4n6i - Revision history

OCA: Redirecting to 4xyn

2015-05-13T12:09:34Z

Redirecting to 4xyn

←Older revision		Revision as of 12:09, 13 May 2015
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-	~~==X-ray structure of human W61 peptide-Ca(2+)-S100B==~~	+	#REDIRECT [[4xyn]] This PDB entry is obsolete and replaced by 4xyn
-	~~<StructureSection load='4n6i' size='340' side='right' caption='~~[[~~4n6i]], [[Resolution\|resolution]] 2.55Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	~~<table><tr><td colspan='2'>[[4n6i~~]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N6I FirstGlance]. <br>	+
-	~~</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>~~	+
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nde\|4nde]]</td></tr>~~	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n6i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n6i RCSB], [http://www.ebi.ac.uk/pdbsum/4n6i PDBsum]</span></td></tr>	+
-	~~</table>~~	+
-	~~== Function ==~~	+
-	[[http://www.uniprot.org/uniprot/RAGE_HUMAN RAGE_HUMAN]] Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.<ref>PMID:19906677</ref> [[http://www.uniprot.org/uniprot/S100B_HUMAN S100B_HUMAN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization.<ref>PMID:20351179</ref>	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Colbert, C L]]~~	+
-	~~[[Category: Jensen, J L]]~~	+
-	~~[[Category: Ca-binding protein]]~~	+
-	~~[[Category: Ef-hand]]~~	+
-	~~[[Category: Membrane protein-metal binding protein complex]]~~	+
-	~~[[Category: Rage-derived peptide]]~~	+

OCA at 20:53, 25 December 2014

2014-12-25T20:53:44Z

←Older revision		Revision as of 20:53, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n6i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n6i RCSB], [http://www.ebi.ac.uk/pdbsum/4n6i PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n6i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n6i RCSB], [http://www.ebi.ac.uk/pdbsum/4n6i PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RAGE_HUMAN RAGE_HUMAN]] Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.<ref>PMID:19906677</ref> [[http://www.uniprot.org/uniprot/S100B_HUMAN S100B_HUMAN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization.<ref>PMID:20351179</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:20, 10 December 2014

2014-12-10T16:20:25Z

←Older revision		Revision as of 16:20, 10 December 2014
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-	'''~~Unreleased structure~~'''	+	==X-ray structure of human W61 peptide-Ca(2+)-S100B==
-		+	<StructureSection load='4n6i' size='340' side='right' caption='[[4n6i]], [[Resolution\|resolution]] 2.55Å' scene=''>
-	~~The entry~~ 4n6i is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4n6i]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N6I FirstGlance]. <br>
-	~~Authors~~: ~~Jensen~~, J.L., Colbert, C.L.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nde\|4nde]]</td></tr>
-	~~Description~~: X-~~ray structure of human W61 peptide~~-~~Ca(2+)~~-~~S100B~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n6i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n6i RCSB], [http://www.ebi.ac.uk/pdbsum/4n6i PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Colbert, C L]]
		+	[[Category: Jensen, J L]]
		+	[[Category: Ca-binding protein]]
		+	[[Category: Ef-hand]]
		+	[[Category: Membrane protein-metal binding protein complex]]
		+	[[Category: Rage-derived peptide]]

OCA at 09:13, 18 December 2013

2013-12-18T09:13:03Z

←Older revision		Revision as of 09:13, 18 December 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4n6i is ON HOLD	+	The entry 4n6i is ON HOLD until Paper Publication

	Authors: Jensen, J.L., Colbert, C.L.		Authors: Jensen, J.L., Colbert, C.L.

	Description: X-ray structure of human W61 peptide-Ca(2+)-S100B		Description: X-ray structure of human W61 peptide-Ca(2+)-S100B

OCA at 06:47, 4 December 2013

2013-12-04T06:47:13Z

←Older revision		Revision as of 06:47, 4 December 2013
Line 5:		Line 5:
	Authors: Jensen, J.L., Colbert, C.L.		Authors: Jensen, J.L., Colbert, C.L.

-	Description: X-ray structure of human ~~W41~~ peptide-Ca(2+)-S100B	+	Description: X-ray structure of human W61 peptide-Ca(2+)-S100B

OCA at 09:45, 27 November 2013

2013-11-27T09:45:17Z

←Older revision		Revision as of 09:45, 27 November 2013
Line 3:		Line 3:
	The entry 4n6i is ON HOLD		The entry 4n6i is ON HOLD

-	Authors: Jensen, J. L. , Colbert, C. L.	+	Authors: Jensen, J.L., Colbert, C.L.

	Description: X-ray structure of human W41 peptide-Ca(2+)-S100B		Description: X-ray structure of human W41 peptide-Ca(2+)-S100B

OCA: Protected "4n6i" [edit=sysop:move=sysop]

2013-10-23T06:15:56Z

Protected "4n6i" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:15, 23 October 2013

OCA: New page: '''Unreleased structure''' The entry 4n6i is ON HOLD Authors: Jensen, J. L. , Colbert, C. L. Description: X-ray structure of human W41 peptide-Ca(2+)-S100B

2013-10-23T06:15:55Z

New page: '''Unreleased structure''' The entry 4n6i is ON HOLD Authors: Jensen, J. L. , Colbert, C. L. Description: X-ray structure of human W41 peptide-Ca(2+)-S100B

New page

'''Unreleased structure'''

The entry 4n6i is ON HOLD

Authors: Jensen, J. L. , Colbert, C. L.

Description: X-ray structure of human W41 peptide-Ca(2+)-S100B