4n81 - Revision history

OCA at 08:56, 20 March 2024

2024-03-20T08:56:44Z

←Older revision		Revision as of 08:56, 20 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4n81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_ZM4_=_ATCC_31821 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N81 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4n81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_ZM4_=_ATCC_31821 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N81 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.901Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n81 OCA], [https://pdbe.org/4n81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n81 RCSB], [https://www.ebi.ac.uk/pdbsum/4n81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n81 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n81 OCA], [https://pdbe.org/4n81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n81 RCSB], [https://www.ebi.ac.uk/pdbsum/4n81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n81 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q5NMB8_ZYMMO Q5NMB8_ZYMMO]		[https://www.uniprot.org/uniprot/Q5NMB8_ZYMMO Q5NMB8_ZYMMO]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	A phosphate group at the C1-atom of inositol-monophosphate (IMP) and fructose-1,6-bisphosphate (FBP) is hydrolyzed by a phosphatase IMPase and FBPase in a metal-dependent way, respectively. The two enzymes are almost indiscernible from each other because of their highly similar sequences and structures. Metal ions are bound to residues on the beta1- and beta2-strands and one mobile loop. However, FBP has another phosphate and FBPases exist as a higher oligomeric state, which may discriminate FBPases from IMPases. There are three genes annotated as FBPases in Zymomonas mobilis, termed also cbbF (ZmcbbF). The revealed crystal structure of one ZmcbbF shows a globular structure formed by five stacked layers. Twenty-five residues in the middle of the sequence form an alpha-helix and a beta-strand, which occupy one side of the catalytic site. A non-polar Leu residue among them is protruded to the active site, pointing out unfavorable access of a bulky charged group to this side. In vitro assays have shown its dimeric form in solution. Interestingly, two beta-strands of beta1 and beta2 are disordered in the ZmcbbF structure. These data indicate that ZmcbbF might structurally belong to IMPase, and imply that its active site would be reorganized in a yet unreported way.
-
-	Crystal structure of cbbF from Zymomonas mobilis and its functional implication.,Hwang HJ, Park SY, Kim JS Biochem Biophys Res Commun. 2014 Feb 28;445(1):78-83. doi:, 10.1016/j.bbrc.2014.01.152. Epub 2014 Jan 31. PMID:24491569<ref>PMID:24491569</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4n81" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Inositol monophosphatase 3D structures\|Inositol monophosphatase 3D structures]]		*[[Inositol monophosphatase 3D structures\|Inositol monophosphatase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:14, 11 January 2023

2023-01-11T08:14:00Z

←Older revision		Revision as of 08:14, 11 January 2023
Line 3:		Line 3:
	<StructureSection load='4n81' size='340' side='right'caption='[[4n81]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4n81' size='340' side='right'caption='[[4n81]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4n81]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Zymmo Zymmo~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N81 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4N81 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4n81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_ZM4_=_ATCC_31821 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N81 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n89\|4n89]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n81 OCA], [https://pdbe.org/4n81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n81 RCSB], [https://www.ebi.ac.uk/pdbsum/4n81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n81 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZMO1518 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264203 ZYMMO])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n81 OCA], [~~http~~://pdbe.org/4n81 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4n81 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4n81 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4n81 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5NMB8_ZYMMO Q5NMB8_ZYMMO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[Inositol ~~Monophosphatase~~\|Inositol ~~Monophosphatase~~]]	+	*[[Inositol monophosphatase 3D structures\|Inositol monophosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Inositol-phosphate phosphatase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Zymmo~~]]	+	[[Category: Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]]
-	[[Category: Hwang~~, H J~~]]	+	[[Category: Hwang HJ]]
-	[[Category: Kim~~, J S~~]]	+	[[Category: Kim JS]]
-	[[Category: Park~~, S Y]]~~	+	[[Category: Park SY]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 08:40, 10 April 2019

2019-04-10T08:40:50Z

←Older revision		Revision as of 08:40, 10 April 2019
Line 1:		Line 1:

	==Another flexible region at the active site of an inositol monophosphatase from Zymomonas mobilis==		==Another flexible region at the active site of an inositol monophosphatase from Zymomonas mobilis==
-	<StructureSection load='4n81' size='340' side='right' caption='[[4n81]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4n81' size='340' side='right'caption='[[4n81]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4n81]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N81 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4n81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zymmo Zymmo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N81 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n89\|4n89]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n89\|4n89]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZMO1518 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264203 ZYMMO])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n81 OCA], [http://pdbe.org/4n81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n81 RCSB], [http://www.ebi.ac.uk/pdbsum/4n81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n81 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n81 OCA], [http://pdbe.org/4n81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n81 RCSB], [http://www.ebi.ac.uk/pdbsum/4n81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n81 ProSAT]</span></td></tr>
Line 26:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Inositol-phosphate phosphatase]]		[[Category: Inositol-phosphate phosphatase]]
		+	[[Category: Large Structures]]
		+	[[Category: Zymmo]]
	[[Category: Hwang, H J]]		[[Category: Hwang, H J]]
	[[Category: Kim, J S]]		[[Category: Kim, J S]]
	[[Category: Park, S Y]]		[[Category: Park, S Y]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 07:42, 11 August 2016

2016-08-11T07:42:31Z

←Older revision		Revision as of 07:42, 11 August 2016
Line 1:		Line 1:
		+
	==Another flexible region at the active site of an inositol monophosphatase from Zymomonas mobilis==		==Another flexible region at the active site of an inositol monophosphatase from Zymomonas mobilis==
	<StructureSection load='4n81' size='340' side='right' caption='[[4n81]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4n81' size='340' side='right' caption='[[4n81]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n89\|4n89]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n89\|4n89]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n81 RCSB], [http://www.ebi.ac.uk/pdbsum/4n81 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n81 OCA], [http://pdbe.org/4n81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n81 RCSB], [http://www.ebi.ac.uk/pdbsum/4n81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n81 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4n81" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Inositol Monophosphatase\|Inositol Monophosphatase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:16, 20 January 2015

2015-01-20T08:16:34Z

←Older revision		Revision as of 08:16, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4n81]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N81 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4n81]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N81 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n89\|4n89]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n89\|4n89]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n81 RCSB], [http://www.ebi.ac.uk/pdbsum/4n81 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n81 RCSB], [http://www.ebi.ac.uk/pdbsum/4n81 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Inositol-phosphate phosphatase]]		[[Category: Inositol-phosphate phosphatase]]
-	[[Category: Hwang, H J.]]	+	[[Category: Hwang, H J]]
-	[[Category: Kim, J S.]]	+	[[Category: Kim, J S]]
-	[[Category: Park, S Y.]]	+	[[Category: Park, S Y]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 00:11, 2 October 2014

2014-10-02T00:11:23Z

←Older revision		Revision as of 00:11, 2 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Another flexible region at the active site of an inositol monophosphatase from Zymomonas mobilis==
		+	<StructureSection load='4n81' size='340' side='right' caption='[[4n81]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4n81]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N81 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n89\|4n89]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n81 RCSB], [http://www.ebi.ac.uk/pdbsum/4n81 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A phosphate group at the C1-atom of inositol-monophosphate (IMP) and fructose-1,6-bisphosphate (FBP) is hydrolyzed by a phosphatase IMPase and FBPase in a metal-dependent way, respectively. The two enzymes are almost indiscernible from each other because of their highly similar sequences and structures. Metal ions are bound to residues on the beta1- and beta2-strands and one mobile loop. However, FBP has another phosphate and FBPases exist as a higher oligomeric state, which may discriminate FBPases from IMPases. There are three genes annotated as FBPases in Zymomonas mobilis, termed also cbbF (ZmcbbF). The revealed crystal structure of one ZmcbbF shows a globular structure formed by five stacked layers. Twenty-five residues in the middle of the sequence form an alpha-helix and a beta-strand, which occupy one side of the catalytic site. A non-polar Leu residue among them is protruded to the active site, pointing out unfavorable access of a bulky charged group to this side. In vitro assays have shown its dimeric form in solution. Interestingly, two beta-strands of beta1 and beta2 are disordered in the ZmcbbF structure. These data indicate that ZmcbbF might structurally belong to IMPase, and imply that its active site would be reorganized in a yet unreported way.

-	~~The entry 4n81 is ON HOLD until Paper Publication~~	+	Crystal structure of cbbF from Zymomonas mobilis and its functional implication.,Hwang HJ, Park SY, Kim JS Biochem Biophys Res Commun. 2014 Feb 28;445(1):78-83. doi:, 10.1016/j.bbrc.2014.01.152. Epub 2014 Jan 31. PMID:24491569<ref>PMID:24491569</ref>

-	~~Authors~~: Hwang, H.J., Park, S.Y.~~, Kim, J.S.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Another flexible region at the active site of an inositol monophosphatase from Zymomonas mobilis~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Inositol-phosphate phosphatase]]
		+	[[Category: Hwang, H J.]]
		+	[[Category: Kim, J S.]]
		+	[[Category: Park, S Y.]]
		+	[[Category: Hydrolase]]

OCA at 07:41, 13 November 2013

2013-11-13T07:41:04Z

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-	The entry 4n81 is ON HOLD	+	The entry 4n81 is ON HOLD until Paper Publication

	Authors: Hwang, H.J., Park, S.Y., Kim, J.S.		Authors: Hwang, H.J., Park, S.Y., Kim, J.S.

	Description: Another flexible region at the active site of an inositol monophosphatase from Zymomonas mobilis		Description: Another flexible region at the active site of an inositol monophosphatase from Zymomonas mobilis

OCA: Protected "4n81" [edit=sysop:move=sysop]

2013-10-23T06:17:58Z

Protected "4n81" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:17, 23 October 2013

OCA: New page: '''Unreleased structure''' The entry 4n81 is ON HOLD Authors: Hwang, H.J., Park, S.Y., Kim, J.S. Description: Another flexible region at the active site of an inositol monophosphatase ...

2013-10-23T06:17:57Z

New page: '''Unreleased structure''' The entry 4n81 is ON HOLD Authors: Hwang, H.J., Park, S.Y., Kim, J.S. Description: Another flexible region at the active site of an inositol monophosphatase ...

New page

'''Unreleased structure'''

The entry 4n81 is ON HOLD

Authors: Hwang, H.J., Park, S.Y., Kim, J.S.

Description: Another flexible region at the active site of an inositol monophosphatase from Zymomonas mobilis