	[[Category: Djinovic-Carugo, K]]
-	[[Category: Guncar, G.]]	+	[[Category: Guncar, G]]
-	[[Category: Lenarcic, B.]]	+	[[Category: Lenarcic, B]]
-	[[Category: Pavsic, M.]]	+	[[Category: Pavsic, M]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Dimer]]		[[Category: Dimer]]
	[[Category: Ectodomain]]		[[Category: Ectodomain]]
	[[Category: Extracellular space]]		[[Category: Extracellular space]]

OCA at 07:09, 10 September 2014

2014-09-10T07:09:42Z

←Older revision		Revision as of 07:09, 10 September 2014
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/EPCAM_HUMAN EPCAM_HUMAN]] May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.<ref>PMID:15195135</ref> <ref>PMID:15922867</ref> <ref>PMID:20064925</ref> <ref>PMID:19785009</ref>		[[http://www.uniprot.org/uniprot/EPCAM_HUMAN EPCAM_HUMAN]] May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.<ref>PMID:15195135</ref> <ref>PMID:15922867</ref> <ref>PMID:20064925</ref> <ref>PMID:19785009</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	EpCAM (epithelial cell adhesion molecule), a stem and carcinoma cell marker, is a cell surface protein involved in homotypic cell-cell adhesion via intercellular oligomerization and proliferative signalling via proteolytic cleavage. Despite its use as a diagnostic marker and being a drug target, structural details of this conserved vertebrate-exclusive protein remain unknown. Here we present the crystal structure of a heart-shaped dimer of the extracellular part of human EpCAM. The structure represents a cis-dimer that would form at cell surfaces and may provide the necessary structural foundation for the proposed EpCAM intercellular trans-tetramerization mediated by a membrane-distal region. By combining biochemical, biological and structural data on EpCAM, we show how proteolytic processing at various sites could influence structural integrity, oligomeric state and associated functionality of the molecule. We also describe the epitopes of this therapeutically important protein and explain the antigenicity of its regions.
		+
		+	Crystal structure and its bearing towards an understanding of key biological functions of EpCAM.,Pavsic M, Guncar G, Djinovic-Carugo K, Lenarcic B Nat Commun. 2014 Aug 28;5:4764. doi: 10.1038/ncomms5764. PMID:25163760<ref>PMID:25163760</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:51, 27 August 2014

2014-08-27T08:51:44Z

←Older revision		Revision as of 08:51, 27 August 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of extracellular part of human EpCAM==
-		+	<StructureSection load='4mzv' size='340' side='right' caption='[[4mzv]], [[Resolution\|resolution]] 1.86Å' scene=''>
-	~~The entry~~ 4mzv is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4mzv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MZV FirstGlance]. <br>
-	~~Authors~~: ~~Pavsic~~, M., ~~Guncar~~, G., Djinovic-Carugo, K., Lenarcic, B.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	~~Description~~: ~~Crystal structure of extracellular part of human EpCAM~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mzv RCSB], [http://www.ebi.ac.uk/pdbsum/4mzv PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/EPCAM_HUMAN EPCAM_HUMAN]] Intestinal epithelial dysplasia;Hereditary nonpolyposis colon cancer. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:18572020</ref> The disease is caused by mutations affecting the gene represented in this entry. HNPCC8 results from heterozygous deletion of 3-prime exons of EPCAM and intergenic regions directly upstream of MSH2, resulting in transcriptional read-through and epigenetic silencing of MSH2 in tissues expressing EPCAM.<ref>PMID:19098912</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/EPCAM_HUMAN EPCAM_HUMAN]] May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.<ref>PMID:15195135</ref> <ref>PMID:15922867</ref> <ref>PMID:20064925</ref> <ref>PMID:19785009</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Djinovic-Carugo, K.]]
		+	[[Category: Guncar, G.]]
		+	[[Category: Lenarcic, B.]]
		+	[[Category: Pavsic, M.]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Dimer]]
		+	[[Category: Ectodomain]]
		+	[[Category: Extracellular space]]

OCA at 09:37, 16 July 2014

2014-07-16T09:37:34Z

←Older revision		Revision as of 09:37, 16 July 2014
Line 5:		Line 5:
	Authors: Pavsic, M., Guncar, G., Djinovic-Carugo, K., Lenarcic, B.		Authors: Pavsic, M., Guncar, G., Djinovic-Carugo, K., Lenarcic, B.

-	Description: Crystal structure of human EpCAM ~~ectodomain~~	+	Description: Crystal structure of extracellular part of human EpCAM

OCA at 07:04, 14 May 2014

2014-05-14T07:04:28Z

←Older revision		Revision as of 07:04, 14 May 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4mzv is ON HOLD	+	The entry 4mzv is ON HOLD until Paper Publication

	Authors: Pavsic, M., Guncar, G., Djinovic-Carugo, K., Lenarcic, B.		Authors: Pavsic, M., Guncar, G., Djinovic-Carugo, K., Lenarcic, B.

	Description: Crystal structure of human EpCAM ectodomain		Description: Crystal structure of human EpCAM ectodomain

OCA: Protected "4mzv" [edit=sysop:move=sysop]

2013-10-10T05:52:07Z

Protected "4mzv" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:52, 10 October 2013

OCA: New page: '''Unreleased structure''' The entry 4mzv is ON HOLD Authors: Pavsic, M., Guncar, G., Djinovic-Carugo, K., Lenarcic, B. Description: Crystal structure of human EpCAM ectodomain

2013-10-10T05:52:06Z

New page: '''Unreleased structure''' The entry 4mzv is ON HOLD Authors: Pavsic, M., Guncar, G., Djinovic-Carugo, K., Lenarcic, B. Description: Crystal structure of human EpCAM ectodomain

New page

'''Unreleased structure'''

The entry 4mzv is ON HOLD

Authors: Pavsic, M., Guncar, G., Djinovic-Carugo, K., Lenarcic, B.

Description: Crystal structure of human EpCAM ectodomain